| Title : Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis - van Es_2008_Nat.Genet_40_29 |
| Author(s) : van Es MA , van Vught PW , Blauw HM , Franke L , Saris CG , Van den Bosch L , de Jong SW , de Jong V , Baas F , van't Slot R , Lemmens R , Schelhaas HJ , Birve A , Sleegers K , Van Broeckhoven C , Schymick JC , Traynor BJ , Wokke JH , Wijmenga C , Robberecht W , Andersen PM , Veldink JH , Ophoff RA , van den Berg LH |
| Ref : Nat Genet , 40 :29 , 2008 |
|
Abstract :
We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies. |
| PubMedSearch : van Es_2008_Nat.Genet_40_29 |
| PubMedID: 18084291 |
van Es MA, van Vught PW, Blauw HM, Franke L, Saris CG, Van den Bosch L, de Jong SW, de Jong V, Baas F, van't Slot R, Lemmens R, Schelhaas HJ, Birve A, Sleegers K, Van Broeckhoven C, Schymick JC, Traynor BJ, Wokke JH, Wijmenga C, Robberecht W, Andersen PM, Veldink JH, Ophoff RA, van den Berg LH (2008)
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
Nat Genet
40 :29
van Es MA, van Vught PW, Blauw HM, Franke L, Saris CG, Van den Bosch L, de Jong SW, de Jong V, Baas F, van't Slot R, Lemmens R, Schelhaas HJ, Birve A, Sleegers K, Van Broeckhoven C, Schymick JC, Traynor BJ, Wokke JH, Wijmenga C, Robberecht W, Andersen PM, Veldink JH, Ophoff RA, van den Berg LH (2008)
Nat Genet
40 :29