6II0
Name : Crystal structure of the Makes Caterpillars Floppy (MCF)-Like effector of Vibrio vulnificus MO6-24\/O
Revelation date : 07-Aug-2019
Family : 6_AlphaBeta_hydrolase
Gene_locus : vibvy-q7mdk6
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Lee, Y., Kim, B.S., Choi, S., Lee, E.Y., Park, S., Hwang, J., Kwon, Y., Hyung, J., Lee, C., Eom, S.H., Kim, M.H.
Precursor of a multifunctional toxin that causes destruction of the actin
cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases
when translocated into the host cytoplasm. Upon translocation into the host
cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain
(also named CPD domain). One of the liberated protein is an alpha\/beta hydrolase
which has a phosphatidylinositol-3-phosphate-specific phospholipase A1
activity which inhibits autophagy and endosomal trafficking
Ligand :
References (1)
| Title : Makes caterpillars floppy-like effector-containing MARTX toxins require host ADP-ribosylation factor (ARF) proteins for systemic pathogenicity - Lee_2019_Proc.Natl.Acad.Sci.U.S.A_116_18031 |
| Author(s) : Lee Y , Kim BS , Choi S , Lee EY , Park S , Hwang J , Kwon Y , Hyun J , Lee C , Kim JF , Eom SH , Kim MH |
| Ref : Proc Natl Acad Sci U S A , 116 :18031 , 2019 |
| PubMedID: 31427506 |
| Gene_locus related to this paper: vibvy-q7mdk6 |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
Databases
PDB-Sum : 6II0 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP : 6II0 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP : 6II0 Structural Classification Of Protein - SCOP server
PROTEOPEDIA : 6II0 3D, interactive encyclopedia of proteins - PROTEOPEDIA server