Benzyl-salicylate
Salicylic acid (SA) is a pivotal phytohormone for plant responses to biotic and abiotic stresses. Plants have evolved two pathways to produce SA: the isochorismate synthase and phenylalanine ammonia lyase (PAL) pathways. In the PAL pathway, benzyl salicylate is hydrolysed to salicylic acid by the cytoplasmic carboxylesterase OSD4. This enayme is present in most plants except Arabidopsis. Zhu et al, Wang et al
General
Type : Salicylic, Aryl ester, Benzoate
Chemical_Nomenclature : benzyl 2-hydroxybenzoate
Canonical SMILES : C1=CC=C(C=C1)COC(=O)C2=CC=CC=C2O
InChI : InChI=1S\/C14H12O3\/c15-13-9-5-4-8-12(13)14(16)17-10-11-6-2-1-3-7-11\/h1-9,15H,10H2
InChIKey : ZCTQGTTXIYCGGC-UHFFFAOYSA-N
Other name(s) : benzyl salicylate || Benzyl 2-hydroxybenzoate || Benzyl o-hydroxybenzoate || Salicylic Acid Benzyl Ester || Salicylic acid, benzyl ester || Phenylmethyl 2-hydroxybenzoate || Benzoic acid, 2-hydroxy-, phenylmethyl ester || SCHEMBL15573 || CHEMBL460124 || SCHEMBL4318917 || SCHEMBL5462574 || SCHEMBL30184766 || CHEBI:165211
MW : 228.24
Formula : C14H12O3
CAS_number : 118-58-1
PubChem : 8363
UniChem : ZCTQGTTXIYCGGC-UHFFFAOYSA-N
Target
Structures : No structure
Families : Plant_carboxylesterase
References (18)
| Title : Complete biosynthesis of salicylic acid from phenylalanine in plants - Zhu_2025_Nature__ |
| Author(s) : Zhu B , Zhang Y , Gao R , Wu Z , Zhang W , Zhang C , Zhang P , Ye C , Yao L , Jin Y , Mao H , Tou P , Huang P , Zhao J , Zhao Q , Liu CJ , Zhang K |
| Ref : Nature , : , 2025 |
| Abstract : |
| PubMedSearch : Zhu_2025_Nature__ |
| PubMedID: 40702181 |
| Gene_locus related to this paper: orysa-q6j657 |
| Title : Deciphering phenylalanine-derived salicylic acid biosynthesis in plants - Wang_2025_Nature__ |
| Author(s) : Wang Y , Song S , Zhang W , Deng Q , Feng Y , Tao M , Kang M , Zhang Q , Yang L , Wang X , Zhu C , Zhu W , Zhu Y , Cao P , Chen J , Pan J , Feng S , Chen X , Dai H , Yang J , Zhao T , Cao F , Tao Z , Shen X , Last RL , Hu J , Yu J , Fan P , Pan R |
| Ref : Nature , : , 2025 |
| Abstract : |
| PubMedSearch : Wang_2025_Nature__ |
| PubMedID: 40702180 |
| Gene_locus related to this paper: orysa-q6j657 |
| Title : Salicylic acid biosynthesis via the PAL pathway requires benzaldehyde synthase and a benzyl salicylate-specific esterase - Ma_2025_Plant.Cell__koaf241 |
| Author(s) : Ma D , Gordon H , Nazir R , Wulff JE , Constabel CP |
| Ref : Plant Cell , :koaf241 , 2025 |
| Abstract : |
| PubMedSearch : Ma_2025_Plant.Cell__koaf241 |
| PubMedID: 41092096 |
| Gene_locus related to this paper: nicta-hsr203j |
| Title : Complete biosynthesis of salicylic acid from phenylalanine in plants - Zhu_2025_Nature__ |
| Author(s) : Zhu B , Zhang Y , Gao R , Wu Z , Zhang W , Zhang C , Zhang P , Ye C , Yao L , Jin Y , Mao H , Tou P , Huang P , Zhao J , Zhao Q , Liu CJ , Zhang K |
| Ref : Nature , : , 2025 |
| Abstract : |
| PubMedSearch : Zhu_2025_Nature__ |
| PubMedID: 40702181 |
| Gene_locus related to this paper: orysa-q6j657 |
| Title : Deciphering phenylalanine-derived salicylic acid biosynthesis in plants - Wang_2025_Nature__ |
| Author(s) : Wang Y , Song S , Zhang W , Deng Q , Feng Y , Tao M , Kang M , Zhang Q , Yang L , Wang X , Zhu C , Zhu W , Zhu Y , Cao P , Chen J , Pan J , Feng S , Chen X , Dai H , Yang J , Zhao T , Cao F , Tao Z , Shen X , Last RL , Hu J , Yu J , Fan P , Pan R |
| Ref : Nature , : , 2025 |
| Abstract : |
| PubMedSearch : Wang_2025_Nature__ |
| PubMedID: 40702180 |
| Gene_locus related to this paper: orysa-q6j657 |
| Title : Salicylic acid biosynthesis via the PAL pathway requires benzaldehyde synthase and a benzyl salicylate-specific esterase - Ma_2025_Plant.Cell__koaf241 |
| Author(s) : Ma D , Gordon H , Nazir R , Wulff JE , Constabel CP |
| Ref : Plant Cell , :koaf241 , 2025 |
| Abstract : |
| PubMedSearch : Ma_2025_Plant.Cell__koaf241 |
| PubMedID: 41092096 |
| Gene_locus related to this paper: nicta-hsr203j |
| Title : Salicylic acid biosynthesis via the PAL pathway requires benzaldehyde synthase and a benzyl salicylate-specific esterase - Ma_2025_Plant.Cell__koaf241 |
| Author(s) : Ma D , Gordon H , Nazir R , Wulff JE , Constabel CP |
| Ref : Plant Cell , :koaf241 , 2025 |
| Abstract : |
| PubMedSearch : Ma_2025_Plant.Cell__koaf241 |
| PubMedID: 41092096 |
| Gene_locus related to this paper: nicta-hsr203j |
| Title : Complete biosynthesis of salicylic acid from phenylalanine in plants - Zhu_2025_Nature__ |
| Author(s) : Zhu B , Zhang Y , Gao R , Wu Z , Zhang W , Zhang C , Zhang P , Ye C , Yao L , Jin Y , Mao H , Tou P , Huang P , Zhao J , Zhao Q , Liu CJ , Zhang K |
| Ref : Nature , : , 2025 |
| Abstract : |
| PubMedSearch : Zhu_2025_Nature__ |
| PubMedID: 40702181 |
| Gene_locus related to this paper: orysa-q6j657 |
| Title : Deciphering phenylalanine-derived salicylic acid biosynthesis in plants - Wang_2025_Nature__ |
| Author(s) : Wang Y , Song S , Zhang W , Deng Q , Feng Y , Tao M , Kang M , Zhang Q , Yang L , Wang X , Zhu C , Zhu W , Zhu Y , Cao P , Chen J , Pan J , Feng S , Chen X , Dai H , Yang J , Zhao T , Cao F , Tao Z , Shen X , Last RL , Hu J , Yu J , Fan P , Pan R |
| Ref : Nature , : , 2025 |
| Abstract : |
| PubMedSearch : Wang_2025_Nature__ |
| PubMedID: 40702180 |
| Gene_locus related to this paper: orysa-q6j657 |
| Title : Hypersensitivity-Related Genes HSR201 and HSR203J Are Regulated by Calmodulin-Binding Protein 60-Type Transcription Factors and Required for Pathogen Signal-Induced Salicylic Acid Synthesis - Takagi_2022_Plant.Cell.Physiol_63_1008 |
| Author(s) : Takagi K , Tasaki K , Komori H , Katou S |
| Ref : Plant Cell Physiol , 63 :1008 , 2022 |
| Abstract : |
| PubMedSearch : Takagi_2022_Plant.Cell.Physiol_63_1008 |
| PubMedID: 35671166 |
| Gene_locus related to this paper: nicta-hsr203j |
| Title : Hypersensitivity-Related Genes HSR201 and HSR203J Are Regulated by Calmodulin-Binding Protein 60-Type Transcription Factors and Required for Pathogen Signal-Induced Salicylic Acid Synthesis - Takagi_2022_Plant.Cell.Physiol_63_1008 |
| Author(s) : Takagi K , Tasaki K , Komori H , Katou S |
| Ref : Plant Cell Physiol , 63 :1008 , 2022 |
| Abstract : |
| PubMedSearch : Takagi_2022_Plant.Cell.Physiol_63_1008 |
| PubMedID: 35671166 |
| Gene_locus related to this paper: nicta-hsr203j |
| Title : Hypersensitivity-Related Genes HSR201 and HSR203J Are Regulated by Calmodulin-Binding Protein 60-Type Transcription Factors and Required for Pathogen Signal-Induced Salicylic Acid Synthesis - Takagi_2022_Plant.Cell.Physiol_63_1008 |
| Author(s) : Takagi K , Tasaki K , Komori H , Katou S |
| Ref : Plant Cell Physiol , 63 :1008 , 2022 |
| Abstract : |
| PubMedSearch : Takagi_2022_Plant.Cell.Physiol_63_1008 |
| PubMedID: 35671166 |
| Gene_locus related to this paper: nicta-hsr203j |
| Title : Hydrolytic metabolism of phenyl and benzyl salicylates, fragrances and flavoring agents in foods, by microsomes of rat and human tissues - Ozaki_2015_Food.Chem.Toxicol_86_116 |
| Author(s) : Ozaki H , Sugihara K , Tamura Y , Fujino C , Watanabe Y , Uramaru N , Sone T , Ohta S , Kitamura S |
| Ref : Food & Chemical Toxicology , 86 :116 , 2015 |
| Abstract : |
| PubMedSearch : Ozaki_2015_Food.Chem.Toxicol_86_116 |
| PubMedID: 26321725 |
| Title : Hydrolytic metabolism of phenyl and benzyl salicylates, fragrances and flavoring agents in foods, by microsomes of rat and human tissues - Ozaki_2015_Food.Chem.Toxicol_86_116 |
| Author(s) : Ozaki H , Sugihara K , Tamura Y , Fujino C , Watanabe Y , Uramaru N , Sone T , Ohta S , Kitamura S |
| Ref : Food & Chemical Toxicology , 86 :116 , 2015 |
| Abstract : |
| PubMedSearch : Ozaki_2015_Food.Chem.Toxicol_86_116 |
| PubMedID: 26321725 |
| Title : Hydrolytic metabolism of phenyl and benzyl salicylates, fragrances and flavoring agents in foods, by microsomes of rat and human tissues - Ozaki_2015_Food.Chem.Toxicol_86_116 |
| Author(s) : Ozaki H , Sugihara K , Tamura Y , Fujino C , Watanabe Y , Uramaru N , Sone T , Ohta S , Kitamura S |
| Ref : Food & Chemical Toxicology , 86 :116 , 2015 |
| Abstract : |
| PubMedSearch : Ozaki_2015_Food.Chem.Toxicol_86_116 |
| PubMedID: 26321725 |
| Title : Preparation of lipophilic alkyl (hydroxy)benzoates by solvent-free lipase-catalyzed esterification and transesterification - Vosmann_2008_Appl.Microbiol.Biotechnol_80_29 |
| Author(s) : Vosmann K , Wiege B , Weitkamp P , Weber N |
| Ref : Applied Microbiology & Biotechnology , 80 :29 , 2008 |
| Abstract : |
| PubMedSearch : Vosmann_2008_Appl.Microbiol.Biotechnol_80_29 |
| PubMedID: 18542947 |
| Title : Preparation of lipophilic alkyl (hydroxy)benzoates by solvent-free lipase-catalyzed esterification and transesterification - Vosmann_2008_Appl.Microbiol.Biotechnol_80_29 |
| Author(s) : Vosmann K , Wiege B , Weitkamp P , Weber N |
| Ref : Applied Microbiology & Biotechnology , 80 :29 , 2008 |
| Abstract : |
| PubMedSearch : Vosmann_2008_Appl.Microbiol.Biotechnol_80_29 |
| PubMedID: 18542947 |
| Title : Preparation of lipophilic alkyl (hydroxy)benzoates by solvent-free lipase-catalyzed esterification and transesterification - Vosmann_2008_Appl.Microbiol.Biotechnol_80_29 |
| Author(s) : Vosmann K , Wiege B , Weitkamp P , Weber N |
| Ref : Applied Microbiology & Biotechnology , 80 :29 , 2008 |
| Abstract : |
| PubMedSearch : Vosmann_2008_Appl.Microbiol.Biotechnol_80_29 |
| PubMedID: 18542947 |