BCHE

Relationship

Family: BCHE

Block: C

Parent Family: Cholinesterase

Comment

Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, Pseudocholinesterase. Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics.Various autosomal recessive mutations of the gene exist in human population

Database

Interpro : IPR000997 Cholinesterase , IPR002018 Carboxylesterase, type B

PIRSF : PIRSF005676 COesterase

Pdoc : PDOC00112

Pfam : PF00135 COesterase

Prints : PR00878

EC Number : 3.1.1.8

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (91)

Genes Proteins in BCHE family (125)

Fragments of genes in BCHE family (193)

Structures in BCHE family (91)

Substrates in BCHE family (61)

Inhibitors in BCHE family (331)

References (5)

Title : Old and new questions about cholinesterases - Massoulie_2008_Chem.Biol.Interact_175_30
Author(s) : Massoulie J , Perrier N , Noureddine H , Liang D , Bon S
Ref : Chemico-Biological Interactions , 175 :30 , 2008
PubMedID: 18541228

Title : The cholinesterases: from genes to proteins - Taylor_1994_Annu.Rev.Pharmacol.Toxicol_34_281
Author(s) : Taylor P , Radic Z
Ref : Annual Review of Pharmacology & Toxicology , 34 :281 , 1994
PubMedID: 8042853

Title : Molecular and cellular biology of cholinesterases -
Author(s) : Massoulie J , Pezzementi L , Bon S , Krejci E , Vallette FM
Ref : Prog Neurobiol , 41 :31 , 1993
PubMedID: 8321908

Title : Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. - Lockridge_1990_Pharmacol.Ther_47_35
Author(s) : Lockridge O
Ref : Pharmacol Ther , 47 :35 , 1990
PubMedID: 2195556
Gene_locus related to this paper: human-BCHE

Title : Comparison of butyrylcholinesterase and acetylcholinesterase. -
Author(s) : Chatonnet A , Lockridge O
Ref : Biochemical Journal , 260 :625 , 1989
PubMedID: 2669736