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human-EPHX2

Homo sapiens (Human) epoxide hydrolase 2, Bifunctional epoxide hydrolase 2 cytosolic (EPHX2) (EC 3.3.2.3) Lipid-phosphate phosphatase (EC 3.1.3.76) Soluble epoxide hydrolase

Comment

The gene EPXH2 encodes for the soluble epoxide hydrolase (sEH), an enzyme involved in the regulation of cardiovascular and renal physiology containing two distinct domains connected via a proline-rich linker. The C-terminal domain contains the EH catalytic activity. The N-terminal domain, has high homology to the haloacid dehalogenase family of phosphatases (not alpha\/beta hydrolase and not included in ESTHER 5MWA is a structure of this part of the protein). Only c-term PfamA Abhydrolase_1 286 540 N-term is HAD haloacid dehalogenase

Relationship

Family : Epoxide_hydrolase

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

1S8O - Human soluble Epoxide Hydrolase 1VJ5 - Human soluble Epoxide Hydrolase- N-cyclohexyl-N'-(4-iodophenyl)urea complex 1ZD2 - Human soluble Epoxide hydrolase 4-(3-cyclohexyluriedo)-ethanoic acid complex 1ZD3 - Human soluble Epoxide hydrolase 4-(3-cyclohexyluriedo)-butyric acid complex 1ZD4 - Human soluble Epoxide hydrolase 4-(3-cyclohexyluriedo)-hexanoic acid complex 1ZD5 - Human soluble Epoxide hydrolase 4-(3-cyclohexyluriedo)-heptanoic acid complex 3ANS - Human soluble Epoxide hydrolase in complex with a synthetic inhibitor 1 3ANT - Human soluble Epoxide hydrolase in complex with a synthetic inhibitor 1 3I1Y - Crystal Structure of human soluble epoxide Hydrolase with inhibitor 33N 3I28 - Crystal Structure of human soluble epoxide Hydrolase with inhibitor 34N 3KOO - Crystal Structure of soluble epoxide Hydrolase with inhibitor 24D 3OTQ - Soluble Epoxide Hydrolase in complex with pyrazole antagonist 3PDC - Crystal structure of hydrolase domain of human soluble epoxide hydrolase complexed with a benzoxazole inhibitor 3WK4 - Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 6 3WK5 - Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 7 3WK6 - Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 8 3WK7 - Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 9 3WK8 - Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 10 3WK9 - Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 1 3WKA - Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 2 3WKB - Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 3 3WKC - Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 4 3WKD - Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 5 3WKE - Crystal structure of soluble epoxide hydrolase in complex with with t-AUCB 4C4X - Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with C9 4C4Y - Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with A4 4C4Z - Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with A8 4HAI - Crystal structure of human soluble human epoxide hydrolase complexed with N-cycloheptyl-1-(mesitylsulfonyl)piperidine-4-carboxamide. 4J03 - Crystal structure of human soluble human epoxide hydrolase complexed with fulvestrant. 4JNC - Soluble Epoxide Hydrolase complexed with a carboxamide inhibitor 4OCZ - Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea 1 4OD0 - Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea 2 4X6X - Human soluble epoxide hydrolase in complex with a three substituted cyclopropane derivative 4X6Y - Human soluble epoxide hydrolase in complex with a cyclopropyl urea derivative 4Y2J - Structure of soluble epoxide hydrolase in complex with N-[(1-methyl-1H-pyrazol-3-yl)methyl]-2-phenylethanamine 4Y2P - Structure of soluble epoxide hydrolase in complex with N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine 4Y2Q - Structure of soluble epoxide hydrolase in complex with 1-[3-(trifluoromethyl)pyridin-2-yl]piperazine 4Y2R - Structure of soluble epoxide hydrolase in complex with 2-(piperazin-1-yl)nicotinonitrile 4Y2S - Structure of soluble epoxide hydrolase in complex with 1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-4-ol 4Y2T - Structure of soluble epoxide hydrolase in complex with 3-[4-(benzyloxy)phenyl]propan-1-ol 4Y2U - Structure of soluble epoxide hydrolase in complex with tert-butyl 1,2,3,4-tetrahydroquinolin-3-ylcarbamate 4Y2V - Structure of soluble epoxide hydrolase in complex with (4-bromo-3-cyclopropyl-1H-pyrazol-1-yl)acetic acid 4Y2X - Structure of soluble epoxide hydrolase in complex with 2-({[2-(adamantan-1-yl)ethyl]amino}methyl)phenol 4Y2Y - Structure of soluble epoxide hydrolase in complex with 2-(2-fluorophenyl)-N-[(5-methyl-2-thienyl)methyl]ethanamine 5AHX - ligand complex structure of human soluble epoxide hydrolase 5AI0 - ligand complex structure of human soluble epoxide hydrolase 5AI4 - ligand complex structure of human soluble epoxide hydrolase 5AI5 - ligand complex structure of human soluble epoxide hydrolase 5AI6 - ligand complex structure of human soluble epoxide hydrolase 5AI8 - ligand complex structure of human soluble epoxide hydrolase 5AI9 - ligand complex structure of human soluble epoxide hydrolase 5AIA - ligand complex structure of human soluble epoxide hydrolase 5AIB - ligand complex structure of human soluble epoxide hydrolase 5AIC - ligand complex structure of human soluble epoxide hydrolase 5AK3 - ligand complex structure of human soluble epoxide hydrolase 5AK4 - ligand complex structure of soluble epoxide hydrolase 5AK5 - ligand complex structure of human soluble epoxide hydrolase 5AK6 - ligand complex structure of human soluble epoxide hydrolase 5AKE - ligand complex structure of human soluble epoxide hydrolase 5AKG - ligand complex structure of human soluble epoxide hydrolase 5AKH - ligand complex structure of human soluble epoxide hydrolase 5AKI - ligand complex structure of human soluble epoxide hydrolase 5AKJ - ligand complex structure of human soluble epoxide hydrolase 5AKK - ligand complex structure of human soluble epoxide hydrolase 5AKL - ligand complex structure of human soluble epoxide hydrolase 5AKX - ligand complex structure of human soluble epoxide hydrolase 5AKY - ligand complex structure of human soluble epoxide hydrolase 5AKZ - ligand complex structure of human soluble epoxide hydrolase 5ALD - ligand complex structure of human soluble epoxide hydrolase 5ALE - ligand complex structure of human soluble epoxide hydrolase 5ALF - ligand complex structure of human soluble epoxide hydrolase 5ALG - ligand complex structure of human soluble epoxide hydrolase 5ALH - ligand complex structure of human soluble epoxide hydrolase 5ALI - ligand complex structure of human soluble epoxide hydrolase 5ALJ - ligand complex structure human of soluble epoxide hydrolase 5ALK - ligand complex structure of human soluble epoxide hydrolase 5ALL - ligand complex structure of human soluble epoxide hydrolase 5ALM - ligand complex structure of human soluble epoxide hydrolase 5ALN - ligand complex structure of human soluble epoxide hydrolase 5ALO - ligand complex structure of human soluble epoxide hydrolase 5ALP - ligand complex structure of human soluble epoxide hydrolase 5ALQ - ligand complex structure of human soluble epoxide hydrolase 5ALR - ligand complex structure of human soluble epoxide hydrolase 5ALS - ligand complex structure of human soluble epoxide hydrolase 5ALT - ligand complex structure of human soluble epoxide hydrolase 5ALU - ligand complex structure of human soluble epoxide hydrolase 5ALV - ligand complex structure of human soluble epoxide hydrolase 5ALW - ligand complex structure of human soluble epoxide hydrolase 5ALX - ligand complex structure of human soluble epoxide hydrolase 5ALY - ligand complex structure of human soluble epoxide hydrolase 5ALZ - ligand complex structure of human soluble epoxide hydrolase 5AM0 - ligand complex structure of human soluble epoxide hydrolase 5AM1 - ligand complex structure of human soluble epoxide hydrolase 5AM2 - ligand complex structure of human soluble epoxide hydrolase 5AM3 - ligand complex structure of human soluble epoxide hydrolase 5AM4 - ligand complex structure of human soluble epoxide hydrolase 5AM5 - ligand complex structure of human soluble epoxide hydrolase 5FP0 - ligand complex structure of human soluble epoxide hydrolase 6AUM - Crystal structure of human soluble epoxide hydrolase complexed with trans-4-[4-(3-trifluoromethoxyphenyl-l-ureido)-cyclohexyloxy]-benzoic acid 6FR2 - Huamn soluble epoxide hydrolase in complex with LK864 polar spirocyclic orally bioavailable urea inhibitor 6HGV - Human soluble epoxide hydrolase in complex with talinolol 6HGW - Human soluble epoxide hydrolase in complex with 2-(4-fluorophenyl)-N-(4-phenoxybenzyl)ethanamine 6HGX - Human soluble epoxide hydrolase in complex with 1-(4-((4-(tert-butyl)morpholin-2-yl)methoxy)phenyl)-3-cyclohexylurea 6I5E - X-ray structure of apo human soluble Epoxide hydrolase C-terminal domain (hsEH CTD) 6I5G - X-ray structure of human soluble Epoxide yhdrolase C-terminal domain (hsEH CTD)in complex with 15d-PGJ2 6YL4 - Soluble epoxide hydrolase in complex with 3-((R)-3-(1-hydroxyureido)but-1-yn-1-yl)-N-((S)-3-phenyl-3-(4-trifluoromethoxy)phenyl)propyl)benzamide 7A7G - Soluble epoxide hydrolase in complex with TK90 7EBA - Soluble epoxide hydrolase in complex with kurarinone 7P4K - Soluble epoxide hydrolase in complex with FL217 8QMZ - Soluble epoxide hydrolase in complex with RK4 8QN0 - Soluble epoxide hydrolase in complex with RK3 8QVF - Comparison of room-temperature and cryogenic structures of soluble Epoxide Hydrolase with ligands bound 8QVH - Comparison of room-temperature and cryogenic structures of soluble Epoxide Hydrolase with ligands bound 8QVI - Comparison of room-temperature and cryogenic structures of soluble Epoxide Hydrolase with ligands bound 8QVK - Comparison of room-temperature and cryogenic structures of soluble Epoxide Hydrolase with ligands bound 8QZD - Soluble epoxide hydrolase in complex with Epoxykinin 8S75 - Soluble epoxide hydrolase in complex with PROTAC FL412 8S76 - Soluble epoxide hydrolase in complex with PROTAC JSF67 8S77 - Soluble epoxide hydrolase in complex with PROTAC JSF234

No kinetic

No disease

1,3-Dicyclohexylurea 15d-PGJ2 24D 33N 34N 4-(3-cyclohexyluriedo)-butyric-acid 4-(3-cyclohexyluriedo)-ethanoic-acid 4-(3-cyclohexyluriedo)-heptanoic-acid 4-(3-cyclohexyluriedo)-hexanoic-acid 4-Phenylchalcone-oxide 5ALG-R4N 5ALH-4UA 5ALI-Q3B 5ALP-QYD 5ALR-8TM 5ALU-HD2 5ALZ-XQ9 5AM1-I5T AEPU ALT-PG2 AS2586144 AUDA Adamantyl-trifluoromethoxy-phenyl-sulfonylurea-4f Adamantyl-urea-Cpd28 Ar9281 B401 Benzothiazole-analogue-13f CHEMBL1234565 CHEMBL1375713 CHEMBL1615212 CHEMBL1615216 CHEMBL1689794 CHEMBL1818384 CHEMBL2094355-S0I-3WKB CHEMBL2313198 CHEMBL2392714 CHEMBL3114611 CHEMBL3233604-S0C-3WK5 CHEMBL3233605-S0D-3WK7 CHEMBL3233606-S0F-3WK9 CHEMBL3233607-S0G-3WKA CHEMBL3233608-S0J-3WKC CHEMBL3233609-S0K-3WKD CHEMBL3401634 CHEMBL3402234 CHEMBL3402235 CHEMBL3402236-49P-4Y2S CHEMBL3402237-49Q-4Y2T CHEMBL3402239-4A5-4Y2V CHEMBL3402240-4A0-4Y2X CHEMBL3633668 CHEMBL442384-S0E-3WK8 CHEMBL4451596 CHEMBL4465514 CHEMBL45663-49N-4Y2Q CHEMBL469792 CHEMBL48137-49O-4Y2R CIU Chlorophenyl-sulfonyl-quinolin-piperidine-carboxamide-4d Dihydroindole-thiourea-73 Dihydroquinazoline-carboxamide-34 Diphenylurea Diuron EC5026 Epoxykinin FAAH_sEH_4.5 FL217 FNDP Fulvestrant G3W GL-B437 GSK2256294A Glimepiride Hexaethylene-glycol LK864 Morpholino-Talinolol N-1-adamantyl-N'-cyclohexylurea OWW-6YL4 PTUPB Regorafenib SB31184-49R-4Y2U SCHEMBL15272467 SCHEMBL19358888 SCHEMBL3454366 SCHEMBL3454366-Boc SCHEMBL3454366-Isobutyryl SCHEMBL7329991 SEH-45-RK3 SEH-48-RK4 SZC Sorafenib TK90 TPPU TPPU-6-Chlorotacrine-12c TPPU-methyl TUPS Talinolol UB-EV-52 Wedelolactone ZINC10109382-S0A-3WK4 ZINC1603176-7WI-4C4Y ZINC395065-W9L-4C4Z ZINC527968-S0B-3WK6 nbAUDA sEH-HDAC6-Cpd28g sEH-HDAC6-IN-M9 sEH-LTA4H-14 t-AUCB t-AUCMB t-MTUCB t-MTUCB-NH t-TUCB

Database

Sequence

Peptide

HGYVTVKPRV RLHFVELGSG PAVCLCHGFP ESWYSWRYQI PALAQAGYRV LAMDMKGYGE SSAPPEIEEY CMEVLCKEMV TFLDKLGLSQ AVFIGHDWGG MLVWYMALFY PERVRAVASL NTPFIPANPN MSPLESIKAN PVFDYQLYFQ EPGVAEAELE QNLSRTFKSL FRASDESVLS MHKVCEAGGL FVNSPEEPSL SRMVTEEEIQ FYVQQFKKSG FRGPLNWYRN MERNWKWACK SLGRKILIPA LMVTAEKDFV LVPQMSQHME DWIPHLKRGH IEDCGHWTQM DKPTEVNQIL IKWLDSDARN PPVVSKM

References (66)

Title : Soluble Epoxide Hydrolase Inhibition Reverses Cognitive Dysfunction in a Mouse Model of Metabolic Syndrome by Modulating Inflammation - Bah_2024_Prostaglandins.Other.Lipid.Mediat__106850
Author(s) : Bah TM , Davis CM , Allen E , Borkar RN , Perez R , Grafe MR , Raber J , Pike MM , Alkayed NJ
Ref : Prostaglandins Other Lipid Mediat , :106850 , 2024
Abstract :
PubMedSearch : Bah_2024_Prostaglandins.Other.Lipid.Mediat__106850
PubMedID: 38735559
Gene_locus related to this paper: human-EPHX2

Title : Water will Find Its Way: Transport through Narrow Tunnels in Hydrolases - Sequeiros-Borja_2024_J.Chem.Inf.Model__
Author(s) : Sequeiros-Borja C , Surpeta B , Thirunavukarasu AS , Dongmo Foumthuim CJ , Marchlewski I , Brezovsky J
Ref : J Chem Inf Model , : , 2024
Abstract :
PubMedSearch : Sequeiros-Borja_2024_J.Chem.Inf.Model__
PubMedID: 38669675
Gene_locus related to this paper: canru-1lipa , rhoso-halo1 , soltu-3epoxy , human-EPHX2

Title : Inhibition of soluble epoxide hydrolase as a therapeutic approach for blood-brain barrier dysfunction - Li_2024_Biochimie__
Author(s) : Li S , Song H , Sun Y , Zhang H , Gao Z
Ref : Biochimie , : , 2024
Abstract :
PubMedSearch : Li_2024_Biochimie__
PubMedID: 38531484
Gene_locus related to this paper: human-EPHX2

Title : Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator - Dotsch_2024_J.Med.Chem__
Author(s) : Dotsch L , Davies C , Hennes E , Schonfeld J , Kumar A , Guita C , Ehrler JHM , Hiesinger K , Thavam S , Janning P , Sievers S , Knapp S , Proschak E , Ziegler S , Waldmann H
Ref : Journal of Medicinal Chemistry , : , 2024
Abstract :
PubMedSearch : Dotsch_2024_J.Med.Chem__
PubMedID: 38470246
Gene_locus related to this paper: human-EPHX2

Title : Photosensitization enables Pauson-Khand-type reactions with nitrenes - Li_2024_Science_383_498
Author(s) : Li F , Zhu WF , Empel C , Datsenko O , Kumar A , Xu Y , Ehrler JHM , Atodiresei I , Knapp S , Mykhailiuk PK , Proschak E , Koenigs RM
Ref : Science , 383 :498 , 2024
Abstract :
PubMedSearch : Li_2024_Science_383_498
PubMedID: 38301027
Gene_locus related to this paper: human-EPHX2

Title : How Robust Is the Ligand Binding Transition State? - Bose_2023_J.Am.Chem.Soc__
Author(s) : Bose S , Lotz SD , Deb I , Shuck M , Lee KSS , Dickson A
Ref : Journal of the American Chemical Society , : , 2023
Abstract :
PubMedSearch : Bose_2023_J.Am.Chem.Soc__
PubMedID: 37943667
Gene_locus related to this paper: human-EPHX2

Title : Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress - Peyman_2023_Biomed.Pharmacother_168_115667
Author(s) : Peyman M , Barroso E , Turcu AL , Estrany F, Jr. , Smith D , Jurado-Aguilar J , Rada P , Morisseau C , Hammock BD , Valverde A M , Palomer X , Galdeano C , Vazquez S , Vazquez-Carrera M
Ref : Biomed Pharmacother , 168 :115667 , 2023
Abstract :
PubMedSearch : Peyman_2023_Biomed.Pharmacother_168_115667
PubMedID: 37826940
Gene_locus related to this paper: human-EPHX2

Title : PROTAC-Mediated Selective Degradation of Cytosolic Soluble Epoxide Hydrolase Enhances ER Stress Reduction - Wang_2023_ACS.Chem.Biol__
Author(s) : Wang Y , Morisseau C , Takamura A , Wan D , Li D , Sidoli S , Yang J , Wolan DW , Hammock BD , Kitamura S
Ref : ACS Chemical Biology , : , 2023
Abstract :
PubMedSearch : Wang_2023_ACS.Chem.Biol__
PubMedID: 36947831
Gene_locus related to this paper: human-EPHX2

Title : Hepatic soluble epoxide hydrolase activity regulates cerebral Abeta metabolism and the pathogenesis of Alzheimer's disease in mice - Wu_2023_Neuron__
Author(s) : Wu Y , Dong JH , Dai YF , Zhu MZ , Wang MY , Zhang Y , Pan YD , Yuan XR , Guo ZX , Wang CX , Li YQ , Zhu XH
Ref : Neuron , : , 2023
Abstract :
PubMedSearch : Wu_2023_Neuron__
PubMedID: 37402372
Gene_locus related to this paper: human-EPHX2

Title : Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis - Musella_2023_J.Med.Chem__
Author(s) : Musella S , D'Avino D , Peltner LK , Di Sarno V , Cerqua I , Merciai F , Vestuto V , Ciaglia T , Smaldone G , Di Matteo F , Di Micco S , Napolitano V , Bifulco G , Pepe G , Sommella EM , Basilicata MG , Aquino G , Gomez-Monterrey IM , Campiglia P , Ostacolo C , Roviezzo F , Werz O , Rossi A , Bertamino A
Ref : Journal of Medicinal Chemistry , : , 2023
Abstract :
PubMedSearch : Musella_2023_J.Med.Chem__
PubMedID: 37334504
Gene_locus related to this paper: human-EPHX2

Title : CRISPR\/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury - Leuillier_2023_J.Adv.Res_43_163
Author(s) : Leuillier M , Duflot T , Menoret S , Messaoudi H , Djerada Z , Groussard D , Denis RGP , Chevalier L , Karoui A , Panthu B , Thiebaut PA , Schmitz-Afonso I , Nobis S , Campart C , Henry T , Sautreuil C , Luquet SH , Beseme O , Feliu C , Peyret H , Nicol L , Henry JP , Renet S , Mulder P , Wan D , Tesson L , Heslan JM , Duche A , Jacques S , Ziegler F , Brunel V , Rautureau GJP , Monteil C , do Rego JL , do Rego JC , Afonso C , Hammock B , Madec AM , Pinet F , Richard V , Anegon I , Guignabert C , Morisseau C , Bellien J
Ref : J Adv Res , 43 :163 , 2023
Abstract :
PubMedSearch : Leuillier_2023_J.Adv.Res_43_163
PubMedID: 36585106
Gene_locus related to this paper: human-EPHX2

Title : Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model - Sun_2022_Proc.Natl.Acad.Sci.U.S.A_119_
Author(s) : Sun CP , Zhou JJ , Yu ZL , Huo XK , Zhang J , Morisseau C , Hammock BD , Ma XC
Ref : Proc Natl Acad Sci U S A , 119 : , 2022
Abstract :
PubMedSearch : Sun_2022_Proc.Natl.Acad.Sci.U.S.A_119_
PubMedID: 35217618
Gene_locus related to this paper: human-EPHX2

Title : Computational insights into the known inhibitors of human soluble epoxide hydrolase - Bzowka_2021_Drug.Discov.Today__
Author(s) : Bzowka M , Mitusinska K , Hopko K , Gora A
Ref : Drug Discov Today , : , 2021
Abstract :
PubMedSearch : Bzowka_2021_Drug.Discov.Today__
PubMedID: 34082135
Gene_locus related to this paper: human-EPHX2

Title : Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor gamma Agonists\/Soluble Epoxide Hydrolase Inhibitors - Lillich_2021_J.Med.Chem_64_17259
Author(s) : Lillich FF , Willems S , Ni X , Kilu W , Borkowsky C , Brodsky M , Kramer JS , Brunst S , Hernandez-Olmos V , Heering J , Schierle S , Kestner RI , Mayser FM , Helmstadter M , Gobel T , Weizel L , Namgaladze D , Kaiser A , Steinhilber D , Pfeilschifter W , Kahnt AS , Proschak A , Chaikuad A , Knapp S , Merk D , Proschak E
Ref : Journal of Medicinal Chemistry , : , 2021
Abstract :
PubMedSearch : Lillich_2021_J.Med.Chem_64_17259
PubMedID: 34818007
Gene_locus related to this paper: human-EPHX2

Title : Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase - Hiesinger_2020_J.Med.Chem_63_11498
Author(s) : Hiesinger K , Kramer JS , Beyer S , Eckes T , Brunst S , Flauaus C , Wittmann SK , Weizel L , Kaiser A , Kretschmer SBM , George S , Angioni C , Heering J , Geisslinger G , Schubert-Zsilavecz M , Schmidtko A , Pogoryelov D , Pfeilschifter J , Hofmann B , Steinhilber D , Schwalm S , Proschak E
Ref : Journal of Medicinal Chemistry , 63 :11498 , 2020
Abstract :
PubMedSearch : Hiesinger_2020_J.Med.Chem_63_11498
PubMedID: 33044073
Gene_locus related to this paper: human-EPHX2

Title : Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation - Wang_2020_Proc.Natl.Acad.Sci.U.S.A_117_8431
Author(s) : Wang Y , Yang J , Wang W , Sanidad KZ , Cinelli MA , Wan D , Hwang SH , Kim D , Lee KSS , Xiao H , Hammock BD , Zhang G
Ref : Proc Natl Acad Sci U S A , 117 :8431 , 2020
Abstract :
PubMedSearch : Wang_2020_Proc.Natl.Acad.Sci.U.S.A_117_8431
PubMedID: 32220957
Gene_locus related to this paper: human-EPHX2

Title : Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase - Hiesinger_2020_ACS.Med.Chem.Lett_11_298
Author(s) : Hiesinger K , Schott A , Kramer JS , Blocher R , Witt F , Wittmann SK , Steinhilber D , Pogoryelov D , Gerstmeier J , Werz O , Proschak E
Ref : ACS Med Chem Lett , 11 :298 , 2020
Abstract :
PubMedSearch : Hiesinger_2020_ACS.Med.Chem.Lett_11_298
PubMedID: 32184960
Gene_locus related to this paper: human-EPHX2

Title : 15-deoxy-Delta(12,14)-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism - Abis_2019_Commun.Biol_2_188
Author(s) : Abis G , Charles RL , Kopec J , Yue WW , Atkinson RA , Bui TTT , Lynham S , Popova S , Sun YB , Fraternali F , Eaton P , Conte MR
Ref : Commun Biol , 2 :188 , 2019
Abstract :
PubMedSearch : Abis_2019_Commun.Biol_2_188
PubMedID: 31123712
Gene_locus related to this paper: human-EPHX2

Title : Computer-Aided Selective Optimization of Side Activities of Talinolol - Hiesinger_2019_ACS.Med.Chem.Lett_10_899
Author(s) : Hiesinger K , Kramer JS , Achenbach J , Moser D , Weber J , Wittmann SK , Morisseau C , Angioni C , Geisslinger G , Kahnt AS , Kaiser A , Proschak A , Steinhilber D , Pogoryelov D , Wagner K , Hammock BD , Proschak E
Ref : ACS Med Chem Lett , 10 :899 , 2019
Abstract :
PubMedSearch : Hiesinger_2019_ACS.Med.Chem.Lett_10_899
PubMedID: 31223445
Gene_locus related to this paper: human-EPHX2

Title : Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase - Kodani_2018_Bioorg.Med.Chem.Lett_28_762
Author(s) : Kodani SD , Bhakta S , Hwang SH , Pakhomova S , Newcomer ME , Morisseau C , Hammock BD
Ref : Bioorganic & Medicinal Chemistry Lett , 28 :762 , 2018
Abstract :
PubMedSearch : Kodani_2018_Bioorg.Med.Chem.Lett_28_762
PubMedID: 29366648
Gene_locus related to this paper: human-EPHX2

Title : Role of sEH R287Q in LDLR expression, LDL binding to LDLR and LDL internalization in BEL-7402 cells - Tang_2018_Gene_667_95
Author(s) : Tang L , Wang G , Jiang L , Chen P , Wang W , Chen J , Wang L
Ref : Gene , 667 :95 , 2018
Abstract :
PubMedSearch : Tang_2018_Gene_667_95
PubMedID: 29665449
Gene_locus related to this paper: human-EPHX2

Title : The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain - Zimmer_2018_Biochim.Biophys.Acta_1863_669
Author(s) : Zimmer B , Angioni C , Osthues T , Toewe A , Thomas D , Pierre SC , Geisslinger G , Scholich K , Sisignano M
Ref : Biochimica & Biophysica Acta , 1863 :669 , 2018
Abstract :
PubMedSearch : Zimmer_2018_Biochim.Biophys.Acta_1863_669
PubMedID: 29625231
Gene_locus related to this paper: human-EPHX2

Title : Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase - Lukin_2018_Bioorg.Chem_80_655
Author(s) : Lukin A , Kramer J , Hartmann M , Weizel L , Hernandez-Olmos V , Falahati K , Burghardt I , Kalinchenkova N , Bagnyukova D , Zhurilo N , Rautio J , Forsberg M , Ihalainen J , Auriola S , Leppanen J , Konstantinov I , Pogoryelov D , Proschak E , Dar'in D , Krasavin M
Ref : Bioorg Chem , 80 :655 , 2018
Abstract :
PubMedSearch : Lukin_2018_Bioorg.Chem_80_655
PubMedID: 30059891
Gene_locus related to this paper: human-EPHX2

Title : Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and omega-Hydroxylases - Hanif_2017_PLoS.One_12_e0169584
Author(s) : Hanif A , Edin ML , Zeldin DC , Morisseau C , Falck JR , Nayeem MA
Ref : PLoS ONE , 12 :e0169584 , 2017
Abstract :
PubMedSearch : Hanif_2017_PLoS.One_12_e0169584
PubMedID: 28056085
Gene_locus related to this paper: human-EPHX2

Title : Fragment Screening of Soluble Epoxide Hydrolase for Lead Generation-Structure-Based Hit Evaluation and Chemistry Exploration - Xue_2016_ChemMedChem_11_497
Author(s) : Xue Y , Olsson T , Johansson CA , Oster L , Beisel HG , Rohman M , Karis D , Backstrom S
Ref : ChemMedChem , 11 :497 , 2016
Abstract :
PubMedSearch : Xue_2016_ChemMedChem_11_497
PubMedID: 26845235
Gene_locus related to this paper: human-EPHX2

Title : Discovery of enantioselectivity of urea inhibitors of soluble epoxide hydrolase - Manickam_2016_Eur.J.Med.Chem_117_113
Author(s) : Manickam M , Pillaiyar T , Boggu P , Venkateswararao E , Jalani HB , Kim ND , Lee SK , Jeon JS , Kim SK , Jung SH
Ref : Eur Journal of Medicinal Chemistry , 117 :113 , 2016
Abstract :
PubMedSearch : Manickam_2016_Eur.J.Med.Chem_117_113
PubMedID: 27092411
Gene_locus related to this paper: human-EPHX2

Title : Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa - Shih_2016_Mol.Psychiatry_21_537
Author(s) : Shih PB , Yang J , Morisseau C , German JB , Zeeland AA , Armando AM , Quehenberger O , Bergen AW , Magistretti P , Berrettini W , Halmi KA , Schork N , Hammock BD , Kaye W
Ref : Mol Psychiatry , 21 :537 , 2016
Abstract :
PubMedSearch : Shih_2016_Mol.Psychiatry_21_537
PubMedID: 25824304
Gene_locus related to this paper: human-EPHX2

Title : Deletion of soluble epoxide hydrolase enhances coronary reactive hyperemia in isolated mouse heart: role of oxylipins and PPARgamma - Hanif_2016_Am.J.Physiol.Regul.Integr.Comp.Physiol_311_R676
Author(s) : Hanif A , Edin ML , Zeldin DC , Morisseau C , Nayeem MA
Ref : American Journal of Physiology Regul Integr Comp Physiol , 311 :R676 , 2016
Abstract :
PubMedSearch : Hanif_2016_Am.J.Physiol.Regul.Integr.Comp.Physiol_311_R676
PubMedID: 27488890
Gene_locus related to this paper: human-EPHX2

Title : A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles - Pilger_2015_Angew.Chem.Int.Ed.Engl_54_6511
Author(s) : Pilger J , Mazur A , Monecke P , Schreuder H , Elshorst B , Bartoschek S , Langer T , Schiffer A , Krimm I , Wegstroth M , Lee D , Hessler G , Wendt KU , Becker S , Griesinger C
Ref : Angew Chem Int Ed Engl , 54 :6511 , 2015
Abstract :
PubMedSearch : Pilger_2015_Angew.Chem.Int.Ed.Engl_54_6511
PubMedID: 25877959
Gene_locus related to this paper: human-EPHX2

Title : Three-dimensional rational approach to the discovery of potent substituted cyclopropyl urea soluble epoxide hydrolase inhibitors - Takai_2015_Bioorg.Med.Chem.Lett_25_1705
Author(s) : Takai K , Chiyo N , Nakajima T , Nariai T , Ishikawa C , Nakatani S , Ikeno A , Yamamoto S , Sone T
Ref : Bioorganic & Medicinal Chemistry Lett , 25 :1705 , 2015
Abstract :
PubMedSearch : Takai_2015_Bioorg.Med.Chem.Lett_25_1705
PubMedID: 25800114
Gene_locus related to this paper: human-EPHX2

Title : Successful generation of structural information for fragment-based drug discovery - Oster_2015_Drug.Discov.Today_20_1104
Author(s) : Oster L , Tapani S , Xue Y , Kack H
Ref : Drug Discov Today , 20 :1104 , 2015
Abstract :
PubMedSearch : Oster_2015_Drug.Discov.Today_20_1104
PubMedID: 25931264
Gene_locus related to this paper: human-EPHX2

Title : Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening - Amano_2015_Bioorg.Med.Chem_23_2310
Author(s) : Amano Y , Tanabe E , Yamaguchi T
Ref : Bioorganic & Medicinal Chemistry , : , 2015
Abstract :
PubMedSearch : Amano_2015_Bioorg.Med.Chem_23_2310
PubMedID: 25862210
Gene_locus related to this paper: human-EPHX2

Title : Arg287Gln variant of EPHX2 and epoxyeicosatrienoic acids are associated with insulin sensitivity in humans - Ramirez_2014_Prostaglandins.Other.Lipid.Mediat_113-115_38
Author(s) : Ramirez CE , Shuey MM , Milne GL , Gilbert K , Hui N , Yu C , Luther JM , Brown NJ
Ref : Prostaglandins Other Lipid Mediat , 113-115 :38 , 2014
Abstract :
PubMedSearch : Ramirez_2014_Prostaglandins.Other.Lipid.Mediat_113-115_38
PubMedID: 25173047
Gene_locus related to this paper: human-EPHX2

Title : Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy - Lee_2014_J.Med.Chem_57_7016
Author(s) : Lee KS , Liu JY , Wagner KM , Pakhomova S , Dong H , Morisseau C , Fu SH , Yang J , Wang P , Ulu A , Mate CA , Nguyen LV , Hwang SH , Edin ML , Mara AA , Wulff H , Newcomer ME , Zeldin DC , Hammock BD
Ref : Journal of Medicinal Chemistry , 57 :7016 , 2014
Abstract :
PubMedSearch : Lee_2014_J.Med.Chem_57_7016
PubMedID: 25079952
Gene_locus related to this paper: human-EPHX2

Title : Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography - Amano_2014_Bioorg.Med.Chem_22_2427
Author(s) : Amano Y , Yamaguchi T , Tanabe E
Ref : Bioorganic & Medicinal Chemistry , 22 :2427 , 2014
Abstract :
PubMedSearch : Amano_2014_Bioorg.Med.Chem_22_2427
PubMedID: 24656800
Gene_locus related to this paper: human-EPHX2

Title : Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides - Morisseau_2013_Bioorg.Med.Chem.Lett_23_3818
Author(s) : Morisseau C , Pakhomova S , Hwang SH , Newcomer ME , Hammock BD
Ref : Bioorganic & Medicinal Chemistry Lett , 23 :3818 , 2013
Abstract :
PubMedSearch : Morisseau_2013_Bioorg.Med.Chem.Lett_23_3818
PubMedID: 23684894
Gene_locus related to this paper: human-EPHX2

Title : Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase - Thalji_2013_Bioorg.Med.Chem.Lett_23_3584
Author(s) : Thalji RK , McAtee JJ , Belyanskaya S , Brandt M , Brown GD , Costell MH , Ding Y , Dodson JW , Eisennagel SH , Fries RE , Gross JW , Harpel MR , Holt DA , Israel DI , Jolivette LJ , Krosky D , Li H , Lu Q , Mandichak T , Roethke T , Schnackenberg CG , Schwartz B , Shewchuk LM , Xie W , Behm DJ , Douglas SA , Shaw AL , Marino JP, Jr.
Ref : Bioorganic & Medicinal Chemistry Lett , 23 :3584 , 2013
Abstract :
PubMedSearch : Thalji_2013_Bioorg.Med.Chem.Lett_23_3584
PubMedID: 23664879
Gene_locus related to this paper: human-EPHX2

Title : Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors - Pecic_2013_Bioorg.Med.Chem.Lett_23_417
Author(s) : Pecic S , Pakhomova S , Newcomer ME , Morisseau C , Hammock BD , Zhu Z , Rinderspacher A , Deng SX
Ref : Bioorganic & Medicinal Chemistry Lett , 23 :417 , 2013
Abstract :
PubMedSearch : Pecic_2013_Bioorg.Med.Chem.Lett_23_417
PubMedID: 23237835
Gene_locus related to this paper: human-EPHX2

Title : Soluble epoxide hydrolase dimerization is required for hydrolase activity - Nelson_2013_J.Biol.Chem_288_7697
Author(s) : Nelson JW , Subrahmanyan RM , Summers SA , Xiao X , Alkayed NJ
Ref : Journal of Biological Chemistry , 288 :7697 , 2013
Abstract :
PubMedSearch : Nelson_2013_J.Biol.Chem_288_7697
PubMedID: 23362272
Gene_locus related to this paper: human-EPHX2

Title : A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors - Tanaka_2011_J.Med.Chem_54_851
Author(s) : Tanaka D , Tsuda Y , Shiyama T , Nishimura T , Chiyo N , Tominaga Y , Sawada N , Mimoto T , Kusunose N
Ref : Journal of Medicinal Chemistry , 54 :851 , 2011
Abstract :
PubMedSearch : Tanaka_2011_J.Med.Chem_54_851
PubMedID: 21192659
Gene_locus related to this paper: human-EPHX2

Title : Discovery of potent inhibitors of soluble epoxide hydrolase by combinatorial library design and structure-based virtual screening - Xing_2011_J.Med.Chem_54_1211
Author(s) : Xing L , McDonald JJ , Kolodziej SA , Kurumbail RG , Williams JM , Warren CJ , O'Neal JM , Skepner JE , Roberds SL
Ref : Journal of Medicinal Chemistry , 54 :1211 , 2011
Abstract :
PubMedSearch : Xing_2011_J.Med.Chem_54_1211
PubMedID: 21302953
Gene_locus related to this paper: human-EPHX2

Title : Substituted pyrazoles as novel sEH antagonist: investigation of key binding interactions within the catalytic domain - Lo_2010_Bioorg.Med.Chem.Lett_20_6379
Author(s) : Lo HY , Man CC , Fleck RW , Farrow NA , Ingraham RH , Kukulka A , Proudfoot JR , Betageri R , Kirrane T , Patel U , Sharma R , Hoermann MA , Kabcenell A , Lombaert SD
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :6379 , 2010
Abstract :
PubMedSearch : Lo_2010_Bioorg.Med.Chem.Lett_20_6379
PubMedID: 20934334
Gene_locus related to this paper: human-EPHX2

Title : Soluble epoxide hydrolase: a new target for cardioprotection - Gross_2009_Curr.Opin.Investig.Drugs_10_253
Author(s) : Gross GJ , Nithipatikom K
Ref : Curr Opin Investig Drugs , 10 :253 , 2009
Abstract :
PubMedSearch : Gross_2009_Curr.Opin.Investig.Drugs_10_253
PubMedID: 19333883
Gene_locus related to this paper: human-EPHX2

Title : Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase - Eldrup_2009_J.Med.Chem_52_5880
Author(s) : Eldrup AB , Soleymanzadeh F , Taylor SJ , Muegge I , Farrow NA , Joseph D , McKellop K , Man CC , Kukulka A , De Lombaert S
Ref : Journal of Medicinal Chemistry , 52 :5880 , 2009
Abstract :
PubMedSearch : Eldrup_2009_J.Med.Chem_52_5880
PubMedID: 19746975
Gene_locus related to this paper: human-EPHX2

Title : Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo - Motoki_2008_Am.J.Physiol.Heart.Circ.Physiol_295_H2128
Author(s) : Motoki A , Merkel MJ , Packwood WH , Cao Z , Liu L , Iliff J , Alkayed NJ , Van Winkle DM
Ref : American Journal of Physiology Heart Circ Physiol , 295 :H2128 , 2008
Abstract :
PubMedSearch : Motoki_2008_Am.J.Physiol.Heart.Circ.Physiol_295_H2128
PubMedID: 18835921
Gene_locus related to this paper: human-EPHX2

Title : Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury - Koerner_2007_J.Neurosci_27_4642
Author(s) : Koerner IP , Jacks R , DeBarber AE , Koop D , Mao P , Grant DF , Alkayed NJ
Ref : Journal of Neuroscience , 27 :4642 , 2007
Abstract :
PubMedSearch : Koerner_2007_J.Neurosci_27_4642
PubMedID: 17460077
Gene_locus related to this paper: human-EPHX2

Title : Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase - Kim_2007_Bioorg.Med.Chem_15_312
Author(s) : Kim IH , Nishi K , Tsai HJ , Bradford T , Koda Y , Watanabe T , Morisseau C , Blanchfield J , Toth I , Hammock BD
Ref : Bioorganic & Medicinal Chemistry , 15 :312 , 2007
Abstract :
PubMedSearch : Kim_2007_Bioorg.Med.Chem_15_312
PubMedID: 17046265
Gene_locus related to this paper: human-EPHX2

Title : Soluble epoxide hydrolase: a novel therapeutic target in stroke - Zhang_2007_J.Cereb.Blood.Flow.Metab_27_1931
Author(s) : Zhang W , Koerner IP , Noppens R , Grafe M , Tsai HJ , Morisseau C , Luria A , Hammock BD , Falck JR , Alkayed NJ
Ref : Journal of Cerebral Blood Flow & Metabolism , 27 :1931 , 2007
Abstract :
PubMedSearch : Zhang_2007_J.Cereb.Blood.Flow.Metab_27_1931
PubMedID: 17440491
Gene_locus related to this paper: human-EPHX2

Title : Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors - Schmelzer_2006_Proc.Natl.Acad.Sci.U.S.A_103_13646
Author(s) : Schmelzer KR , Inceoglu B , Kubala L , Kim IH , Jinks SL , Eiserich JP , Hammock BD
Ref : Proc Natl Acad Sci U S A , 103 :13646 , 2006
Abstract :
PubMedSearch : Schmelzer_2006_Proc.Natl.Acad.Sci.U.S.A_103_13646
PubMedID: 16950874
Gene_locus related to this paper: human-EPHX2

Title : Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels - Olearczyk_2006_J.Pharmacol.Exp.Ther_318_1307
Author(s) : Olearczyk JJ , Field MB , Kim IH , Morisseau C , Hammock BD , Imig JD
Ref : Journal of Pharmacology & Experimental Therapeutics , 318 :1307 , 2006
Abstract :
PubMedSearch : Olearczyk_2006_J.Pharmacol.Exp.Ther_318_1307
PubMedID: 16772540
Gene_locus related to this paper: human-EPHX2

Title : Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids - Gomez_2006_Protein.Sci_15_58
Author(s) : Gomez GA , Morisseau C , Hammock BD , Christianson DW
Ref : Protein Science , 15 :58 , 2006
Abstract :
PubMedSearch : Gomez_2006_Protein.Sci_15_58
PubMedID: 16322563
Gene_locus related to this paper: human-EPHX2

Title : The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke - Fornage_2005_Hum.Mol.Genet_14_2829
Author(s) : Fornage M , Lee CR , Doris PA , Bray MS , Heiss G , Zeldin DC , Boerwinkle E
Ref : Hum Mol Genet , 14 :2829 , 2005
Abstract :
PubMedSearch : Fornage_2005_Hum.Mol.Genet_14_2829
PubMedID: 16115816
Gene_locus related to this paper: human-EPHX2

Title : Soluble epoxide hydrolase is a therapeutic target for acute inflammation - Schmelzer_2005_Proc.Natl.Acad.Sci.U.S.A_102_9772
Author(s) : Schmelzer KR , Kubala L , Newman JW , Kim IH , Eiserich JP , Hammock BD
Ref : Proc Natl Acad Sci U S A , 102 :9772 , 2005
Abstract :
PubMedSearch : Schmelzer_2005_Proc.Natl.Acad.Sci.U.S.A_102_9772
PubMedID: 15994227
Gene_locus related to this paper: human-EPHX2

Title : Complete sequencing and characterization of 21,243 full-length human cDNAs - Ota_2004_Nat.Genet_36_40
Author(s) : Ota T , Suzuki Y , Nishikawa T , Otsuki T , Sugiyama T , Irie R , Wakamatsu A , Hayashi K , Sato H , Nagai K , Kimura K , Makita H , Sekine M , Obayashi M , Nishi T , Shibahara T , Tanaka T , Ishii S , Yamamoto J , Saito K , Kawai Y , Isono Y , Nakamura Y , Nagahari K , Murakami K , Yasuda T , Iwayanagi T , Wagatsuma M , Shiratori A , Sudo H , Hosoiri T , Kaku Y , Kodaira H , Kondo H , Sugawara M , Takahashi M , Kanda K , Yokoi T , Furuya T , Kikkawa E , Omura Y , Abe K , Kamihara K , Katsuta N , Sato K , Tanikawa M , Yamazaki M , Ninomiya K , Ishibashi T , Yamashita H , Murakawa K , Fujimori K , Tanai H , Kimata M , Watanabe M , Hiraoka S , Chiba Y , Ishida S , Ono Y , Takiguchi S , Watanabe S , Yosida M , Hotuta T , Kusano J , Kanehori K , Takahashi-Fujii A , Hara H , Tanase TO , Nomura Y , Togiya S , Komai F , Hara R , Takeuchi K , Arita M , Imose N , Musashino K , Yuuki H , Oshima A , Sasaki N , Aotsuka S , Yoshikawa Y , Matsunawa H , Ichihara T , Shiohata N , Sano S , Moriya S , Momiyama H , Satoh N , Takami S , Terashima Y , Suzuki O , Nakagawa S , Senoh A , Mizoguchi H , Goto Y , Shimizu F , Wakebe H , Hishigaki H , Watanabe T , Sugiyama A , Takemoto M , Kawakami B , Watanabe K , Kumagai A , Itakura S , Fukuzumi Y , Fujimori Y , Komiyama M , Tashiro H , Tanigami A , Fujiwara T , Ono T , Yamada K , Fujii Y , Ozaki K , Hirao M , Ohmori Y , Kawabata A , Hikiji T , Kobatake N , Inagaki H , Ikema Y , Okamoto S , Okitani R , Kawakami T , Noguchi S , Itoh T , Shigeta K , Senba T , Matsumura K , Nakajima Y , Mizuno T , Morinaga M , Sasaki M , Togashi T , Oyama M , Hata H , Komatsu T , Mizushima-Sugano J , Satoh T , Shirai Y , Takahashi Y , Nakagawa K , Okumura K , Nagase T , Nomura N , Kikuchi H , Masuho Y , Yamashita R , Nakai K , Yada T , Ohara O , Isogai T , Sugano S
Ref : Nat Genet , 36 :40 , 2004
Abstract :
PubMedSearch : Ota_2004_Nat.Genet_36_40
PubMedID: 14702039
Gene_locus related to this paper: human-ABHD1 , human-ABHD4 , human-ABHD12 , human-ABHD16A , human-ACOT1 , human-LDAH , human-ABHD18 , human-CES1 , human-CES4A , human-CES5A , human-CPVL , human-DAGLB , human-EPHX2 , human-KANSL3 , human-LIPA , human-LPL , human-MEST , human-NDRG1 , human-NLGN1 , human-NLGN4X , human-PRCP , human-PRSS16 , human-SERAC1 , human-TMEM53

Title : Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study - Fornage_2004_Circulation_109_335
Author(s) : Fornage M , Boerwinkle E , Doris PA , Jacobs D , Liu K , Wong ND
Ref : Circulation , 109 :335 , 2004
Abstract :
PubMedSearch : Fornage_2004_Circulation_109_335
PubMedID: 14732757
Gene_locus related to this paper: human-EPHX2

Title : Soluble epoxide hydrolase variant (Glu287Arg) modifies plasma total cholesterol and triglyceride phenotype in familial hypercholesterolemia: intrafamilial association study in an eight-generation hyperlipidemic kindred - Sato_2004_J.Hum.Genet_49_29
Author(s) : Sato K , Emi M , Ezura Y , Fujita Y , Takada D , Ishigami T , Umemura S , Xin Y , Wu LL , Larrinaga-Shum S , Stephenson SH , Hunt SC , Hopkins PN
Ref : J Hum Genet , 49 :29 , 2004
Abstract :
PubMedSearch : Sato_2004_J.Hum.Genet_49_29
PubMedID: 14673705
Gene_locus related to this paper: human-EPHX2

Title : Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis - Gomez_2004_Biochemistry_43_4716
Author(s) : Gomez GA , Morisseau C , Hammock BD , Christianson DW
Ref : Biochemistry , 43 :4716 , 2004
Abstract :
PubMedSearch : Gomez_2004_Biochemistry_43_4716
PubMedID: 15096040
Gene_locus related to this paper: human-EPHX2

Title : The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity - Newman_2003_Proc.Natl.Acad.Sci.U.S.A_100_1558
Author(s) : Newman JW , Morisseau C , Harris TR , Hammock BD
Ref : Proc Natl Acad Sci U S A , 100 :1558 , 2003
Abstract :
PubMedSearch : Newman_2003_Proc.Natl.Acad.Sci.U.S.A_100_1558
PubMedID: 12574510
Gene_locus related to this paper: human-EPHX2

Title : Polymorphisms in human soluble epoxide hydrolase - Przybyla-Zawislak_2003_Mol.Pharmacol_64_482
Author(s) : Przybyla-Zawislak BD , Srivastava PK , Vazquez-Matias J , Mohrenweiser HW , Maxwell JE , Hammock BD , Bradbury JA , Enayetallah AE , Zeldin DC , Grant DF
Ref : Molecular Pharmacology , 64 :482 , 2003
Abstract :
PubMedSearch : Przybyla-Zawislak_2003_Mol.Pharmacol_64_482
PubMedID: 12869654
Gene_locus related to this paper: human-EPHX2

Title : Seventy genetic variations in human microsomal and soluble epoxide hydrolase genes (EPHX1 and EPHX2) in the Japanese population - Saito_2001_J.Hum.Genet_46_325
Author(s) : Saito S , Iida A , Sekine A , Eguchi C , Miura Y , Nakamura Y
Ref : J Hum Genet , 46 :325 , 2001
Abstract :
PubMedSearch : Saito_2001_J.Hum.Genet_46_325
PubMedID: 11393535
Gene_locus related to this paper: human-EPHX2

Title : Identification of 6 new polymorphisms, g.11177G>A, g.14622C>T (R49C), g.17540T>C, g.17639T>C, g.30929T>C, g.31074G>A (R454Q), in the human microsomal epoxide hydrolase gene (EPHX1) in a French population -
Author(s) : Belmahdi F , Chevalier D , Lo-Guidice JM , Allorge D , Cauffiez C , Lafitte JJ , Broly F
Ref : Hum Mutat , 16 :450 , 2000
PubMedID: 11058921
Gene_locus related to this paper: human-EPHX1 , human-EPHX2

Title : Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms - Sandberg_2000_J.Biol.Chem_275_28873
Author(s) : Sandberg M , Hassett C , Adman ET , Meijer J , Omiecinski CJ
Ref : Journal of Biological Chemistry , 275 :28873 , 2000
Abstract :
PubMedSearch : Sandberg_2000_J.Biol.Chem_275_28873
PubMedID: 10862610
Gene_locus related to this paper: human-EPHX2

Title : Structural characterization of the human soluble epoxide hydrolase gene (EPHX2) - Sandberg_1996_Biochem.Biophys.Res.Commun_221_333
Author(s) : Sandberg M , Meijer J
Ref : Biochemical & Biophysical Research Communications , 221 :333 , 1996
Abstract :
PubMedSearch : Sandberg_1996_Biochem.Biophys.Res.Commun_221_333
PubMedID: 8619856
Gene_locus related to this paper: human-EPHX2

Title : Localization of the human soluble epoxide hydrolase gene (EPHX2) to chromosomal region 8p21-p12 - Larsson_1995_Hum.Genet_95_356
Author(s) : Larsson C , White I , Johansson C , Stark A , Meijer J
Ref : Hum Genet , 95 :356 , 1995
Abstract :
PubMedSearch : Larsson_1995_Hum.Genet_95_356
PubMedID: 7868134
Gene_locus related to this paper: human-EPHX2

Title : cDNA cloning and expression of a soluble epoxide hydrolase from human liver - Beetham_1993_Arch.Biochem.Biophys_305_197
Author(s) : Beetham JK , Tian T , Hammock BD
Ref : Archives of Biochemistry & Biophysics , 305 :197 , 1993
Abstract :
PubMedSearch : Beetham_1993_Arch.Biochem.Biophys_305_197
PubMedID: 8342951
Gene_locus related to this paper: human-EPHX2

Title : Purification of human liver cytosolic epoxide hydrolase and comparison to the microsomal enzyme - Wang_1982_Biochemistry_21_5769
Author(s) : Wang P , Meijer J , Guengerich FP
Ref : Biochemistry , 21 :5769 , 1982
Abstract :
PubMedSearch : Wang_1982_Biochemistry_21_5769
PubMedID: 6185139
Gene_locus related to this paper: human-EPHX1 , human-EPHX2