| Title : Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions - Papa_2022_Eur.J.Med.Chem_246_114952 |
| Author(s) : Papa A , Pasquini S , Galvani F , Cammarota M , Contri C , Carullo G , Gemma S , Ramunno A , Lamponi S , Gorelli B , Saponara S , Varani K , Mor M , Campiani G , Boscia F , Vincenzi F , Lodola A , Butini S |
| Ref : Eur Journal of Medicinal Chemistry , 246 :114952 , 2022 |
| Abstract : |
| PubMedSearch : Papa_2022_Eur.J.Med.Chem_246_114952 |
| PubMedID: 36462439 |
| Title : Mechanistic Modeling of Monoglyceride Lipase Covalent Modification Elucidates the Role of Leaving Group Expulsion and Discriminates Inhibitors with High and Low Potency - Galvani_2022_J.Chem.Inf.Model__ |
| Author(s) : Galvani F , Scalvini L , Rivara S , Lodola A , Mor M |
| Ref : J Chem Inf Model , : , 2022 |
| Abstract : |
| PubMedSearch : Galvani_2022_J.Chem.Inf.Model__ |
| PubMedID: 35580195 |
| Gene_locus related to this paper: human-MGLL |
| Title : Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteines - Castelli_2020_J.Med.Chem_63_1261 |
| Author(s) : Castelli R , Scalvini L , Vacondio F , Lodola A , Anselmi M , Vezzosi S , Carmi C , Bassi M , Ferlenghi F , Rivara S , Moller IR , Rand KD , Daglian J , Wei D , Dotsey EY , Ahmed F , Jung KM , Stella N , Singh S , Mor M , Piomelli D |
| Ref : Journal of Medicinal Chemistry , 63 :1261 , 2020 |
| Abstract : |
| PubMedSearch : Castelli_2020_J.Med.Chem_63_1261 |
| PubMedID: 31714779 |
| Title : Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents - Montanari_2016_J.Med.Chem_59_6387 |
| Author(s) : Montanari S , Scalvini L , Bartolini M , Belluti F , Gobbi S , Andrisano V , Ligresti A , Di Marzo V , Rivara S , Mor M , Bisi A , Rampa A |
| Ref : Journal of Medicinal Chemistry , 59 :6387 , 2016 |
| Abstract : |
| PubMedSearch : Montanari_2016_J.Med.Chem_59_6387 |
| PubMedID: 27309570 |
| Title : Monoglyceride lipase: Structure and inhibitors - Scalvini_2016_Chem.Phys.Lipids_197_13 |
| Author(s) : Scalvini L , Piomelli D , Mor M |
| Ref : Chemistry & Physic of Lipids , 197 :13 , 2016 |
| Abstract : |
| PubMedSearch : Scalvini_2016_Chem.Phys.Lipids_197_13 |
| PubMedID: 26216043 |
| Title : Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL - Scalvini_2016_Sci.Rep_6_31046 |
| Author(s) : Scalvini L , Vacondio F , Bassi M , Pala D , Lodola A , Rivara S , Jung KM , Piomelli D , Mor M |
| Ref : Sci Rep , 6 :31046 , 2016 |
| Abstract : |
| PubMedSearch : Scalvini_2016_Sci.Rep_6_31046 |
| PubMedID: 27499063 |
| Title : Discovery of potent and reversible monoacylglycerol lipase inhibitors - King_2009_Chem.Biol_16_1045 |
| Author(s) : King AR , Dotsey EY , Lodola A , Jung KM , Ghomian A , Qiu Y , Fu J , Mor M , Piomelli D |
| Ref : Chemical Biology , 16 :1045 , 2009 |
| Abstract : |
| PubMedSearch : King_2009_Chem.Biol_16_1045 |
| PubMedID: 19875078 |
| Title : A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors - King_2009_Br.J.Pharmacol_157_974 |
| Author(s) : King AR , Lodola A , Carmi C , Fu J , Mor M , Piomelli D |
| Ref : British Journal of Pharmacology , 157 :974 , 2009 |
| Abstract : |
| PubMedSearch : King_2009_Br.J.Pharmacol_157_974 |
| PubMedID: 19486005 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity - Morini_2008_Bioorg.Med.Chem_16_9911 |
| Author(s) : Morini G , Comini M , Rivara M , Rivara S , Bordi F , Plazzi PV , Flammini L , Saccani F , Bertoni S , Ballabeni V , Barocelli E , Mor M |
| Ref : Bioorganic & Medicinal Chemistry , 16 :9911 , 2008 |
| Abstract : |
| PubMedSearch : Morini_2008_Bioorg.Med.Chem_16_9911 |
| PubMedID: 18976927 |
| Title : URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices - King_2007_Chem.Biol_14_1357 |
| Author(s) : King AR , Duranti A , Tontini A , Rivara S , Rosengarth A , Clapper JR , Astarita G , Geaga JA , Luecke H , Mor M , Tarzia G , Piomelli D |
| Ref : Chemical Biology , 14 :1357 , 2007 |
| Abstract : |
| PubMedSearch : King_2007_Chem.Biol_14_1357 |
| PubMedID: 18096504 |
| Title : The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues - Clapper_2006_Pharmacol.Res_54_341 |
| Author(s) : Clapper JR , Duranti A , Tontini A , Mor M , Tarzia G , Piomelli D |
| Ref : Pharmacol Res , 54 :341 , 2006 |
| Abstract : |
| PubMedSearch : Clapper_2006_Pharmacol.Res_54_341 |
| PubMedID: 16935521 |
| Title : Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597) - Piomelli_2006_CNS.Drug.Rev_12_21 |
| Author(s) : Piomelli D , Tarzia G , Duranti A , Tontini A , Mor M , Compton TR , Dasse O , Monaghan EP , Parrott JA , Putman D |
| Ref : CNS Drug Rev , 12 :21 , 2006 |
| Abstract : |
| PubMedSearch : Piomelli_2006_CNS.Drug.Rev_12_21 |
| PubMedID: 16834756 |
| Title : Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors - Tarzia_2003_J.Med.Chem_46_2352 |
| Author(s) : Tarzia G , Duranti A , Tontini A , Piersanti G , Mor M , Rivara S , Plazzi PV , Park C , Kathuria S , Piomelli D |
| Ref : Journal of Medicinal Chemistry , 46 :2352 , 2003 |
| Abstract : |
| PubMedSearch : Tarzia_2003_J.Med.Chem_46_2352 |
| PubMedID: 12773040 |