VF-EX2
The dye/enzyme hybrids are composed of a photoinduced electron transfer (PeT)-based fluorescent voltage indicator and complementary enzyme expressed on the cell surface. Action of the exogenous enzyme on the dye results in fluorogenic activation of the dye, enabling fast voltage imaging in defined neurons, with sensitivity surpassing purely genetically-encoded approaches. VF dyes localize to the outer leaflet of cell membranes to sense voltage
General
Type : Fluorescent Probe, Sulfur Compound, Xanthene, Cyclopropyl
Chemical_Nomenclature : ((9-(4-((E)-4-((E)-4-(dimethylamino)styryl)styryl)-2-((((1-methylcyclopropane-1-carbonyl)oxy)methoxy)sulfonyl)phenyl)-3-oxo-3H-xanthen-6-yl)oxy)methyl 1-methylcyclopropane-1-carboxylate
Canonical SMILES : C13=CC(=C(C=C1OC2=CC(C(=CC2=C3C4=CC=C(C=C4[S](=O)(OCOC(=O)C5(C)CC5)=O)C=CC6=CC=C(C=C6)N(C)C)Cl)=O)OCOC(=O)C7(C)CC7)Cl
InChI : InChI=1S\/C41H37Cl2NO10S\/c1-40(13-14-40)38(46)51-22-50-35-21-34-29(19-31(35)43)37(28-18-30(42)32(45)20-33(28)54-34)27-12-9-25(6-5-24-7-10-26(11-8-24)44(3)4)17-36(27)55(48,49)53-23-52-39(47)41(2)15-16-41\/h5-12,17-21H,13-16,22-23H2,1-4H3
InChIKey : CXSFMAMKDCZZCO-UHFFFAOYSA-N
Other name(s) :
Target
Structures : No structure
Families : Carb_B_Chordata
References (1)
| Title : Fluorogenic Targeting of Voltage-Sensitive Dyes to Neurons - Liu_2017_J.Am.Chem.Soc_139_17334 |
| Author(s) : Liu P , Grenier V , Hong W , Muller VR , Miller EW |
| Ref : Journal of the American Chemical Society , 139 :17334 , 2017 |
| Abstract : |
| PubMedSearch : Liu_2017_J.Am.Chem.Soc_139_17334 |
| PubMedID: 29154543 |