| Title : Synthesis and biological activity of (+\/-)-7,3',4'-trihydroxyhomoisoflavan and its analogs - Noshita_2020_Bioorg.Med.Chem.Lett__127674 |
| Author(s) : Noshita T , Fujita K , Koga T , Ouchi H , Tai A |
| Ref : Bioorganic & Medicinal Chemistry Lett , :127674 , 2020 |
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Abstract :
Acetylcholinesterase (AChE) inhibitors and neurite outgrowth promoters are thought to alleviate the symptoms of degenerative brain disorders, such as Alzheimer's disease. We designed and synthesized a series of homoisoflavonoids based on the structure of natural homoisoflavan isolated from Dracaena cambodiana dragon's blood. The homoisoflavonoids were then evaluated as AChE inhibitors and neurite outgrowth promoters. The catechol structure of the homoisoflavan B rings was important for AChE inhibition, and some of the homoisoflavonoids significantly promoted neurite outgrowth induced by nerve growth factor (NGF). |
| PubMedSearch : Noshita_2020_Bioorg.Med.Chem.Lett__127674 |
| PubMedID: 33161123 |
Noshita T, Fujita K, Koga T, Ouchi H, Tai A (2020)
Synthesis and biological activity of (+\/-)-7,3',4'-trihydroxyhomoisoflavan and its analogs
Bioorganic & Medicinal Chemistry Lett
:127674
Noshita T, Fujita K, Koga T, Ouchi H, Tai A (2020)
Bioorganic & Medicinal Chemistry Lett
:127674