Epoxide_hydrolase

Relationship

Family: Epoxide_hydrolase

Block: X

Parent Family: Epoxide-hydrolase_like

Comment

Epoxide hydrolases catalyze the conversion of epoxides to corresponding diols. The catalytic triad nucleophile is an invariable aspartate that opens the epoxide ring by nuclophile attack. The mammalian soluble EHs contain 2 evolutionarily distinct domains, the N-terminal domain is similar to bacterial haloacid dehalogenase (not related to alpha/beta-hydrolase fold), while the C-terminal domain is similar to soluble plant EH, microsomal EH, and bacterial haloalkane_dehalogenase (HLD). In InterPro IPR000639 groups Epoxide hydrolase and Haloalkane dehalogenase. IPR000639; Epoxide hydrolase contains some Carboxymethylbutenolide_lactonase (trembl Q9WWZ4) Carbon-carbon_bond_hydrolase (trembl Q98I15 Q9KH20 Q9K5C1 Q9KWQ6 Q9ZAY1 Q9ZNJ3 Q9RBF3 Q9RBT0) Monoglyceridelipase_lysophospholip (trembl Q97TG8). In ESTHER they are classified in the later sub family. (there are also epoxide hydrolases not related to a/b hydrolases ex: 1NWW limonene-1,2-epoxide hydrolase Arand et al. 2003) Zhu et al. (2003) identified compound heterozygosity for 2 mutations in the EPHX1 gene, which resulted in a significant decrease in EPHX1 promoter activity.

Database

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (171)

Genes Proteins in Epoxide_hydrolase family (1166)

Fragments of genes in Epoxide_hydrolase family (81)

Structures in Epoxide_hydrolase family (171)

Substrates in Epoxide_hydrolase family (42)

Inhibitors in Epoxide_hydrolase family (128)

References (10)

Title : Hepatic soluble epoxide hydrolase activity regulates cerebral Abeta metabolism and the pathogenesis of Alzheimer's disease in mice - Wu_2023_Neuron__
Author(s) : Wu Y , Dong JH , Dai YF , Zhu MZ , Wang MY , Zhang Y , Pan YD , Yuan XR , Guo ZX , Wang CX , Li YQ , Zhu XH
Ref : Neuron , : , 2023
PubMedID: 37402372
Gene_locus related to this paper: human-EPHX2

Title : Evolution of tunnels in alpha\/beta-hydrolase fold proteins-What can we learn from studying epoxide hydrolases? - Bzowka_2022_PLoS.Comput.Biol_18_e1010119
Author(s) : Bzowka M , Mitusinska K , Raczynska A , Skalski T , Samol A , Bagrowska W , Magdziarz T , Gora A
Ref : PLoS Comput Biol , 18 :e1010119 , 2022
PubMedID: 35580137

Title : Expanding the Catalytic Triad in Epoxide Hydrolases and Related Enzymes - Amrein_2015_ACS.Catal_5_5702
Author(s) : Amrein BA , Bauer P , Duarte F , Carlsson AJ , Naworyta A , Mowbray SL , Widersten M , Kamerlin SCL
Ref : ACS Catal , 5 :5702 , 2015
PubMedID: 26527505
Gene_locus related to this paper: soltu-3epoxy

Title : EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides - Decker_2012_J.Lipid.Res_53_2038
Author(s) : Decker M , Adamska M , Cronin A , Di Giallonardo F , Burgener J , Marowsky A , Falck JR , Morisseau C , Hammock BD , Gruzdev A , Zeldin DC , Arand M
Ref : J Lipid Res , 53 :2038 , 2012
PubMedID: 22798687
Gene_locus related to this paper: human-EPHX3 , human-EPHX4

Title : Diversity and biocatalytic potential of epoxide hydrolases identified by genome analysis - van Loo_2006_Appl.Environ.Microbiol_72_2905
Author(s) : van Loo B , Kingma J , Arand M , Wubbolts MG , Janssen DB
Ref : Applied Environmental Microbiology , 72 :2905 , 2006
PubMedID: 16597997
Gene_locus related to this paper: agrra-echA , bacsu-yfhM , corsp-cEH , deira-DR2549 , myctu-ephF , nosp7-b2j4w6 , nosp7-b2iv02 , psepu-PP4624 , rhopa-q6n645 , strco-2SCG4.13 , thefy-q47qj2

Title : Inhibition of human m-epoxide hydrolase gene expression in a case of hypercholanemia - Zhu_2003_Biochim.Biophys.Acta_1638_208
Author(s) : Zhu QS , Xing W , Qian B , von Dippe P , Shneider BL , Fox VL , Levy D
Ref : Biochimica & Biophysica Acta , 1638 :208 , 2003
PubMedID: 12878321
Gene_locus related to this paper: human-EPHX1

Title : Epoxide hydrolases: biochemistry and molecular biology - Fretland_2000_Chem.Biol.Interact_129_41
Author(s) : Fretland AJ , Omiecinski CJ
Ref : Chemico-Biological Interactions , 129 :41 , 2000
PubMedID: 11154734

Title : Gene evolution of epoxide hydrolases and recommended nomenclature - Beetham_1995_DNA.Cell.Biol_14_61
Author(s) : Beetham JK , Grant D , Arand M , Garbarino J , Kiyosue T , Pinot F , Oesch F , Belknap WR , Shinozaki K , Hammock BD
Ref : DNA & Cell Biology , 14 :61 , 1995
PubMedID: 7832993
Gene_locus related to this paper: mouse-hyes

Title : Microsomal and soluble epoxide hydrolases are members of the same family of C-X bond hydrolase enzymes - Lacourciere_1994_Chem.Res.Toxicol_7_121
Author(s) : Lacourciere GM , Armstrong RN
Ref : Chemical Research in Toxicology , 7 :121 , 1994
PubMedID: 8199297

Title : cDNA cloning and expression of a soluble epoxide hydrolase from human liver - Beetham_1993_Arch.Biochem.Biophys_305_197
Author(s) : Beetham JK , Tian T , Hammock BD
Ref : Archives of Biochemistry & Biophysics , 305 :197 , 1993
PubMedID: 8342951
Gene_locus related to this paper: human-EPHX2