Carb_B_Chordata

Relationship

Family: Carb_B_Chordata

Block: C

Parent Family: Carboxylesterase

Comment

This family was extracted from the previous Carboxylesterase COesterase family. This family corresponds to the Carbohydrate Esterase family CE10 in CAZy - Carbohydrate-Active enZYmes database (CE_10). Mammalian liver carboxylesterases (CESs; EC 3.1.1.1) hydrolyze various xenobiotics and endogenous substrates with ester, thioester, or amide bonds and are thought to function mainly in drug metabolism and detoxication of harmful chemicals. CES1 is also responsible for hydrolysis of stored cholesterol esters in macrophage foam cells and release of free cholesterol for high density lipoprotein-mediated cholesterol efflux

Database

Interpro : IPR002018 Carboxylesterase, type B

PIRSF : PIRSF005676 COesterase

Pdoc : PDOC00112

Pfam : PF00135 COesterase

Prints : No Print

EC Number : 3.1.1.1

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (22)

Genes Proteins in Carb_B_Chordata family (543)

Fragments of genes in Carb_B_Chordata family (295)

Structures in Carb_B_Chordata family (22)

Substrates in Carb_B_Chordata family (145)

Inhibitors in Carb_B_Chordata family (67)

References (15)

Title : Carboxylesterases in lipid metabolism: from mouse to human - Lian_2018_Protein.Cell_9_178
Author(s) : Lian J , Nelson R , Lehner R
Ref : Protein Cell , 9 :178 , 2018
PubMedID: 28677105
Gene_locus related to this paper: human-CES1

Title : Nomenclature for alleles of the human carboxylesterase 1 gene -
Author(s) : Rasmussen HB , Madsen MB , Hansen PR
Ref : Pharmacogenet Genomics , 27 :78 , 2017
PubMedID: 27831961
Gene_locus related to this paper: human-CES1

Title : Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases - Fukami_2015_Eur.J.Pharm.Sci_78_47
Author(s) : Fukami T , Kariya M , Kurokawa T , Iida A , Nakajima M
Ref : Eur J Pharm Sci , 78 :47 , 2015
PubMedID: 26164127
Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2

Title : Carboxylesterases: structure, function and polymorphism in mammals - Satoh_2010_J.Pestic.Sci_35_218
Author(s) : Satoh T , Hosokawa M
Ref : Journal of Pesticide Science , 35 :218 , 2010
PubMedID:

Title : Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins - Holmes_2010_Mamm.Genome_21_427
Author(s) : Holmes RS , Wright MW , Laulederkind SJ , Cox LA , Hosokawa M , Imai T , Ishibashi S , Lehner R , Miyazaki M , Perkins EJ , Potter PM , Redinbo MR , Robert J , Satoh T , Yamashita T , Yan B , Yokoi T , Zechner R , Maltais LJ
Ref : Mamm Genome , 21 :427 , 2010
PubMedID: 20931200
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A

Title : Genomic analysis of the carboxylesterases: identification and classification of novel forms - Williams_2010_Mol.Phylogenet.Evol_57_23
Author(s) : Williams ET , Wang H , Wrighton SA , Qian YW , Perkins EJ
Ref : Mol Phylogenet Evol , 57 :23 , 2010
PubMedID: 20510380
Gene_locus related to this paper: macfa-a0a2k5uar1

Title : Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin - Hemmert_2010_Mol.Pharmacol_77_508
Author(s) : Hemmert AC , Otto TC , Wierdl M , Edwards CC , Fleming CD , MacDonald M , Cashman JR , Potter PM , Cerasoli DM , Redinbo MR
Ref : Molecular Pharmacology , 77 :508 , 2010
PubMedID: 20051531
Gene_locus related to this paper: human-CES1

Title : Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs - Hosokawa_2008_Molecules_13_412
Author(s) : Hosokawa M
Ref : Molecules , 13 :412 , 2008
PubMedID: 18305428

Title : Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun - Fleming_2007_Biochemistry_46_5063
Author(s) : Fleming CD , Edwards CC , Kirby SD , Maxwell DM , Potter PM , Cerasoli DM , Redinbo MR
Ref : Biochemistry , 46 :5063 , 2007
PubMedID: 17407327
Gene_locus related to this paper: human-CES1

Title : Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1 - Bencharit_2006_J.Mol.Biol_363_201
Author(s) : Bencharit S , Edwards CC , Morton CL , Howard-Williams EL , Kuhn P , Potter PM , Redinbo MR
Ref : Journal of Molecular Biology , 363 :201 , 2006
PubMedID: 16962139
Gene_locus related to this paper: human-CES1

Title : Structure, function and regulation of carboxylesterases - Satoh_2006_Chem.Biol.Interact_162_195
Author(s) : Satoh T , Hosokawa M
Ref : Chemico-Biological Interactions , 162 :195 , 2006
PubMedID: 16919614

Title : Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil - Fleming_2005_J.Mol.Biol_352_165
Author(s) : Fleming CD , Bencharit S , Edwards CC , Hyatt JL , Tsurkan L , Bai F , Fraga C , Morton CL , Howard-Williams EL , Potter PM , Redinbo MR
Ref : Journal of Molecular Biology , 352 :165 , 2005
PubMedID: 16081098
Gene_locus related to this paper: human-CES1

Title : Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition - Bencharit_2003_Chem.Biol_10_341
Author(s) : Bencharit S , Morton CL , Hyatt JL , Kuhn P , Danks MK , Potter PM , Redinbo MR
Ref : Chemical Biology , 10 :341 , 2003
PubMedID: 12725862
Gene_locus related to this paper: human-CES1

Title : Structural insights into CPT-11 activation by mammalian carboxylesterases - Bencharit_2002_Nat.Struct.Biol_9_337
Author(s) : Bencharit S , Morton CL , Howard-Williams EL , Danks MK , Potter PM , Redinbo MR
Ref : Nat Struct Biol , 9 :337 , 2002
PubMedID: 11967565
Gene_locus related to this paper: rabit-1cxes

Title : On the origins of esterases - Myers_1988_Mol.Biol.Evol_5_113
Author(s) : Myers M , Richmond RC , Oakeshott JG
Ref : Molecular Biology Evolution , 5 :113 , 1988
PubMedID: 3163407