2I03

Name : Crystal structure of human dipeptidyl peptidase 4 (DPP-IV) with potent alkynyl cyanopyrrolidine (ABT-279)

Revelation date : 12-Dec-2006

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP4

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Longenecker, K.L., Madar, D.J

Ligand :

References (1)

Title : Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes - Madar_2006_J.Med.Chem_49_6416
Author(s) : Madar DJ , Kopecka H , Pireh D , Yong H , Pei Z , Li X , Wiedeman PE , Djuric SW , von Geldern TW , Fickes MG , Bhagavatula L , McDermott T , Wittenberger S , Richards SJ , Longenecker KL , Stewart KD , Lubben TH , Ballaron SJ , Stashko MA , Long MA , Wells H , Zinker BA , Mika AK , Beno DW , Kempf-Grote AJ , Polakowski J , Segreti J , Reinhart GA , Fryer RM , Sham HL , Trevillyan JM
Ref : Journal of Medicinal Chemistry , 49 :6416 , 2006
PubMedID: 17034148
Gene_locus related to this paper: human-DPP4

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 2I03 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 2I03 Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 2I03 Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 2I03 3D, interactive encyclopedia of proteins - PROTEOPEDIA server