| Title : Protein engineering of alpha\/beta-hydrolase fold enzymes - Jochens_2011_Chembiochem_12_1508 |
| Author(s) : Jochens H , Hesseler M , Stiba K , Padhi SK , Kazlauskas RJ , Bornscheuer UT |
| Ref : Chembiochem , 12 :1508 , 2011 |
| Abstract : The superfamily of alpha/beta-hydrolase fold enzymes is one of the largest known protein families, including a broad range of synthetically useful enzymes such as lipases, esterases, amidases, hydroxynitrile lyases, epoxide hydrolases and dehalogenases. This minireview covers methods developed for efficient protein engineering of these enzymes. Special emphasis is placed on the alteration of enzyme properties such as substrate range, thermostability and enantioselectivity for their application in biocatalysis. In addition, concepts for the investigation of the evolutionary relationship between the different members of this protein superfamily are covered, together with successful examples. |
| ESTHER : Jochens_2011_Chembiochem_12_1508 |
| PubMedSearch : Jochens_2011_Chembiochem_12_1508 |
| PubMedID: 21506229 |
| Gene_locus related to this paper: canan-lipasA |
| Gene_locus related to this paper: canan-lipasA |
Jochens H, Hesseler M, Stiba K, Padhi SK, Kazlauskas RJ, Bornscheuer UT (2011)
Protein engineering of alpha\/beta-hydrolase fold enzymes
Chembiochem
12 :1508
Jochens H, Hesseler M, Stiba K, Padhi SK, Kazlauskas RJ, Bornscheuer UT (2011)
Chembiochem
12 :1508