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human-DPP4

Homo sapiens (Human) dipeptidyl peptidase IV (DPP4), T-cell activation antigen CD26

Comment

Dipeptidyl peptidase 4 regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Cleaves glucagon like peptide. This activity is inhibited by incretin fo example, reducing hyperglycemia without inducing hypoglycemia used in type 2 diabetes mellitus. DPP4 also acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor\/CD3-dependent manner ADABP Adenosine deaminase complexing protein 2. The novel emerging coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV) binds cells through DPP4. Inhibition of CD26\/DPP4 ameliorates lipopolysaccharide (LPS)-induced lung injury in mice, with anti-inflammatory effects on the lungs endothelial cells. CD26\/DPP4 mediates inflammatory responses in the pulmonary endothelium

Relationship

Family : DPP4N_Peptidase_S9

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

1J2E - Human Dipeptidyl Peptidase IV(DPP-IV) 1N1M - Human Dipeptidyl Peptidase IV\/CD26 in complex with an inhibitor (substrate analogue) 1NU6 - Human Dipeptidyl Peptidase IV(DPP-IV) 1NU8 - Human Dipeptidyl Peptidase IV(DPP-IV) in complex with Diprotin A (ILI) 1PFQ - Crystal Structure Of Human Apo Dipeptidyl Peptidase IV \/ Cd26 1R9M - Crystal Structure of Human Dipeptidyl Peptidase IV at 2.1 Ang. Resolution. 1R9N - Crystal Structure of human dipeptidyl peptidase IV in complex with a decapeptide (tNPY) at 2.3 Ang. Resolution 1RWQ - Human Dipeptidyl peptidase IV in complex with 5-aminomethyl-6-(2,4-dichloro-phenyl)-2-(3,5-dimethoxy-phenyl)-pyrimidin-4-amine 1TK3 - Crystal Structure Of Human Apo Dipeptidyl Peptidase IV \/ Cd26 2 1TKR - Human Dipeptidyl Peptidase IV\/CD26 inhibited with Diisopropyl FluoroPhosphate 1U8E - Human Dipeptidyl Peptidase IV\/CD26 Mutant Y547F (1U8E replaced 1T07) 1W1I - Human dipeptidyl peptidase IV (DPPIV or CD26) in complex with adenosine deaminase 1WCY - Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A 1X70 - Human dipeptidyl peptidase IV in complex with a beta amino acid inhibitor 2AJL - X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor 2BGN - HIV-1 Tat protein derived N-terminal nonapeptide Trp2-Tat(1-9) bound to the active site of Dipeptidyl peptidase IV (CD26) 2BGR - HIV-1 Tat Derived Nonapeptides Tat(1-9) Bound To The Active Site Of Dipeptidyl Peptidase IV (Cd26) 2BUB - Crystal structure of human dipaptidyl peptidase IV (CD26) in complex with a reverse amide inhibitor 2FJP - Human dipeptidyl peptidase IV\/CD26 in complex with an inhibitor 2G5P - crystal structure of human dipeptidyl peptidase IV (dppIV) complexed with cyanopyrrolidine (C5-pro-pro) inhibitor 21ac 2G5T - crystal structure of human dipeptidyl peptidase IV (dppIV) complexed with cyanopyrrolidine (C5-pro-pro) inhibitor 21ag 2G63 - crystal structure of human dipeptidyl peptidase IV (dppIV) complexed with cyanopyrrolidine (C5-pro-pro) inhibitor 24b 2HHA - The structure of DPP4 in complex with an oxadiazole inhibitor 2I03 - Crystal structure of human dipeptidyl peptidase 4 (DPP-IV) with potent alkynyl cyanopyrrolidine (ABT-279) 2I78 - Crystal structure of human dipeptidyl peptidase IV (DPPIV) complexed with ABT-341, a cyclohexene-constrained phenethylamine inhbitor 2IIT - Human dipeptidyl peptidase 4 in complex with a diazepan-2-one inhibitor 2IIV - Human dipeptidyl peptidase 4 in complex with a diazepan-2-one inhibitor (compound 18) 2JID - Human Dipeptidyl peptidase IV in complex with 1-(3,4-Dimethoxy-phenyl) -3-m-tolyl-piperidine-4-ylamine 2OAG - Crystal structure of human dipeptidyl peptidase IV (DPPIV) with pyrrolidine-constrained phenethylamine 29g 2OGZ - Crystal structure of DPP-IV complexed with Lilly aryl ketone inhibitor 2OLE - Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Cyclic Hydrazine Derivatives 2ONC - Crystal structure of human DPP-4 with inhibitor Alogliptin 2OPH - Human dipeptidyl peptidase IV in complex with an alpha amino acid inhibitor 2OQI - Human Dipeptidyl Peptidase IV (DPP4) with Piperidinone-constrained phenethylamine 2OQV - Human Dipeptidyl Peptidase IV (DPP4) with piperidine-constrained phenethylamine 2P8S - Human dipeptidyl peptidase IV\/CD26 in complex with a cyclohexalamine inhibitor 2QJR - Dipepdyl peptidase IV in complex with inhibitor PZF 2QKY - complex structure of dipeptidyl peptidase IV and a oxadiazolyl ketone 2QOE - Human dipeptidyl peptidase VI in complex with a triazolopiperazine-based beta amino acid inhibitor 2QT9 - Human dipeptidyl peptidase IV\/CD26 in complex with 4-aryl cyclohexylanine inhibitor 2 2QTB - Human dipeptidyl peptidase IV\/CD26 in complex with 4-aryl cyclohexylanine inhibitor 1 2RGU - Crystal structure of complex of human DPP4 and (BI 1356): A Highly Potent, Selective, Long-Acting, and Orally Bioavailable inhibitor 2RIP - Structure of DPPIV in complex with substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl inhibitor 3BJM - Crystal structure of human DPP-IV in complex with (1S,3S, 5S)-2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1- yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile (CAS)OR BMS-477118 3C43 - Human dipeptidyl peptidase IV\/CD26 in complex with a flouroolefin inhibitor 1 3C45 - Human dipeptidyl peptidase IV\/CD26 in complex with a flouroolefin inhibitor 2 3CCB - Crystal Structure of Human DPP4 in complex with a benzimidazole derivative 1 3CCC - Crystal Structure of Human DPP4 in complex with a benzimidazole derivative 2 3D4L - Human dipeptidyl peptidase IV\/CD26 in complex with a novel inhibitor 3EIO - Crystal Structure Analysis of DPPIV Inhibitor 3F8S - Crystal structure of dipeptidyl peptidase IV in complex with inhibitor 3G0B - Crystal Structure of Dipeptidyl Peptidase IV in complex with TAK-322 3G0C - Crystal structure of Dipeptidyl Peptidase IV in complex with a pyrimidinedione inhibitor 1 3G0D - Crystal structure of Dipeptidyl Peptidase IV in complex with a pyrimidinedione inhibitor 2 3G0G - Crystal structure of Dipeptidyl Peptidase IV in complex with a pyrimidinone inhibitor 3H0C - Crystal Structure of Human Dipeptidyl Peptidase IV (CD26) in Complex with a Reversed Amide Inhibitor 3HAB - The structure of DPP4 in complex with piperidine fused benzimidazole 25 3HAC - The structure of DPP4 in complex with piperidine fused benzimidazole 34 3KWF - human DPP-IV with carmegliptin (S)-1-((2S,3S,11bS)-2-Amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one 3KWJ - Strucutre of human DPP-IV with (2S,3S,11bS)-3-(3-Fluoromethyl-phenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ylamine 3NOX - Crystal structure of human DPP-IV in complex with Sa-(+)-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(morpholino)methanone 3O95 - Crystal Structure of Human DPP4 Bound to TAK-100 3O9V - Crystal Structure of Human DPP4 Bound to TAK-986 3OC0 - Structure of human DPP-IV with HTS hit (2S,3S,11bS)-3-Butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ylamine (entry 3OC0 superseeds 3KWH 12-Jan-2010) 3OPM - Crystal Structure of Human DPP4 Bound to TAK-294 3Q0T - Crystal structure of human dpp-IV in complex with SA-(+)- methyl2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl- 7-oxo-5H-pyrrolo[3,4-B]pyridin-6(7H)-yl)acetate 3Q8W - A b-aminoacyl containing thiazolidine derivative and DPPIV complex 3QBJ - Crystal structure of dipeptidyl peptidase IV in complex with inhibitor 3SWW - Crystal structure of human DPP-IV in complex with SA-(+)-3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyethyl)-2-methyl-5H-pyrrolo[3,4-B]pyridin-7(6H)-one 3SX4 - Crystal structure of human DPP-IV in complex with SA-(+)-3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)-2-methyl-5H-pyrrolo[3,4-B]pyridin-7(6H)-one 3VJK - Crystal structure of human dipeptidyl peptidase IV (DPP-4) in complex with MP-513 3VJL - Crystal structure of human dipeptidyl peptidase IV (DPP-4) in complex with a prolylthiazolidine inhibitor 2 3VJM - Crystal structure of human dipeptidyl peptidase IV (DPP-4) in complex witha prolylthiazolidine inhibitor 1 3W2T - Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with vildagliptin 3WQH - Crystal Structure of human DPP-IV in complex with Anagliptin 4A5S - Crystal Structure of human DDP4 in complex with a novel heterocyclic DPP4 inhibitor 4DSA - Crystal Structure of DPP-IV with Compound C1 4DSZ - Crystal Structure of DPP-IV with Compound C2 4DTC - Crystal Structure of DPP-IV with Compound C5 4G1F - Crystal Structure of human Dipeptidyl Peptidase IV in complex with a pyridopyrimidinedione analogue 4J3J - Crystal Structure of DPP-IV with Compound C3 4JH0 - Crystal structure of dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2) (DPP-IV-WT) complex with bms-767778 AKA 2-(3-(aminomethyl)-4-(2,4- dichlorophenyl)-2-methyl-5-oxo-5,7-dihydro-6h-pyrrolo[3,4- b]pyridin-6-yl)-n,n-dimethylacetamide 4KR0 - Complex structure of MERS-CoV spike RBD bound to CD26 4L72 - Crystal structure of MERS-CoV complexed with human DPP4 4LKO - Crystal structure of human DPP-IV in complex with BMS-744891 4N8D - DPP4 complexed with syn-7aa 4N8E - DPP4 complexed with compound 12a 4PNZ - Human dipeptidyl peptidase IV\/CD26 in complex with the long-acting inhibitor Omarigliptin (MK-3102) 4PV7 - Cocrystal structure of dipeptidyl-peptidase 4 with an indole scaffold inhibitor 4QZV - Bat-derived coronavirus HKU4 uses MERS-CoV receptor human CD26 for cell entry 5I7U - Human DPP4 in complex with a novel tricyclic hetero-cycle inhibitor 5ISM - Human DPP4 in complex with a novel 5,5,6-tricyclic pyrrolidine inhibitor 5J3J - Crystal Structure of human DPP-IV in complex with HL1 5KBY - Crystal structure of dipeptidyl peptidase IV in complex with SYR-472 5T4B - Human DPP4 in complex with a ligand 34a 5T4E - Human DPP4 in complex with a ligand 19a 5T4F - Human DPP4 in complex with a ligand 34p 5T4H - Human DPP4 in complex with a ligand 34n 5Y7H - Crystal structure of human DPP4 in complex with inhibitor DA-12166 5Y7J - Crystal structure of human DPP4 in complex with inhibitor DA-12228 5Y7K - Crystal structure of human DPP4 in complex with inhibitor Evogliptin 5ZID - Crystal structure of human DPP-IV in complex with HL2 6B1E - The structure of DPP4 in complex with Vildagliptin 6B1O - The structure of DPP4 in complex with Vildagliptin Analog 8WKU - Complex structure of MjHKU4r-CoV-1 spike RBD bound to human CD26 8ZDX - Crystal structure of MjHKU4r-CoV-1 RBD bound to human DPP4 9GOH - Crystal structure of DPP4 in complex with sulphostin 9JMJ - The complex of GD-BatCoV-RBD and human DPP4 9JMM - The complex of SE-PangolinCoV-RBD and human DPP4 9K9N - Cryo-EM structure of MjHKU4r-CoV-1 receptor-binding domain complexed with human CD26 9LBT - Crystal structure of human DPP4 DPPIV in complex with tetrapeptide VAMP

No kinetic

No disease

1,3,4-oxadiazolyl-ketone-18h 1-valylpyrrolidine 2-phenylbenzylamine 23Q 3-amino-4-phenyl-pyrrolidine-15B 3TP 4-aminocyclohexylalanine-derivative-25 4-aryl-cyclohexylalanine-inhibitor-1 4-aryl-cyclohexylalanine-inhibitor-2 5AP 5ISM-6DG 75J-34n 75L-5T4E 75M-5T4F 75N-5T4B AAF ABT-279 ABT-341 ACF ADF Ala(1-naph)-Pro-CN Alogliptin Anagliptin B2Q BMS-744891 Benzimidazole-derivative-2 Benzodioxo-purin-amine-cpd1 CHEMBL1214943 CHEMBL1215376 CHEMBL1688431-Cpd4e7 CHEMBL1909991 CHEMBL1910111 CHEMBL1910114 CHEMBL1951424 CHEMBL2058971 CHEMBL2147710 CHEMBL2159182 CHEMBL233360 CHEMBL2441952 CHEMBL3112960-Cpd20d CHEMBL3112961 CHEMBL3112966 CHEMBL3687984 CHEMBL4241199-Cpd7s CHEMBL4241199-like-phenylphenyl-Cpd7q CHEMBL4245414-Cpd2g Carboxamide-triflurophenyl-D5C Carmegliptin Cofrogliptin Cyclic-Hydrazine-Derivative D3C DA-12166 DA-12228 DB07181 DBX-AP DFP DLI DPP4-inhibitor-Cpd46 Diazepan-AJH Diazepanone-Analog-1 Diazepanone-Analog-18 Diprotin-A Diprotin-B Dutogliptin Evogliptin FPB FPB-derived-7k Flouroolefin-1 Flouroolefin-2 Fotagliptin GVB Gemigliptin Gosogliptin H-Lys(4-nitro-Z)-pyrrolidide HL2 HY-155961 Indolesufonamide1 Isoleucyl-thiazolidine JNH Lilly-aryl-ketone Linagliptin MK0626 NVP-DPP728 Neogliptin Omarigliptin Piperidine-constrained-phenethylamine-42 Piperidine-fused-benzimidazole-25 Piperidine-fused-benzimidazole-34 Piperidinone-constrained-phenethylamine-31 Prusogliptin Pyrimidinone-inhibitor1 Pyrimidinone-inhibitor3 Retagliptin SCHEMBL13923509 SCHEMBL19305555 Saxagliptin Sitagliptin Sulfonamide-D1C Sulphostin TAK-100 TAK-294 TAK-986 Tat-(1-9) Teneligliptin Trelagliptin Triazol-triflurophenyl-DC3 Triazolopiperazine-based-beta-amino-acid Trp2-Tat-(1-9) VAMP VildaSaxagliptin-analogue Vildagliptin Xanthine-inhibitor-4 beta-aminoacyl-thiazolidine-2da cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl-34Q

Database

Sequence

Peptide

MKTPWRVLLG LLGAAALVTI ITVPVVLLNK GTDDATADSR KTYTLTDYLK NTYRLKLYSL RWISDHEYLY KQENNILVFN AEYGNSSVFL ENSTFDEFGH SINDYSISPD GQFILLEYNY VKQWRHSYTA SYDIYDLNKR QLITEERIPN NTQWVTWSPV GHKLAYVWNN DIYVKIEPNL PSYRITWTGK EDIIYNGITD WVYEEEVFSA YSALWWSPNG TFLAYAQFND TEVPLIEYSF YSDESLQYPK TVRVPYPKAG AVNPTVKFFV VNTDSLSSVT NATSIQITAP ASMLIGDHYL CDVTWATQER ISLQWLRRIQ NYSVMDICDY DESSGRWNCL VARQHIEMST TGWVGRFRPS EPHFTLDGNS FYKIISNEEG YRHICYFQID KKDCTFITKG TWEVIGIEAL TSDYLYYISN EYKGMPGGRN LYKIQLSDYT KVTCLSCELN PERCQYYSVS FSKEAKYYQL RCSGPGLPLY TLHSSVNDKG LRVLEDNSAL DKMLQNVQMP SKKLDFIILN ETKFWYQMIL PPHFDKSKKY PLLLDVYAGP CSQKADIVFR LNWATYLAST ENIIVASFDG RGSGYQGDKI MHAINRRLGT FEVEDQIEAA RQFSKMGFVD NKRIAIWGWS YGGYVTSMVL GSGSGVFKCG IAVAPVSRWE YYESVYTERY MGLPTPEDNL DHYRNSTVMS RAENFKQVEY LLIHGTADDN VHFQQSAQIS KALVDVGVDF QAMWYTDEDH GIASSTAHQH IYTHMSHFIK QCFSLP

References (99)

Title : CAR-macrophages targets CD26 to eliminate chronic myeloid leukemia stem cells - Guoyun_2025_Exp.Hematol.Oncol_14_14
Author(s) : Guoyun J , Yuefeng Q , Zhenglan H , Zuowei Y , Hongyan Z , Ying Y , Wenli F
Ref : Experimental Hematology Oncol , 14 :14 , 2025
Abstract :
PubMedSearch : Guoyun_2025_Exp.Hematol.Oncol_14_14
PubMedID: 39948620
Gene_locus related to this paper: human-DPP4

Title : alpha-chaconine increases the sensitivity of HER2+ breast cancer cells to trastuzumab by targeting acetylcholinesterase - Hermawan_2025_Comput.Biol.Med_188_109809
Author(s) : Hermawan A , Pamungkas Putri DD , Fatimah N , Rhamandana Putra IM , Lestari IA
Ref : Computers in Biology & Medicine , 188 :109809 , 2025
Abstract :
PubMedSearch : Hermawan_2025_Comput.Biol.Med_188_109809
PubMedID: 39955879
Gene_locus related to this paper: human-DPP4

Title : Macrocyclic phage display for identification of selective protease substrates - Faucher_2025_bioRxiv__
Author(s) : Faucher FF , Lovell S , Bertolini M , Blazkova K , Cosco ED , Bogyo M , Barniol-Xicota M
Ref : Biorxiv , : , 2025
Abstract :
PubMedSearch : Faucher_2025_bioRxiv__
PubMedID: 40161698
Gene_locus related to this paper: human-DPP4 , human-FAP

Title : Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors - Sewald_2025_Nat.Commun_16_3208
Author(s) : Sewald L , Tabak WWA , Fehr L , Zolg S , Najdzion M , Verhoef CJA , Podlesainski D , Geiss-Friedlander R , Lammens A , Kaschani F , Hellerschmied D , Huber R , Kaiser M
Ref : Nat Commun , 16 :3208 , 2025
Abstract :
PubMedSearch : Sewald_2025_Nat.Commun_16_3208
PubMedID: 40180908
Gene_locus related to this paper: human-DPP4 , human-DPP8 , human-DPP9

Title : Contribution of amino acids in the active site of dipeptidyl peptidase 4 to the catalytic action of the enzyme - Gnoth_2024_PLoS.One_19_e0289239
Author(s) : Gnoth K , Bar JW , Rosche F , Rahfeld JU , Demuth HU
Ref : PLoS ONE , 19 :e0289239 , 2024
Abstract :
PubMedSearch : Gnoth_2024_PLoS.One_19_e0289239
PubMedID: 38625918
Gene_locus related to this paper: human-DPP4

Title : A novel bifunctional peptide VAMP mined from hemp seed protein hydrolysates improves glucose homeostasis by inhibiting intestinal DPP-IV and increasing the abundance of Akkermansia muciniphila - Chen_2024_Biorxiv__
Author(s) : Chen H , Li W , Hu W , Xu B , Wang Y , Liu J , Zhang C , Zhang X , Nie Q , Xing XH
Ref : Biorxiv , : , 2024
Abstract :
PubMedSearch : Chen_2024_Biorxiv__
PubMedID:
Gene_locus related to this paper: human-DPP4

Title : Dipeptidyl Peptidase 4 (DPP4) Exacerbates Osteoarthritis Progression in an Enzyme-Independent Manner - Li_2024_Adv.Sci.(Weinh)__e2410525
Author(s) : Li X , Zhang Z , Jiang W , Ju Y , Guo W , Huang Z
Ref : Adv Sci (Weinh) , :e2410525 , 2024
Abstract :
PubMedSearch : Li_2024_Adv.Sci.(Weinh)__e2410525
PubMedID: 39680708
Gene_locus related to this paper: human-DPP4

Title : Transcriptome Analysis of Fibroblasts in Hypoxia-Induced Vascular Remodeling: Functional Roles of CD26\/DPP4 - Suzuki_2024_Int.J.Mol.Sci_25_12599
Author(s) : Suzuki Y , Kawasaki T , Tatsumi K , Okaya T , Sato S , Shimada A , Misawa T , Hatano R , Morimoto C , Kasuya Y , Hasegawa Y , Ohara O , Suzuki T
Ref : Int J Mol Sci , 25 : , 2024
Abstract :
PubMedSearch : Suzuki_2024_Int.J.Mol.Sci_25_12599
PubMedID: 39684311
Gene_locus related to this paper: human-DPP4

Title : High-Throughput Screening of DPPIV Inhibitors Antagonizing GLP-1 Degradation Using an Enzymatic Activated Fluorescent Probe - Zhang_2024_Anal.Chem__
Author(s) : Zhang M , He S , Han C , Wu Y , Cui J , Feng L , Huo X , Li D , Chen Q , Ma X , Wang C
Ref : Analytical Chemistry , : , 2024
Abstract :
PubMedSearch : Zhang_2024_Anal.Chem__
PubMedID: 39733350
Gene_locus related to this paper: human-DPP4

Title : Molecular insights on the coronavirus MERS-CoV interaction with the CD26 receptor - Failayev_2024_Virus.Res__199330
Author(s) : Failayev H , Ganoth A , Tsfadia Y
Ref : Virus Res , :199330 , 2024
Abstract :
PubMedSearch : Failayev_2024_Virus.Res__199330
PubMedID: 38272241
Gene_locus related to this paper: human-DPP4

Title : Deep quantification of substrate turnover defines protease subsite cooperativity - Gudipati_2024_Mol.Syst.Biol__
Author(s) : Gudipati RK , Gaidatzis D , Seebacher J , Muehlhaeusser S , Kempf G , Cavadini S , Hess D , Soneson C , Grosshans H
Ref : Mol Syst Biol , : , 2024
Abstract :
PubMedSearch : Gudipati_2024_Mol.Syst.Biol__
PubMedID: 39468329
Gene_locus related to this paper: caeel-K02F2.1 , human-DPP4

Title : Targeting DPP4-RBD interactions by sitagliptin and linagliptin delivers a potential host-directed therapy against pan-SARS-CoV-2 infections - Mani_2023_Int.J.Biol.Macromol_245_125444
Author(s) : Mani S , Kaur A , Jakhar K , Kumari G , Sonar S , Kumar A , Das S , Kumar S , Kumar V , Kundu R , Pandey AK , Singh UP , Majumdar T
Ref : Int J Biol Macromol , 245 :125444 , 2023
Abstract :
PubMedSearch : Mani_2023_Int.J.Biol.Macromol_245_125444
PubMedID: 37385308
Gene_locus related to this paper: human-DPP4

Title : A review upon medicinal perspective and designing rationale of DPP-4 inhibitors - Kumar_2021_Bioorg.Med.Chem_46_116354
Author(s) : Kumar S , Mittal A
Ref : Bioorganic & Medicinal Chemistry , 46 :116354 , 2021
Abstract :
PubMedSearch : Kumar_2021_Bioorg.Med.Chem_46_116354
PubMedID: 34428715
Gene_locus related to this paper: human-DPP4

Title : Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes - Li_2019_J.Med.Chem_62_2348
Author(s) : Li S , Qin C , Cui S , Xu H , Wu F , Wang J , Su M , Fang X , Li D , Jiao Q , Zhang M , Xia C , Zhu L , Wang R , Li J , Jiang H , Zhao Z , Li H
Ref : Journal of Medicinal Chemistry , 62 :2348 , 2019
Abstract :
PubMedSearch : Li_2019_J.Med.Chem_62_2348
PubMedID: 30694668
Gene_locus related to this paper: human-DPP4

Title : A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice - Berger_2018_Endocrinol.Diabetes.Metab_1_e00002
Author(s) : Berger JP , SinhaRoy R , Pocai A , Kelly TM , Scapin G , Gao YD , Pryor KAD , Wu JK , Eiermann GJ , Xu SS , Zhang X , Tatosian DA , Weber AE , Thornberry NA , Carr RD
Ref : Endocrinol Diabetes Metab , 1 :e00002 , 2018
Abstract :
PubMedSearch : Berger_2018_Endocrinol.Diabetes.Metab_1_e00002
PubMedID: 30815539
Gene_locus related to this paper: human-DPP4

Title : Unique binding mode of Evogliptin with human dipeptidyl peptidase IV - Lee_2017_Biochem.Biophys.Res.Commun_494_452
Author(s) : Lee HK , Kim MK , Kim HD , Kim HJ , Kim JW , Lee JO , Kim CW , Kim EE
Ref : Biochemical & Biophysical Research Communications , 494 :452 , 2017
Abstract :
PubMedSearch : Lee_2017_Biochem.Biophys.Res.Commun_494_452
PubMedID: 29061303
Gene_locus related to this paper: human-DPP4

Title : Mapping the Specific Amino Acid Residues That Make Hamster DPP4 Functional as a Receptor for Middle East Respiratory Syndrome Coronavirus - van Doremalen_2016_J.Virol_90_5499
Author(s) : van Doremalen N , Miazgowicz KL , Munster VJ
Ref : J Virol , 90 :5499 , 2016
Abstract :
PubMedSearch : van Doremalen_2016_J.Virol_90_5499
PubMedID: 27030263
Gene_locus related to this paper: human-DPP4

Title : The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors - Cox_2016_Bioorg.Med.Chem.Lett_26_2622
Author(s) : Cox JM , Chu HD , Kuethe JT , Gao YD , Scapin G , Eiermann G , He H , Li X , Lyons KA , Metzger J , Petrov A , Wu JK , Xu S , Sinha-Roy R , Weber AE , Biftu T
Ref : Bioorganic & Medicinal Chemistry Lett , 26 :2622 , 2016
Abstract :
PubMedSearch : Cox_2016_Bioorg.Med.Chem.Lett_26_2622
PubMedID: 27106708
Gene_locus related to this paper: human-DPP4

Title : Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors - Pissarnitski_2016_Bioorg.Med.Chem_24_5534
Author(s) : Pissarnitski DA , Zhao Z , Cole D , Wu WL , Domalski M , Clader JW , Scapin G , Voigt J , Soriano A , Kelly T , Powles MA , Yao Z , Burnett DA
Ref : Bioorganic & Medicinal Chemistry , 24 :5534 , 2016
Abstract :
PubMedSearch : Pissarnitski_2016_Bioorg.Med.Chem_24_5534
PubMedID: 27670099
Gene_locus related to this paper: human-DPP4

Title : Discovery and Rational Design of Natural-Product-Derived 2-Phenyl-3,4-dihydro-2H-benzo[f]chromen-3-amine Analogs as Novel and Potent Dipeptidyl Peptidase 4 (DPP-4) Inhibitors for the Treatment of Type 2 Diabetes - Li_2016_J.Med.Chem_59_6772
Author(s) : Li S , Xu H , Cui S , Wu F , Zhang Y , Su M , Gong Y , Qiu S , Jiao Q , Qin C , Shan J , Zhang M , Wang J , Yin Q , Xu M , Liu X , Wang R , Zhu L , Li J , Xu Y , Jiang H , Zhao Z , Li H
Ref : Journal of Medicinal Chemistry , 59 :6772 , 2016
Abstract :
PubMedSearch : Li_2016_J.Med.Chem_59_6772
PubMedID: 27396490
Gene_locus related to this paper: human-DPP4

Title : Trelagliptin (SYR-472, Zafatek), Novel Once-Weekly Treatment for Type 2 Diabetes, Inhibits Dipeptidyl Peptidase-4 (DPP-4) via a Non-Covalent Mechanism - Grimshaw_2016_PLoS.One_11_e0157509
Author(s) : Grimshaw CE , Jennings A , Kamran R , Ueno H , Nishigaki N , Kosaka T , Tani A , Sano H , Kinugawa Y , Koumura E , Shi L , Takeuchi K
Ref : PLoS ONE , 11 :e0157509 , 2016
Abstract :
PubMedSearch : Grimshaw_2016_PLoS.One_11_e0157509
PubMedID: 27328054
Gene_locus related to this paper: human-DPP4

Title : Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes - Wu_2016_ACS.Med.Chem.Lett_7_498
Author(s) : Wu WL , Hao J , Domalski M , Burnett DA , Pissarnitski D , Zhao Z , Stamford A , Scapin G , Gao YD , Soriano A , Kelly TM , Yao Z , Powles MA , Chen S , Mei H , Hwa J
Ref : ACS Med Chem Lett , 7 :498 , 2016
Abstract :
PubMedSearch : Wu_2016_ACS.Med.Chem.Lett_7_498
PubMedID: 27190600
Gene_locus related to this paper: human-DPP4

Title : Anagliptin, a potent dipeptidyl peptidase IV inhibitor: its single-crystal structure and enzyme interactions - Watanabe_2015_J.Enzyme.Inhib.Med.Chem_30_981
Author(s) : Watanabe YS , Yasuda Y , Kojima Y , Okada S , Motoyama T , Takahashi R , Oka M
Ref : J Enzyme Inhib Med Chem , 30 :981 , 2015
Abstract :
PubMedSearch : Watanabe_2015_J.Enzyme.Inhib.Med.Chem_30_981
PubMedID: 26147347
Gene_locus related to this paper: human-DPP4

Title : Identification of residues on human receptor DPP4 critical for MERS-CoV binding and entry - Song_2014_Virology_471-473C_49
Author(s) : Song W , Wang Y , Wang N , Wang D , Guo J , Fu L , Shi X
Ref : Virology , 471-473C :49 , 2014
Abstract :
PubMedSearch : Song_2014_Virology_471-473C_49
PubMedID: 25461530
Gene_locus related to this paper: human-DPP4

Title : Discovery of dipeptidyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold - Xiao_2014_Chin.Chem.Lett_25_673
Author(s) : Xiao P , Guo R , Huang S , Cui H , Ye S , Zhang Z
Ref : Chin Chem Lett , 25 :673 , 2014
Abstract :
PubMedSearch : Xiao_2014_Chin.Chem.Lett_25_673
PubMedID:
Gene_locus related to this paper: human-DPP4

Title : Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes - Biftu_2014_J.Med.Chem_57_3205
Author(s) : Biftu T , Sinha-Roy R , Chen P , Qian X , Feng D , Kuethe JT , Scapin G , Gao YD , Yan Y , Krueger D , Bak A , Eiermann G , He J , Cox J , Hicks J , Lyons K , He H , Salituro G , Tong S , Patel S , Doss G , Petrov A , Wu J , Xu SS , Sewall C , Zhang X , Zhang B , Thornberry NA , Weber AE
Ref : Journal of Medicinal Chemistry , 57 :3205 , 2014
Abstract :
PubMedSearch : Biftu_2014_J.Med.Chem_57_3205
PubMedID: 24660890
Gene_locus related to this paper: human-DPP4

Title : Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26 - Wang_2014_Cell.Host.Microbe_16_328
Author(s) : Wang Q , Qi J , Yuan Y , Xuan Y , Han P , Wan Y , Ji W , Li Y , Wu Y , Wang J , Iwamoto A , Woo PC , Yuen KY , Yan J , Lu G , Gao GF
Ref : Cell Host Microbe , 16 :328 , 2014
Abstract :
PubMedSearch : Wang_2014_Cell.Host.Microbe_16_328
PubMedID: 25211075
Gene_locus related to this paper: human-DPP4

Title : Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV - Namoto_2014_Bioorg.Med.Chem.Lett_24_731
Author(s) : Namoto K , Sirockin F , Ostermann N , Gessier F , Flohr S , Sedrani R , Gerhartz B , Trappe J , Hassiepen U , Duttaroy A , Ferreira S , Sutton JM , Clark DE , Fenton G , Beswick M , Baeschlin DK
Ref : Bioorganic & Medicinal Chemistry Lett , 24 :731 , 2014
Abstract :
PubMedSearch : Namoto_2014_Bioorg.Med.Chem.Lett_24_731
PubMedID: 24439847
Gene_locus related to this paper: human-DPP4

Title : Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 - Lu_2013_Nature_500_227
Author(s) : Lu G , Hu Y , Wang Q , Qi J , Gao F , Li Y , Zhang Y , Zhang W , Yuan Y , Bao J , Zhang B , Shi Y , Yan J , Gao GF
Ref : Nature , 500 :227 , 2013
Abstract :
PubMedSearch : Lu_2013_Nature_500_227
PubMedID: 23831647
Gene_locus related to this paper: human-DPP4

Title : Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4 - Wang_2013_Cell.Res_23_986
Author(s) : Wang N , Shi X , Jiang L , Zhang S , Wang D , Tong P , Guo D , Fu L , Cui Y , Liu X , Arledge KC , Chen YH , Zhang L , Wang X
Ref : Cell Res , 23 :986 , 2013
Abstract :
PubMedSearch : Wang_2013_Cell.Res_23_986
PubMedID: 23835475
Gene_locus related to this paper: human-DPP4

Title : Design and synthesis of 4-(2,4,5-trifluorophenyl)butane-1,3-diamines as dipeptidyl peptidase IV inhibitors - Zhu_2013_ChemMedChem_8_1104
Author(s) : Zhu L , Li Y , Qiu L , Su M , Wang X , Xia C , Qu Y , Li J , Xiong B , Shen J
Ref : ChemMedChem , 8 :1104 , 2013
Abstract :
PubMedSearch : Zhu_2013_ChemMedChem_8_1104
PubMedID: 23671024
Gene_locus related to this paper: human-DPP4

Title : A Comparative Study of the Binding Modes of Recently Launched Dipeptidyl Peptidase IV Inhibitors in the Active Site - Nabeno_2013_Biochem.Biophys.Res.Commun_434_191
Author(s) : Nabeno M , Akahoshi F , Kishida H , Miyaguchi I , Tanaka Y , Ishii S , Kadowaki T
Ref : Biochemical & Biophysical Research Communications , 434 :191 , 2013
Abstract :
PubMedSearch : Nabeno_2013_Biochem.Biophys.Res.Commun_434_191
PubMedID: 23501107
Gene_locus related to this paper: human-DPP4

Title : Optimization of Activity, Selectivity, and Liability Profiles in 5-Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (Sa)-2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]py ridin-6(7H)-yl)-N,N-dimethylacetamide (BMS-767778) - Devasthale_2013_J.Med.Chem_56_7343
Author(s) : Devasthale P , Wang Y , Wang W , Fevig J , Feng J , Wang A , Harrity T , Egan D , Morgan N , Cap M , Fura A , Klei HE , Kish K , Weigelt C , Sun L , Levesque P , Moulin F , Li YX , Zahler R , Kirby MS , Hamann LG
Ref : Journal of Medicinal Chemistry , 56 :7343 , 2013
Abstract :
PubMedSearch : Devasthale_2013_J.Med.Chem_56_7343
PubMedID: 23964740
Gene_locus related to this paper: human-DPP4

Title : Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-y lcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Yoshida_2012_Bioorg.Med.Chem_20_5705
Author(s) : Yoshida T , Akahoshi F , Sakashita H , Kitajima H , Nakamura M , Sonda S , Takeuchi M , Tanaka Y , Ueda N , Sekiguchi S , Ishige T , Shima K , Nabeno M , Abe Y , Anabuki J , Soejima A , Yoshida K , Takashina Y , Ishii S , Kiuchi S , Fukuda S , Tsutsumiuchi R , Kosaka K , Murozono T , Nakamaru Y , Utsumi H , Masutomi N , Kishida H , Miyaguchi I , Hayashi Y
Ref : Bioorganic & Medicinal Chemistry , 20 :5705 , 2012
Abstract :
PubMedSearch : Yoshida_2012_Bioorg.Med.Chem_20_5705
PubMedID: 22959556
Gene_locus related to this paper: human-DPP4

Title : Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors - Lam_2012_Bioorg.Med.Chem.Lett_22_6628
Author(s) : Lam B , Zhang Z , Stafford JA , Skene RJ , Shi L , Gwaltney SL, 2nd
Ref : Bioorganic & Medicinal Chemistry Lett , 22 :6628 , 2012
Abstract :
PubMedSearch : Lam_2012_Bioorg.Med.Chem.Lett_22_6628
PubMedID: 23025999
Gene_locus related to this paper: human-DPP4

Title : Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group - Yoshida_2012_Bioorg.Med.Chem_20_5033
Author(s) : Yoshida T , Akahoshi F , Sakashita H , Sonda S , Takeuchi M , Tanaka Y , Nabeno M , Kishida H , Miyaguchi I , Hayashi Y
Ref : Bioorganic & Medicinal Chemistry , 20 :5033 , 2012
Abstract :
PubMedSearch : Yoshida_2012_Bioorg.Med.Chem_20_5033
PubMedID: 22824762
Gene_locus related to this paper: human-DPP4

Title : Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes. - Sutton_2012_Bioorg.Med.Chem.Lett_22_1464
Author(s) : Sutton JM , Clark DE , Dunsdon SJ , Fenton G , Fillmore A , Harris NV , Higgs C , Hurley CA , Krintel SL , Mackenzie RE , Duttaroy A , Gangl E , Maniara W , Sedrani R , Namoto K , Ostermann N , Gerhartz B , Sirockin F , Trappe J , Hassiepen U , Baeschlin DK
Ref : Bioorganic & Medicinal Chemistry Lett , 22 :1464 , 2012
Abstract :
PubMedSearch : Sutton_2012_Bioorg.Med.Chem.Lett_22_1464
PubMedID: 22177783
Gene_locus related to this paper: human-DPP4

Title : Discovery of beta-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors - Park_2011_Bioorg.Med.Chem.Lett_21_1366
Author(s) : Park WS , Kang SK , Jun MA , Shin MS , Kim KY , Rhee SD , Bae MA , Kim MS , Kim KR , Kang NS , Yoo SE , Lee JO , Song DH , Silinski P , Schneider SE , Ahn JH , Kim SS
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :1366 , 2011
Abstract :
PubMedSearch : Park_2011_Bioorg.Med.Chem.Lett_21_1366
PubMedID: 21306895
Gene_locus related to this paper: human-DPP4

Title : Role of a propeller loop in the quaternary structure and enzymatic activity of prolyl dipeptidases DPP-IV and DPP9 - Tang_2011_FEBS.Lett_585_3409
Author(s) : Tang HK , Chen KC , Liou GG , Cheng SC , Chien CH , Tang HY , Huang LH , Chang HP , Chou CY , Chen X
Ref : FEBS Letters , 585 :3409 , 2011
Abstract :
PubMedSearch : Tang_2011_FEBS.Lett_585_3409
PubMedID: 22001206
Gene_locus related to this paper: human-DPP4 , human-DPP9

Title : Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IV - Zhang_2011_J.Med.Chem_54_510
Author(s) : Zhang Z , Wallace MB , Feng J , Stafford JA , Skene RJ , Shi L , Lee B , Aertgeerts K , Jennings A , Xu R , Kassel DB , Kaldor SW , Navre M , Webb DR , Gwaltney SL
Ref : Journal of Medicinal Chemistry , 54 :510 , 2011
Abstract :
PubMedSearch : Zhang_2011_J.Med.Chem_54_510
PubMedID: 21186796
Gene_locus related to this paper: human-DPP4

Title : Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor - Miyamoto_2011_J.Med.Chem_54_831
Author(s) : Miyamoto Y , Banno Y , Yamashita T , Fujimoto T , Oi S , Moritoh Y , Asakawa T , Kataoka O , Yashiro H , Takeuchi K , Suzuki N , Ikedo K , Kosaka T , Tsubotani S , Tani A , Sasaki M , Funami M , Amano M , Yamamoto Y , Aertgeerts K , Yano J , Maezaki H
Ref : Journal of Medicinal Chemistry , 54 :831 , 2011
Abstract :
PubMedSearch : Miyamoto_2011_J.Med.Chem_54_831
PubMedID: 21218817
Gene_locus related to this paper: human-DPP4

Title : 7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site - Wang_2011_Bioorg.Med.Chem.Lett_21_6646
Author(s) : Wang W , Devasthale P , Wang A , Harrity T , Egan D , Morgan N , Cap M , Fura A , Klei HE , Kish K , Weigelt C , Sun L , Levesque P , Li YX , Zahler R , Kirby MS , Hamann LG
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :6646 , 2011
Abstract :
PubMedSearch : Wang_2011_Bioorg.Med.Chem.Lett_21_6646
PubMedID: 21996520
Gene_locus related to this paper: human-DPP4

Title : Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: a new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554 - Banno_2011_Bioorg.Med.Chem_19_4953
Author(s) : Banno Y , Miyamoto Y , Sasaki M , Oi S , Asakawa T , Kataoka O , Takeuchi K , Suzuki N , Ikedo K , Kosaka T , Tsubotani S , Tani A , Funami M , Tawada M , Yamamoto Y , Aertgeerts K , Yano J , Maezaki H
Ref : Bioorganic & Medicinal Chemistry , 19 :4953 , 2011
Abstract :
PubMedSearch : Banno_2011_Bioorg.Med.Chem_19_4953
PubMedID: 21764322
Gene_locus related to this paper: human-DPP4

Title : Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554 - Maezaki_2011_Bioorg.Med.Chem_19_4482
Author(s) : Maezaki H , Banno Y , Miyamoto Y , Moritoh Y , Asakawa T , Kataoka O , Takeuchi K , Suzuki N , Ikedo K , Kosaka T , Sasaki M , Tsubotani S , Tani A , Funami M , Yamamoto Y , Tawada M , Aertgeerts K , Yano J , Oi S
Ref : Bioorganic & Medicinal Chemistry , 19 :4482 , 2011
Abstract :
PubMedSearch : Maezaki_2011_Bioorg.Med.Chem_19_4482
PubMedID: 21741847
Gene_locus related to this paper: human-DPP4

Title : Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxa mides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors - Meng_2010_J.Med.Chem_53_5620
Author(s) : Meng W , Brigance RP , Chao HJ , Fura A , Harrity T , Marcinkeviciene J , O'Connor SP , Tamura JK , Xie D , Zhang Y , Klei HE , Kish K , Weigelt CA , Turdi H , Wang A , Zahler R , Kirby MS , Hamann LG
Ref : Journal of Medicinal Chemistry , 53 :5620 , 2010
Abstract :
PubMedSearch : Meng_2010_J.Med.Chem_53_5620
PubMedID: 20684603
Gene_locus related to this paper: human-DPP4

Title : Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors - Boehringer_2010_Bioorg.Med.Chem.Lett_20_1106
Author(s) : Boehringer M , Fischer H , Hennig M , Hunziker D , Huwyler J , Kuhn B , Loeffler BM , Luebbers T , Mattei P , Narquizian R , Sebokova E , Sprecher U , Wessel HP
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :1106 , 2010
Abstract :
PubMedSearch : Boehringer_2010_Bioorg.Med.Chem.Lett_20_1106
PubMedID: 20031408
Gene_locus related to this paper: human-DPP4

Title : Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Mattei_2010_Bioorg.Med.Chem.Lett_20_1109
Author(s) : Mattei P , Boehringer M , Di Giorgio P , Fischer H , Hennig M , Huwyler J , Kocer B , Kuhn B , Loeffler BM , Macdonald A , Narquizian R , Rauber E , Sebokova E , Sprecher U
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :1109 , 2010
Abstract :
PubMedSearch : Mattei_2010_Bioorg.Med.Chem.Lett_20_1109
PubMedID: 20031405
Gene_locus related to this paper: human-DPP4

Title : (3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrr olidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor - Ammirati_2009_Bioorg.Med.Chem.Lett_19_1991
Author(s) : Ammirati MJ , Andrews KM , Boyer DD , Brodeur AM , Danley DE , Doran SD , Hulin B , Liu S , McPherson RK , Orena SJ , Parker JC , Polivkova J , Qiu X , Soglia CB , Treadway JL , VanVolkenburg MA , Wilder DC , Piotrowski DW
Ref : Bioorganic & Medicinal Chemistry Lett , 19 :1991 , 2009
Abstract :
PubMedSearch : Ammirati_2009_Bioorg.Med.Chem.Lett_19_1991
PubMedID: 19275964
Gene_locus related to this paper: human-DPP4

Title : Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors - Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097
Author(s) : Edmondson SD , Mastracchio A , Cox JM , Eiermann GJ , He H , Lyons KA , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Xu S , Zhu B , Thornberry NA , Roy RS , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 19 :4097 , 2009
Abstract :
PubMedSearch : Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097
PubMedID: 19539471
Gene_locus related to this paper: human-DPP4

Title : Discovery of beta-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV - Nordhoff_2009_Bioorg.Med.Chem.Lett_19_4201
Author(s) : Nordhoff S , Cerezo-Galvez S , Deppe H , Hill O , Lopez-Canet M , Rummey C , Thiemann M , Matassa VG , Edwards PJ , Feurer A
Ref : Bioorganic & Medicinal Chemistry Lett , 19 :4201 , 2009
Abstract :
PubMedSearch : Nordhoff_2009_Bioorg.Med.Chem.Lett_19_4201
PubMedID: 19515557
Gene_locus related to this paper: human-DPP4

Title : Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors - Wallace_2008_Bioorg.Med.Chem.Lett_18_2362
Author(s) : Wallace MB , Feng J , Zhang Z , Skene RJ , Shi L , Caster CL , Kassel DB , Xu R , Gwaltney SL, 2nd
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :2362 , 2008
Abstract :
PubMedSearch : Wallace_2008_Bioorg.Med.Chem.Lett_18_2362
PubMedID: 18346892
Gene_locus related to this paper: human-DPP4

Title : Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors - Ahn_2008_Bioorg.Med.Chem.Lett_18_6525
Author(s) : Ahn JH , Park WS , Jun MA , Shin MS , Kang SK , Kim KY , Rhee SD , Bae MA , Kim KR , Kim SG , Kim SY , Sohn SK , Kang NS , Lee JO , Lee DH , Cheon HG , Kim SS
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :6525 , 2008
Abstract :
PubMedSearch : Ahn_2008_Bioorg.Med.Chem.Lett_18_6525
PubMedID: 18996694
Gene_locus related to this paper: human-DPP4

Title : Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors - Edmondson_2008_Bioorg.Med.Chem.Lett_18_2409
Author(s) : Edmondson SD , Wei L , Xu J , Shang J , Xu S , Pang J , Chaudhary A , Dean DC , He H , Leiting B , Lyons KA , Patel RA , Patel SB , Scapin G , Wu JK , Beconi MG , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :2409 , 2008
Abstract :
PubMedSearch : Edmondson_2008_Bioorg.Med.Chem.Lett_18_2409
PubMedID: 18331795
Gene_locus related to this paper: human-DPP4

Title : Synthesis and biological evaluation of pyrazoline analogues with beta-amino acyl group as dipeptidyl peptidase IV inhibitors - Jun_2008_Eur.J.Med.Chem_43_1889
Author(s) : Jun MA , Park WS , Kang SK , Kim KY , Kim KR , Rhee SD , Bae MA , Kang NS , Sohn SK , Kim SG , Lee JO , Lee DH , Cheon HG , Kim SS , Ahn JH
Ref : Eur Journal of Medicinal Chemistry , 43 :1889 , 2008
Abstract :
PubMedSearch : Jun_2008_Eur.J.Med.Chem_43_1889
PubMedID: 18243422
Gene_locus related to this paper: human-DPP4

Title : Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design - Liang_2008_Bioorg.Med.Chem.Lett_18_3706
Author(s) : Liang GB , Qian X , Biftu T , Singh S , Gao YD , Scapin G , Patel S , Leiting B , Patel R , Wu J , Zhang X , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :3706 , 2008
Abstract :
PubMedSearch : Liang_2008_Bioorg.Med.Chem.Lett_18_3706
PubMedID: 18524582
Gene_locus related to this paper: human-DPP4

Title : Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation - Metzler_2008_Protein.Sci_17_240
Author(s) : Metzler WJ , Yanchunas J , Weigelt C , Kish K , Klei HE , Xie D , Zhang Y , Corbett M , Tamura JK , He B , Hamann LG , Kirby MS , Marcinkeviciene J
Ref : Protein Science , 17 :240 , 2008
Abstract :
PubMedSearch : Metzler_2008_Protein.Sci_17_240
PubMedID: 18227430
Gene_locus related to this paper: human-DPP4

Title : (3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization - Wright_2007_Bioorg.Med.Chem.Lett_17_5638
Author(s) : Wright SW , Ammirati MJ , Andrews KM , Brodeur AM , Danley DE , Doran SD , Lillquist JS , Liu S , McClure LD , McPherson RK , Olson TV , Orena SJ , Parker JC , Rocke BN , Soeller WC , Soglia CB , Treadway JL , VanVolkenburg MA , Zhao Z , Cox ED
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :5638 , 2007
Abstract :
PubMedSearch : Wright_2007_Bioorg.Med.Chem.Lett_17_5638
PubMedID: 17822893
Gene_locus related to this paper: human-DPP4

Title : [(S)-gamma-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors - Yoshida_2007_Bioorg.Med.Chem.Lett_17_2618
Author(s) : Yoshida T , Sakashita H , Akahoshi F , Hayashi Y
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :2618 , 2007
Abstract :
PubMedSearch : Yoshida_2007_Bioorg.Med.Chem.Lett_17_2618
PubMedID: 17317162
Gene_locus related to this paper: human-DPP4

Title : Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors - Kowalchick_2007_Bioorg.Med.Chem.Lett_17_5934
Author(s) : Kowalchick JE , Leiting B , Pryor KD , Marsilio F , Wu JK , He H , Lyons KA , Eiermann GJ , Petrov A , Scapin G , Patel RA , Thornberry NA , Weber AE , Kim D
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :5934 , 2007
Abstract :
PubMedSearch : Kowalchick_2007_Bioorg.Med.Chem.Lett_17_5934
PubMedID: 17827003
Gene_locus related to this paper: human-DPP4

Title : 4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV - Kaelin_2007_Bioorg.Med.Chem.Lett_17_5806
Author(s) : Kaelin DE , Smenton AL , Eiermann GJ , He H , Leiting B , Lyons KA , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Thornberry NA , Weber AE , Duffy JL
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :5806 , 2007
Abstract :
PubMedSearch : Kaelin_2007_Bioorg.Med.Chem.Lett_17_5806
PubMedID: 17851076
Gene_locus related to this paper: human-DPP4

Title : 1,3-disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors - Lubbers_2007_Bioorg.Med.Chem.Lett_17_2966
Author(s) : Lubbers T , Bohringer M , Gobbi L , Hennig M , Hunziker D , Kuhn B , Loffler B , Mattei P , Narquizian R , Peters JU , Ruff Y , Wessel HP , Wyss P
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :2966 , 2007
Abstract :
PubMedSearch : Lubbers_2007_Bioorg.Med.Chem.Lett_17_2966
PubMedID: 17418568
Gene_locus related to this paper: human-DPP4

Title : Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors - Ahn_2007_Bioorg.Med.Chem.Lett_17_2622
Author(s) : Ahn JH , Shin MS , Jun MA , Jung SH , Kang SK , Kim KR , Rhee SD , Kang NS , Kim SY , Sohn SK , Kim SG , Jin MS , Lee JO , Cheon HG , Kim SS
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :2622 , 2007
Abstract :
PubMedSearch : Ahn_2007_Bioorg.Med.Chem.Lett_17_2622
PubMedID: 17331715
Gene_locus related to this paper: human-DPP4

Title : Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site - Sheehan_2007_Bioorg.Med.Chem.Lett_17_1765
Author(s) : Sheehan SM , Mest HJ , Watson BM , Klimkowski VJ , Timm DE , Cauvin A , Parsons SH , Shi Q , Canada EJ , Wiley MR , Ruehter G , Evers B , Petersen S , Blaszczak LC , Pulley SR , Margolis BJ , Wishart GN , Renson B , Hankotius D , Mohr M , Zechel JC , Michael Kalbfleisch J , Dingess-Hammond EA , Boelke A , Weichert AG
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :1765 , 2007
Abstract :
PubMedSearch : Sheehan_2007_Bioorg.Med.Chem.Lett_17_1765
PubMedID: 17239592
Gene_locus related to this paper: human-DPP4

Title : (3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)- 1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Biftu_2007_Bioorg.Med.Chem.Lett_17_49
Author(s) : Biftu T , Feng D , Qian X , Liang GB , Kieczykowski G , Eiermann G , He H , Leiting B , Lyons K , Petrov A , Sinha-Roy R , Zhang B , Scapin G , Patel S , Gao YD , Singh S , Wu J , Zhang X , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :49 , 2007
Abstract :
PubMedSearch : Biftu_2007_Bioorg.Med.Chem.Lett_17_49
PubMedID: 17055272
Gene_locus related to this paper: human-DPP4

Title : Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit - Backes_2007_Bioorg.Med.Chem.Lett_17_2005
Author(s) : Backes BJ , Longenecker K , Hamilton GL , Stewart K , Lai C , Kopecka H , von Geldern TW , Madar DJ , Pei Z , Lubben TH , Zinker BA , Tian Z , Ballaron SJ , Stashko MA , Mika AK , Beno DW , Kempf-Grote AJ , Black-Schaefer C , Sham HL , Trevillyan JM
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :2005 , 2007
Abstract :
PubMedSearch : Backes_2007_Bioorg.Med.Chem.Lett_17_2005
PubMedID: 17276063
Gene_locus related to this paper: ratno-dpp4 , human-DPP4

Title : Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin - Biftu_2007_Bioorg.Med.Chem.Lett_17_3384
Author(s) : Biftu T , Scapin G , Singh S , Feng D , Becker JW , Eiermann G , He H , Lyons K , Patel S , Petrov A , Sinha-Roy R , Zhang B , Wu J , Zhang X , Doss GA , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :3384 , 2007
Abstract :
PubMedSearch : Biftu_2007_Bioorg.Med.Chem.Lett_17_3384
PubMedID: 17433672
Gene_locus related to this paper: human-DPP4

Title : Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors - Corbett_2007_Bioorg.Med.Chem.Lett_17_6707
Author(s) : Corbett JW , Dirico K , Song W , Boscoe BP , Doran SD , Boyer D , Qiu X , Ammirati M , VanVolkenburg MA , McPherson RK , Parker JC , Cox ED
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :6707 , 2007
Abstract :
PubMedSearch : Corbett_2007_Bioorg.Med.Chem.Lett_17_6707
PubMedID: 17977724
Gene_locus related to this paper: human-DPP4

Title : 4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV - Duffy_2007_Bioorg.Med.Chem.Lett_17_2879
Author(s) : Duffy JL , Kirk BA , Wang L , Eiermann GJ , He H , Leiting B , Lyons KA , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :2879 , 2007
Abstract :
PubMedSearch : Duffy_2007_Bioorg.Med.Chem.Lett_17_2879
PubMedID: 17350841
Gene_locus related to this paper: human-DPP4

Title : 8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylme thyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes - Eckhardt_2007_J.Med.Chem_50_6450
Author(s) : Eckhardt M , Langkopf E , Mark M , Tadayyon M , Thomas L , Nar H , Pfrengle W , Guth B , Lotz R , Sieger P , Fuchs H , Himmelsbach F
Ref : Journal of Medicinal Chemistry , 50 :6450 , 2007
Abstract :
PubMedSearch : Eckhardt_2007_J.Med.Chem_50_6450
PubMedID: 18052023
Gene_locus related to this paper: human-DPP4

Title : Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV - Feng_2007_J.Med.Chem_50_2297
Author(s) : Feng J , Zhang Z , Wallace MB , Stafford JA , Kaldor SW , Kassel DB , Navre M , Shi L , Skene RJ , Asakawa T , Takeuchi K , Xu R , Webb DR , Gwaltney SL, 2nd
Ref : Journal of Medicinal Chemistry , 50 :2297 , 2007
Abstract :
PubMedSearch : Feng_2007_J.Med.Chem_50_2297
PubMedID: 17441705
Gene_locus related to this paper: human-DPP4

Title : Crystal structures of human dipeptidyl peptidase IV in its apo and diprotin B-complexed forms - Hiramatsu_2007_Acta.Biochim.Biophys.Sin.(Shanghai)_39_335
Author(s) : Hiramatsu H , Kyono K , Yamamoto A , Saeki K , Shima H , Sugiyama S , Inaka K , Shimizu R
Ref : Acta Biochim Biophys Sin (Shanghai) , 39 :335 , 2007
Abstract :
PubMedSearch : Hiramatsu_2007_Acta.Biochim.Biophys.Sin.(Shanghai)_39_335
PubMedID: 17492130
Gene_locus related to this paper: human-DPP4

Title : Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: oxadiazolyl ketones - Koo_2007_Bioorg.Med.Chem.Lett_17_4167
Author(s) : Koo KD , Kim MJ , Kim S , Kim KH , Hong SY , Hur GC , Yim HJ , Kim GT , Han HO , Kwon OH , Kwon TS , Koh JS , Lee CS
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :4167 , 2007
Abstract :
PubMedSearch : Koo_2007_Bioorg.Med.Chem.Lett_17_4167
PubMedID: 17544668
Gene_locus related to this paper: human-DPP4

Title : Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors - Pei_2007_J.Med.Chem_50_1983
Author(s) : Pei Z , Li X , von Geldern TW , Longenecker K , Pireh D , Stewart KD , Backes BJ , Lai C , Lubben TH , Ballaron SJ , Beno DW , Kempf-Grote AJ , Sham HL , Trevillyan JM
Ref : Journal of Medicinal Chemistry , 50 :1983 , 2007
Abstract :
PubMedSearch : Pei_2007_J.Med.Chem_50_1983
PubMedID: 17367123
Gene_locus related to this paper: human-DPP4

Title : Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors - Xu_2006_Bioorg.Med.Chem.Lett_16_5373
Author(s) : Xu J , Wei L , Mathvink RJ , Edmondson SD , Eiermann GJ , He H , Leone JF , Leiting B , Lyons KA , Marsilio F , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 16 :5373 , 2006
Abstract :
PubMedSearch : Xu_2006_Bioorg.Med.Chem.Lett_16_5373
PubMedID: 16919457
Gene_locus related to this paper: human-DPP4

Title : Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Pei_2006_J.Med.Chem_49_6439
Author(s) : Pei Z , Li X , von Geldern TW , Madar DJ , Longenecker K , Yong H , Lubben TH , Stewart KD , Zinker BA , Backes BJ , Judd AS , Mulhern M , Ballaron SJ , Stashko MA , Mika AK , Beno DW , Reinhart GA , Fryer RM , Preusser LC , Kempf-Grote AJ , Sham HL , Trevillyan JM
Ref : Journal of Medicinal Chemistry , 49 :6439 , 2006
Abstract :
PubMedSearch : Pei_2006_J.Med.Chem_49_6439
PubMedID: 17064063
Gene_locus related to this paper: human-DPP4

Title : [(S)-gamma-(Arylamino)prolyl]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitors - Sakashita_2006_Bioorg.Med.Chem_14_3662
Author(s) : Sakashita H , Akahoshi F , Kitajima H , Tsutsumiuchi R , Hayashi Y
Ref : Bioorganic & Medicinal Chemistry , 14 :3662 , 2006
Abstract :
PubMedSearch : Sakashita_2006_Bioorg.Med.Chem_14_3662
PubMedID: 16460948
Gene_locus related to this paper: human-DPP4

Title : (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]tr iazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Edmondson_2006_J.Med.Chem_49_3614
Author(s) : Edmondson SD , Mastracchio A , Mathvink RJ , He J , Harper B , Park YJ , Beconi M , Di Salvo J , Eiermann GJ , He H , Leiting B , Leone JF , Levorse DA , Lyons K , Patel RA , Patel SB , Petrov A , Scapin G , Shang J , Roy RS , Smith A , Wu JK , Xu S , Zhu B , Thornberry NA , Weber AE
Ref : Journal of Medicinal Chemistry , 49 :3614 , 2006
Abstract :
PubMedSearch : Edmondson_2006_J.Med.Chem_49_3614
PubMedID: 16759103
Gene_locus related to this paper: human-DPP4

Title : Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes - Madar_2006_J.Med.Chem_49_6416
Author(s) : Madar DJ , Kopecka H , Pireh D , Yong H , Pei Z , Li X , Wiedeman PE , Djuric SW , von Geldern TW , Fickes MG , Bhagavatula L , McDermott T , Wittenberger S , Richards SJ , Longenecker KL , Stewart KD , Lubben TH , Ballaron SJ , Stashko MA , Long MA , Wells H , Zinker BA , Mika AK , Beno DW , Kempf-Grote AJ , Polakowski J , Segreti J , Reinhart GA , Fryer RM , Sham HL , Trevillyan JM
Ref : Journal of Medicinal Chemistry , 49 :6416 , 2006
Abstract :
PubMedSearch : Madar_2006_J.Med.Chem_49_6416
PubMedID: 17034148
Gene_locus related to this paper: human-DPP4

Title : Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors - Pei_2006_J.Med.Chem_49_3520
Author(s) : Pei Z , Li X , Longenecker K , von Geldern TW , Wiedeman PE , Lubben TH , Zinker BA , Stewart K , Ballaron SJ , Stashko MA , Mika AK , Beno DW , Long M , Wells H , Kempf-Grote AJ , Madar DJ , McDermott TS , Bhagavatula L , Fickes MG , Pireh D , Solomon LR , Lake MR , Edalji R , Fry EH , Sham HL , Trevillyan JM
Ref : Journal of Medicinal Chemistry , 49 :3520 , 2006
Abstract :
PubMedSearch : Pei_2006_J.Med.Chem_49_3520
PubMedID: 16759095
Gene_locus related to this paper: human-DPP4

Title : Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors - Qiao_2006_Bioorg.Med.Chem.Lett_16_123
Author(s) : Qiao L , Baumann CA , Crysler CS , Ninan NS , Abad MC , Spurlino JC , Desjarlais RL , Kervinen J , Neeper MP , Bayoumy SS , Williams R , Deckman IC , Dasgupta M , Reed RL , Huebert ND , Tomczuk BE , Moriarty KJ
Ref : Bioorganic & Medicinal Chemistry Lett , 16 :123 , 2006
Abstract :
PubMedSearch : Qiao_2006_Bioorg.Med.Chem.Lett_16_123
PubMedID: 16236500
Gene_locus related to this paper: human-DPP4

Title : Crystal structures of HIV-1 Tat-derived nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) bound to the active site of dipeptidyl-peptidase IV (CD26) - Weihofen_2005_J.Biol.Chem_280_14911
Author(s) : Weihofen WA , Liu J , Reutter W , Saenger W , Fan H
Ref : Journal of Biological Chemistry , 280 :14911 , 2005
Abstract :
PubMedSearch : Weihofen_2005_J.Biol.Chem_280_14911
PubMedID: 15695814
Gene_locus related to this paper: human-DPP4

Title : (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)- yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Kim_2005_J.Med.Chem_48_141
Author(s) : Kim D , Wang L , Beconi M , Eiermann GJ , Fisher MH , He H , Hickey GJ , Kowalchick JE , Leiting B , Lyons K , Marsilio F , McCann ME , Patel RA , Petrov A , Scapin G , Patel SB , Roy RS , Wu JK , Wyvratt MJ , Zhang BB , Zhu L , Thornberry NA , Weber AE
Ref : Journal of Medicinal Chemistry , 48 :141 , 2005
Abstract :
PubMedSearch : Kim_2005_J.Med.Chem_48_141
PubMedID: 15634008
Gene_locus related to this paper: human-DPP4

Title : Crystal structure of CD26\/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface - Weihofen_2004_J.Biol.Chem_279_43330
Author(s) : Weihofen WA , Liu J , Reutter W , Saenger W , Fan H
Ref : Journal of Biological Chemistry , 279 :43330 , 2004
Abstract :
PubMedSearch : Weihofen_2004_J.Biol.Chem_279_43330
PubMedID: 15213224
Gene_locus related to this paper: human-DPP4

Title : Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation - Aertgeerts_2004_Protein.Sci_13_412
Author(s) : Aertgeerts K , Ye S , Tennant MG , Kraus ML , Rogers J , Sang BC , Skene RJ , Webb DR , Prasad GS
Ref : Protein Science , 13 :412 , 2004
Abstract :
PubMedSearch : Aertgeerts_2004_Protein.Sci_13_412
PubMedID: 14718659
Gene_locus related to this paper: human-DPP4

Title : Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV - Bjelke_2004_J.Biol.Chem_279_34691
Author(s) : Bjelke JR , Christensen J , Branner S , Wagtmann N , Olsen C , Kanstrup AB , Rasmussen HB
Ref : Journal of Biological Chemistry , 279 :34691 , 2004
Abstract :
PubMedSearch : Bjelke_2004_J.Biol.Chem_279_34691
PubMedID: 15175333
Gene_locus related to this paper: human-DPP4

Title : The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A - Hiramatsu_2004_Biol.Chem_385_561
Author(s) : Hiramatsu H , Yamamoto A , Kyono K , Higashiyama Y , Fukushima C , Shima H , Sugiyama S , Inaka K , Shimizu R
Ref : Biol Chem , 385 :561 , 2004
Abstract :
PubMedSearch : Hiramatsu_2004_Biol.Chem_385_561
PubMedID: 15255191
Gene_locus related to this paper: human-DPP4

Title : Aminomethylpyrimidines as novel DPP-IV inhibitors: a 10(5)-fold activity increase by optimization of aromatic substituents - Peters_2004_Bioorg.Med.Chem.Lett_14_1491
Author(s) : Peters JU , Weber S , Kritter S , Weiss P , Wallier A , Boehringer M , Hennig M , Kuhn B , Loeffler BM
Ref : Bioorganic & Medicinal Chemistry Lett , 14 :1491 , 2004
Abstract :
PubMedSearch : Peters_2004_Bioorg.Med.Chem.Lett_14_1491
PubMedID: 15006388
Gene_locus related to this paper: human-DPP4

Title : Crystal structure of human dipeptidyl peptidase IV\/CD26 in complex with a substrate analog - Rasmussen_2003_Nat.Struct.Biol_10_19
Author(s) : Rasmussen HB , Branner S , Wiberg FC , Wagtmann N
Ref : Nat Struct Biol , 10 :19 , 2003
Abstract :
PubMedSearch : Rasmussen_2003_Nat.Struct.Biol_10_19
PubMedID: 12483204
Gene_locus related to this paper: human-DPP4

Title : Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV - Thoma_2003_Structure_11_947
Author(s) : Thoma R , Loffler B , Stihle M , Huber W , Ruf A , Hennig M
Ref : Structure , 11 :947 , 2003
Abstract :
PubMedSearch : Thoma_2003_Structure_11_947
PubMedID: 12906826
Gene_locus related to this paper: human-DPP4

Title : 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties - Villhauer_2003_J.Med.Chem_46_2774
Author(s) : Villhauer EB , Brinkman JA , Naderi GB , Burkey BF , Dunning BE , Prasad K , Mangold BL , Russell ME , Hughes TE
Ref : Journal of Medicinal Chemistry , 46 :2774 , 2003
Abstract :
PubMedSearch : Villhauer_2003_J.Med.Chem_46_2774
PubMedID: 12801240
Gene_locus related to this paper: human-DPP4

Title : The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold - Hiramatsu_2003_Biochem.Biophys.Res.Commun_302_849
Author(s) : Hiramatsu H , Kyono K , Higashiyama Y , Fukushima C , Shima H , Sugiyama S , Inaka K , Yamamoto A , Shimizu R
Ref : Biochemical & Biophysical Research Communications , 302 :849 , 2003
Abstract :
PubMedSearch : Hiramatsu_2003_Biochem.Biophys.Res.Commun_302_849
PubMedID: 12646248
Gene_locus related to this paper: human-DPP4

Title : High-resolution structure of human apo dipeptidyl peptidase IV\/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine - Oefner_2003_Acta.Crystallogr.D.Biol.Crystallogr_59_1206
Author(s) : Oefner C , D'Arcy A , Mac Sweeney A , Pierau S , Gardiner R , Dale GE
Ref : Acta Crystallographica D Biol Crystallogr , 59 :1206 , 2003
Abstract :
PubMedSearch : Oefner_2003_Acta.Crystallogr.D.Biol.Crystallogr_59_1206
PubMedID: 12832764
Gene_locus related to this paper: human-DPP4

Title : Human dipeptidyl peptidase IV gene promoter: tissue-specific regulation from a TATA-less GC-rich sequence characteristic of a housekeeping gene promoter - Bohm_1995_Biochem.J_311 ( Pt 3)_835
Author(s) : Bohm SK , Gum JR, Jr. , Erickson RH , Hicks JW , Kim YS
Ref : Biochemical Journal , 311 ( Pt 3) :835 , 1995
Abstract :
PubMedSearch : Bohm_1995_Biochem.J_311 ( Pt 3)_835
PubMedID: 7487939
Gene_locus related to this paper: human-DPP4

Title : Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene - Abbott_1994_Immunogenetics_40_331
Author(s) : Abbott CA , Baker E , Sutherland GR , McCaughan GW
Ref : Immunogenetics , 40 :331 , 1994
Abstract :
PubMedSearch : Abbott_1994_Immunogenetics_40_331
PubMedID: 7927537
Gene_locus related to this paper: human-DPP4

Title : Cloning and functional expression of the T cell activation antigen CD26 -
Author(s) : Tanaka T
Ref : J Immunol , 150 :2090 , 1993
PubMedID: 8094732
Gene_locus related to this paper: human-DPP4

Title : Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like colon cancer cell lines HT-29 and Caco-2. Cloning of the complete human coding sequence and changes of dipeptidyl peptidase IV mRNA levels during cell differentiation - Darmoul_1992_J.Biol.Chem_267_4824
Author(s) : Darmoul D , Lacasa M , Baricault L , Marguet D , Sapin C
Ref : Journal of Biological Chemistry , 267 :4824 , 1992
Abstract :
PubMedSearch : Darmoul_1992_J.Biol.Chem_267_4824
PubMedID: 1347043
Gene_locus related to this paper: human-DPP4

Title : Cloning and functional expression of the T cell activation antigen CD26 - Tanaka_1992_J.Immunol_149_481
Author(s) : Tanaka T , Camerini D , Seed B , Torimoto Y , Dang NH , Kameoka J , Dahlberg HN , Schlossman SF , Morimoto C
Ref : J Immunol , 149 :481 , 1992
Abstract :
PubMedSearch : Tanaka_1992_J.Immunol_149_481
PubMedID: 1352530
Gene_locus related to this paper: human-DPP4

Title : Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface - Misumi_1992_Biochim.Biophys.Acta_1131_333
Author(s) : Misumi Y , Hayashi Y , Arakawa F , Ikehara Y
Ref : Biochimica & Biophysica Acta , 1131 :333 , 1992
Abstract :
PubMedSearch : Misumi_1992_Biochim.Biophys.Acta_1131_333
PubMedID: 1352704
Gene_locus related to this paper: human-DPP4

Title : Isolation of a cDNA probe for the human intestinal dipeptidylpeptidase IV and assignment of the gene locus DPP4 to chromosome 2 - Darmoul_1990_Ann.Hum.Genet_54_191
Author(s) : Darmoul D , Lacasa M , Chantret I , Swallow DM , Trugnan G
Ref : Ann Hum Genet , 54 :191 , 1990
Abstract :
PubMedSearch : Darmoul_1990_Ann.Hum.Genet_54_191
PubMedID: 1977364
Gene_locus related to this paper: human-DPP4