Glycidyl-1-naphthyl-ether
Optically pure epoxides are essential chiral precursors for the production of (S)-propranolol, (S)-alprenolol, and other beta-adrenergic receptor blocking drugs
General
Type : Naphthalen
Chemical_Nomenclature : 2-(naphthalen-1-yloxymethyl)oxirane
Canonical SMILES : C1C(O1)COC2=CC=CC3=CC=CC=C32
InChI : InChI=1S\/C13H12O2\/c1-2-6-12-10(4-1)5-3-7-13(12)15-9-11-8-14-11\/h1-7,11H,8-9H2
InChIKey : QYYCPWLLBSSFBW-UHFFFAOYSA-N
Other name(s) : Glycidyl 1-naphthyl ether || alpha-naphthyl glycidyl ether || 2-[(1-Naphthyloxy)methyl]oxirane || Naphthyl glycidyl ether || 1-Naphthyl glycidyl ether || 2-((Naphthalen-1-yloxy)methyl)oxirane || 2-[(naphthalen-1-yloxy)methyl]oxirane
MW : 200.23
Formula : C13H12O2
CAS_number : 2461-42-9
PubChem : 91521
UniChem : QYYCPWLLBSSFBW-UHFFFAOYSA-N
Target
Structures : 4IO0
Families : Epoxide_hydrolase
References (1)
| Title : Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates - Kong_2014_Proc.Natl.Acad.Sci.U.S.A_111_15717 |
| Author(s) : Kong XD , Yuan S , Li L , Chen S , Xu JH , Zhou J |
| Ref : Proc Natl Acad Sci U S A , 111 :15717 , 2014 |
| Abstract : |
| PubMedSearch : Kong_2014_Proc.Natl.Acad.Sci.U.S.A_111_15717 |
| PubMedID: 25331869 |
| Gene_locus related to this paper: bacme-g9bex6 |