| Title : Synthesis of a new class of camptothecin derivatives, the long-chain fatty acid esters of 10-hydroxycamptothecin, as a potent prodrug candidate, and their in vitro metabolic conversion by carboxylesterases - Takayama_1998_Bioorg.Med.Chem.Lett_8_415 |
| Author(s) : Takayama H , Watanabe A , Hosokawa M , Chiba K , Satoh T , Aimi N |
| Ref : Bioorganic & Medicinal Chemistry Lett , 8 :415 , 1998 |
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Abstract :
Five (20S)-10-hydroxycamptothecin derivatives carrying the long-chain fatty acid esters were prepared for the development of a new class of prodrug-type agents. In vitro experiments using three kinds of purified carboxylesterase isozymes from the liver microsomes of rat, pig, and human demonstrated that these derivatives were efficiently metabolized by enzymes compared with CPT-11. |
| PubMedSearch : Takayama_1998_Bioorg.Med.Chem.Lett_8_415 |
| PubMedID: 9871589 |
Takayama H, Watanabe A, Hosokawa M, Chiba K, Satoh T, Aimi N (1998)
Synthesis of a new class of camptothecin derivatives, the long-chain fatty acid esters of 10-hydroxycamptothecin, as a potent prodrug candidate, and their in vitro metabolic conversion by carboxylesterases
Bioorganic & Medicinal Chemistry Lett
8 :415
Takayama H, Watanabe A, Hosokawa M, Chiba K, Satoh T, Aimi N (1998)
Bioorganic & Medicinal Chemistry Lett
8 :415