Type : Piperidine,Imidazole
Chemical_Nomenclature : (E)-but-2-enedioic acid\;2-[1-[2-[[5-(piperidin-1-ylmethyl)furan-2-yl]methylamino]ethyl]imidazolidin-2-ylidene]propanedinitrile
Canonical SMILES : C1CCN(CC1)CC2=CC=C(O2)CNCCN3CCNC3=C(C#N)C#N.C(=CC(=O)O)C(=O)O
InChI : InChI=1S\/C19H26N6O.C4H4O4\/c20-12-16(13-21)19-23-7-11-25(19)10-6-22-14-17-4-5-18(26-17)15-24-8-2-1-3-9-24\;5-3(6)1-2-4(7)8\/h4-5,22-23H,1-3,6-11,14-15H2\;1-2H,(H,5,6)(H,7,8) || InChI=1S\/C19H26N6O.C4H4O4\/c20-12-16(13-21)19-23-7-11-25(19)10-6-22-14-17-4-5-18(26-17)15-24-8-2-1-3-9-24\;5-3(6)1-2-4(7)8\/h4-5,22-23H,1-3,6-11,14-15H2\;1-2H,(H,5,6)(H,7,8)\/b\;2-1+
InChIKey : ULJCVCIVEVXIKD-UHFFFAOYSA-N || ULJCVCIVEVXIKD-WLHGVMLRSA-N
Other name(s) : Propanedinitrile, but-2-enedioic acid,2-[1-[2-[[5-(1-piperidylmethyl)-2-furyl]methylamino]ethyl]imidazolidin-2-ylidene]propanedinitrile
MW : 354.45
Formula : C19H26N6O
CAS_number : 135017-85-5
UniChem : ULJCVCIVEVXIKD-UHFFFAOYSA-N || ULJCVCIVEVXIKD-WLHGVMLRSA-N
Families : KW-5092 ligand of proteins in family
ACHE
Title : Effects of KW-5092 on antroduodenal coordination and gastric emptying in guinea-pigs - Kishibayashi_1998_J.Pharm.Pharmacol_50_1045 |
Author(s) : Kishibayashi N , Karasawa A |
Ref : J Pharm Pharmacol , 50 :1045 , 1998 |
Abstract : Kishibayashi_1998_J.Pharm.Pharmacol_50_1045 |
ESTHER : Kishibayashi_1998_J.Pharm.Pharmacol_50_1045 |
PubMedSearch : Kishibayashi_1998_J.Pharm.Pharmacol_50_1045 |
PubMedID: 9811166 |
Title : Effect of KW-5092, novel gastroprokinetic agent, on the peristalsis in the isolated guinea pig ileum - Suzuki_1997_Jpn.J.Pharmacol_74_91 |
Author(s) : Suzuki M , Kishibayashi N , Yokoyama T , Karasawa A |
Ref : Japanese Journal of Pharmacology , 74 :91 , 1997 |
Abstract : Suzuki_1997_Jpn.J.Pharmacol_74_91 |
ESTHER : Suzuki_1997_Jpn.J.Pharmacol_74_91 |
PubMedSearch : Suzuki_1997_Jpn.J.Pharmacol_74_91 |
PubMedID: 9195302 |
Title : Enhancement of defecation and distal colonic motor activity by KW-5092, a novel gastroprokinetic agent, in rats - Kishibayashi_1995_Arch.Int.Pharmacodyn.Ther_329_295 |
Author(s) : Kishibayashi N , Yokoyama T , Karasawa A |
Ref : Archives Internationales de Pharmacodynamie et de Therapie , 329 :295 , 1995 |
Abstract : Kishibayashi_1995_Arch.Int.Pharmacodyn.Ther_329_295 |
ESTHER : Kishibayashi_1995_Arch.Int.Pharmacodyn.Ther_329_295 |
PubMedSearch : Kishibayashi_1995_Arch.Int.Pharmacodyn.Ther_329_295 |
PubMedID: 8540768 |
Title : Effects of KW-5092, a novel gastroprokinetic agent, on intestinal water and electrolyte transport in rats - Kishibayashi_1995_Biol.Pharm.Bull_18_1671 |
Author(s) : Kishibayashi N , Karasawa A |
Ref : Biol Pharm Bull , 18 :1671 , 1995 |
Abstract : Kishibayashi_1995_Biol.Pharm.Bull_18_1671 |
ESTHER : Kishibayashi_1995_Biol.Pharm.Bull_18_1671 |
PubMedSearch : Kishibayashi_1995_Biol.Pharm.Bull_18_1671 |
PubMedID: 8787786 |
Title : Inhibitory effects of KW-5092, a novel gastroprokinetic agent, on the activity of acetylcholinesterase in guinea pig ileum - Kishibayashi_1994_Jpn.J.Pharmacol_66_397 |
Author(s) : Kishibayashi N , Ishii A , Karasawa A |
Ref : Japanese Journal of Pharmacology , 66 :397 , 1994 |
Abstract : Kishibayashi_1994_Jpn.J.Pharmacol_66_397 |
ESTHER : Kishibayashi_1994_Jpn.J.Pharmacol_66_397 |
PubMedSearch : Kishibayashi_1994_Jpn.J.Pharmacol_66_397 |
PubMedID: 7723214 |
Array ( [id] => 5301 [inhibitor] => KW-5092 [type] => Array ( [0] => Piperidine [1] => Imidazole ) [other_name] => Array ( [0] => Propanedinitrile, but-2-enedioic acid [1] => 2-[1-[2-[[5-(1-piperidylmethyl)-2-furyl]methylamino]ethyl]imidazolidin-2-ylidene]propanedinitrile ) [chemical_nomenclature] => (E)-but-2-enedioic acid\;2-[1-[2-[[5-(piperidin-1-ylmethyl)furan-2-yl]methylamino]ethyl]imidazolidin-2-ylidene]propanedinitrile [formula] => C19H26N6O [cas_number] => 135017-85-5 [mw] => 354.45 [pick_me_to_call] => display_script [kinetic_parameter] => [paper] => Suzuki_1997_Jpn.J.Pharmacol_74_91 || Kishibayashi_1998_J.Pharm.Pharmacol_50_1045 || Kishibayashi_1995_Arch.Int.Pharmacodyn.Ther_329_295 || Kishibayashi_1995_Biol.Pharm.Bull_18_1671 || Kishibayashi_1994_Jpn.J.Pharmacol_66_397 [comment] => [gene_locus] => [kin_inhibitor] => [cid] => 131845 || 6439389 [family] => ACHE [inchikey] => ULJCVCIVEVXIKD-UHFFFAOYSA-N || ULJCVCIVEVXIKD-WLHGVMLRSA-N [canonicalsmiles] => C1CCN(CC1)CC2=CC=C(O2)CNCCN3CCNC3=C(C#N)C#N.C(=CC(=O)O)C(=O)O [inchi] => InChI=1S\/C19H26N6O.C4H4O4\/c20-12-16(13-21)19-23-7-11-25(19)10-6-22-14-17-4-5-18(26-17)15-24-8-2-1-3-9-24\;5-3(6)1-2-4(7)8\/h4-5,22-23H,1-3,6-11,14-15H2\;1-2H,(H,5,6)(H,7,8) || InChI=1S\/C19H26N6O.C4H4O4\/c20-12-16(13-21)19-23-7-11-25(19)10-6-22-14-17-4-5-18(26-17)15-24-8-2-1-3-9-24\;5-3(6)1-2-4(7)8\/h4-5,22-23H,1-3,6-11,14-15H2\;1-2H,(H,5,6)(H,7,8)\/b\;2-1+ [wikipedia] => [iupharlig] => [structure] => [substrate] => [interact_gene_locus] => [mutation] => [comment2] => [extoxnet] => [news] => [theoretical_model] => )