Chloramphenicol-diacetate
chloramphenicol acetyltransferase (CAT) transfers acetate to chloramphenicol thereby inactivating the antibiotic. .EstDL136 catalyzed the deacetylation of 1- and 3- acetyl and 1,3-diacetyl derivates counteracting CAT and restoring Chloramphenicol. EstDL136 also acts as a chloramphenicol hydrolase.It cleaves the amide linkage at C2 of chloramphenicol and thereby confers resistance to bacteria
General
Type : Antibiotic, Acetate, pNP
Chemical_Nomenclature : [(2~{R},3~{R})-3-acetyloxy-2-[(2,2-dichloroacetyl)amino]-3-(4-nitrophenyl)propyl] acetate
Canonical SMILES : CC(=O)OCC(C(C1=CC=C(C=C1)[N+](=O)[O-])OC(=O)C)NC(=O)C(Cl)Cl
InChI : InChI=1S\/C15H16Cl2N2O7\/c1-8(20)25-7-12(18-15(22)14(16)17)13(26-9(2)21)10-3-5-11(6-4-10)19(23)24\/h3-6,12-14H,7H2,1-2H3,(H,18,22)\/t12-,13-\/m1\/s1
InChIKey : RBAMFWWUJRFUPC-CHWSQXEVSA-N
Other name(s) : 1,3-Diacetylchloramphenicol || 1,3-Diacetyl chloramphenicol || 1,3-Dacp || Chloramphenicol diacetate || AC1Q3GZE || AC1L4OI1
MW : 407.2
Formula : C15H16Cl2N2O7
CAS_number : 10318-17-9
PubChem : 160933
UniChem : RBAMFWWUJRFUPC-CHWSQXEVSA-N
Target
Structures : No structure
Families : No family
References (1)
| Title : Crystal structure of chloramphenicol-metabolizing enzyme EstDL136 from a metagenome - Kim_2019_PLoS.One_14_e0210298 |
| Author(s) : Kim SH , Kang PA , Han K , Lee SW , Rhee S |
| Ref : PLoS ONE , 14 :e0210298 , 2019 |
| Abstract : |
| PubMedSearch : Kim_2019_PLoS.One_14_e0210298 |
| PubMedID: 30645605 |
| Gene_locus related to this paper: 9bact-g3cr02 |