Whitcomb R

Title : Pharmacokinetics and pharmacodynamics of AR9281, an inhibitor of soluble epoxide hydrolase, in single- and multiple-dose studies in healthy human subjects - Chen_2012_J.Clin.Pharmacol_52_319

Author(s) : Chen D , Whitcomb R , MacIntyre E , Tran V , Do ZN , Sabry J , Patel DV , Anandan SK , Gless R , Webb HK

Ref : Journal of Clinical Pharmacology , 52 :319 , 2012

Abstract :

PubMedSearch : Chen_2012_J.Clin.Pharmacol_52_319

PubMedID: 21422238

Title : 1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia - Anandan_2011_Bioorg.Med.Chem.Lett_21_983

Author(s) : Anandan SK , Webb HK , Chen D , Wang YX , Aavula BR , Cases S , Cheng Y , Do ZN , Mehra U , Tran V , Vincelette J , Waszczuk J , White K , Wong KR , Zhang LN , Jones PD , Hammock BD , Patel DV , Whitcomb R , MacIntyre DE , Sabry J , Gless R

Ref : Bioorganic & Medicinal Chemistry Lett , 21 :983 , 2011

Abstract :

PubMedSearch : Anandan_2011_Bioorg.Med.Chem.Lett_21_983

PubMedID: 21211973

Whitcomb R

References (2)

1. Pharmacokinetics and pharmacodynamics of AR9281, an inhibitor of soluble epoxide hydrolase, in single- and multiple-dose studies in healthy human subjects - Chen_2012_J.Clin.Pharmacol_52_319

2. 1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia - Anandan_2011_Bioorg.Med.Chem.Lett_21_983