canan-lipasA
Candida antarctica (Trichosporon oryzae) (yeast) CalA Lipase A
Comment
Ericsson, D.J., Kasrayan, A., Johansson, P., Bergfors, T., Sandstrom, A.G., Backvall, J.E., Mowbray, S.L. X-Ray Structure of Candida Antarctica Lipase A Shows a Novel Lid Structure and a Likely Mode of Interfacial Activation. Sold under the name lipase novozym 735 Novocor AD L || CalA promiscuous activity 36\/96 substrates Martinez-Martinez et al. 2018<\/A>
Relationship
Family : Fungal-Bact_LIP
Block : X
Position in NCBI Life Tree : Candida antarctica
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Dikarya N E > Basidiomycota N E > Ustilaginomycotina N E > Ustilaginomycetes N E > Ustilaginales N E > Ustilaginaceae N E > Moesziomyces N E > Moesziomyces antarcticus N EMolecular evidence
Sequence
Peptide
APATETLDRR AALPNPYDDP FYTTPSNIGT FAKGQVIQSR KVPTDIGNAN NAASFQLQYR TTNTQNEAVA DVATVWIPAK PASPPKIFSY QVYEDATALD CAPSYSYLTG LDQPNKVTAV LDTPIIIGWA LQQGYYVVSS DHEGFKAAFI AGYEEGMAIL DGIRALKNYQ NLPSDSKVAL EGYSGGAHAT VWATSLADSY APELNIVGAS HGGTPVSAKD TFTFLNGGPF AGFALAGVSG LSLAHPDMES FIEARLNAKG QQTLKQIRGR GFCLPQVVLT YPFLNVFSLV NDTNLLNEAP IAGILKQETV VQAEASYTVS VPKFPRFIWH AIPDEIVPYQ PAATYVKEQC AKGANINFSP YPIAEHLTAE IFGLVPSLWF IKQAFDGTTP KVICGTPIPA IAGITTPSAD QVLGSDLANQ LRSLNGKQSA FGKPFGPITP P
References (20)
| Title : Microplate method for regioselective lipase screening with structured punicic acid triglycerides: finding Lip4 lipase as sn-2-regioselective from Candida rugosa isoforms - Ordaz_2025_Anal.Biochem__115769 |
| Author(s) : Ordaz E , Gomez-Secundino O , Guerrero-Elias HY , Camacho-Ruiz MA , Espinosa-Salgado R , Escobedo-Reyes A , Mateos-Diaz JC , Rodriguez JA |
| Ref : Analytical Biochemistry , :115769 , 2025 |
| Abstract : |
| PubMedSearch : Ordaz_2025_Anal.Biochem__115769 |
| PubMedID: 39805383 |
| Gene_locus related to this paper: canan-lipasA , canru-1lipa , canru-4lipa , human-PNLIP , humla-1lipa , rhimi-lipas |
| Title : Tuning Selectivity in CalA Lipase: Beyond Tunnel Engineering - Alejaldre_2022_Biochemistry__ |
| Author(s) : Alejaldre L , Lemay-St-Denis C , Pelletier JN , Quaglia D |
| Ref : Biochemistry , : , 2022 |
| Abstract : |
| PubMedSearch : Alejaldre_2022_Biochemistry__ |
| PubMedID: 36580299 |
| Gene_locus related to this paper: canan-lipasA |
| Title : Holistic engineering of Cal-A lipase chain-length selectivity identifies triglyceride binding hot-spot - Quaglia_2019_PLoS.One_14_e0210100 |
| Author(s) : Quaglia D , Alejaldre L , Ouadhi S , Rousseau O , Pelletier JN |
| Ref : PLoS ONE , 14 :e0210100 , 2019 |
| Abstract : |
| PubMedSearch : Quaglia_2019_PLoS.One_14_e0210100 |
| PubMedID: 30640952 |
| Gene_locus related to this paper: canan-lipasA |
| Title : Transesterification of a Tertiary Alcohol by Engineered Candida antarctica Lipase A - Lofgren_2019_Chembiochem_20_1438 |
| Author(s) : Lofgren J , Gorbe T , Oschmann M , Svedendahl Humble M , Backvall JE |
| Ref : Chembiochem , 20 :1438 , 2019 |
| Abstract : |
| PubMedSearch : Lofgren_2019_Chembiochem_20_1438 |
| PubMedID: 30676685 |
| Gene_locus related to this paper: canan-lipasA |
| Title : Comparative features between recombinant lipases CALA-like from U. maydis and CALA from C. antarctica in thermal stability and selectivity - Robles-Machuca_2019_Biotechnol.Lett_41_241 |
| Author(s) : Robles-Machuca M , Del Campo MM , Camacho-Ruiz M , Ordaz E , Zamora-Gonzalez EO , Muller-Santos M , Rodriguez JA |
| Ref : Biotechnol Lett , 41 :241 , 2019 |
| Abstract : |
| PubMedSearch : Robles-Machuca_2019_Biotechnol.Lett_41_241 |
| PubMedID: 30519796 |
| Gene_locus related to this paper: canan-lipasA , ustma-q4p903 |
| Title : Rationale behind the near-ideal catalysis of Candida antarctica lipase A (CAL-A) for highly concentrating omega-3 polyunsaturated fatty acids into monoacylglycerols - He_2017_Food.Chem_219_230 |
| Author(s) : He Y , Li J , Kodali S , Chen B , Guo Z |
| Ref : Food Chem , 219 :230 , 2017 |
| Abstract : |
| PubMedSearch : He_2017_Food.Chem_219_230 |
| PubMedID: 27765222 |
| Gene_locus related to this paper: canan-lipasA |
| Title : Elucidation of a key position for acyltransfer activity in Candida parapsilosis lipase\/acyltransferase (CpLIP2) and in Pseudozyma antarctica lipase A (CAL-A) by rational design - Jan_2016_Biochim.Biophys.Acta_1864_187 |
| Author(s) : Jan AH , Subileau M , Deyrieux C , Perrier V , Dubreucq E |
| Ref : Biochimica & Biophysica Acta , 1864 :187 , 2016 |
| Abstract : |
| PubMedSearch : Jan_2016_Biochim.Biophys.Acta_1864_187 |
| PubMedID: 26602447 |
| Gene_locus related to this paper: canan-lipasA , candc-CduLAc , canpa-LIP2 |
| Title : Peculiar features of four enzymes of the CaLA superfamily in aqueous media: Differences in substrate specificities and abilities to catalyze alcoholysis - Neang_2013_J.Mol.Catal.B.Enzym_94_36 |
| Author(s) : Neang PM , Subileau M , Perrier V , Dubreucq E |
| Ref : J Mol Catal B Enzym , 94 :36 , 2013 |
| Abstract : |
| PubMedSearch : Neang_2013_J.Mol.Catal.B.Enzym_94_36 |
| PubMedID: |
| Gene_locus related to this paper: aspor-q2uix9 , canan-lipasA , canpa-LIP2 , cantt-c5mag0 |
| Title : Towards quantitative computer-aided studies of enzymatic enantioselectivity: the case of Candida antarctica lipase A - Frushicheva_2012_Chembiochem_13_215 |
| Author(s) : Frushicheva MP , Warshel A |
| Ref : Chembiochem , 13 :215 , 2012 |
| Abstract : |
| PubMedSearch : Frushicheva_2012_Chembiochem_13_215 |
| PubMedID: 22190449 |
| Gene_locus related to this paper: canan-lipasA |
| Title : Combinatorial reshaping of the Candida antarctica lipase A substrate pocket for enantioselectivity using an extremely condensed library - Sandstrom_2012_Proc.Natl.Acad.Sci.U.S.A_109_78 |
| Author(s) : Sandstrom AG , Wikmark Y , Engstrom K , Nyhlen J , Backvall JE |
| Ref : Proc Natl Acad Sci U S A , 109 :78 , 2012 |
| Abstract : |
| PubMedSearch : Sandstrom_2012_Proc.Natl.Acad.Sci.U.S.A_109_78 |
| PubMedID: 22178758 |
| Gene_locus related to this paper: canan-lipasA |
| Title : Creation of a lipase highly selective for trans fatty acids by protein engineering - Brundiek_2012_Angew.Chem.Int.Ed.Engl_51_412 |
| Author(s) : Brundiek HB , Evitt AS , Kourist R , Bornscheuer UT |
| Ref : Angew Chem Int Ed Engl , 51 :412 , 2012 |
| Abstract : |
| PubMedSearch : Brundiek_2012_Angew.Chem.Int.Ed.Engl_51_412 |
| PubMedID: 22113941 |
| Gene_locus related to this paper: canan-lipasA |
| Title : Protein engineering of alpha\/beta-hydrolase fold enzymes - Jochens_2011_Chembiochem_12_1508 |
| Author(s) : Jochens H , Hesseler M , Stiba K , Padhi SK , Kazlauskas RJ , Bornscheuer UT |
| Ref : Chembiochem , 12 :1508 , 2011 |
| Abstract : |
| PubMedSearch : Jochens_2011_Chembiochem_12_1508 |
| PubMedID: 21506229 |
| Gene_locus related to this paper: canan-lipasA |
| Title : Suppression of water as a nucleophile in Candida antarctica lipase B catalysis - Larsen_2010_Chembiochem_11_796 |
| Author(s) : Larsen MW , Zielinska DF , Martinelle M , Hidalgo A , Jensen LJ , Bornscheuer UT , Hult K |
| Ref : Chembiochem , 11 :796 , 2010 |
| Abstract : |
| PubMedSearch : Larsen_2010_Chembiochem_11_796 |
| PubMedID: 20235107 |
| Gene_locus related to this paper: canan-lipasA |
| Title : Formation and hydrolysis of amide bonds by lipase A from Candida antarctica\; exceptional features - Liljeblad_2010_Org.Biomol.Chem_8_886 |
| Author(s) : Liljeblad A , Kallio P , Vainio M , Niemi J , Kanerva LT |
| Ref : Org Biomol Chem , 8 :886 , 2010 |
| Abstract : |
| PubMedSearch : Liljeblad_2010_Org.Biomol.Chem_8_886 |
| PubMedID: 20135048 |
| Gene_locus related to this paper: canan-lipasA |
| Title : Directed evolution of an enantioselective lipase with broad substrate scope for hydrolysis of alpha-substituted esters - Engstrom_2010_J.Am.Chem.Soc_132_7038 |
| Author(s) : Engstrom K , Nyhlen J , Sandstrom AG , Backvall JE |
| Ref : Journal of the American Chemical Society , 132 :7038 , 2010 |
| Abstract : |
| PubMedSearch : Engstrom_2010_J.Am.Chem.Soc_132_7038 |
| PubMedID: 20450151 |
| Gene_locus related to this paper: canan-lipasA |
| Title : X-ray structure of Candida antarctica lipase A shows a novel lid structure and a likely mode of interfacial activation - Ericsson_2008_J.Mol.Biol_376_109 |
| Author(s) : Ericsson DJ , Kasrayan A , Johansson P , Bergfors T , Sandstrom AG , Backvall JE , Mowbray SL |
| Ref : Journal of Molecular Biology , 376 :109 , 2008 |
| Abstract : |
| PubMedSearch : Ericsson_2008_J.Mol.Biol_376_109 |
| PubMedID: 18155238 |
| Gene_locus related to this paper: canan-lipasA |
| Title : The crystal structure of lipase a from Candida Antarctica - Brandt_2008_Acta.Crystallogr.A.Found.Crystallogr_64_C245 |
| Author(s) : Brandt AM , Nymalm-Rejstrom Y , Airenne T , Salminen T |
| Ref : Acta Crystallogr A Found Crystallogr , A64 :C245 , 2008 |
| Abstract : |
| PubMedSearch : Brandt_2008_Acta.Crystallogr.A.Found.Crystallogr_64_C245 |
| PubMedID: |
| Gene_locus related to this paper: canan-lipasA |
| Title : Enzymatic removal of carboxyl protecting groups. 1. Cleavage of the tert-butyl moiety - Schmidt_2005_J.Org.Chem_70_3737 |
| Author(s) : Schmidt M , Barbayianni E , Fotakopoulou I , Hohne M , Constantinou-Kokotou V , Bornscheuer UT , Kokotos G |
| Ref : J Org Chem , 70 :3737 , 2005 |
| Abstract : |
| PubMedSearch : Schmidt_2005_J.Org.Chem_70_3737 |
| PubMedID: 15845019 |
| Gene_locus related to this paper: canan-lipasA |
| Title : The use of methoxy acetoxy esters significantly enhances reaction rates in the lipase-catalyzed preparation of enantiopure 1-(4-chloro phenyl) ethyl amines - Wagegg_1998_J.Biotechnol_61_75 |
| Author(s) : Wagegg T , Enzelberger MM , Bornscheuer UT , Schmid RD |
| Ref : J Biotechnol , 61 :75 , 1998 |
| Abstract : |
| PubMedSearch : Wagegg_1998_J.Biotechnol_61_75 |
| PubMedID: |
| Gene_locus related to this paper: canar-LipB , canan-lipasA |