Lateef M

References (5)

Title : Crotofoligandrin, a new endoperoxide crotofolane-type diterpenoid from the twigs of Croton oligandrus Pierre ex. Hutch (Euphorbiaceae) - Tatsinda_2023_Z.Naturforsch.C.J.Biosci__
Author(s) : Tatsinda Tsapi VB , Fotsing Fongang YS , Awantu AF , Kezetas Bankeu JJ , Lateef M , Chouna JR , Nkeng-Efouet-Alango P , Ali MS , Lenta BN
Ref : Z Naturforsch C J Biosci , : , 2023
Abstract : Crotofoligandrin (1), a new endoperoxide crotofolane-type diterpenoid was isolated from the dichloromethane/methanol (1:1) extract of the twigs of Croton oligandrus Pierre Ex Hutch along with thirteen known secondary metabolites including 1-nonacosanol (2), lupenone (3), friedelin (4), beta-sitosterol (5), taraxerol (6), (-)-hardwickiic acid (7), apigenin (8), acetyl aleuritolic acid (9), betulinic acid (10), fokihodgin C 3-acetate (11), D-mannitol (12), scopoletin (13) and quercetin (14). The structures of the isolated compounds were determined based on their spectroscopic data. The crude extract and the isolated compounds were assessed in vitro for their antioxidant, lipoxygenase, butyrylcholinesterase (BChE), urease and glucosidase inhibitory potentials. Compounds 1-3, and 10 displayed activities on all the performed bioassays. All the tested samples showed strong to significant antioxidant activity with compound 1 being the most potent (IC(50) 39.4 microM).
ESTHER : Tatsinda_2023_Z.Naturforsch.C.J.Biosci__
PubMedSearch : Tatsinda_2023_Z.Naturforsch.C.J.Biosci__
PubMedID: 36803991

Title : Multi-activity tetracoordinated pallado-oxadiazole thiones as anti-inflammatory, anti-Alzheimer, and anti-microbial agents: Structure, stability and bioactivity comparison with pallado-hydrazides - Qurrat_2021_Biomed.Pharmacother_146_112561
Author(s) : Qurrat Ul A , Abid A , Lateef M , Rafiq N , Eijaz S , Tauseef S
Ref : Biomed Pharmacother , 146 :112561 , 2021
Abstract : Herein, we report a comparative study based on structure, thermal and solution stability, and biopotency against lipoxygenase (LOX), butyrylcholinesterase (BChE) and microbes for Pd(II) compounds of N,O,S bearing 5-(C(5)H(4)XR)-1,3,4-oxadiazole-2-thiones (L') of type [PdL'Cl(2)] (P'n) and N,O bearing respective hydrazides (L) of type trans-[PdL(2)Cl(2)] (Pn) {X = C, R = 4-I, 2-Br, 4-NO(2), 3-NO(2), 2-Cl, 3-Cl (n = 1-6, serially); X = N (n = 7)}. Spectral techniques (IR, EI-MS, NMR) and physicochemical evaluations successfully characterized the new compounds. The L' behaved as bidentate S-N donors bonded through exocyclic sulfur and N-3' nitrogen, while L acted as amino N donors. UV-vis (solution speciation) and thermal degradation profiles consistently confirmed the greater stability for P'n than Pn compounds. These compounds manifested varying degree in vitro potential to inhibit LOX, BChE and several bacteria and fungi, affected mainly by Pd(II) presence, M-L binding mode, nature and position of R, or halo groups electronegativity. Molecular docking with human 5-LOX and BChE further validated the respective experimental inhibition findings and explored several putative mechanistic interactions (H-bonding, Pi-stacking, Pi-alkyl, Pi-S, etc.) at the enzyme active sites. Pn generally offered superior antimicrobial and anti-LOX (anti-inflammatory) potential than respective P'n compounds, with P3/P'5, P(2,3,7)/P'3, and P6 being comparable, better and equivalent to ampicillin, nystatin and baicalein, the reference antibacterial, antifungal and anti-LOX drugs, respectively. Contrarily, the anti-BChE activity of P'n was found better than Pn compounds, showing P'2/P1 as the most promising anti-Alzheimer drug candidates. This study bares important structural and mechanistic aspects in optimizing antimicrobial, anti-inflammatory and anti-Alzheimer activities, highlighting some potential future pallado-drug candidates.
ESTHER : Qurrat_2021_Biomed.Pharmacother_146_112561
PubMedSearch : Qurrat_2021_Biomed.Pharmacother_146_112561
PubMedID: 34965504

Title : Crotoliganfuran, a new clerodane-type furano-diterpenoid from Croton oligandrus Pierre ex Hutch - Yannick_2019_Nat.Prod.Res__1
Author(s) : Yannick Stephane FF , Dawe A , Angelbert Fusi A , Jean Jules BK , Ulrich KKD , Lateef M , Bruno LN , Ali MS , Ngouela SA
Ref : Nat Prod Res , :1 , 2019
Abstract : The phytochemical investigation of the methanol extract of the bark of Croton oligandrus Pierre ex Hutch yielded a new clerodane-type diterpenoid crotoliganfuran (1) along with ten other compounds including 12-epicrotocorylifuran (2), lupeol (3), syringic acid (4), aleuritolic acid acetate (5), aleuritolic acid (6), scopoletin (7), geddic acid (8), beta-sitosterol (9), vanilic acid (10) and stigmastane-3,6-dione (11). Their structures were established by spectroscopic means. The extract and all the isolates were screened for their inhibitory properties against butyrylcholinesterase and urease enzymes, respectively. The extract and compounds 1, 4 and 7 displayed the most potent urease inhibitory properties with IC50 values, 22.2, 26.7 and 28.5 microM, respectively. Compound 9 was the most active of all the tested compounds against butyrylcholinesterase enzyme with an IC50 value of 36.3 microM.
ESTHER : Yannick_2019_Nat.Prod.Res__1
PubMedSearch : Yannick_2019_Nat.Prod.Res__1
PubMedID: 31148485

Title : In silico and BSA binding study of some new biological analogs of 1,2,4-triazolependant with azinane through microwave and conventional synthesis - Virk_2018_Pak.J.Pharm.Sci_31_2645
Author(s) : Virk NA , Rehman A , Abbasi MA , Siddiqui SZ , Ashraf A , Lateef M , Javed H , Iqbal J , Khalid H , Khan S
Ref : Pak J Pharm Sci , 31 :2645 , 2018
Abstract : Microwave and conventional techniques were employed to synthesize a novel array of compounds 7a-g with 1,2,4-triazole and piperidine rings having great biological importance. The microwave assisted method has a better operational scope with respect to time and yield comparative to the conventional method. 1H-NMR, 13C-NMR and IR techniques were employed to justify the structure of synthesized compounds. The antioxidant, butyrylcholinesterase inhibition and urease inhibition potential of every synthesized compound was evaluated. Every member of the synthesized series was found potent against mentioned activities. Compound 7g was the most active anti-urease agent having IC50 (muM) value 16.5+/-0.09 even better than the thiourea with an IC50(muM) value of 24.3+/-0.24. The better urease inhibition potential of 7g was also elaborated and explained by docking and bovine serum albumin (BSA) binding studies.
ESTHER : Virk_2018_Pak.J.Pharm.Sci_31_2645
PubMedSearch : Virk_2018_Pak.J.Pharm.Sci_31_2645
PubMedID: 30587474

Title : New anthrarobin acyl derivatives as butyrylcholinesterase inhibitors: synthesis, in vitro and in silico studies - Lateef_2017_Heliyon_3_e00350
Author(s) : Lateef M , Azhar A , Siddiqui BS , Zarina S , Uddin N , Anwar MF , Siddiqui K , Azhar KF , Iqbal L , Mehmood R , Perveen S
Ref : Heliyon , 3 :e00350 , 2017
Abstract : To treat Alzheimer's disease (AD), the available candidates are effective only against mild AD or have side effects. So, a study was planned to synthesis new candidates that may have good potential to treat AD. A series of new anthrarobin acyl derivatives (2-8) were synthesized by the reaction of anthrarobin (1) and acetic anhydride/acyl chlorides. The product were characterized by 1H NMR and EI-MS, and evaluated for butyrylcholinesterase (BuChE) inhibition activity. Compounds 5 and 4 showed notable BuChE inhibitory potential with IC50 5.3 +/- 1.23 and 17.2 +/- 0.47 muM, respectively when compared with the standard eserine (IC50 7.8 +/- 0.27 muM), compound 5 showed potent BuChE inhibition potential than the standard eserine. The active compounds 5 and 4 have acyl groups at 2-OH and 10-OH positions which may be responsible for inhibitory potential as this orientation is absent in other products. In silico studies of 5 and 4 products revealed the high inhibitory potential due to stable binding of ligand with the BuChE active sites with docking energy score -18.8779 kcal/mol and -23.1159 kcal/mol, respectively. Subsequently, compound 5 that have potent BuChE inhibitory activity could be the potential candidate for drug development for Alzheimer's disease.
ESTHER : Lateef_2017_Heliyon_3_e00350
PubMedSearch : Lateef_2017_Heliyon_3_e00350
PubMedID: 28725871