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TADE

The IC50 for AChE and BuChE were 229.1 +/- 1.2 and 59.84 +/- 1.1 nM respectively. Selectivity ratio of 0.261 towards AChE

General

Type : Derivative of Tacrine

Chemical_Nomenclature : N'-(1,2,3,4-tetrahydroacridin-9-yl)ethane-1,2-diamine

Canonical SMILES : C1CCC2=NC3=CC=CC=C3C(=C2C1)NCCN

InChI : InChI=1S\/C15H19N3\/c16-9-10-17-15-11-5-1-3-7-13(11)18-14-8-4-2-6-12(14)15\/h1,3,5,7H,2,4,6,8-10,16H2,(H,17,18)

InChIKey : MTPGMAOIWNBPSP-UHFFFAOYSA-N

Other name(s) : CHEMBL407765,N-(1,2,3,4-tetrahydroacridin-9-yl)ethane-1,2-diamine dihydrochloride,SCHEMBL5492091,ZX-ANR000018,ALBB-030121

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MW : 241.33

Formula : C15H19N3

CAS_number :

PubChem : 11658774

UniChem : MTPGMAOIWNBPSP-UHFFFAOYSA-N

Target

Families : TADE ligand of proteins in family
ACHE BCHE

References (1)

1. Potent Acetylcholinesterase Selective and Reversible Homodimeric Agent Based on Tacrine for Theranostics

Title : Potent Acetylcholinesterase Selective and Reversible Homodimeric Agent Based on Tacrine for Theranostics - Meena_2019_Mol.Pharm_16_2296

Author(s) : Meena VK , Chaturvedi S , Sharma RK , Mishra AK , Hazari PP

Ref : Mol Pharm , 16 :2296 , 2019

Abstract : Meena_2019_Mol.Pharm_16_2296

ESTHER : Meena_2019_Mol.Pharm_16_2296

PubMedSearch : Meena_2019_Mol.Pharm_16_2296

PubMedID: 31059278

Array
(
    [id] => 4098
    [inhibitor] => TADE
    [type] => Array
        (
            [0] => Derivative of Tacrine
        )

    [other_name] => Array
        (
            [0] => CHEMBL407765
            [1] => N-(1,2,3,4-tetrahydroacridin-9-yl)ethane-1,2-diamine dihydrochloride
            [2] => SCHEMBL5492091
            [3] => ZX-ANR000018
            [4] => ALBB-030121
        )

    [chemical_nomenclature] => N'-(1,2,3,4-tetrahydroacridin-9-yl)ethane-1,2-diamine
    [formula] => C15H19N3
    [cas_number] => 
    [mw] => 241.33
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Meena_2019_Mol.Pharm_16_2296
    [comment] => The IC50  for AChE and BuChE were 229.1 +\/- 1.2 and 59.84 +\/- 1.1 nM respectively. Selectivity ratio of 0.261 towards AChE
    [gene_locus] => 
    [kin_inhibitor] => 
    [cid] => 11658774
    [family] => ACHE || BCHE
    [inchikey] => MTPGMAOIWNBPSP-UHFFFAOYSA-N
    [canonicalsmiles] => C1CCC2=NC3=CC=CC=C3C(=C2C1)NCCN
    [inchi] => InChI=1S\/C15H19N3\/c16-9-10-17-15-11-5-1-3-7-13(11)18-14-8-4-2-6-12(14)15\/h1,3,5,7H,2,4,6,8-10,16H2,(H,17,18)
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)