5J3J

Name : Crystal Structure of human DPP-IV in complex with HL1

Revelation date : 05-Apr-2017

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP4

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Wu, F., Li, H., Zhao, Z., Zhu, L., Xu, H., Li, S.

Ligand :

References (2)

Title : Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes - Li_2019_J.Med.Chem_62_2348
Author(s) : Li S , Qin C , Cui S , Xu H , Wu F , Wang J , Su M , Fang X , Li D , Jiao Q , Zhang M , Xia C , Zhu L , Wang R , Li J , Jiang H , Zhao Z , Li H
Ref : Journal of Medicinal Chemistry , 62 :2348 , 2019
PubMedID: 30694668
Gene_locus related to this paper: human-DPP4

Title : Discovery and Rational Design of Natural-Product-Derived 2-Phenyl-3,4-dihydro-2H-benzo[f]chromen-3-amine Analogs as Novel and Potent Dipeptidyl Peptidase 4 (DPP-4) Inhibitors for the Treatment of Type 2 Diabetes - Li_2016_J.Med.Chem_59_6772
Author(s) : Li S , Xu H , Cui S , Wu F , Zhang Y , Su M , Gong Y , Qiu S , Jiao Q , Qin C , Shan J , Zhang M , Wang J , Yin Q , Xu M , Liu X , Wang R , Zhu L , Li J , Xu Y , Jiang H , Zhao Z , Li H
Ref : Journal of Medicinal Chemistry , 59 :6772 , 2016
PubMedID: 27396490
Gene_locus related to this paper: human-DPP4

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 5J3J Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 5J3J Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 5J3J Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 5J3J 3D, interactive encyclopedia of proteins - PROTEOPEDIA server