| Title : Buchwald-Hartwig Amination Approach for the Synthesis of Functionalized 1,2,3,4-Tetrahydroacridine Derivatives - de Sousa_2014_European.J.Org.Chem_2014_3468 |
| Author(s) : de Sousa J , Brown RCD , Baati R |
| Ref : European J Org Chem , 2014 :3468 , 2014 |
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Abstract :
Electrophilic 1,2,3,4-tetrahydroacridin-9-yl trifluoromethanesulfonates have been prepared and applied for the first time in the synthesis of functionalized tacrines with high efficacy by using the Buchwald-Hartwig amination reaction. Remarkably, secondary, poor nucleophilic, and functionalized amines also reacted efficiently by using our conditions. The versatility and convenience of these highly reactive derivatives is illustrated through their application in other valuable C-C (Sonogashira, Suzuki, and cyanation cross-coupling), C-S, and C-O bond-forming reactions under palladium catalysis. |
| PubMedSearch : de Sousa_2014_European.J.Org.Chem_2014_3468 |
| PubMedID: |
de Sousa J, Brown RCD, Baati R (2014)
Buchwald-Hartwig Amination Approach for the Synthesis of Functionalized 1,2,3,4-Tetrahydroacridine Derivatives
European J Org Chem
2014 :3468
de Sousa J, Brown RCD, Baati R (2014)
European J Org Chem
2014 :3468