33N
derivative of 34N
General
Type : Pyridine,Nicotinamide,Carboxamide
Chemical_Nomenclature : N-(3,3-diphenylpropyl)pyridine-3-carboxamide
Canonical SMILES : C1=CC=C(C=C1)C(CCNC(=O)C2=CN=CC=C2)C3=CC=CC=C3
InChI : InChI=1S\/C21H20N2O\/c24-21(19-12-7-14-22-16-19)23-15-13-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18\/h1-12,14,16,20H,13,15H2,(H,23,24)
InChIKey : GDHXZIQAOUBZCC-UHFFFAOYSA-N
Other name(s) : CHEMBL560537,N-(3,3-diphenylpropyl)pyridine-3-carboxamide,N-(3,3-Diphenylpropyl)Nicotinamide,N-(3,3-diphenyl-propyl)-nicotinamide,3i1y,AC1MS8VU
MW : 316.40
Formula : C21H20N2O
CAS_number :
PubChem : 3530525
UniChem : GDHXZIQAOUBZCC-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : 33N ligand of proteins in family: Epoxide_hydrolase
Stucture : 3I1Y Crystal Structure of human soluble epoxide Hydrolase with inhibitor 33N
Protein : human-EPHX2
References (2)
| Title : Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase - Eldrup_2009_J.Med.Chem_52_5880 |
| Author(s) : Eldrup AB , Soleymanzadeh F , Taylor SJ , Muegge I , Farrow NA , Joseph D , McKellop K , Man CC , Kukulka A , De Lombaert S |
| Ref : Journal of Medicinal Chemistry , 52 :5880 , 2009 |
| Abstract : Eldrup_2009_J.Med.Chem_52_5880 |
| ESTHER : Eldrup_2009_J.Med.Chem_52_5880 |
| PubMedSearch : Eldrup_2009_J.Med.Chem_52_5880 |
| PubMedID: 19746975 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase - Taylor_2009_Bioorg.Med.Chem.Lett_19_5864 |
| Author(s) : Taylor SJ , Soleymanzadeh F , Eldrup AB , Farrow NA , Muegge I , Kukulka A , Kabcenell AK , De Lombaert S |
| Ref : Bioorganic & Medicinal Chemistry Lett , 19 :5864 , 2009 |
| Abstract : Taylor_2009_Bioorg.Med.Chem.Lett_19_5864 |
| ESTHER : Taylor_2009_Bioorg.Med.Chem.Lett_19_5864 |
| PubMedSearch : Taylor_2009_Bioorg.Med.Chem.Lett_19_5864 |
| PubMedID: 19758802 |