| Title : The design and synthesis of novel inhibitors of NADH:ubiquinone oxidoreductase - Lindell_2004_Bioorg.Med.Chem.Lett_14_511 |
| Author(s) : Lindell SD , Ort O , Lummen P , Klein R |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :511 , 2004 |
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Abstract :
Potent new inhibitors of NADH:ubiquinone oxidoreductase (complex I) have been designed, with the help of molecular modelling, by hybridisation of known complex I inhibitors with inhibitors of cytochrome c oxidoreductase. The most interesting compound was the chromone 7 which was a selective inhibitor of complex I (IC(50) 15 nM) and showed acaricidal activity against spider mites. |
| PubMedSearch : Lindell_2004_Bioorg.Med.Chem.Lett_14_511 |
| PubMedID: 14698192 |
Lindell SD, Ort O, Lummen P, Klein R (2004)
The design and synthesis of novel inhibitors of NADH:ubiquinone oxidoreductase
Bioorganic & Medicinal Chemistry Lett
14 :511
Lindell SD, Ort O, Lummen P, Klein R (2004)
Bioorganic & Medicinal Chemistry Lett
14 :511