de Oliveira_2014_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_162_77

Reference

Title : Transient modulation of acetylcholinesterase activity caused by exposure to dextran-coated iron oxide nanoparticles in brain of adult zebrafish - de Oliveira_2014_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_162_77
Author(s) : de Oliveira GM , Kist LW , Pereira TC , Bortolotto JW , Paquete FL , de Oliveira EM , Leite CE , Bonan CD , de Souza Basso NR , Papaleo RM , Bogo MR
Ref : Comparative Biochemistry & Physiology C Pharmacol Toxicol , 162 :77 , 2014
Abstract :

Superparamagnetic iron oxide nanoparticles (SPIONs) are of great interest in nanomedicine due to their capability to act simultaneously as a contrast agent and as a targeted drug delivery system. At present, one of the biggest concerns about the use of SPIONs remains around its toxicity and, for this reason, it is important to establish the safe upper limit for each use. In the present study, SPION coated with cross-linked aminated dextran (CLIO-NH(2)) were synthesized and their toxicity to zebrafish brain was investigated. We have evaluated the effect of different CLIO-NH(2) doses (20, 50, 100, 140 and 200 mg/kg) as a function of time after exposure (one, 16, 24 and 48 h) on AChE activity and ache expression in zebrafish brain. The animals exposed to 200 mg/kg and tested 24 h after administration of the nanoparticles have shown decreased AChE activity, reduction in the exploratory performance, significantly higher level of ferric iron in the brains and induction of casp8, casp 9 and jun genes. Taken together, these findings suggest acute brain toxicity by the inhibition of acetylcholinesterase and induction of apoptosis.

PubMedSearch : de Oliveira_2014_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_162_77
PubMedID: 24704546
Gene_locus related to this paper: danre-ACHE

Related information

Gene_locus danre-ACHE

Citations formats

de Oliveira GM, Kist LW, Pereira TC, Bortolotto JW, Paquete FL, de Oliveira EM, Leite CE, Bonan CD, de Souza Basso NR, Papaleo RM, Bogo MR (2014)
Transient modulation of acetylcholinesterase activity caused by exposure to dextran-coated iron oxide nanoparticles in brain of adult zebrafish
Comparative Biochemistry & Physiology C Pharmacol Toxicol 162 :77

de Oliveira GM, Kist LW, Pereira TC, Bortolotto JW, Paquete FL, de Oliveira EM, Leite CE, Bonan CD, de Souza Basso NR, Papaleo RM, Bogo MR (2014)
Comparative Biochemistry & Physiology C Pharmacol Toxicol 162 :77