Antibiotic

Antimicrobial substance active against bacteria. Target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Protein synthesis inhibitors (macrolides, lincosamides, and tetracyclines) are usually bacteriostatic (with the exception of bactericidal aminoglycosides). Some alpha\/beta hydrolases are involved in the biosynthesis or the activation or hydrolysis of these compounds
Substrate Main targeted enzyme families Type Structure
BrefeldinA Hormone-sensitive_lipase_like Natural Antibiotic Macrocycle Toxin
Patulin Pancreatic_lipase Dienelactone_hydrolase Natural Toxin Antibiotic
CLsuGG yjfP_esterase-like BioH Antibiotic Drug pNP Pro-Drug Organochlorine
Rhodomycin-D Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Tylosin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Tilmicosin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Tildipirosin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Josamycin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Leucomycin-a5 Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Midecamycin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Momomycin Thioesterase Macrolide Polyketide Peptide Natural Antibiotic
Spiramycin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Ochratoxin-A 6_AlphaBeta_hydrolase Natural Antibiotic Peptide Propionate Toxin Chromen Organochlorine
Tiancimycin-B Tiancimycin-TnmK-Tripeptidase-HIP Natural Antibiotic Polyketide Alkyne
Bacilysocin Monoglyceridelipase_lysophospholip Phospholipid Antibiotic Tetradecanoate Myristate
Thiostrepton 6_AlphaBeta_hydrolase Natural Peptide Antibiotic Macrocycle Quinoline
Tiancimycin-H Tiancimycin-TnmK-Tripeptidase-HIP Natural Antibiotic Polyketide Alkyne
Omphalotin-A S9N_PPCE_Peptidase_S9 Peptide Natural Macrolide Polyketide Antibiotic
Skyllamycin-A Thioesterase Peptide Natural Macrolide Polyketide Antibiotic Azabicyclo
Skyllamycin-like-precursor Thioesterase Peptide Natural Polyketide Macrolide Antibiotic
Pimaricin Thioesterase Natural Macrolide Polyketide Antibiotic
Rifapentine Arylacetamide_deacetylase Pro-Drug Drug Not AlphaBeta Hydrolase target Piperazine Antibiotic
Rifabutin Arylacetamide_deacetylase Pro-Drug Drug Not AlphaBeta Hydrolase target Piperidine Antibiotic
Rifampicin Arylacetamide_deacetylase Drug Not AlphaBeta Hydrolase target Acetate Natural Antibiotic
Bottromycin-A2-MKW BotH Antibiotic Azabicyclo Sulfur Compound Thiazole
Bottromycin-A2 BotH Antibiotic Propionate tert-Butyl Azabicyclo Sulfur Compound Thiazole
Bottromycin-A2-derivative-MRB BotH Antibiotic Propionate tert-Butyl Azabicyclo Sulfur Compound Thiazole
Bottromycin-A2-derivative-MQZ BotH Antibiotic Propionate Azabicyclo Sulfur Compound Thiazole
Florfenicol Hormone-sensitive_lipase_like Antibiotic Sulfonyl Sulfur Compound Organochlorine
Chloramphenicol-diacetate Antibiotic Acetate pNP Organochlorine
Chloramphenicol Hormone-sensitive_lipase_like Antibiotic Drug pNP Organochlorine
7-Aminocephalosporanic-acid Acetyl-esterase_deacetylase BD-FAE Natural Antibiotic Azabicyclo
Cephalosporin-C Homoserine_transacetylase Acetyl-esterase_deacetylase BD-FAE Natural Antibiotic Azabicyclo
Puromycin PMH_Peptidase_S9 Antibiotic
Ampicillin Cocaine_esterase Peptidase_S15 Carb_B_Chordata Antibiotic Azabicyclo
Amoxicillin Carb_B_Chordata Antibiotic Azabicyclo
N-alanyl-secovicenilactam-ethyl-ester Proline_iminopeptidase Antibiotic Analogue of substrate
Deacetylcephalosporin-C Homoserine_transacetylase Natural Antibiotic Azabicyclo
Aclarubicin Aclacinomycin-methylesterase_RdmC Antibiotic Natural Polyketide
Aclacinomycin Aclacinomycin-methylesterase_RdmC Antibiotic Natural Polyketide
BrefeldinA Hormone-sensitive_lipase_like Natural Antibiotic Macrocycle Toxin
Patulin Pancreatic_lipase Dienelactone_hydrolase Natural Toxin Antibiotic
CLsuGG yjfP_esterase-like BioH Antibiotic Drug pNP Pro-Drug Organochlorine
Rhodomycin-D Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Tylosin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Tilmicosin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Tildipirosin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Josamycin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Leucomycin-a5 Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Midecamycin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Momomycin Thioesterase Macrolide Polyketide Peptide Natural Antibiotic
Spiramycin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Ochratoxin-A 6_AlphaBeta_hydrolase Natural Antibiotic Peptide Propionate Toxin Chromen Organochlorine
Tiancimycin-B Tiancimycin-TnmK-Tripeptidase-HIP Natural Antibiotic Polyketide Alkyne
Bacilysocin Monoglyceridelipase_lysophospholip Phospholipid Antibiotic Tetradecanoate Myristate
Thiostrepton 6_AlphaBeta_hydrolase Natural Peptide Antibiotic Macrocycle Quinoline
Tiancimycin-H Tiancimycin-TnmK-Tripeptidase-HIP Natural Antibiotic Polyketide Alkyne
Omphalotin-A S9N_PPCE_Peptidase_S9 Peptide Natural Macrolide Polyketide Antibiotic
Skyllamycin-A Thioesterase Peptide Natural Macrolide Polyketide Antibiotic Azabicyclo
Skyllamycin-like-precursor Thioesterase Peptide Natural Polyketide Macrolide Antibiotic
Pimaricin Thioesterase Natural Macrolide Polyketide Antibiotic
Rifapentine Arylacetamide_deacetylase Pro-Drug Drug Not AlphaBeta Hydrolase target Piperazine Antibiotic
Rifabutin Arylacetamide_deacetylase Pro-Drug Drug Not AlphaBeta Hydrolase target Piperidine Antibiotic
Rifampicin Arylacetamide_deacetylase Drug Not AlphaBeta Hydrolase target Acetate Natural Antibiotic
Bottromycin-A2-MKW BotH Antibiotic Azabicyclo Sulfur Compound Thiazole
Bottromycin-A2 BotH Antibiotic Propionate tert-Butyl Azabicyclo Sulfur Compound Thiazole
Bottromycin-A2-derivative-MRB BotH Antibiotic Propionate tert-Butyl Azabicyclo Sulfur Compound Thiazole
Bottromycin-A2-derivative-MQZ BotH Antibiotic Propionate Azabicyclo Sulfur Compound Thiazole
Florfenicol Hormone-sensitive_lipase_like Antibiotic Sulfonyl Sulfur Compound Organochlorine
Chloramphenicol-diacetate Antibiotic Acetate pNP Organochlorine
Chloramphenicol Hormone-sensitive_lipase_like Antibiotic Drug pNP Organochlorine
7-Aminocephalosporanic-acid Acetyl-esterase_deacetylase BD-FAE Natural Antibiotic Azabicyclo
Cephalosporin-C Homoserine_transacetylase Acetyl-esterase_deacetylase BD-FAE Natural Antibiotic Azabicyclo
Puromycin PMH_Peptidase_S9 Antibiotic
Ampicillin Cocaine_esterase Peptidase_S15 Carb_B_Chordata Antibiotic Azabicyclo
Amoxicillin Carb_B_Chordata Antibiotic Azabicyclo
N-alanyl-secovicenilactam-ethyl-ester Proline_iminopeptidase Antibiotic Analogue of substrate
Deacetylcephalosporin-C Homoserine_transacetylase Natural Antibiotic Azabicyclo
Aclarubicin Aclacinomycin-methylesterase_RdmC Antibiotic Natural Polyketide
Aclacinomycin Aclacinomycin-methylesterase_RdmC Antibiotic Natural Polyketide
BrefeldinA Hormone-sensitive_lipase_like Natural Antibiotic Macrocycle Toxin
Patulin Pancreatic_lipase Dienelactone_hydrolase Natural Toxin Antibiotic
CLsuGG yjfP_esterase-like BioH Antibiotic Drug pNP Pro-Drug Organochlorine
Rhodomycin-D Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Tylosin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Tilmicosin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Tildipirosin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Josamycin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Leucomycin-a5 Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Midecamycin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Momomycin Thioesterase Macrolide Polyketide Peptide Natural Antibiotic
Spiramycin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Ochratoxin-A 6_AlphaBeta_hydrolase Natural Antibiotic Peptide Propionate Toxin Chromen Organochlorine
Tiancimycin-B Tiancimycin-TnmK-Tripeptidase-HIP Natural Antibiotic Polyketide Alkyne
Bacilysocin Monoglyceridelipase_lysophospholip Phospholipid Antibiotic Tetradecanoate Myristate
Thiostrepton 6_AlphaBeta_hydrolase Natural Peptide Antibiotic Macrocycle Quinoline
Tiancimycin-H Tiancimycin-TnmK-Tripeptidase-HIP Natural Antibiotic Polyketide Alkyne
Omphalotin-A S9N_PPCE_Peptidase_S9 Peptide Natural Macrolide Polyketide Antibiotic
Skyllamycin-A Thioesterase Peptide Natural Macrolide Polyketide Antibiotic Azabicyclo
Skyllamycin-like-precursor Thioesterase Peptide Natural Polyketide Macrolide Antibiotic
Pimaricin Thioesterase Natural Macrolide Polyketide Antibiotic
Rifapentine Arylacetamide_deacetylase Pro-Drug Drug Not AlphaBeta Hydrolase target Piperazine Antibiotic
Rifabutin Arylacetamide_deacetylase Pro-Drug Drug Not AlphaBeta Hydrolase target Piperidine Antibiotic
Rifampicin Arylacetamide_deacetylase Drug Not AlphaBeta Hydrolase target Acetate Natural Antibiotic
Bottromycin-A2-MKW BotH Antibiotic Azabicyclo Sulfur Compound Thiazole
Bottromycin-A2 BotH Antibiotic Propionate tert-Butyl Azabicyclo Sulfur Compound Thiazole
Bottromycin-A2-derivative-MRB BotH Antibiotic Propionate tert-Butyl Azabicyclo Sulfur Compound Thiazole
Bottromycin-A2-derivative-MQZ BotH Antibiotic Propionate Azabicyclo Sulfur Compound Thiazole
Florfenicol Hormone-sensitive_lipase_like Antibiotic Sulfonyl Sulfur Compound Organochlorine
Chloramphenicol-diacetate Antibiotic Acetate pNP Organochlorine
Chloramphenicol Hormone-sensitive_lipase_like Antibiotic Drug pNP Organochlorine
7-Aminocephalosporanic-acid Acetyl-esterase_deacetylase BD-FAE Natural Antibiotic Azabicyclo
Cephalosporin-C Homoserine_transacetylase Acetyl-esterase_deacetylase BD-FAE Natural Antibiotic Azabicyclo
Puromycin PMH_Peptidase_S9 Antibiotic
Ampicillin Cocaine_esterase Peptidase_S15 Carb_B_Chordata Antibiotic Azabicyclo
Amoxicillin Carb_B_Chordata Antibiotic Azabicyclo
N-alanyl-secovicenilactam-ethyl-ester Proline_iminopeptidase Antibiotic Analogue of substrate
Deacetylcephalosporin-C Homoserine_transacetylase Natural Antibiotic Azabicyclo
Aclarubicin Aclacinomycin-methylesterase_RdmC Antibiotic Natural Polyketide
Aclacinomycin Aclacinomycin-methylesterase_RdmC Antibiotic Natural Polyketide