| Title : Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones - dos Santos Pisoni_2010_Eur.J.Med.Chem_45_526 |
| Author(s) : dos Santos Pisoni D , Sobieski da Costa J , Gamba D , Petzhold CL , de Amorim Borges AC , Ceschi MA , Lunardi P , Saraiva Goncalves CA |
| Ref : Eur Journal of Medicinal Chemistry , 45 :526 , 2010 |
|
Abstract :
This work describes the enantioselective synthesis of a new series of terpenic chiral 9-aminotetrahydroacridine analogues. Several chiral ketones were synthesized from natural monoterpenes in an optically active form and subjected to the cyclodehydration reactions with anthranilonitrile in the presence of BF(3).Et(2)O as catalyst. The 9-aminotetrahydroacridine analogues were tested as acetylcholinesterase (AChE) inhibitors. Based on qualitative structure-activity relationship some trends are suggested. |
| PubMedSearch : dos Santos Pisoni_2010_Eur.J.Med.Chem_45_526 |
| PubMedID: 19954865 |
dos Santos Pisoni D, Sobieski da Costa J, Gamba D, Petzhold CL, de Amorim Borges AC, Ceschi MA, Lunardi P, Saraiva Goncalves CA (2010)
Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones
Eur Journal of Medicinal Chemistry
45 :526
dos Santos Pisoni D, Sobieski da Costa J, Gamba D, Petzhold CL, de Amorim Borges AC, Ceschi MA, Lunardi P, Saraiva Goncalves CA (2010)
Eur Journal of Medicinal Chemistry
45 :526