canan-lipasA

Candida antarctica (Trichosporon oryzae) (yeast) CalA Lipase A

Comment

Ericsson, D.J., Kasrayan, A., Johansson, P., Bergfors, T., Sandstrom, A.G., Backvall, J.E., Mowbray, S.L. X-Ray Structure of Candida Antarctica Lipase A Shows a Novel Lid Structure and a Likely Mode of Interfacial Activation. Sold under the name lipase novozym 735 Novocor AD L || CalA promiscuous activity 36\/96 substrates Martinez-Martinez et al. 2018

Relationship

Family : Fungal-Bact_LIP

Block : X

Position in NCBI Life Tree : Candida antarctica

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Dikarya N E > Basidiomycota N E > Ustilaginomycotina N E > Ustilaginomycetes N E > Ustilaginales N E > Ustilaginaceae N E > Moesziomyces N E > Moesziomyces antarcticus N E

Molecular evidence

Database

No Genbank

Sequence

Peptide

APATETLDRR AALPNPYDDP FYTTPSNIGT FAKGQVIQSR KVPTDIGNAN NAASFQLQYR TTNTQNEAVA DVATVWIPAK PASPPKIFSY QVYEDATALD CAPSYSYLTG LDQPNKVTAV LDTPIIIGWA LQQGYYVVSS DHEGFKAAFI AGYEEGMAIL DGIRALKNYQ NLPSDSKVAL EGYSGGAHAT VWATSLADSY APELNIVGAS HGGTPVSAKD TFTFLNGGPF AGFALAGVSG LSLAHPDMES FIEARLNAKG QQTLKQIRGR GFCLPQVVLT YPFLNVFSLV NDTNLLNEAP IAGILKQETV VQAEASYTVS VPKFPRFIWH AIPDEIVPYQ PAATYVKEQC AKGANINFSP YPIAEHLTAE IFGLVPSLWF IKQAFDGTTP KVICGTPIPA IAGITTPSAD QVLGSDLANQ LRSLNGKQSA FGKPFGPITP P

References (17)

Title : Tuning Selectivity in CalA Lipase: Beyond Tunnel Engineering - Alejaldre_2022_Biochemistry__
Author(s) : Alejaldre L , Lemay-St-Denis C , Pelletier JN , Quaglia D
Ref : Biochemistry , : , 2022
PubMedID: 36580299
Gene_locus related to this paper: canan-lipasA

Title : Holistic engineering of Cal-A lipase chain-length selectivity identifies triglyceride binding hot-spot - Quaglia_2019_PLoS.One_14_e0210100
Author(s) : Quaglia D , Alejaldre L , Ouadhi S , Rousseau O , Pelletier JN
Ref : PLoS ONE , 14 :e0210100 , 2019
PubMedID: 30640952
Gene_locus related to this paper: canan-lipasA

Title : Transesterification of a Tertiary Alcohol by Engineered Candida antarctica Lipase A - Lofgren_2019_Chembiochem_20_1438
Author(s) : Lofgren J , Gorbe T , Oschmann M , Svedendahl Humble M , Backvall JE
Ref : Chembiochem , 20 :1438 , 2019
PubMedID: 30676685
Gene_locus related to this paper: canan-lipasA

Title : Determinants and prediction of esterase substrate promiscuity patterns - Martinez-Martinez_2018_ACS.Chem.Biol_13_225
Author(s) : Martinez-Martinez M , Coscolin C , Santiago G , Chow J , Stogios PJ , Bargiela R , Gertler C , Navarro-Fernandez J , Bollinger A , Thies S , Mendez-Garcia C , Popovic A , Brown G , Chernikova TN , Garcia-Moyano A , Bjergah GE , Perez-Garcia P , Hai T , Del Pozo MV , Stokke R , Steen IH , Cui H , Xu X , Nocek BP , Alcaide M , Distaso M , Mesa V , Pelaez AI , Sanchez J , Buchholz PCF , Pleiss J , Fernandez-Guerra A , Glockner FO , Golyshina OV , Yakimov MM , Savchenko A , Jaeger KE , Yakunin AF , Streit WR , Golyshin PN , Guallar V , Ferrer M
Ref : ACS Chemical Biology , 13 :225 , 2018
PubMedID: 29182315
Gene_locus related to this paper: 9zzzz-a0a2k8jn75 , 9zzzz-a0a2k8jt94 , 9zzzz-a0a0g3fj44 , 9zzzz-a0a0g3fh10 , 9zzzz-a0a0g3fh03 , 9bact-a0a1s5qkj8 , 9zzzz-a0a0g3feh5 , 9zzzz-a0a0g3fkz4 , 9zzzz-a0a0g3fh07 , 9zzzz-a0a0g3fh34 , 9zzzz-a0a0g3fh31 , 9bact-KY458167 , alcbs-q0vqa3 , 9bact-a0a1s5qki8 , 9zzzz-a0a0g3feq8 , 9zzzz-a0a0g3feh8 , 9zzzz-a0a0g3fh19 , 9bact-KY203037 , 9bact-a0a1s5ql22 , 9bact-a0a1s5qm34 , 9bact-KY203034 , 9bact-r9qzg0 , 9bact-a0a1s5qly8 , 9zzzz-a0a0g3fkz8 , 9zzzz-a0a0g3feg9 , 9zzzz-KY203033 , 9zzzz-a0a0g3fes4 , 9zzzz-a0a0g3fh42 , 9bact-a0a1s5qlx2 , 9zzzz-KY483651 , 9bact-a0a1s5qmh4 , 9zzzz-KY203032 , 9zzzz-EH87 , 9zzzz-a0a0g3fei1 , 9zzzz-a0a0g3fet2 , 9zzzz-KY483647 , 9zzzz-EH82 , 9zzzz-a0a0g3fe15 , 9bact-KY203031 , 9bact-t1w006 , 9zzzz-a0a0g3fet6 , 9bact-KY458164 , geoth-g8myf3 , 9bact-a0a1s5ql04 , 9gamm-a0a1y0ihk7 , 9bact-a0a1s5qly6 , 9bact-a0a1s5qkg4 , 9bact-a0a1s5qkm4 , 9gamm-s5tv80 , 9gamm-a0a0c4zhg2 , 9zzzz-t1b379 , 9gamm-KY483646 , 9bact-KY458160 , 9zzzz-a0a0g3fj57 , 9gamm-s5t8349 , 9arch-KY203036 , 9bact-KY458168 , 9zzzz-a0a0g3fes0 , 9zzzz-t1be47 , 9bact-KY458159 , 9zzzz-a0a0g3fh39 , 9bact-t1vzd5 , 9prot-EH41 , 9bact-Lip114 , alcbs-q0vt77 , 9bact-a0a1s5qke6 , 9bact-a0a1s5qkf3 , 9prot-SRP030024 , 9gamm-s5t532 , 9bact-a0a1s5qkl2 , 9bact-a0a1s5qkk8 , 9zzzz-KY203030 , 9zzzz-t1d4I7 , 9prot-KY019260 , 9bact-a0a1s5qm38 , 9arch-KY458161 , 9prot-KY010302 , 9zzzz-a0a0g3fl25 , 9actn-KY010298 , 9gamm-s5u059 , 9bact-a0a1s5qmi7 , 9bact-KY010297 , 9bact-KY483642 , 9bact-a0a1s5qkj1 , 9bact-KY010299 , 9bact-KY483648 , alcbs-q0vtl7 , 9bact-a0a1s5qf1 , 9bact-a0a1s5qkg0 , 9bact-a0a0h4tgu6 , 9bact-MilE3 , 9bact-LAE6 , 9alte-MGS-MT1 , 9bact-r9qzf7 , 9gamm-k0c6t6 , alcbs-q0vl36 , alcbs-q0vlq1 , alcbs-q0vq49 , bacsu-pnbae , canar-LipB , canan-lipasA , geost-lipas , marav-a1u5n0 , pseps-i7k8x5 , staep-GEHD , symth-q67mr3 , altma-s5cfn7 , cycsp-k0c2b8 , alcbs-q0vlk5 , 9bact-k7qe48 , 9bact-MGS-M1 , 9bact-MGS-M2 , 9bact-a0a0b5kns5 , 9zzzz-a0a0g3fej4 , 9zzzz-a0a0g3fj60 , 9zzzz-a0a0g3fej0 , 9zzzz-a0a0g3fj64 , 9bact-a0a0b5kc16 , 9zzzz-a0a0g3feg6 , 9zzzz-a0a0g3feu6

Title : Rationale behind the near-ideal catalysis of Candida antarctica lipase A (CAL-A) for highly concentrating omega-3 polyunsaturated fatty acids into monoacylglycerols - He_2017_Food.Chem_219_230
Author(s) : He Y , Li J , Kodali S , Chen B , Guo Z
Ref : Food Chem , 219 :230 , 2017
PubMedID: 27765222
Gene_locus related to this paper: canan-lipasA

Title : Elucidation of a key position for acyltransfer activity in Candida parapsilosis lipase\/acyltransferase (CpLIP2) and in Pseudozyma antarctica lipase A (CAL-A) by rational design - Jan_2016_Biochim.Biophys.Acta_1864_187
Author(s) : Jan AH , Subileau M , Deyrieux C , Perrier V , Dubreucq E
Ref : Biochimica & Biophysica Acta , 1864 :187 , 2016
PubMedID: 26602447
Gene_locus related to this paper: canan-lipasA , candc-CduLAc , canpa-LIP2

Title : Peculiar features of four enzymes of the CaLA superfamily in aqueous media: Differences in substrate specificities and abilities to catalyze alcoholysis - Neang_2013_J.Mol.Catal.B.Enzym_94_36
Author(s) : Neang PM , Subileau M , Perrier V , Dubreucq E
Ref : J Mol Catal B Enzym , 94 :36 , 2013
PubMedID:
Gene_locus related to this paper: aspor-q2uix9 , canan-lipasA , canpa-LIP2 , cantt-c5mag0

Title : Creation of a lipase highly selective for trans fatty acids by protein engineering - Brundiek_2012_Angew.Chem.Int.Ed.Engl_51_412
Author(s) : Brundiek HB , Evitt AS , Kourist R , Bornscheuer UT
Ref : Angew Chem Int Ed Engl , 51 :412 , 2012
PubMedID: 22113941
Gene_locus related to this paper: canan-lipasA

Title : Towards quantitative computer-aided studies of enzymatic enantioselectivity: the case of Candida antarctica lipase A - Frushicheva_2012_Chembiochem_13_215
Author(s) : Frushicheva MP , Warshel A
Ref : Chembiochem , 13 :215 , 2012
PubMedID: 22190449
Gene_locus related to this paper: canan-lipasA

Title : Combinatorial reshaping of the Candida antarctica lipase A substrate pocket for enantioselectivity using an extremely condensed library - Sandstrom_2012_Proc.Natl.Acad.Sci.U.S.A_109_78
Author(s) : Sandstrom AG , Wikmark Y , Engstrom K , Nyhlen J , Backvall JE
Ref : Proc Natl Acad Sci U S A , 109 :78 , 2012
PubMedID: 22178758
Gene_locus related to this paper: canan-lipasA

Title : Protein engineering of alpha\/beta-hydrolase fold enzymes - Jochens_2011_Chembiochem_12_1508
Author(s) : Jochens H , Hesseler M , Stiba K , Padhi SK , Kazlauskas RJ , Bornscheuer UT
Ref : Chembiochem , 12 :1508 , 2011
PubMedID: 21506229
Gene_locus related to this paper: canan-lipasA

Title : Suppression of water as a nucleophile in Candida antarctica lipase B catalysis - Larsen_2010_Chembiochem_11_796
Author(s) : Larsen MW , Zielinska DF , Martinelle M , Hidalgo A , Jensen LJ , Bornscheuer UT , Hult K
Ref : Chembiochem , 11 :796 , 2010
PubMedID: 20235107
Gene_locus related to this paper: canan-lipasA

Title : Formation and hydrolysis of amide bonds by lipase A from Candida antarctica\; exceptional features - Liljeblad_2010_Org.Biomol.Chem_8_886
Author(s) : Liljeblad A , Kallio P , Vainio M , Niemi J , Kanerva LT
Ref : Org Biomol Chem , 8 :886 , 2010
PubMedID: 20135048
Gene_locus related to this paper: canan-lipasA

Title : Directed evolution of an enantioselective lipase with broad substrate scope for hydrolysis of alpha-substituted esters - Engstrom_2010_J.Am.Chem.Soc_132_7038
Author(s) : Engstrom K , Nyhlen J , Sandstrom AG , Backvall JE
Ref : Journal of the American Chemical Society , 132 :7038 , 2010
PubMedID: 20450151
Gene_locus related to this paper: canan-lipasA

Title : X-ray structure of Candida antarctica lipase A shows a novel lid structure and a likely mode of interfacial activation - Ericsson_2008_J.Mol.Biol_376_109
Author(s) : Ericsson DJ , Kasrayan A , Johansson P , Bergfors T , Sandstrom AG , Backvall JE , Mowbray SL
Ref : Journal of Molecular Biology , 376 :109 , 2008
PubMedID: 18155238
Gene_locus related to this paper: canan-lipasA

Title : The crystal structure of lipase a from Candida Antarctica - Brandt_2008_Acta.Crystallogr.A.Found.Crystallogr_64_C245
Author(s) : Brandt AM , Nymalm-Rejstrom Y , Airenne T , Salminen T
Ref : Acta Crystallogr A Found Crystallogr , A64 :C245 , 2008
PubMedID:
Gene_locus related to this paper: canan-lipasA

Title : Enzymatic removal of carboxyl protecting groups. 1. Cleavage of the tert-butyl moiety - Schmidt_2005_J.Org.Chem_70_3737
Author(s) : Schmidt M , Barbayianni E , Fotakopoulou I , Hohne M , Constantinou-Kokotou V , Bornscheuer UT , Kokotos G
Ref : J Org Chem , 70 :3737 , 2005
PubMedID: 15845019
Gene_locus related to this paper: canan-lipasA