3OC0

Name : Structure of human DPP-IV with HTS hit (2S,3S,11bS)-3-Butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ylamine (entry 3OC0 superseeds 3KWH 12-Jan-2010)

Revelation date : 25-Aug-2010

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP4

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Hennig, M., Stihle, M., Thoma, R. Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

Ligand :

References (1)

Title : Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Mattei_2010_Bioorg.Med.Chem.Lett_20_1109
Author(s) : Mattei P , Boehringer M , Di Giorgio P , Fischer H , Hennig M , Huwyler J , Kocer B , Kuhn B , Loeffler BM , Macdonald A , Narquizian R , Rauber E , Sebokova E , Sprecher U
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :1109 , 2010
PubMedID: 20031405
Gene_locus related to this paper: human-DPP4

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 3OC0 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 3OC0 Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 3OC0 Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 3OC0 3D, interactive encyclopedia of proteins - PROTEOPEDIA server