| Title : Synthesis of hydroxymethylglutathione from glutathione and L-serine catalyzed by carboxypeptidase Y - Okumura_2003_Biosci.Biotechnol.Biochem_67_434 |
| Author(s) : Okumura R , Koizumi Y , Sekiya J |
| Ref : Biosci Biotechnol Biochem , 67 :434 , 2003 |
| Abstract : Hydroxymethylglutathione (gamma-L-glutamyl-L-cysteinyl-L-serine; hmGSH) occurs in many species belonging to the family Gramineae, but the biosynthetic pathway for hmGSH has not been identified. We found that carboxypeptidase Y (CPY), but not carboxypeptidase A, catalyzed hmGSH synthesis from glutathione and L-serine in vitro at acidic pH. CPY also catalyzed methylglutathione synthesis from glutathione and L-alanine. These findings suggested that a carboxypeptidase-like enzyme may be involved in hmGSH synthesis in vivo. |
| ESTHER : Okumura_2003_Biosci.Biotechnol.Biochem_67_434 |
| PubMedSearch : Okumura_2003_Biosci.Biotechnol.Biochem_67_434 |
| PubMedID: 12729016 |
Okumura R, Koizumi Y, Sekiya J (2003)
Synthesis of hydroxymethylglutathione from glutathione and L-serine catalyzed by carboxypeptidase Y
Biosci Biotechnol Biochem
67 :434
Okumura R, Koizumi Y, Sekiya J (2003)
Biosci Biotechnol Biochem
67 :434