Name : Crystal structure of alpha-beta hydrolase (ABH) and Makes Caterpillars Floppy (MCF)-Like effectors of Vibrio vulnificus MO6-24\/O

Revelation date : 07-Aug-2019

Family : 6_AlphaBeta_hydrolase

Gene_locus : vibvy-q7mdk6

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Lee, Y., Kim, B.S., Choi, S., Lee, E.Y., Park, S., Hwang, J., Kwon, Y., Hyung, J., Lee, C., Eom, S.H., Kim, M.H.
Precursor of a multifunctional toxin that causes destruction of the actin
cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases
when translocated into the host cytoplasm. Upon translocation into the host
cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain
(also named CPD domain). One of the liberated protein is an alpha\/beta hydrolase
which has a phosphatidylinositol-3-phosphate-specific phospholipase A1
activity which inhibits autophagy and endosomal trafficking

Ligand :

References (1)

Title : Makes caterpillars floppy-like effector-containing MARTX toxins require host ADP-ribosylation factor (ARF) proteins for systemic pathogenicity - Lee_2019_Proc.Natl.Acad.Sci.U.S.A_116_18031
Author(s) : Lee Y , Kim BS , Choi S , Lee EY , Park S , Hwang J , Kwon Y , Hyun J , Lee C , Kim JF , Eom SH , Kim MH
Ref : Proc Natl Acad Sci U S A , 116 :18031 , 2019
PubMedID: 31427506
Gene_locus related to this paper: vibvy-q7mdk6

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server


PDB-Sum : 6II2 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 6II2 Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 6II2 Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 6II2 3D, interactive encyclopedia of proteins - PROTEOPEDIA server