3KWF

Name : human DPP-IV with carmegliptin (S)-1-((2S,3S,11bS)-2-Amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one

Revelation date : 12-Jan-2010

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP4

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Hennig, M., Stihle, M., Thoma, R.

Ligand :

References (1)

Title : Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Mattei_2010_Bioorg.Med.Chem.Lett_20_1109
Author(s) : Mattei P , Boehringer M , Di Giorgio P , Fischer H , Hennig M , Huwyler J , Kocer B , Kuhn B , Loeffler BM , Macdonald A , Narquizian R , Rauber E , Sebokova E , Sprecher U
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :1109 , 2010
PubMedID: 20031405
Gene_locus related to this paper: human-DPP4

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 3KWF Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 3KWF Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 3KWF Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 3KWF 3D, interactive encyclopedia of proteins - PROTEOPEDIA server