von Schwarzenfeld_1975_Acta.Biol.Med.Ger_34_1525

Centrally acting cholinomimetic drugs like arecoline stimulate active ion transport processes in the synaptic region. Regarding the connection between cellular metabolism and active Na"-K+-transport the effect of arecoline on the cerebral metabolic status was proved. Arecoline decreased the level of high energic phosphates and glycogen (energy charge diminished from 0,57 to 0,48) and increased the glucose consumption and lactate production. Thus, the increased rate of CoA acetylation via oxidative breakdown of pyruvate seems to be prerequisite for the cholinergically stimulated ACh synthesis.