Name : Crystal structure of complex of human DPP4 and (BI 1356): A Highly Potent, Selective, Long-Acting, and Orally Bioavailable inhibitor

Revelation date : 06-Nov-2007

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP4

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Eckhardt, M., Langkopf, E., Mark, M., Taddayon, M., Thomas, L., Nar, H., Pfrengle, W., Guth, B., Lotz, R., Sieger, P., Fuchs, H., Himmelsbach, F.

Ligand : Inhibitor Linagliptin Ligand in structure: Ligplot

References (1)

Title : 8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylme thyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes - Eckhardt_2007_J.Med.Chem_50_6450
Author(s) : Eckhardt M , Langkopf E , Mark M , Tadayyon M , Thomas L , Nar H , Pfrengle W , Guth B , Lotz R , Sieger P , Fuchs H , Himmelsbach F
Ref : Journal of Medicinal Chemistry , 50 :6450 , 2007
Abstract :
PubMedSearch : Eckhardt_2007_J.Med.Chem_50_6450
PubMedID: 18052023
Gene_locus related to this paper: human-DPP4

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server


PDB-Sum : 2RGU Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 2RGU Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 2RGU Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 2RGU 3D, interactive encyclopedia of proteins - PROTEOPEDIA server