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Reactivator Report for: 4-PAM

3-PAM and 4-PAM are meta and para positioned oxime groups with respect to the pyridinium methyl group respectively. The dodecyliodide of 2-PAM is PAD, the methylchloride is PAC,the methane sulfonate is P2s/contrathion


General
Type Oxime, Pyridinium
Chemical_Nomenclature (1-methylpyridin-4-ylidene)methyl-oxoazanium
Canonical SMILES C[n+]1ccc(C=NO)cc1
InChI InChI=1S/C7H8N2O/c1-9-4-2-7(3-5-9)6-8-10/h2-6H,1H3/p+1
InChIKey RYQHXWDFNMMYSD-UHFFFAOYSA-O
Other name(s) Pyridine-4-aldoxime ; 4-pyridine aldoxime ; 4-PA ; AC1NTCBQ ; CHEMBL349682 ; SCHEMBL14429827 ; MolPort-023-292-413 ; STL371159
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MW|137.15
Formula|C7H9N2O
CAS_number|
PubChem|5426152
UniChem|RYQHXWDFNMMYSD-UHFFFAOYSA-O
IUPHAR|
Wikipedia|

Target

References:
Search PubMed for references concerning: 4-PAM
    Title: Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach
    da Silva JAV, Nepovimova E, Ramalho TC, Kuca K, Franca TCC
    Ref: J Enzyme Inhib Med Chem, 34:1018, 2019 : PubMed

            

    Title: Reactivation of model cholinesterases by oximes and intermediate phosphyloximes: a computational study
    Vyas S, Hadad CM
    Ref: Chemico-Biological Interactions, 175:187, 2008 : PubMed

            


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