Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, Pseudocholinesterase. Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics.Various autosomal recessive mutations of the gene exist in human population
Interpro : IPR000997 Cholinesterase , IPR002018 Carboxylesterase, type B
PIRSF : PIRSF005676 COesterase
Pdoc : PDOC00112
Pfam : PF00135 COesterase
Prints : PR00878
EC Number : 3.1.1.8
Structures (91)
Genes Proteins in BCHE family (125)
Fragments of genes in BCHE family (193)
Structures in BCHE family (91)Substrates in BCHE family (59)
Inhibitors in BCHE family (329)
Title : Old and new questions about cholinesterases - Massoulie_2008_Chem.Biol.Interact_175_30 |
Author(s) : Massoulie J , Perrier N , Noureddine H , Liang D , Bon S |
Ref : Chemico-Biological Interactions , 175 :30 , 2008 |
Abstract : Massoulie_2008_Chem.Biol.Interact_175_30 |
ESTHER : Massoulie_2008_Chem.Biol.Interact_175_30 |
PubMedSearch : Massoulie_2008_Chem.Biol.Interact_175_30 |
PubMedID: 18541228 |
Title : The cholinesterases: from genes to proteins - Taylor_1994_Annu.Rev.Pharmacol.Toxicol_34_281 |
Author(s) : Taylor P , Radic Z |
Ref : Annual Review of Pharmacology & Toxicology , 34 :281 , 1994 |
Abstract : Taylor_1994_Annu.Rev.Pharmacol.Toxicol_34_281 |
ESTHER : Taylor_1994_Annu.Rev.Pharmacol.Toxicol_34_281 |
PubMedSearch : Taylor_1994_Annu.Rev.Pharmacol.Toxicol_34_281 |
PubMedID: 8042853 |
Title : Molecular and cellular biology of cholinesterases - |
Author(s) : Massoulie J , Pezzementi L , Bon S , Krejci E , Vallette FM |
Ref : Prog Neurobiol , 41 :31 , 1993 |
PubMedID: 8321908 |
Title : Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. - Lockridge_1990_Pharmacol.Ther_47_35 |
Author(s) : Lockridge O |
Ref : Pharmacol Ther , 47 :35 , 1990 |
Abstract : Lockridge_1990_Pharmacol.Ther_47_35 |
ESTHER : Lockridge_1990_Pharmacol.Ther_47_35 |
PubMedSearch : Lockridge_1990_Pharmacol.Ther_47_35 |
PubMedID: 2195556 |
Gene_locus related to this paper: human-BCHE |
Title : Comparison of butyrylcholinesterase and acetylcholinesterase. - |
Author(s) : Chatonnet A , Lockridge O |
Ref : Biochemical Journal , 260 :625 , 1989 |
PubMedID: 2669736 |