| Title : A Galantamine-Curcumin Hybrid Decreases the Cytotoxicity of Amyloid-Beta Peptide on SH-SY5Y Cells - Mladenova_2021_Int.J.Mol.Sci_22_ |
| Author(s) : Mladenova K , Stavrakov G , Philipova I , Atanasova M , Petrova S , Doumanov J , Doytchinova I |
| Ref : Int J Mol Sci , 22 : , 2021 |
| Abstract : Misfolded amyloid beta (Abeta) peptides aggregate and form neurotoxic oligomers. Membrane and mitochondrial damages, calcium dysregulation, oxidative stress, and fibril deposits are among the possible mechanisms of Abeta cytotoxicity. Galantamine (GAL) prevents apoptosis induced by Abeta mainly through the ability to stimulate allosterically the alpha7 nAChRs and to regulate the calcium cytosolic concentration. Here, we examined the cytoprotective effects of two GAL derivatives, namely compounds 4b and 8, against Abeta cytotoxicity on the human neuroblastoma cell line SH-SY5Y. The protective effects were tested at simultaneous administration, pre-incubation and post-incubation, with Abeta. GAL and curcumin (CU) were used in the study as reference compounds. It was found that 4b protects cells in a similar mode as GAL, while compound 8 and CU potentiate the toxic effects of Abeta. Allosteric stimulation of alpha7 nAChRs is suggested as a possible mechanism of the cytoprotectivity of 4b. These and previous findings characterize 4b as a prospective non-toxic multi-target agent against neurodegenerative disorders with inhibitory activity on acetylcholinesterase, antioxidant, and cytoprotective properties. |
| ESTHER : Mladenova_2021_Int.J.Mol.Sci_22_ |
| PubMedSearch : Mladenova_2021_Int.J.Mol.Sci_22_ |
| PubMedID: 34299209 |
Mladenova K, Stavrakov G, Philipova I, Atanasova M, Petrova S, Doumanov J, Doytchinova I (2021)
A Galantamine-Curcumin Hybrid Decreases the Cytotoxicity of Amyloid-Beta Peptide on SH-SY5Y Cells
Int J Mol Sci
22 :
Mladenova K, Stavrakov G, Philipova I, Atanasova M, Petrova S, Doumanov J, Doytchinova I (2021)
Int J Mol Sci
22 :