Monoglyceridelipase_lysophospholip

Relationship

Family: Monoglyceridelipase_lysophospholip

Block: X

Parent Family: Hydrolase_4

Comment

This family consists of Monoglyceridelipase_lysophospholipase but different of phospholipases and carboxylesterases with broad substrate specificity. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.The closest family is CarbLipBact

Database

Interpro : IPR022742 Alpha\/beta hydrolase, N-terminal

PIRSF : PIRSF000869 monoglyceride lipase

Pdoc : No Pdoc

Pfam : PF12146 Hydrolase_4

Prints : No Print

EC Number : 3.1.1.23

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (34)

Genes Proteins in Monoglyceridelipase_lysophospholip family (1182)

Fragments of genes in Monoglyceridelipase_lysophospholip family (102)

Structures in Monoglyceridelipase_lysophospholip family (34)

Substrates in Monoglyceridelipase_lysophospholip family (24)

Inhibitors in Monoglyceridelipase_lysophospholip family (76)

References (14)

Title : Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan - Chen_2019_Nat.Chem.Biol_15_453
Author(s) : Chen AL , Lum KM , Lara-Gonzalez P , Ogasawara D , Cognetta AB, 3rd , To A , Parsons WH , Simon GM , Desai A , Petrascheck M , Bar-Peled L , Cravatt BF
Ref : Nat Chemical Biology , 15 :453 , 2019
PubMedID: 30911178

Title : Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB1 receptor-mediated discriminative stimulus in mice - Owens_2017_Neuropharmacol_125_80
Author(s) : Owens RA , Mustafa MA , Ignatowska-Jankowska BM , Damaj MI , Beardsley PM , Wiley JL , Niphakis MJ , Cravatt BF , Lichtman AH
Ref : Neuropharmacology , 125 :80 , 2017
PubMedID: 28673548

Title : Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase - Butler_2017_J.Med.Chem_60_9860
Author(s) : Butler CR , Beck EM , Harris A , Huang Z , McAllister LA , Am Ende CW , Fennell K , Foley TL , Fonseca K , Hawrylik SJ , Johnson DS , Knafels JD , Mente S , Noell GS , Pandit J , Phillips TB , Piro JR , Rogers BN , Samad TA , Wang J , Wan S , Brodney MA
Ref : Journal of Medicinal Chemistry , 60 :9860 , 2017
PubMedID: 29148769
Gene_locus related to this paper: human-MGLL

Title : Crystal structure of the Saccharomyces cerevisiae monoglyceride lipase Yju3p - Aschauer_2016_Biochim.Biophys.Acta_1861_462
Author(s) : Aschauer P , Rengachari S , Lichtenegger J , Schittmayer M , Das KM , Mayer N , Breinbauer R , Birner-Gruenberger R , Gruber CC , Zimmermann R , Gruber K , Oberer M
Ref : Biochimica & Biophysica Acta , 1861 :462 , 2016
PubMedID: 26869448
Gene_locus related to this paper: yeast-mgll

Title : Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents - Griebel_2015_Sci.Rep_5_7642
Author(s) : Griebel G , Pichat P , Beeske S , Leroy T , Redon N , Jacquet A , Francon D , Bert L , Even L , Lopez-Grancha M , Tolstykh T , Sun F , Yu Q , Brittain S , Arlt H , He T , Zhang B , Wiederschain D , Bertrand T , Houtmann J , Rak A , Vallee F , Michot N , Auge F , Menet V , Bergis OE , George P , Avenet P , Mikol V , Didier M , Escoubet J
Ref : Sci Rep , 5 :7642 , 2015
PubMedID: 25560837
Gene_locus related to this paper: mouse-ABHD6

Title : Purification, crystallization and preliminary X-ray diffraction analysis of a soluble variant of the monoglyceride lipase Yju3p from the yeast Saccharomyces cerevisiae - Rengachari_2015_Acta.Crystallogr.F.Struct.Biol.Commun_71_243
Author(s) : Rengachari S , Aschauer P , Sturm C , Oberer M
Ref : Acta Crystallographica F Struct Biol Commun , 71 :243 , 2015
PubMedID: 25664804
Gene_locus related to this paper: yeast-mgll

Title : Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 A resolution - Schalk-Hihi_2011_Protein.Sci_20_670
Author(s) : Schalk-Hihi C , Schubert C , Alexander R , Bayoumy S , Clemente JC , Deckman I , Desjarlais RL , Dzordzorme KC , Flores CM , Grasberger B , Kranz JK , Lewandowski F , Liu L , Ma H , Maguire D , Macielag MJ , McDonnell ME , Mezzasalma Haarlander T , Miller R , Milligan C , Reynolds C , Kuo LC
Ref : Protein Science , 20 :670 , 2011
PubMedID: 21308848
Gene_locus related to this paper: human-MGLL

Title : Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice - Pan_2011_J.Neurosci_31_13420
Author(s) : Pan B , Wang W , Zhong P , Blankman JL , Cravatt BF , Liu QS
Ref : Journal of Neuroscience , 31 :13420 , 2011
PubMedID: 21940435
Gene_locus related to this paper: human-MGLL , mouse-MGLL

Title : Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum - Zhong_2011_J.Physiol_589_4847
Author(s) : Zhong P , Pan B , Gao XP , Blankman JL , Cravatt BF , Liu QS
Ref : Journal de Physiologie , 589 :4847 , 2011
PubMedID: 21911610
Gene_locus related to this paper: human-MGLL , mouse-MGLL

Title : Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling - Labar_2010_Chembiochem_11_218
Author(s) : Labar G , Bauvois C , Borel F , Ferrer JL , Wouters J , Lambert DM
Ref : Chembiochem , 11 :218 , 2010
PubMedID: 19957260
Gene_locus related to this paper: human-MGLL

Title : Structural basis for human monoglyceride lipase inhibition - Bertrand_2010_J.Mol.Biol_396_663
Author(s) : Bertrand T , Auge F , Houtmann J , Rak A , Vallee F , Mikol V , Berne PF , Michot N , Cheuret D , Hoornaert C , Mathieu M
Ref : Journal of Molecular Biology , 396 :663 , 2010
PubMedID: 19962385
Gene_locus related to this paper: human-MGLL

Title : Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomycescerevisiae - Heier_2010_Biochim.Biophys.Acta_1801_1063
Author(s) : Heier C , Taschler U , Rengachari S , Oberer M , Wolinski H , Natter K , Kohlwein SD , Leber R , Zimmermann R
Ref : Biochimica & Biophysica Acta , 1801 :1063 , 2010
PubMedID: 20554061
Gene_locus related to this paper: human-MGLL , mouse-MGLL , yeast-mgll

Title : Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis - Nomura_2010_Cell_140_49
Author(s) : Nomura DK , Long JZ , Niessen S , Hoover HS , Ng SW , Cravatt BF
Ref : Cell , 140 :49 , 2010
PubMedID: 20079333
Gene_locus related to this paper: human-MGLL , mouse-MGLL

Title : Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase - Vila_2007_Biochemistry_46_9578
Author(s) : Vila A , Rosengarth A , Piomelli D , Cravatt B , Marnett LJ
Ref : Biochemistry , 46 :9578 , 2007
PubMedID: 17649977
Gene_locus related to this paper: human-MGLL , mouse-MGLL