The flowers of Cassia spectabilis yielded three new piperidine alkaloids, (-)-3-O-acetylspectaline (1), (-)-7-hydroxyspectaline (2), and iso-6-spectaline (3), together with the known (-)-spectaline (4). The green fruits of this plant were also investigated, resulting in the isolation of 1 and 4. Their structures were elucidated using a combination of multidimensional NMR and MS techniques, and relative stereochemistries were established by NOESY correlations and analysis of coupling constants. The DNA-damaging activity of these compounds was evaluated using a mutant yeast, Saccharomyces cerevisiae, assay.
Viegas C, Jr., da SBV, Furlan M, Barreiro EJ, Young MC, Tomazela D, Eberlin MN (2004) Further bioactive piperidine alkaloids from the flowers and green fruits of Cassia spectabilis Journal of Natural Products67: 908-10
Viegas C, Jr., da SBV, Furlan M, Barreiro EJ, Young MC, Tomazela D, Eberlin MN (2004) Journal of Natural Products67: 908-10
