| Title : Effects of sage extract on memory performance in mice and acetylcholinesterase activity - Smach_2015_Ann.Pharm.Fr_73_281 |
| Author(s) : Smach MA , Hafsa J , Charfeddine B , Dridi H , Limem K |
| Ref : Ann Pharm Fr , 73 :281 , 2015 |
| Abstract : INTRODUCTION: Salvia officinalis L. (sage) has been widely used in the Tunisian traditional medicine for the treatment of digestive system and memory disorders. OBJECTIVES: This work aims to investigate the anti-amnesiac and antioxidant activity of aqueous extract of S. officinalis (ASOE) in mice. MATERIALS AND METHODS: Evaluation of memory functions in rodents was assessed by Y-maze active test after an initial acquisition phase. RESULTS: Results showed that the S. officinalis aqueous extract had high total phenolic contents (6.2mg gallic E/g extract) and flavonoids (2.44mg catechin E/g extract). It exhibited an interesting scavenging activity (IC50=14.5mug/ml). The mice treated with 300mg/kg body weight for 7 days exhibited a significant decrease in avoidance and discrimination errors during a retention trial compared to control group (P<0.05). Acetylcholinesterase (AChE) activity significantly decreased in mice treated with the extract of sage. CONCLUSION: These findings suggested that aqueous extract of sage leaves possess a mnemonic effect on adult male mice, confirming their use in traditional medicine. |
| ESTHER : Smach_2015_Ann.Pharm.Fr_73_281 |
| PubMedSearch : Smach_2015_Ann.Pharm.Fr_73_281 |
| PubMedID: 25934446 |
Smach MA, Hafsa J, Charfeddine B, Dridi H, Limem K (2015)
Effects of sage extract on memory performance in mice and acetylcholinesterase activity
Ann Pharm Fr
73 :281
Smach MA, Hafsa J, Charfeddine B, Dridi H, Limem K (2015)
Ann Pharm Fr
73 :281