Title : Neuroprotection elicited by resveratrol in a rat model of hypothyroidism: possible involvement of cholinergic signaling and redox status - de Souza Cardoso_2021_Mol.Cell.Endocrinol__111157 |
Author(s) : de Souza Cardoso J , Baldissarelli J , Reichert KP , Teixeira F , Pereira Soares MS , Chitolina Schetinger MR , Morsch VM , Farias Martins Filho AO , Duarte Junior HR , Ribeiro Coriolano FH , Spanevello RM , Stefanello FM , Tavares RG |
Ref : Mol Cell Endocrinol , :111157 , 2021 |
Abstract :
Both the cholinergic pathway and oxidative stress are important mechanisms involved in the pathogenesis of hypothyroidism, a condition characterized by low levels of thyroid hormone that predispose the patient to brains dysfunction. Phenolic compounds have numerous health benefits, including antioxidant activity. This study evaluates the preventive effects of resveratrol in the cholinergic system and redox status in rats with methimazole-induced hypothyroidism. Hypothyroidism increases acetylcholinesterase (AChE) activity and density in the cerebral cortex and hippocampus and decreases the alpha7 and M1 receptor densities in the hippocampus. Hypothyroidism also increases cellular levels of reactive oxygen species (ROS) and thiobarbituric acid reactive substances (TBARS), but reduces total thiol content, and catalase and superoxide dismutase activities in the serum. In the cerebral cortex and hippocampus, hypothyroidism increases the levels of ROS and nitrites. In this study, resveratrol (50 mg/kg) treatment prevented the observed increase in AChE in the cerebral cortex, and increased the protein levels of NeuN, a marker of mature neurons. Resveratrol also prevented changes in serum ROS levels and brain structure, as well as the levels of TBARS, total thiol content, and serum catalase enzyme activity. These collective findings suggest that resveratrol has a high antioxidant capacity and can restore hypothyroidism-triggered alterations related to neurotransmission. Thus, it is a promising agent for the prevention of brain damage resulting from hypothyroidism. |
PubMedSearch : de Souza Cardoso_2021_Mol.Cell.Endocrinol__111157 |
PubMedID: 33421531 |
de Souza Cardoso J, Baldissarelli J, Reichert KP, Teixeira F, Pereira Soares MS, Chitolina Schetinger MR, Morsch VM, Farias Martins Filho AO, Duarte Junior HR, Ribeiro Coriolano FH, Spanevello RM, Stefanello FM, Tavares RG (2021)
Neuroprotection elicited by resveratrol in a rat model of hypothyroidism: possible involvement of cholinergic signaling and redox status
Mol Cell Endocrinol
:111157
de Souza Cardoso J, Baldissarelli J, Reichert KP, Teixeira F, Pereira Soares MS, Chitolina Schetinger MR, Morsch VM, Farias Martins Filho AO, Duarte Junior HR, Ribeiro Coriolano FH, Spanevello RM, Stefanello FM, Tavares RG (2021)
Mol Cell Endocrinol
:111157