Title : Three-dimensional structures of enzymes useful for beta-lactam antibiotic production - Barends_2004_Curr.Opin.Biotechnol_15_356 |
Author(s) : Barends TR , Yoshida H , Dijkstra BW |
Ref : Curr Opin Biotechnol , 15 :356 , 2004 |
Abstract :
Significant advances have been made in the structure-based engineering of enzymes useful for beta-lactam antibiotic production. Structure-based engineering of penicillin G acylase and cephalosporin acylase has resulted in improved enzymes for use in enzymatic production processes. The structures of many other enzymes that could be used in the production of beta-lactam antibiotics, such as enzymes from the beta-lactam biosynthetic pathway and beta-lactam antibiotic-converting enzymes, have been determined. The interest in these structures suggests that the future may see an even more extensive use of rationally engineered biocatalysts in antibiotic production than today. |
PubMedSearch : Barends_2004_Curr.Opin.Biotechnol_15_356 |
PubMedID: 15358004 |
Barends TR, Yoshida H, Dijkstra BW (2004)
Three-dimensional structures of enzymes useful for beta-lactam antibiotic production
Curr Opin Biotechnol
15 :356
Barends TR, Yoshida H, Dijkstra BW (2004)
Curr Opin Biotechnol
15 :356