Antibiotic

Antimicrobial substance active against bacteria. Target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Protein synthesis inhibitors (macrolides, lincosamides, and tetracyclines) are usually bacteriostatic (with the exception of bactericidal aminoglycosides). Some alpha\/beta hydrolases are involved in the biosynthesis or the activation or hydrolysis of these compounds
Substrate Main targeted enzyme familyes Type Structure
BrefeldinA Hormone-sensitive_lipase_like Natural Antibiotic Macrocycle Toxin
Ochratoxin-A 6_AlphaBeta_hydrolase Natural Antibiotic Peptide Propionate Toxin
Tiancimycin-B Tiancimycin-TnmK-Tripeptidase-HIP Natural Antibiotic Polyketide
Bacilysocin Monoglyceridelipase_lysophospholip Phospholipid Antibiotic Tetradecanoate
Thiostrepton 6_AlphaBeta_hydrolase Natural Peptide Antibiotic Macrocycle Quinoline
Tiancimycin-H Tiancimycin-TnmK-Tripeptidase-HIP Natural Antibiotic Polyketide
Omphalotin-A S9N_PPCE_Peptidase_S9 Peptide Natural Macrolide Antibiotic
Skyllamycin-A Thioesterase Peptide Natural Macrolide Antibiotic Azabicyclo
Skyllamycin-like-precursor Thioesterase Peptide Natural Macrolide Antibiotic
Pimaricin Thioesterase Natural Macrolide Antibiotic
Rifapentine Arylacetamide_deacetylase Pro-Drug Drug Not A\/B H target Piperazine Antibiotic
Rifabutin Arylacetamide_deacetylase Pro-Drug Drug Not A\/B H target Piperidine Antibiotic
Rifampicin Arylacetamide_deacetylase Drug Not A\/B H target Acetate Natural Antibiotic
Bottromycin-A2-MKW BotH Antibiotic Azabicyclo
Bottromycin-A2 BotH Antibiotic Propionate tert-Butyl Azabicyclo
Bottromycin-A2-derivative-MRB BotH Antibiotic Propionate tert-Butyl
Bottromycin-A2-derivative-MQZ BotH Antibiotic Propionate Azabicyclo
Florfenicol Hormone-sensitive_lipase_like Antibiotic Sulfonyl Sulfur compound
Chloramphenicol-diacetate Antibiotic Acetate pNP
Chloramphenicol Hormone-sensitive_lipase_like Antibiotic pNP
7-Aminocephalosporanic-acid Acetyl-esterase_deacetylase BD-FAE Natural Antibiotic Azabicyclo
Cephalosporin-C Homoserine_transacetylase Acetyl-esterase_deacetylase BD-FAE Natural Antibiotic Azabicyclo
Puromycin PMH_Peptidase_S9 Antibiotic
Ampicillin Cocaine_esterase Peptidase_S15 Carb_B_Chordata Antibiotic Azabicyclo
Amoxicillin Carb_B_Chordata Antibiotic Azabicyclo
N-alanyl-secovicenilactam-ethyl-ester Proline_iminopeptidase Antibiotic Analogue of substrate
Deacetylcephalosporin-C Homoserine_transacetylase Natural Antibiotic Azabicyclo
Aclarubicin Aclacinomycin-methylesterase_RdmC Antibiotic
Aclacinomycin Aclacinomycin-methylesterase_RdmC Antibiotic