Gibson JE

References (4)

Title : Reanalysis with optimized power of red blood cell acetylcholinesterase activity from a 1-year dietary treatment of dogs to chlorpyrifos - Mattsson_2001_Toxicology_160_155
Author(s) : Mattsson JL , Holden L , Eisenbrandt DL , Gibson JE
Ref : Toxicology , 160 :155 , 2001
Abstract : A no-observed-effect level (NOEL) of 0.1 mg/kg/day was reported for inhibition of red blood cell (RBC) acetylcholinesterase (AChE) in two groups of Beagle dogs fed chlorpyrifos (0, 0.01, 0.03, 0.1, 1 or 3 mg/kg/day) in the diet for 1 or 2 years (McCollister et al., Food Cosmet. Toxicol. 12 (1974) 45-61). The statistical analyses were by t-test that had low statistical power due to small sample sizes. Common time points for blood samples in both phases allowed a reanalysis of the grouped data over a 1-year time period. The reanalysis increased statistical power by increasing the sample size to n=14 from n=3 or 4, and decreasing the variance, by statistical step-by-step aggregation of the data from both phases, both sexes, and four sample periods. Factors retained in the ANOVA were dose, sex, and phase (sex-by-dose was not significant). Contrasts with one-sided t-tests indicated the 1 and 3 mg/kg/day groups had significantly inhibited RBC AChE (P<0.0001). At alpha=0.05, the uncorrected one-sided model had 80% power to detect a 12% decrease, 93% power for a 15% decrease, and 99.5% power for a 20% decrease in AChE activity. Overall, the reanalysis had high power to detect a clinically significant decrease in RBC AChE activity, and substantiated the original NOEL for chronic treatment of dogs to dietary chlorpyrifos at 0.1 mg/kg/day.
ESTHER : Mattsson_2001_Toxicology_160_155
PubMedSearch : Mattsson_2001_Toxicology_160_155
PubMedID: 11246135

Title : Human Exposure and Risk From Indoor Use of Chlorpyrifos - Gibson_1998_Environ.Health.Perspect_106_303
Author(s) : Gibson JE , Peterson RKD , Shurdut BA
Ref : Environmental Health Perspectives , 106 :303 , 1998
Abstract : The toxicity, exposure, and risk from chlorpyrifos are briefly discussed in juxtaposition with two recent articles in Environmental Health Perspectives concerning potential exposures to children. In studies conducted according to EPA guidelines, chlorpyrifos has been shown not to be mutagenic, carcinogenic, or teratogenic, nor does it adversely affect reproduction. Chlorpyrifos toxicity does not occur in the absence of significant cholinesterase inhibition. If exposures are less than those that cause significant cholinesterase depression, then no signs or symptoms related to chlorpyrifos exposure occur. The weight of empirical evidence indicates that the risk of adults or children experiencing an adverse health effect from exposure to chlorpyrifos through both nondietary and dietary sources is negligible. Both the research supporting the registration of these products and their long history of widespread use suggest that unless these products are seriously misused, their margins of safety are wide enough to protect everyone with the potential to be exposed. A weight-of-evidence review of the entire scientific knowledge base relating to chlorpyrifos products supports these conclusions.
ESTHER : Gibson_1998_Environ.Health.Perspect_106_303
PubMedSearch : Gibson_1998_Environ.Health.Perspect_106_303
PubMedID: 9618344

Title : Bidrin: perinatal toxicity and effect on the development of brain acetylcholinesterase and choline acetyltransferase in mice -
Author(s) : Bus JS , Gibson JE
Ref : Food Cosmet Toxicol , 12 :313 , 1974
PubMedID: 4442814

Title : Brain catecholamines and serotonin levels in various strains and genera of mice and a possible interpretation for the correlations of amine levels with electroshock latency and behavior -
Author(s) : Scudder CL , Karczmar AG , Everett GM , Gibson JE , Rifkin M
Ref : International Journal of Neuropharmacology , 5 :343 , 1966
PubMedID: 5970990