The most potent FAAH inhibitor (IC50; 520 nM) inhibited also MGL-like activity in rat cerebellar membranes with an IC50 value of 31 microM
Type : Carbamate,FAAH inhibitor,Multitarget,Sulfur Compound
Chemical_Nomenclature : [4-(4,5-dihydro-1,3-thiazol-2-yl)phenyl] N-butylcarbamate
Canonical SMILES : CCCCNC(=O)OC1=CC=C(C=C1)C2=NCCS2
InChI : InChI=1S\/C14H18N2O2S\/c1-2-3-8-16-14(17)18-12-6-4-11(5-7-12)13-15-9-10-19-13\/h4-7H,2-3,8-10H2,1H3,(H,16,17)
InChIKey : OUBMDYCXTDANEM-UHFFFAOYSA-N
Other name(s) : CHEMBL457882,4-(4,5-dihydrothiazol-2-yl)phenyl butylcarbamate,HMS1669K08,ZINC4394394,BDBM50274981,SPB 01403
MW : 278.37
Formula : C14H18N2O2S
CAS_number :
PubChem : 2743568
UniChem : OUBMDYCXTDANEM-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Families : SPB01403 ligand of proteins in family: Monoglyceridelipase_lysophospholip
Stucture :
Protein :
Title : URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices - King_2007_Chem.Biol_14_1357 |
Author(s) : King AR , Duranti A , Tontini A , Rivara S , Rosengarth A , Clapper JR , Astarita G , Geaga JA , Luecke H , Mor M , Tarzia G , Piomelli D |
Ref : Chemical Biology , 14 :1357 , 2007 |
Abstract : King_2007_Chem.Biol_14_1357 |
ESTHER : King_2007_Chem.Biol_14_1357 |
PubMedSearch : King_2007_Chem.Biol_14_1357 |
PubMedID: 18096504 |
Title : Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system - Saario_2006_J.Med.Chem_49_4650 |
Author(s) : Saario SM , Poso A , Juvonen RO , Jarvinen T , Salo-Ahen OM |
Ref : Journal of Medicinal Chemistry , 49 :4650 , 2006 |
Abstract : Saario_2006_J.Med.Chem_49_4650 |
ESTHER : Saario_2006_J.Med.Chem_49_4650 |
PubMedSearch : Saario_2006_J.Med.Chem_49_4650 |
PubMedID: 16854070 |