Title : Enzyme-responsive sulfatocyclodextrin\/prodrug supramolecular assembly for controlled release of anti-cancer drug chlorambucil - Guan_2019_Chem.Commun.(Camb)_55_953 |
Author(s) : Guan X , Chen Y , Wu X , Li P , Liu Y |
Ref : Chem Commun (Camb) , 55 :953 , 2019 |
Abstract :
Supramolecular drug delivery systems are becoming an increasingly important part in controlled drug release. In this work, we report a novel enzyme-responsive supramolecular assembly directly constructed using biocompatible sulfato-beta-cyclodextrin (SCD) and an anti-cancer prodrug, i.e. choline modified anti-cancer drug chlorambucil (QA-Cbl). The supramolecular assembly acts as an effective drug delivery system via the controlled drug loading and enzyme-responsive drug release, because the butyrylcholinesterase (BChE) can cleave the ester bond of QA-Cbl prodrug, resulting in the release of anti-cancer drug chlorambucil (Cbl). Compared to other sophisticated drug delivery systems, the present system provides a feasible and functional approach for achievement of controlled drug release. |
PubMedSearch : Guan_2019_Chem.Commun.(Camb)_55_953 |
PubMedID: 30604783 |
Substrate | QA-Cbl |
Guan X, Chen Y, Wu X, Li P, Liu Y (2019)
Enzyme-responsive sulfatocyclodextrin\/prodrug supramolecular assembly for controlled release of anti-cancer drug chlorambucil
Chem Commun (Camb)
55 :953
Guan X, Chen Y, Wu X, Li P, Liu Y (2019)
Chem Commun (Camb)
55 :953