Hammock BD

General

Full name : Hammock Bruce D

First name : Bruce D

Mail : Department of Entomology, University of California, Davis, One Shields Avenue, Davis, CA 95616-8584

Zip Code :

City :

Country : USA

Email : bdhammock@ucdavis.edu

Phone :

Fax :

Website : \/\/www.biopestlab.ucdavis.edu\/

Directory :

References (424)

Title : Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase - Kelly_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2314085121
Author(s) : Kelly AG , Wang W , Rothenberger E , Yang J , Gilligan MM , Kipper FC , Attaya A , Gartung A , Hwang SH , Gillespie MJ , Bayer RL , Quinlivan KM , Torres KL , Huang S , Mitsiades N , Yang H , Hammock BD , Panigrahy D
Ref : Proc Natl Acad Sci U S A , 121 :e2314085121 , 2024
PubMedID: 38330013

Title : Design and Synthesis of Dual-Targeting Inhibitors of sEH and HDAC6 for the Treatment of Neuropathic Pain and Lipopolysaccharide-Induced Mortality - Chen_2024_J.Med.Chem__
Author(s) : Chen Y , Sun J , Tong H , Wang J , Cao R , Xu H , Chen L , Morisseau C , Zhang M , Shi Y , Han C , Zhuang J , Jing Y , Liu Z , Hammock BD , Chen G
Ref : Journal of Medicinal Chemistry , : , 2024
PubMedID: 38236416

Title : Insect immune resolution with EpOME\/DiHOME and its dysregulation by their analogs leading to pathogen hypersensitivity - Hossain_2024_Insect.Biochem.Mol.Biol__104104
Author(s) : Hossain Hrithik MT , Shahmohammadi N , Jin G , Lee DH , Singh N , Vik A , Hammock BD , Kim Y
Ref : Insect Biochemistry & Molecular Biology , :104104 , 2024
PubMedID: 38494144

Title : Role of the soluble epoxide hydrolase in keratinocyte proliferation and sensitivity of skin to inflammatory stimuli - Naeem_2024_Biomed.Pharmacother_171_116127
Author(s) : Naeem Z , Zukunft S , Huard A , Hu J , Hammock BD , Weigert A , Fromel T , Fleming I
Ref : Biomed Pharmacother , 171 :116127 , 2024
PubMedID: 38198951

Title : Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury - Zhang_2023_ACS.Cent.Sci_9_440
Author(s) : Zhang J , Zhang M , Huo XK , Ning J , Yu ZL , Morisseau C , Sun CP , Hammock BD , Ma XC
Ref : ACS Cent Sci , 9 :440 , 2023
PubMedID: 36968547

Title : Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury - Zhang_2023_Int.J.Biol.Sci_19_294
Author(s) : Zhang J , Luan ZL , Huo XK , Zhang M , Morisseau C , Sun CP , Hammock BD , Ma XC
Ref : Int J Biol Sci , 19 :294 , 2023
PubMedID: 36594097

Title : Quantification of soluble epoxide hydrolase inhibitors in experimental and clinical samples using the nanobody-based ELISA - Yang_2023_J.Pharm.Anal_13_1013
Author(s) : Yang H , Qi M , He Q , Hwang SH , Yang J , McCoy M , Morisseau C , Zhao S , Hammock BD
Ref : J Pharm Anal , 13 :1013 , 2023
PubMedID: 37842656

Title : Role of soluble epoxide hydrolase in the abnormal activation of fibroblast-like synoviocytes from patients with rheumatoid arthritis - Pu_2023_Clin.Immunol__109850
Author(s) : Pu Y , Cheng R , Zhang Q , Huang T , Lu C , Tang Z , Zhong Y , Wu L , Hammock BD , Hashimoto K , Luo Y , Liu Y
Ref : Clin Immunol , :109850 , 2023
PubMedID: 38013165

Title : Inhibition of Soluble Epoxide Hydrolase Reduces Paraquat Neurotoxicity in Rodents - Atone_2023_Environ.Toxicol.Pharmacol__104070
Author(s) : Atone J , Wagner K , Koike S , Yang J , Hwang SH , Hammock BD
Ref : Environ Toxicol Pharmacol , :104070 , 2023
PubMedID: 36682504

Title : Fluorine and chlorine substituted adamantyl-urea as molecular tools for inhibition of human soluble epoxide hydrolase with picomolar efficacy - Burmistrov_2023_J.Enzyme.Inhib.Med.Chem_38_2274797
Author(s) : Burmistrov VV , Morisseau C , Danilov DV , Gladkikh BP , D'Yachenko V S , Zefirov NA , Zefirova ON , Butov GM , Hammock BD
Ref : J Enzyme Inhib Med Chem , 38 :2274797 , 2023
PubMedID: 37975322

Title : Neuroprotective effect of herbal extracts inhibiting soluble epoxide hydrolase (sEH) and cyclooxygenase (COX) against chemotherapy-induced cognitive impairment in mice - Kulkarni_2023_Biochem.Biophys.Res.Commun_667_64
Author(s) : Kulkarni R , Mehta R , Goswami SK , Hammock BD , Morisseau C , Hwang SH , Mallappa O , Azeemuddin MM , Rafiq M , S NM
Ref : Biochemical & Biophysical Research Communications , 667 :64 , 2023
PubMedID: 37209564

Title : Insect immune resolution with EpOME\/DiHOME and its dysregulation by their analogs leading to pathogen hypersensitivity - Hrithrik_2023_bioRxiv__
Author(s) : Hrithrik MTH , Lee DH , Singh N , Vik A , Hammock BD , Kim Y
Ref : Biorxiv , : , 2023
PubMedID: 37461499

Title : Structure-Directed Discovery of Potent Soluble Epoxide Hydrolase Inhibitors for the Treatment of Inflammatory Diseases - Chen_2023_J.Med.Chem__
Author(s) : Chen Y , Chen L , Xu H , Cao R , Morisseau C , Zhang M , Shi Y , Hammock BD , Wang J , Zhuang J , Liu Z , Chen G
Ref : Journal of Medicinal Chemistry , : , 2023
PubMedID: 36689364

Title : COX-2\/sEH-mediated macrophage activation is a target for pulmonary protection in mouse models of chronic obstructive pulmonary disease - Duan_2023_Lab.Invest__100319
Author(s) : Duan JX , Guan XX , Cheng W , Deng DD , Chen P , Liu C , Zhou Y , Hammock BD , Yang HH
Ref : Lab Invest , :100319 , 2023
PubMedID: 38158123

Title : Eicosanoid profiles in an arthritis model: Effects of a soluble epoxide hydrolase inhibitor - Trindade-da-Silva_2023_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1869_159432
Author(s) : Trindade-da-Silva CA , Yang J , Fonseca F , Pham H , Napimoga MH , Abdalla HB , Aver G , De Oliveira MJA , Hammock BD , Clemente-Napimoga JT
Ref : Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids , 1869 :159432 , 2023
PubMedID: 37984607

Title : Aflatoxin B(1) Increases Soluble Epoxide Hydrolase in the Brain and Induces Neuroinflammation and Dopaminergic Neurotoxicity - Wang_2023_Int.J.Mol.Sci_24_9938
Author(s) : Wang W , Wang Y , Wagner KM , Lee RD , Hwang SH , Morisseau C , Wulff H , Hammock BD
Ref : Int J Mol Sci , 24 :9938 , 2023
PubMedID: 37373086

Title : Hepatic Transcriptome and Its Regulation Following Soluble Epoxide Hydrolase Inhibition in Alcohol-Associated Liver Disease - Warner_2023_Am.J.Pathol__
Author(s) : Warner JB , Hardesty JE , Song YL , Floyd AT , Deng Z , Jebet A , He L , Zhang X , McClain CJ , Hammock BD , Warner DR , Kirpich IA
Ref : American Journal of Pathology , : , 2023
PubMedID: 37925018

Title : Screening and Biological Evaluation of Soluble Epoxide Hydrolase Inhibitors: Assessing the Role of Hydrophobicity in the Pharmacophore-Guided Search of Novel Hits - Vazquez_2023_J.Chem.Inf.Model__
Author(s) : Vazquez J , Ginex T , Herrero A , Morisseau C , Hammock BD , Luque FJ
Ref : J Chem Inf Model , : , 2023
PubMedID: 37141492

Title : The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling - Luo_2023_J.Transl.Med_21_71
Author(s) : Luo A , Wu Z , Li S , McReynolds CB , Wang D , Liu H , Huang C , He T , Zhang X , Wang Y , Liu C , Hammock BD , Hashimoto K , Yang C
Ref : J Transl Med , 21 :71 , 2023
PubMedID: 36732752

Title : Modulating the sEH\/EETs Axis Restrains Specialized Proresolving Mediator Impairment and Regulates T Cell Imbalance in Experimental Periodontitis - Abdalla_2023_J.Immunol__
Author(s) : Abdalla HB , Puhl L , Rivas CA , Wu YC , Rojas P , Trindade-da-Silva CA , Hammock BD , Maddipati KR , Soares MQS , Clemente-Napimoga JT , Kantarci A , Napimoga MH , Van Dyke TE
Ref : J Immunol , : , 2023
PubMedID: 38117781

Title : Mix-and-Read Nanobody-Based Sandwich Homogeneous Split-Luciferase Assay for the Rapid Detection of Human Soluble Epoxide Hydrolase - He_2023_Anal.Chem__
Author(s) : He Q , McCoy MR , Yang H , Lin M , Cui X , Zhao S , Morisseau C , Li D , Hammock BD
Ref : Analytical Chemistry , : , 2023
PubMedID: 36972550

Title : Effects of chronic secondhand smoke exposure on cardiovascular regulation and the role of soluble epoxide hydrolase in mice - Pan_2023_Front.Physiol_14_1185744
Author(s) : Pan S , Karey E , Nieves-Cintron M , Chen YJ , Hwang SH , Hammock BD , Pinkerton KE , Chen CY
Ref : Front Physiol , 14 :1185744 , 2023
PubMedID: 37362438

Title : The Generation of a Nanobody-Based ELISA for Human Microsomal Epoxide Hydrolase - He_2023_Int.J.Mol.Sci_24_
Author(s) : He Q , McCoy MR , Qi M , Morisseau C , Yang H , Xu C , Shey R , Goodman MC , Zhao S , Hammock BD
Ref : Int J Mol Sci , 24 : , 2023
PubMedID: 37834144

Title : Hepatocyte-specific disruption of soluble epoxide hydrolase attenuates abdominal aortic aneurysm formation: novel role of the liver in aneurysm pathogenesis - Kim_2023_bioRxiv__
Author(s) : Kim D , Horimatsu T , Ogbi M , Goo B , Shi H , Veerapaneni P , Chouhaita R , Moses M , Prasad R , Benson TW , Harb R , Aboud G , Seller H , Haigh S , Fulton DJ , Csanyi G , Huo Y , Long X , Coffey P , Lee R , Guha A , Zeldin D , Hwang SH , Hammock BD , Weintraub NL , Kim HW
Ref : Biorxiv , : , 2023
PubMedID: 37503031

Title : Soluble Epoxide Hydrolase Contributes to Cell Senescence and ER Stress in Aging Mice Colon - Wang_2023_Int.J.Mol.Sci_24_4570
Author(s) : Wang W , Wagner KM , Wang Y , Singh N , Yang J , He Q , Morisseau C , Hammock BD
Ref : Int J Mol Sci , 24 :4570 , 2023
PubMedID: 36901999

Title : Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase attenuated particulate matter 2.5 exposure mediated lung injury - Zhang_2023_J.Hazard.Mater_458_131890
Author(s) : Zhang J , Zhang WH , Morisseau C , Zhang M , Dong HJ , Zhu QM , Huo XK , Sun CP , Hammock BD , Ma XC
Ref : J Hazard Mater , 458 :131890 , 2023
PubMedID: 37406527

Title : Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress - Peyman_2023_Biomed.Pharmacother_168_115667
Author(s) : Peyman M , Barroso E , Turcu AL , Estrany F, Jr. , Smith D , Jurado-Aguilar J , Rada P , Morisseau C , Hammock BD , Valverde A M , Palomer X , Galdeano C , Vazquez S , Vazquez-Carrera M
Ref : Biomed Pharmacother , 168 :115667 , 2023
PubMedID: 37826940
Gene_locus related to this paper: human-EPHX2

Title : Soluble epoxide hydrolase inhibitor blockage microglial cell activation in subnucleus caudalis in a persistent model of arthritis - Tarkany_2023_Int.Immunopharmacol_120_110320
Author(s) : Tarkany Basting R , Henrique Napimoga M , Antonio Trindade Silva C , Ballassini Abdalla H , Campos Durso B , Henrique Barboza Martins L , de Abreu Cavalcanti H , Hammock BD , Trindade Clemente-Napimoga J
Ref : Int Immunopharmacol , 120 :110320 , 2023
PubMedID: 37230034

Title : PROTAC-Mediated Selective Degradation of Cytosolic Soluble Epoxide Hydrolase Enhances ER Stress Reduction - Wang_2023_ACS.Chem.Biol__
Author(s) : Wang Y , Morisseau C , Takamura A , Wan D , Li D , Sidoli S , Yang J , Wolan DW , Hammock BD , Kitamura S
Ref : ACS Chemical Biology , : , 2023
PubMedID: 36947831
Gene_locus related to this paper: human-EPHX2

Title : Adamantyl-ureas with pyrazoles substituted by fluoroalkanes as soluble epoxide hydrolase inhibitors - Burmistrov_2023_J.Fluor.Chem_266_
Author(s) : Burmistrov VV , Morisseau C , Shkineva TK , Danilov DV , Gladkikh B , Butov GM , Fayzullin RR , Dutova TY , Hammock BD , Dalinger IL
Ref : J Fluor Chem , 266 : , 2023
PubMedID: 37638129

Title : Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model - Sun_2022_Proc.Natl.Acad.Sci.U.S.A_119_
Author(s) : Sun CP , Zhou JJ , Yu ZL , Huo XK , Zhang J , Morisseau C , Hammock BD , Ma XC
Ref : Proc Natl Acad Sci U S A , 119 : , 2022
PubMedID: 35217618
Gene_locus related to this paper: human-EPHX2

Title : Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease - Codony_2022_J.Med.Chem_65_4909
Author(s) : Codony S , Pont C , Grinan-Ferre C , Di Pede-Mattatelli A , Calvo-Tusell C , Feixas F , Osuna S , Jarne-Ferrer J , Naldi M , Bartolini M , Loza MI , Brea J , Perez B , Bartra C , Sanfeliu C , Juarez-Jimenez J , Morisseau C , Hammock BD , Pallas M , Vazquez S , Munoz-Torrero D
Ref : Journal of Medicinal Chemistry , 65 :4909 , 2022
PubMedID: 35271276

Title : Structure-guided discovery of potent and oral soluble epoxide hydrolase inhibitors for the treatment of neuropathic pain - Du_2022_Acta.Pharm.Sin.B_12_1377
Author(s) : Du F , Cao R , Chen L , Sun J , Shi Y , Fu Y , Hammock BD , Zheng Z , Liu Z , Chen G
Ref : Acta Pharm Sin B , 12 :1377 , 2022
PubMedID: 35530144

Title : Soluble epoxide hydrolase inhibition enhances Specialized Pro-resolving Lipid Mediator production and promotes macrophage plasticity - Abdalla_2022_Br.J.Pharmacol__
Author(s) : Abdalla HB , Alvarez C , Wu YC , Rojas P , Hammock BD , Maddipati KR , Trindade-da-Silva CA , Soares MQS , Clemente-Napimoga JT , Kantarci A , Napimoga MH , Van Dyke TE
Ref : British Journal of Pharmacology , : , 2022
PubMedID: 36508312

Title : Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth - Naeem_2022_Pflugers.Arch__
Author(s) : Naeem Z , Zukunft S , Gunther S , Liebner S , Weigert A , Hammock BD , Fromel T , Fleming I
Ref : Pflugers Arch , : , 2022
PubMedID: 35648219

Title : Aflatoxin B(1) exposure disrupts the intestinal immune function via a soluble epoxide hydrolase-mediated manner - Wang_2022_Ecotoxicol.Environ.Saf_249_114417
Author(s) : Wang W , Wang Y , Yang J , Wagner KM , Hwang SH , Cheng J , Singh N , Edwards P , Morisseau C , Zhang G , Panigrahy D , Hammock BD
Ref : Ecotoxicology & Environmental Safety , 249 :114417 , 2022
PubMedID: 36525946

Title : Novel aerosol treatment of airway hyper-reactivity and inflammation in a murine model of asthma with a soluble epoxide hydrolase inhibitor - Zhang_2022_PLoS.One_17_e0266608
Author(s) : Zhang C , Li W , Li X , Wan D , Mack S , Zhang J , Wagner K , Wang C , Tan B , Chen J , Wu CW , Tsuji K , Takeuchi M , Chen Z , Hammock BD , Pinkerton KE , Yang J
Ref : PLoS ONE , 17 :e0266608 , 2022
PubMedID: 35443010

Title : Anti-Inflammatory Activity of Soluble Epoxide Hydrolase Inhibitors Based on Selenoureas Bearing an Adamantane Moiety - Burmistrov_2022_Int.J.Mol.Sci_23_
Author(s) : Burmistrov V , Morisseau C , Babkov DA , Golubeva T , Pitushkin D , Sokolova EV , Vasipov V , Kuznetsov Y , Bazhenov SV , Novoyatlova US , Bondarev NA , Manukhov IV , Osipova V , Berberova N , Spasov AA , Butov GM , Hammock BD
Ref : Int J Mol Sci , 23 : , 2022
PubMedID: 36142611

Title : Soluble epoxide hydrolase inhibition avoid formalin-induced inflammatory hyperalgesia in the temporomandibular joint - Abdalla_2022_Inflammopharmacology__
Author(s) : Abdalla HB , Napimoga MH , Teixeira JM , Trindade-da-Silva CA , Pieroni VL , Dos Santos Araujo FSM , Hammock BD , Clemente-Napimoga JT
Ref : Inflammopharmacology , : , 2022
PubMedID: 35303234

Title : Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors - Codony_2022_J.Med.Chem_65_13660
Author(s) : Codony S , Entrena JM , Calvo-Tusell C , Jora B , Gonzalez-Cano R , Osuna S , Corpas R , Morisseau C , Perez B , Barniol-Xicota M , Grinan-Ferre C , Perez C , Rodriguez-Franco MI , Martinez AL , Loza MI , Pallas M , Verhelst SHL , Sanfeliu C , Feixas F , Hammock BD , Brea J , Cobos EJ , Vazquez S
Ref : Journal of Medicinal Chemistry , 65 :13660 , 2022
PubMedID: 36222708

Title : Soluble epoxide hydrolase inhibition alleviates chemotherapy induced neuropathic pain - Takeshita_2022_Front.Pain.Res.(Lausanne)_3_1100524
Author(s) : Takeshita AA , Hammock BD , Wagner KM
Ref : Front Pain Res (Lausanne) , 3 :1100524 , 2022
PubMedID: 36700145

Title : sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury - Bergmann_2022_Proc.Natl.Acad.Sci.U.S.A_119_e2120691119
Author(s) : Bergmann CB , McReynolds CB , Wan D , Singh N , Goetzman H , Caldwell CC , Supp DM , Hammock BD
Ref : Proc Natl Acad Sci U S A , 119 :e2120691119 , 2022
PubMedID: 35312372

Title : Structure-activity relationship studies of benzothiazole-phenyl analogs as multi-target ligands to alleviate pain without affecting normal behavior - Angelia_2022_Prostaglandins.Other.Lipid.Mediat__106702
Author(s) : Angelia J , Weng X , Solomatov A , Chin C , Fernandez A , Hudson PK , Morisseau C , Hammock BD , Kandasamy R , Pecic S
Ref : Prostaglandins Other Lipid Mediat , :106702 , 2022
PubMedID: 36529320

Title : Soluble Epoxide Hydrolase Is Associated with Postprandial Anxiety Decrease in Healthy Adult Women - Nguyen_2022_Int.J.Mol.Sci_23_
Author(s) : Nguyen N , Morisseau C , Li D , Yang J , Lam E , Woodside DB , Hammock BD , Shih PB
Ref : Int J Mol Sci , 23 : , 2022
PubMedID: 36233100

Title : Inhibition of the Soluble Epoxide Hydrolase as an Analgesic Strategy: A Review of Preclinical Evidence - Wang_2021_J.Pain.Res_14_61
Author(s) : Wang Y , Wagner KM , Morisseau C , Hammock BD
Ref : J Pain Res , 14 :61 , 2021
PubMedID: 33488116

Title : Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis - Du_2021_Eur.J.Med.Chem_223_113678
Author(s) : Du F , Sun W , Morisseau C , Hammock BD , Bao X , Liu Q , Wang C , Zhang T , Yang H , Zhou J , Xiao W , Liu Z , Chen G
Ref : Eur Journal of Medicinal Chemistry , 223 :113678 , 2021
PubMedID: 34218083

Title : Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase\/fatty acid amide hydrolase inhibitors - Wilt_2021_Bioorg.Med.Chem_51_116507
Author(s) : Wilt S , Kodani S , Valencia L , Hudson PK , Sanchez S , Quintana T , Morisseau C , Hammock BD , Kandasamy R , Pecic S
Ref : Bioorganic & Medicinal Chemistry , 51 :116507 , 2021
PubMedID: 34794001

Title : Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers - Tiwari_2021_Sci.Rep_11_7042
Author(s) : Tiwari S , Yang J , Morisseau C , Durbin-Johnson B , Hammock BD , Gomes AV
Ref : Sci Rep , 11 :7042 , 2021
PubMedID: 33782432

Title : Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative - Hammock_2021_J.Med.Chem__
Author(s) : Hammock BD , McReynolds CB , Wagner K , Buckpitt A , Cortes-Puch I , Croston G , Lee KSS , Yang J , Schmidt WK , Hwang SH
Ref : Journal of Medicinal Chemistry , : , 2021
PubMedID: 33550801

Title : Differential Effects of 17,18-EEQ and 19,20-EDP Combined with Soluble Epoxide Hydrolase Inhibitor t-TUCB on Diet-Induced Obesity in Mice - Yang_2021_Int.J.Mol.Sci_22_
Author(s) : Yang Y , Xu X , Wu H , Yang J , Chen J , Morisseau C , Hammock BD , Bettaieb A , Zhao L
Ref : Int J Mol Sci , 22 : , 2021
PubMedID: 34361032

Title : Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease - Mello_2021_Cell.Mol.Gastroenterol.Hepatol_11_815
Author(s) : Mello A , Hsu MF , Koike S , Chu B , Cheng J , Yang J , Morisseau C , Torok NJ , Hammock BD , Haj FG
Ref : Cell Mol Gastroenterol Hepatol , 11 :815 , 2021
PubMedID: 33068774

Title : Target-Mediated Drug Disposition-A Class Effect of Soluble Epoxide Hydrolase Inhibitors - An_2021_J.Clin.Pharmacol_61_531
Author(s) : An G , Lee KSS , Yang J , Hammock BD
Ref : Journal of Clinical Pharmacology , 61 :531 , 2021
PubMedID: 33078430

Title : Inhibition of sEH via stabilizing the level of EETs alleviated Alzheimer's disease through GSK3beta signaling pathway - Sun_2021_Food.Chem.Toxicol_156_112516
Author(s) : Sun CP , Zhang XY , Zhou JJ , Huo XK , Yu ZL , Morisseau C , Hammock BD , Ma XC
Ref : Food & Chemical Toxicology , 156 :112516 , 2021
PubMedID: 34411643

Title : TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function - Bergmann_2021_Sci.Rep_11_16555
Author(s) : Bergmann CB , Hammock BD , Wan D , Gogolla F , Goetzman H , Caldwell CC , Supp DM
Ref : Sci Rep , 11 :16555 , 2021
PubMedID: 34400718

Title : Activity of sEH and Oxidant Status during Systemic Bovine Coliform Mastitis - Mavangira_2021_Antioxidants.(Basel)_10_
Author(s) : Mavangira V , Kuhn MJ , Abuelo A , Morisseau C , Hammock BD , Sordillo LM
Ref : Antioxidants (Basel) , 10 : , 2021
PubMedID: 34065244

Title : Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues - Morisseau_2021_Int.J.Mol.Sci_22_
Author(s) : Morisseau C , Kodani SD , Kamita SG , Yang J , Lee KSS , Hammock BD
Ref : Int J Mol Sci , 22 : , 2021
PubMedID: 34066758

Title : Adrenic Acid-Derived Epoxy Fatty Acids Are Naturally Occurring Lipids and Their Methyl Ester Prodrug Reduces Endoplasmic Reticulum Stress and Inflammatory Pain - Singh_2021_ACS.Omega_6_7165
Author(s) : Singh N , Barnych B , Wagner KM , Wan D , Morisseau C , Hammock BD
Ref : ACS Omega , 6 :7165 , 2021
PubMedID: 33748630

Title : From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis - Codony_2021_J.Med.Chem__
Author(s) : Codony S , Calvo-Tusell C , Valverde E , Osuna S , Morisseau C , Loza MI , Brea J , Perez C , Rodriguez-Franco MI , Pizarro-Delgado J , Corpas R , Grinan-Ferre C , Pallas M , Sanfeliu C , Vazquez-Carrera M , Hammock BD , Feixas F , Vazquez S
Ref : Journal of Medicinal Chemistry , : , 2021
PubMedID: 33945278

Title : Soluble Epoxide Hydrolase in Aged Female Mice and Human Explanted Hearts Following Ischemic Injury - Jamieson_2021_Int.J.Mol.Sci_22_
Author(s) : Jamieson KL , Darwesh AM , Sosnowski DK , Zhang H , Shah S , Zhabyeyev P , Yang J , Hammock BD , Edin ML , Zeldin DC , Oudit GY , Kassiri Z , Seubert JM
Ref : Int J Mol Sci , 22 : , 2021
PubMedID: 33567578

Title : Species Differences in Metabolism of Soluble Epoxide Hydrolase Inhibitor, EC1728, Highlight the Importance of Clinically Relevant Screening Mechanisms in Drug Development - McReynolds_2021_Molecules_26_
Author(s) : McReynolds CB , Yang J , Guedes A , Morisseau C , Garcia R , Knych H , Tearney C , Hamamoto B , Hwang SH , Wagner K , Hammock BD
Ref : Molecules , 26 : , 2021
PubMedID: 34443621

Title : Dual sEH\/COX-2 Inhibition Using PTUPB-A Promising Approach to Antiangiogenesis-Induced Nephrotoxicity - Jankiewicz_2021_Front.Pharmacol_12_744776
Author(s) : Jankiewicz WK , Barnett SD , Stavniichuk A , Hwang SH , Hammock BD , Belayet JB , Khan AH , Imig JD
Ref : Front Pharmacol , 12 :744776 , 2021
PubMedID: 34955823

Title : Multitarget molecule,PTUPB, to treat diabetic nephropathy in rats - Hye_2021_Br.J.Pharmacol_178_4468
Author(s) : Hye Khan MA , Hwang SH , Barnett SD , Stavniichuk A , Jankiewicz WK , Hammock BD , Imig JD
Ref : British Journal of Pharmacology , 178 :4468 , 2021
PubMedID: 34255857

Title : COX-2\/sEH Dual Inhibitor PTUPB Alleviates CCl (4) -Induced Liver Fibrosis and Portal Hypertension - Zhao_2021_Front.Med.(Lausanne)_8_761517
Author(s) : Zhao Z , Zhang C , Lin J , Zheng L , Li H , Qi X , Huo H , Lou X , Hammock BD , Hwang SH , Bao Y , Luo M
Ref : Front Med (Lausanne) , 8 :761517 , 2021
PubMedID: 35004731

Title : Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat diet-induced pancreatic beta-cell dysfunction and loss - Koike_2021_Free.Radic.Biol.Med__
Author(s) : Koike S , Hsu MF , Bettaieb A , Chu B , Matsumoto N , Morisseau C , Havel PJ , Huising MO , Hammock BD , Haj FG
Ref : Free Radic Biol Med , : , 2021
PubMedID: 34038767

Title : A Soluble Epoxide Hydrolase Inhibitor, 1-TrifluoromethoxyPhenyl-3-(1-Propionylpiperidin-4-yl) Urea, Ameliorates Experimental Autoimmune Encephalomyelitis - Jonnalagadda_2021_Int.J.Mol.Sci_22_
Author(s) : Jonnalagadda D , Wan D , Chun J , Hammock BD , Kihara Y
Ref : Int J Mol Sci , 22 : , 2021
PubMedID: 33925035

Title : Ingestion of Faecalibaculum rodentium causes depression-like phenotypes in resilient Ephx2 knock-out mice: A role of brain-gut-microbiota axis via the subdiaphragmatic vagus nerve - Wang_2021_J.Affect.Disord_292_565
Author(s) : Wang S , Ishima T , Qu Y , Shan J , Chang L , Wei Y , Zhang J , Pu Y , Fujita Y , Tan Y , Wang X , Ma L , Wan X , Hammock BD , Hashimoto K
Ref : J Affect Disord , 292 :565 , 2021
PubMedID: 34147969

Title : Role of epoxide hydrolases and cytochrome P450s on metabolism of KZR-616, a first-in-class selective inhibitor of the immunoproteasome - Fang_2021_Drug.Metab.Dispos__
Author(s) : Fang Y , Johnson H , Anderl JL , Muchamuel T , McMinn D , Morisseau C , Hammock BD , Kirk C , Wang J
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2021
PubMedID: 34234005
Gene_locus related to this paper: human-EPHX1

Title : Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections - McReynolds_2021_Front.Physiol_12_663869
Author(s) : McReynolds CB , Cortes-Puch I , Ravindran R , Khan IH , Hammock BG , Shih PB , Hammock BD , Yang J
Ref : Front Physiol , 12 :663869 , 2021
PubMedID: 33868029

Title : EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence - Gautheron_2021_Elife_10_
Author(s) : Gautheron J , Morisseau C , Chung WK , Zammouri J , Auclair M , Baujat G , Capel E , Moulin C , Wang Y , Yang J , Hammock BD , Cerame B , Phan F , Feve B , Vigouroux C , Andreelli F , Jeru I
Ref : Elife , 10 : , 2021
PubMedID: 34342583
Gene_locus related to this paper: human-EPHX1

Title : New Alkoxy- Analogues of Epoxyeicosatrienoic Acids Attenuate Cisplatin Nephrotoxicity In Vitro via Reduction of Mitochondrial Dysfunction, Oxidative Stress, Mitogen-Activated Protein Kinase Signaling, and Caspase Activation - Singh_2021_Chem.Res.Toxicol__
Author(s) : Singh N , Vik A , Lybrand DB , Morisseau C , Hammock BD
Ref : Chemical Research in Toxicology , : , 2021
PubMedID: 34817988

Title : Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products - Sun_2021_J.Med.Chem_64_184
Author(s) : Sun CP , Zhang XY , Morisseau C , Hwang SH , Zhang ZJ , Hammock BD , Ma XC
Ref : Journal of Medicinal Chemistry , 64 :184 , 2021
PubMedID: 33369424

Title : Soluble Epoxide Hydrolase Deletion Limits High-Fat Diet-Induced Inflammation - Wagner_2021_Front.Pharmacol_12_778470
Author(s) : Wagner KM , Yang J , Morisseau C , Hammock BD
Ref : Front Pharmacol , 12 :778470 , 2021
PubMedID: 34975481
Gene_locus related to this paper: mouse-hyes

Title : 2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity - Martin-Lopez_2021_Pharmaceuticals.(Basel)_14_
Author(s) : Martin-Lopez J , Codony S , Bartra C , Morisseau C , Loza MI , Sanfeliu C , Hammock BD , Brea J , Vazquez S
Ref : Pharmaceuticals (Basel) , 14 : , 2021
PubMedID: 34959721

Title : Increased expression of soluble epoxide hydrolase in the brain and liver from patients with major psychiatric disorders: A role of brain - liver axis - Zhang_2020_J.Affect.Disord_270_131
Author(s) : Zhang J , Tan Y , Chang L , Hammock BD , Hashimoto K
Ref : J Affect Disord , 270 :131 , 2020
PubMedID: 32339103

Title : Soluble Epoxide Hydrolase Inhibition Improves Cognitive Function and Parenchymal Artery Dilation in a Hypertensive Model of Chronic Cerebral Hypoperfusion - Matin_2020_Microcirculation__e12653
Author(s) : Matin N , Fisher C , Lansdell TA , Hammock BD , Yang J , Jackson WF , Dorrance AM
Ref : Microcirculation , :e12653 , 2020
PubMedID: 32767848

Title : Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation - Wang_2020_Proc.Natl.Acad.Sci.U.S.A_117_8431
Author(s) : Wang Y , Yang J , Wang W , Sanidad KZ , Cinelli MA , Wan D , Hwang SH , Kim D , Lee KSS , Xiao H , Hammock BD , Zhang G
Ref : Proc Natl Acad Sci U S A , 117 :8431 , 2020
PubMedID: 32220957
Gene_locus related to this paper: human-EPHX2

Title : Protostane-type triterpenoids as natural soluble epoxide hydrolase inhibitors: Inhibition potentials and molecular dynamics - Sun_2020_Bioorg.Chem_96_103637
Author(s) : Sun CP , Zhang J , Zhao WY , Yi J , Yan JK , Wang YL , Morisseau C , Liu ZB , Hammock BD , Ma XC
Ref : Bioorg Chem , 96 :103637 , 2020
PubMedID: 32032849

Title : Assessment of Soluble Epoxide Hydrolase Activity In Vivo: A Metabolomic Approach - Stefanovski_2020_Prostaglandins.Other.Lipid.Mediat__106410
Author(s) : Stefanovski D , Shih PB , Hammock BD , Watanabe RM , Youn JH
Ref : Prostaglandins Other Lipid Mediat , :106410 , 2020
PubMedID: 31931080

Title : Vascular Lipidomic Profiling of Potential Endogenous Fatty Acid PPAR Ligands Reveals the Coronary Artery as Major Producer of CYP450-Derived Epoxy Fatty Acids - Edin_2020_Cells_9_
Author(s) : Edin ML , Lih FB , Hammock BD , Thomson S , Zeldin DC , Bishop-Bailey D
Ref : Cells , 9 : , 2020
PubMedID: 32365470

Title : Soluble epoxide hydrolase inhibitor mediated analgesia lacks tolerance in rat models - Wagner_2020_Brain.Res_1728_146573
Author(s) : Wagner KM , Atone J , Hammock BD
Ref : Brain Research , 1728 :146573 , 2020
PubMedID: 31790682

Title : Development of multitarget inhibitors for the treatment of pain: Design, synthesis, biological evaluation and molecular modeling studies - Wilt_2020_Bioorg.Chem_103_104165
Author(s) : Wilt S , Kodani S , Le TNH , Nguyen L , Vo N , Ly T , Rodriguez M , Hudson PK , Morisseau C , Hammock BD , Pecic S
Ref : Bioorg Chem , 103 :104165 , 2020
PubMedID: 32891856

Title : Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase - Pu_2020_Proc.Natl.Acad.Sci.U.S.A__
Author(s) : Pu Y , Yang J , Chang L , Qu Y , Wang S , Zhang K , Xiong Z , Zhang J , Tan Y , Wang X , Fujita Y , Ishima T , Wan D , Hwang SH , Hammock BD , Hashimoto K
Ref : Proc Natl Acad Sci U S A , : , 2020
PubMedID: 32398374

Title : Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease - Grinan-Ferre_2020_Neurotherapeutics__
Author(s) : Grinan-Ferre C , Codony S , Pujol E , Yang J , Leiva R , Escolano C , Puigoriol-Illamola D , Companys-Alemany J , Corpas R , Sanfeliu C , Perez B , Loza MI , Brea J , Morisseau C , Hammock BD , Vazquez S , Pallas M , Galdeano C
Ref : Neurotherapeutics , : , 2020
PubMedID: 32488482

Title : Selection of Potent Inhibitors of Soluble Epoxide Hydrolase for Usage in Veterinary Medicine - Shihadih_2020_Front.Vet.Sci_7_580
Author(s) : Shihadih DS , Harris TR , Kodani SD , Hwang SH , Lee KSS , Mavangira V , Hamamoto B , Guedes A , Hammock BD , Morisseau C
Ref : Front Vet Sci , 7 :580 , 2020
PubMedID: 33005645

Title : An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer's disease - Ghosh_2020_Sci.Transl.Med_12_
Author(s) : Ghosh A , Comerota MM , Wan D , Chen F , Propson NE , Hwang SH , Hammock BD , Zheng H
Ref : Sci Transl Med , 12 : , 2020
PubMedID: 33298560

Title : Soluble Epoxide Hydrolase Inhibition by t-TUCB Promotes Brown Adipogenesis and Reduces Serum Triglycerides in Diet-Induced Obesity - Overby_2020_Int.J.Mol.Sci_21_
Author(s) : Overby H , Yang Y , Xu X , Graham K , Hildreth K , Choi S , Wan D , Morisseau C , Zeldin DC , Hammock BD , Wang S , Bettaieb A , Zhao L
Ref : Int J Mol Sci , 21 : , 2020
PubMedID: 32987880

Title : Soluble epoxide hydrolase inhibitor, TPPU, increases regulatory T cells pathway in an arthritis model - Trindade-da-Silva_2020_FASEB.J__
Author(s) : Trindade-da-Silva CA , Clemente-Napimoga JT , Abdalla HB , Rosa SM , Ueira-Vieira C , Morisseau C , Verri WA, Jr. , Montalli VAM , Hammock BD , Napimoga MH
Ref : FASEB Journal , : , 2020
PubMedID: 32400048

Title : 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor, lowers L-NAME-induced hypertension through suppression of angiotensin-converting enzyme in rats - Bukhari_2020_Eur.Rev.Med.Pharmacol.Sci_24_8143
Author(s) : Bukhari IA , Alorainey BI , Al-Motrefi AA , Mahmoud A , Campbell WB , Hammock BD
Ref : Eur Rev Med Pharmacol Sci , 24 :8143 , 2020
PubMedID: 32767352

Title : Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19? - Panigrahy_2020_Cancer.Metastasis.Rev__
Author(s) : Panigrahy D , Gilligan MM , Huang S , Gartung A , Cortes-Puch I , Sime PJ , Phipps RP , Serhan CN , Hammock BD
Ref : Cancer Metastasis Rev , : , 2020
PubMedID: 32385712

Title : Development of Improved Double Nanobody Sandwich ELISAs for Human Soluble Epoxide Hydrolase Detection in PBMCs of Diabetic and Pre-frontal Cortex of Multiple Sclerosis Patients - Li_2020_Anal.Chem_92_7334
Author(s) : Li D , Morisseau C , McReynolds CB , Duflot T , Bellien J , Nagra RM , Taha AY , Hammock BD
Ref : Analytical Chemistry , 92 :7334 , 2020
PubMedID: 32253910

Title : PTUPB ameliorates high-fat diet-induced non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in mice - Sun_2020_Biochem.Biophys.Res.Commun__
Author(s) : Sun CC , Zhang CY , Duan JX , Guan XX , Yang HH , Jiang HL , Hammock BD , Hwang SH , Zhou Y , Guan CX , Liu SK , Zhang J
Ref : Biochemical & Biophysical Research Communications , : , 2020
PubMedID: 31973813

Title : A COX-2\/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation - Yang_2020_Theranostics_10_4749
Author(s) : Yang HH , Duan JX , Liu SK , Xiong JB , Guan XX , Zhong WJ , Sun CC , Zhang CY , Luo XQ , Zhang YF , Chen P , Hammock BD , Hwang SH , Jiang JX , Zhou Y , Guan CX
Ref : Theranostics , 10 :4749 , 2020
PubMedID: 32308747

Title : A COX-2\/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress - Zhang_2020_Biomed.Pharmacother_126_109907
Author(s) : Zhang YF , Sun CC , Duan JX , Yang HH , Zhang CY , Xiong JB , Zhong WJ , Zu C , Guan XX , Jiang HL , Hammock BD , Hwang SH , Zhou Y , Guan CX
Ref : Biomed Pharmacother , 126 :109907 , 2020
PubMedID: 32114358

Title : COX-2\/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence - Zhang_2020_FEBS.J_287_1666
Author(s) : Zhang CY , Duan JX , Yang HH , Sun CC , Zhong WJ , Tao JH , Guan XX , Jiang HL , Hammock BD , Hwang SH , Zhou Y , Guan CX
Ref : Febs J , 287 :1666 , 2020
PubMedID: 31646730

Title : Imidazolidine-2,4,5- and pirimidine-2,4,6-triones - New primary pharmacophore for soluble epoxide hydrolase inhibitors with enhanced water solubility - Burmistrov_2020_Bioorg.Med.Chem.Lett_30_126908
Author(s) : Burmistrov V , Morisseau C , D'Yachenko V , Karlov D , Butov GM , Hammock BD
Ref : Bioorganic & Medicinal Chemistry Lett , 30 :126908 , 2020
PubMedID: 31870649

Title : N-Benzyl-linoleamide, a Constituent of Lepidium meyenii (Maca), Is an Orally Bioavailable Soluble Epoxide Hydrolase Inhibitor That Alleviates Inflammatory Pain - Singh_2020_J.Nat.Prod_83_3689
Author(s) : Singh N , Barnych B , Morisseau C , Wagner KM , Wan D , Takeshita A , Pham H , Xu T , Dandekar A , Liu JY , Hammock BD
Ref : Journal of Natural Products , 83 :3689 , 2020
PubMedID: 33320645

Title : Development of potent inhibitors of the human microsomal epoxide hydrolase - Barnych_2020_Eur.J.Med.Chem_193_112206
Author(s) : Barnych B , Singh N , Negrel S , Zhang Y , Magis D , Roux C , Hua X , Ding Z , Morisseau C , Tantillo DJ , Siegel JB , Hammock BD
Ref : Eur Journal of Medicinal Chemistry , 193 :112206 , 2020
PubMedID: 32203787
Gene_locus related to this paper: human-EPHX1 , mouse-EPHX1

Title : Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell-based therapy - Sirish_2020_Stem.Cells.Transl.Med_9_1570
Author(s) : Sirish P , Thai PN , Lee JH , Yang J , Zhang XD , Ren L , Li N , Timofeyev V , Lee KSS , Nader CE , Rowland DJ , Yechikov S , Ganaga S , Young N , Lieu DK , Yamoah EN , Hammock BD , Chiamvimonvat N
Ref : Stem Cells Transl Med , 9 :1570 , 2020
PubMedID: 32790136

Title : Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain - Wagner_2020_Neurotherapeutics_17_900
Author(s) : Wagner KM , Gomes A , McReynolds CB , Hammock BD
Ref : Neurotherapeutics , 17 :900 , 2020
PubMedID: 32875445

Title : 2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis - Codony_2020_J.Med.Chem_63_9237
Author(s) : Codony S , Pujol E , Pizarro J , Feixas F , Valverde E , Loza MI , Brea JM , Saez E , Oyarzabal J , Pineda-Lucena A , Perez B , Perez C , Rodriguez-Franco MI , Leiva R , Osuna S , Morisseau C , Hammock BD , Vazquez-Carrera M , Vazquez S
Ref : Journal of Medicinal Chemistry , 63 :9237 , 2020
PubMedID: 32787085

Title : Bioisosteric substitution of adamantane with bicyclic lipophilic groups improves water solubility of human soluble epoxide hydrolase inhibitors - Burmistrov_2020_Bioorg.Med.Chem.Lett_30_127430
Author(s) : Burmistrov V , Morisseau C , Karlov D , Pitushkin D , Vernigora A , Rasskazova E , Butov GM , Hammock BD
Ref : Bioorganic & Medicinal Chemistry Lett , 30 :127430 , 2020
PubMedID: 32736212

Title : Cytochrome P450-derived linoleic acid metabolites EpOMEs and DiHOMEs: A review of recent studies - Hildreth_2020_J.Nutr.Biochem__108484
Author(s) : Hildreth K , Kodani SD , Hammock BD , Zhao L
Ref : J Nutr Biochem , :108484 , 2020
PubMedID: 32827665

Title : Carcinogenesis: Failure of resolution of inflammation? - Fishbein_2020_Pharmacol.Ther__107670
Author(s) : Fishbein A , Hammock BD , Serhan CN , Panigrahy D
Ref : Pharmacol Ther , :107670 , 2020
PubMedID: 32891711

Title : Preparation and evaluation of soluble epoxide hydrolase inhibitors with improved physical properties and potencies for treating diabetic neuropathic pain - Lee_2020_Bioorg.Med.Chem_28_115735
Author(s) : Lee KSS , Ng JC , Yang J , Hwang SH , Morisseau C , Wagner K , Hammock BD
Ref : Bioorganic & Medicinal Chemistry , 28 :115735 , 2020
PubMedID: 33007552

Title : Development of a Highly Sensitive Enzyme-Linked Immunosorbent Assay for Mouse Soluble Epoxide Hydrolase Detection by Combining a Polyclonal Capture Antibody with a Nanobody Tracer - Li_2020_Anal.Chem_92_11654
Author(s) : Li D , Cui Y , Morisseau C , Wagner KM , Cho YS , Hammock BD
Ref : Analytical Chemistry , 92 :11654 , 2020
PubMedID: 32786492

Title : Eicosanoids: The Overlooked Storm in Coronavirus Disease 2019 (COVID-19)? - Hammock_2020_Am.J.Pathol_190_1782
Author(s) : Hammock BD , Wang W , Gilligan MM , Panigrahy D
Ref : American Journal of Pathology , 190 :1782 , 2020
PubMedID: 32650004

Title : Lack of rewarding effects of a soluble epoxide hydrolase inhibitor TPPU in mice: Comparison with morphine - Wan_2020_Neuropsychopharmacol.Rep_40_412
Author(s) : Wan X , Fujita Y , Chang L , Wei Y , Ma L , Wuyun G , Pu Y , Hammock BD , Hashimoto K
Ref : Neuropsychopharmacol Rep , 40 :412 , 2020
PubMedID: 32896112

Title : In vitro and in vivo Metabolism of a Potent Inhibitor of Soluble Epoxide Hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea - Wan_2019_Front.Pharmacol_10_464
Author(s) : Wan D , Yang J , McReynolds CB , Barnych B , Wagner KM , Morisseau C , Hwang SH , Sun J , Blocher R , Hammock BD
Ref : Front Pharmacol , 10 :464 , 2019
PubMedID: 31143115

Title : Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain - Kramer_2019_J.Med.Chem_62_8443
Author(s) : Kramer JS , Woltersdorf S , Duflot T , Hiesinger K , Lillich FF , Knoll F , Wittmann SK , Klingler FM , Brunst S , Chaikuad A , Morisseau C , Hammock BD , Buccellati C , Sala A , Rovati GE , Leuillier M , Fraineau S , Rondeaux J , Hernandez-Olmos V , Heering J , Merk D , Pogoryelov D , Steinhilber D , Knapp S , Bellien J , Proschak E
Ref : Journal of Medicinal Chemistry , 62 :8443 , 2019
PubMedID: 31436984

Title : N-Substituted amino acid inhibitors of the phosphatase domain of the soluble epoxide hydrolase - Matsumoto_2019_Biochem.Biophys.Res.Commun_515_248
Author(s) : Matsumoto N , Kataoka M , Hirosaki H , Morisseau C , Hammock BD , Suzuki E , Hasumi K
Ref : Biochemical & Biophysical Research Communications , 515 :248 , 2019
PubMedID: 31146915

Title : Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model - Shen_2019_Brain.Behav.Immun_81_535
Author(s) : Shen Y , Peng W , Chen Q , Hammock BD , Liu J , Li D , Yang J , Ding J , Wang X
Ref : Brain Behavior & Immunity , 81 :535 , 2019
PubMedID: 31306773

Title : Phytochemical constituents from Scutellaria baicalensis in soluble epoxide hydrolase inhibition: Kinetics and interaction mechanism merged with simulations - Liu_2019_Int.J.Biol.Macromol_133_1187
Author(s) : Liu ZB , Sun CP , Xu JX , Morisseau C , Hammock BD , Qiu F
Ref : Int J Biol Macromol , 133 :1187 , 2019
PubMedID: 30980876

Title : Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation - Ma_2019_Proc.Natl.Acad.Sci.U.S.A_116_7083
Author(s) : Ma M , Ren Q , Yang J , Zhang K , Xiong Z , Ishima T , Pu Y , Hwang SH , Toyoshima M , Iwayama Y , Hisano Y , Yoshikawa T , Hammock BD , Hashimoto K
Ref : Proc Natl Acad Sci U S A , 116 :7083 , 2019
PubMedID: 30890645

Title : Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors - Codony_2019_Bioorg.Med.Chem_27_115078
Author(s) : Codony S , Valverde E , Leiva R , Brea J , Isabel Loza M , Morisseau C , Hammock BD , Vazquez S
Ref : Bioorganic & Medicinal Chemistry , 27 :115078 , 2019
PubMedID: 31488357

Title : Pharmacological Blockade of Soluble Epoxide Hydrolase Attenuates the Progression of Congestive Heart Failure Combined With Chronic Kidney Disease: Insights From Studies With Fawn-Hooded Hypertensive Rats - Vackova_2019_Front.Pharmacol_10_18
Author(s) : Vackova S , Kopkan L , Kikerlova S , Huskova Z , Sadowski J , Kompanowska-Jezierska E , Hammock BD , Imig JD , Taborsky M , Melenovsky V , Cervenka L
Ref : Front Pharmacol , 10 :18 , 2019
PubMedID: 30728778

Title : Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimer's Disease-Like Complications of Diabetes - Pardeshi_2019_Front.Pharmacol_10_288
Author(s) : Pardeshi R , Bolshette N , Gadhave K , Arfeen M , Ahmed S , Jamwal R , Hammock BD , Lahkar M , Goswami SK
Ref : Front Pharmacol , 10 :288 , 2019
PubMedID: 31068802

Title : Humble beginnings with big goals: Small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders - Zarriello_2019_Prog.Neurobiol_172_23
Author(s) : Zarriello S , Tuazon JP , Corey S , Schimmel S , Rajani M , Gorsky A , Incontri D , Hammock BD , Borlongan CV
Ref : Prog Neurobiol , 172 :23 , 2019
PubMedID: 30447256

Title : Brain oxylipin concentrations following hypercapnia\/ischemia: effects of brain dissection and dissection time - Hennebelle_2019_J.Lipid.Res_60_671
Author(s) : Hennebelle M , Metherel AH , Kitson AP , Otoki Y , Yang J , Lee KSS , Hammock BD , Bazinet RP , Taha AY
Ref : J Lipid Res , 60 :671 , 2019
PubMedID: 30463986

Title : Inhibition of soluble epoxide hydrolase attenuates a high-fat diet-mediated renal injury by activating PAX2 and AMPK - Luo_2019_Proc.Natl.Acad.Sci.U.S.A_116_5154
Author(s) : Luo Y , Wu MY , Deng BQ , Huang J , Hwang SH , Li MY , Zhou CY , Zhang QY , Yu HB , Zhao DK , Zhang G , Qin L , Peng A , Hammock BD , Liu JY
Ref : Proc Natl Acad Sci U S A , 116 :5154 , 2019
PubMedID: 30804206

Title : Computer-Aided Selective Optimization of Side Activities of Talinolol - Hiesinger_2019_ACS.Med.Chem.Lett_10_899
Author(s) : Hiesinger K , Kramer JS , Achenbach J , Moser D , Weber J , Wittmann SK , Morisseau C , Angioni C , Geisslinger G , Kahnt AS , Kaiser A , Proschak A , Steinhilber D , Pogoryelov D , Wagner K , Hammock BD , Proschak E
Ref : ACS Med Chem Lett , 10 :899 , 2019
PubMedID: 31223445
Gene_locus related to this paper: human-EPHX2

Title : Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis - McReynolds_2019_Front.Pharmacol_10_533
Author(s) : McReynolds CB , Hwang SH , Yang J , Wan D , Wagner K , Morisseau C , Li D , Schmidt WK , Hammock BD
Ref : Front Pharmacol , 10 :533 , 2019
PubMedID: 31214021

Title : Inhibition of soluble epoxide hydrolase ameliorates hyperhomocysteinemia-induced hepatic steatosis by enhancing beta-oxidation of fatty acid in mice - Yao_2019_Am.J.Physiol.Gastrointest.Liver.Physiol_316_G527
Author(s) : Yao L , Cao B , Cheng Q , Cai W , Ye C , Liang J , Liu W , Tan L , Yan M , Li B , He J , Hwang SH , Zhang X , Wang C , Ai D , Hammock BD , Zhu Y
Ref : American Journal of Physiology Gastrointest Liver Physiol , 316 :G527 , 2019
PubMedID: 30789748

Title : 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) Urea, a Selective and Potent Dual Inhibitor of Soluble Epoxide Hydrolase and p38 Kinase Intervenes in Alzheimer's Signaling in Human Nerve Cells - Liang_2019_ACS.Chem.Neurosci_10_4018
Author(s) : Liang Z , Zhang B , Xu M , Morisseau C , Hwang SH , Hammock BD , Li QX
Ref : ACS Chem Neurosci , 10 :4018 , 2019
PubMedID: 31378059

Title : Suppression of chemotherapy-induced cytokine\/lipid mediator surge and ovarian cancer by a dual COX-2\/sEH inhibitor - Gartung_2019_Proc.Natl.Acad.Sci.U.S.A_116_1698
Author(s) : Gartung A , Yang J , Sukhatme VP , Bielenberg DR , Fernandes D , Chang J , Schmidt BA , Hwang SH , Zurakowski D , Huang S , Kieran MW , Hammock BD , Panigrahy D
Ref : Proc Natl Acad Sci U S A , 116 :1698 , 2019
PubMedID: 30647111

Title : Effect Of Dual sEH\/COX-2 Inhibition on Allergen-Induced Airway Inflammation - Dileepan_2019_Front.Pharmacol_10_1118
Author(s) : Dileepan M , Rastle-Simpson S , Greenberg Y , Wijesinghe DS , Kumar NG , Yang J , Hwang SH , Hammock BD , Sriramarao P , Rao SP
Ref : Front Pharmacol , 10 :1118 , 2019
PubMedID: 31611798

Title : Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB\/W F1 mice - Klocke_2019_Sci.Rep_9_8993
Author(s) : Klocke J , Ulu A , Wu K , Rudolph B , Dragun D , Gollasch M , Schunck WH , Hammock BD , Riemekasten G , Enghard P
Ref : Sci Rep , 9 :8993 , 2019
PubMedID: 31222024

Title : The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors - de Oliveira_2019_Int.J.Biol.Macromol_129_653
Author(s) : de Oliveira GS , Adriani PP , Ribeiro JA , Morisseau C , Hammock BD , Dias MVB , Chambergo FS
Ref : Int J Biol Macromol , 129 :653 , 2019
PubMedID: 30771398
Gene_locus related to this paper: hypjq-g0r7e2

Title : Substrate and inhibitor selectivity, and biological activity of an epoxide hydrolase from Trichoderma reesei - de Oliveira_2019_Mol.Biol.Rep_46_371
Author(s) : de Oliveira GS , Adriani PP , Wu H , Morisseau C , Hammock BD , Chambergo FS
Ref : Mol Biol Rep , 46 :371 , 2019
PubMedID: 30426381
Gene_locus related to this paper: hypjq-g0r7e2

Title : Development of multitarget agents possessing soluble epoxide hydrolase inhibitory activity - Hiesinger_2019_Prostaglandins.Other.Lipid.Mediat_140_31
Author(s) : Hiesinger K , Wagner KM , Hammock BD , Proschak E , Hwang SH
Ref : Prostaglandins Other Lipid Mediat , 140 :31 , 2019
PubMedID: 30593866

Title : Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function - Yamanashi_2018_J.Lipid.Res_59_684
Author(s) : Yamanashi H , Boeglin WE , Morisseau C , Davis RW , Sulikowski GA , Hammock BD , Brash AR
Ref : J Lipid Res , 59 :684 , 2018
PubMedID: 29459481

Title : Soluble epoxide hydrolase inhibitor, APAU, protects dopaminergic neurons against rotenone induced neurotoxicity: Implications for Parkinson's disease - Lakkappa_2018_Neurotoxicol_70_135
Author(s) : Lakkappa N , Krishnamurthy PT , M DP , Hammock BD , Hwang SH
Ref : Neurotoxicology , 70 :135 , 2018
PubMedID: 30472438

Title : Combined Inhibition of Soluble Epoxide Hydrolase and Renin-Angiotensin System Exhibits Superior Renoprotection to Renin-Angiotensin System Blockade in 5\/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats with Established Chronic Kidney Disease - Certikova_2018_Kidney.Blood.Press.Res_43_329
Author(s) : Certikova Chabova V , Kujal P , Skaroupkova P , Varnourkova Z , Vackova S , Huskova Z , Kikerlova S , Sadowski J , Kompanowska-Jezierska E , Baranowska I , Hwang SH , Hammock BD , Imig JD , Tesar V , Cervenka L
Ref : Kidney Blood Press Res , 43 :329 , 2018
PubMedID: 29529602

Title : Inhibition of soluble epoxide hydrolase attenuates eosinophil recruitment and food allergen-induced gastrointestinal inflammation - Bastan_2018_J.Leukoc.Biol_104_109
Author(s) : Bastan I , Ge XN , Dileepan M , Greenberg YG , Guedes AG , Hwang SH , Hammock BD , Washabau RJ , Rao SP , Sriramarao P
Ref : J Leukoc Biol , 104 :109 , 2018
PubMedID: 29345370

Title : Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase - Kodani_2018_Bioorg.Med.Chem.Lett_28_762
Author(s) : Kodani SD , Bhakta S , Hwang SH , Pakhomova S , Newcomer ME , Morisseau C , Hammock BD
Ref : Bioorganic & Medicinal Chemistry Lett , 28 :762 , 2018
PubMedID: 29366648
Gene_locus related to this paper: human-EPHX2

Title : Orally Available Soluble Epoxide Hydrolase\/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain - Blocher_2018_J.Med.Chem_61_3541
Author(s) : Blocher R , Wagner KM , Gopireddy RR , Harris TR , Wu H , Barnych B , Hwang SH , Xiang YK , Proschak E , Morisseau C , Hammock BD
Ref : Journal of Medicinal Chemistry , 61 :3541 , 2018
PubMedID: 29614224

Title : Effect of angiotensin-converting enzyme blockade, alone or combined with blockade of soluble epoxide hydrolase, on the course of congestive heart failure and occurrence of renal dysfunction in Ren-2 transgenic hypertensive rats with aorto-caval fistula - Kala_2018_Physiol.Res_67_401
Author(s) : Kala P , Sedlakova L , Skaroupkova P , Kopkan L , Vanourkova Z , Taborsky M , Nishiyama A , Hwang SH , Hammock BD , Sadowski J , Melenovsky V , Imig JD , Cervenka L
Ref : Physiol Res , 67 :401 , 2018
PubMedID: 29527914

Title : Adamantyl thioureas as soluble epoxide hydrolase inhibitors - Burmistrov_2018_Bioorg.Med.Chem.Lett_28_2302
Author(s) : Burmistrov V , Morisseau C , Pitushkin D , Karlov D , Fayzullin RR , Butov GM , Hammock BD
Ref : Bioorganic & Medicinal Chemistry Lett , 28 :2302 , 2018
PubMedID: 29803731

Title : Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia - Tu_2018_Sci.Rep_8_5279
Author(s) : Tu R , Armstrong J , Lee KSS , Hammock BD , Sapirstein A , Koehler RC
Ref : Sci Rep , 8 :5279 , 2018
PubMedID: 29588470

Title : Pharmacokinetics and antinociceptive effects of the soluble epoxide hydrolase inhibitor t-TUCB in horses with experimentally induced radiocarpal synovitis - Guedes_2018_J.Vet.Pharmacol.Ther_41_230
Author(s) : Guedes AGP , Aristizabal F , Sole A , Adedeji A , Brosnan R , Knych H , Yang J , Hwang SH , Morisseau C , Hammock BD
Ref : J Vet Pharmacol Ther , 41 :230 , 2018
PubMedID: 29067696

Title : Metabolic\/inflammatory\/vascular comorbidity in psychiatric disorders\; soluble epoxide hydrolase (sEH) as a possible new target - Swardfager_2018_Neurosci.Biobehav.Rev_87_56
Author(s) : Swardfager W , Hennebelle M , Yu D , Hammock BD , Levitt AJ , Hashimoto K , Taha AY
Ref : Neurosci Biobehav Rev , 87 :56 , 2018
PubMedID: 29407524

Title : Estrogen-dependent epigenetic regulation of soluble epoxide hydrolase via DNA methylation - Yang_2018_Proc.Natl.Acad.Sci.U.S.A_115_613
Author(s) : Yang YM , Sun D , Kandhi S , Froogh G , Zhuge J , Huang W , Hammock BD , Huang A
Ref : Proc Natl Acad Sci U S A , 115 :613 , 2018
PubMedID: 29295935

Title : An inhibitor of soluble epoxide hydrolase ameliorates diabetes-induced learning and memory impairment in rats - Minaz_2018_Prostaglandins.Other.Lipid.Mediat_136_84
Author(s) : Minaz N , Razdan R , Hammock BD , Goswami SK
Ref : Prostaglandins Other Lipid Mediat , 136 :84 , 2018
PubMedID: 29751149

Title : Evaluation of antiparkinson activity of PTUPB by measuring dopamine and its metabolites in Drosophila melanogaster: LC-MS\/MS method development - Lakkappa_2018_J.Pharm.Biomed.Anal_149_457
Author(s) : Lakkappa N , Krishnamurthy PT , Yamjala K , Hwang SH , Hammock BD , Babu B
Ref : J Pharm Biomed Anal , 149 :457 , 2018
PubMedID: 29169114

Title : COX-2\/sEH Dual Inhibitor PTUPB Potentiates the Antitumor Efficacy of Cisplatin - Wang_2018_Mol.Cancer.Ther_17_474
Author(s) : Wang F , Zhang H , Ma AH , Yu W , Zimmermann M , Yang J , Hwang SH , Zhu D , Lin TY , Malfatti M , Turteltaub KW , Henderson PT , Airhart S , Hammock BD , Yuan J , de Vere White RW , Pan CX
Ref : Mol Cancer Ther , 17 :474 , 2018
PubMedID: 29284644

Title : Design and Potency of Dual Soluble Epoxide Hydrolase\/Fatty Acid Amide Hydrolase Inhibitors - Kodani_2018_ACS.Omega_3_14076
Author(s) : Kodani SD , Wan D , Wagner KM , Hwang SH , Morisseau C , Hammock BD
Ref : ACS Omega , 3 :14076 , 2018
PubMedID: 30411058

Title : Novel piperidine-derived amide sEH inhibitors as mediators of lipid metabolism with improved stability - Pecic_2018_Prostaglandins.Other.Lipid.Mediat_136_90
Author(s) : Pecic S , Zeki AA , Xu X , Jin GY , Zhang S , Kodani S , Halim M , Morisseau C , Hammock BD , Deng SX
Ref : Prostaglandins Other Lipid Mediat , 136 :90 , 2018
PubMedID: 29567338

Title : Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation - Zhang_2017_J.Neurochem_140_814
Author(s) : Zhang Y , Hong G , Lee KS , Hammock BD , Gebremedhin D , Harder DR , Koehler RC , Sapirstein A
Ref : Journal of Neurochemistry , 140 :814 , 2017
PubMedID: 28002622

Title : Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase - Hvorecny_2017_Structure_25_697
Author(s) : Hvorecny KL , Bahl CD , Kitamura S , Lee KSS , Hammock BD , Morisseau C , Madden DR
Ref : Structure , 25 :697 , 2017
PubMedID: 28392259
Gene_locus related to this paper: pseae-PA2934

Title : Exploring adduct formation between human serum albumin and eleven organophosphate ester flame retardants and plasticizers using MALDI-TOF\/TOF and LC-Q\/TOF - Chu_2017_Chemosphere_180_169
Author(s) : Chu S , Baker MR , Leong G , Letcher RJ , Gee SJ , Hammock BD , Li QX
Ref : Chemosphere , 180 :169 , 2017
PubMedID: 28407546

Title : Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order Brassicales - Kitamura_2017_PLoS.One_12_e0176571
Author(s) : Kitamura S , Morisseau C , Harris TR , Inceoglu B , Hammock BD
Ref : PLoS ONE , 12 :e0176571 , 2017
PubMedID: 28472063

Title : In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s - Wang_2017_Drug.Metab.Dispos_45_712
Author(s) : Wang Z , Fang Y , Teague J , Wong H , Morisseau C , Hammock BD , Rock DA
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 45 :712 , 2017
PubMedID: 28428366

Title : Soluble epoxide hydrolase activity and pharmacologic inhibition in horses with chronic severe laminitis - Guedes_2017_Equine.Vet.J_49_345
Author(s) : Guedes A , Galuppo L , Hood D , Hwang SH , Morisseau C , Hammock BD
Ref : Equine Vet J , 49 :345 , 2017
PubMedID: 27338788

Title : Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase - Lee_2017_Arch.Biochem.Biophys_613_1
Author(s) : Lee KS , Henriksen NM , Ng CJ , Yang J , Jia W , Morisseau C , Andaya A , Gilson MK , Hammock BD
Ref : Archives of Biochemistry & Biophysics , 613 :1 , 2017
PubMedID: 27983948

Title : Inhibitors of soluble epoxide hydrolase minimize ischemia-reperfusion-induced cardiac damage in normal, hypertensive, and diabetic rats - Islam_2017_Cardiovasc.Ther_35_
Author(s) : Islam O , Patil P , Goswami SK , Razdan R , Inamdar MN , Rizwan M , Mathew J , Inceoglu B , Stephen Lee KS , Hwang SH , Hammock BD
Ref : Cardiovasc Ther , 35 : , 2017
PubMedID: 28296232

Title : Soluble Epoxide Hydrolase Inhibitor Attenuates Lipopolysaccharide-Induced Acute Lung Injury and Improves Survival in Mice - Zhou_2017_Shock_47_638
Author(s) : Zhou Y , Liu T , Duan JX , Li P , Sun GY , Liu YP , Zhang J , Dong L , Lee KSS , Hammock BD , Jiang JX , Guan CX
Ref : Shock , 47 :638 , 2017
PubMedID: 27753791

Title : Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases - Wagner_2017_Pharmacol.Ther_180_62
Author(s) : Wagner KM , McReynolds CB , Schmidt WK , Hammock BD
Ref : Pharmacol Ther , 180 :62 , 2017
PubMedID: 28642117

Title : Soluble Epoxide Hydrolase Pharmacological Inhibition Decreases Alveolar Bone Loss by Modulating Host Inflammatory Response, RANK-Related Signaling, Endoplasmic Reticulum Stress, and Apoptosis - Trindade-da-Silva_2017_J.Pharmacol.Exp.Ther_361_408
Author(s) : Trindade-da-Silva CA , Bettaieb A , Napimoga MH , Lee KSS , Inceoglu B , Ueira-Vieira C , Bruun D , Goswami SK , Haj FG , Hammock BD
Ref : Journal of Pharmacology & Experimental Therapeutics , 361 :408 , 2017
PubMedID: 28356494

Title : Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability - Burmistrov_2017_Bioorg.Chem_76_510
Author(s) : Burmistrov V , Morisseau C , Harris TR , Butov G , Hammock BD
Ref : Bioorg Chem , 76 :510 , 2017
PubMedID: 29310082

Title : Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators - Flitter_2017_Proc.Natl.Acad.Sci.U.S.A_114_136
Author(s) : Flitter BA , Hvorecny KL , Ono E , Eddens T , Yang J , Kwak DH , Bahl CD , Hampton TH , Morisseau C , Hammock BD , Liu X , Lee JS , Kolls JK , Levy BD , Madden DR , Bomberger JM
Ref : Proc Natl Acad Sci U S A , 114 :136 , 2017
PubMedID: 27980032
Gene_locus related to this paper: pseae-PA2934

Title : Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension - Orcholski_2017_Am.J.Physiol.Lung.Cell.Mol.Physiol_313_L252
Author(s) : Orcholski ME , Khurshudyan A , Shamskhou EA , Yuan K , Chen IY , Kodani SD , Morisseau C , Hammock BD , Hong EM , Alexandrova L , Alastalo TP , Berry G , Zamanian RT , de Jesus Perez VA
Ref : American Journal of Physiology Lung Cell Mol Physiol , 313 :L252 , 2017
PubMedID: 28473326
Gene_locus related to this paper: human-CES1

Title : Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study - Hennebelle_2017_Psychiatry.Res_252_94
Author(s) : Hennebelle M , Otoki Y , Yang J , Hammock BD , Levitt AJ , Taha AY , Swardfager W
Ref : Psychiatry Res , 252 :94 , 2017
PubMedID: 28259037

Title : Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy - Hu_2017_Nature_552_248
Author(s) : Hu J , Dziumbla S , Lin J , Bibli SI , Zukunft S , de Mos J , Awwad K , Fromel T , Jungmann A , Devraj K , Cheng Z , Wang L , Fauser S , Eberhart CG , Sodhi A , Hammock BD , Liebner S , Muller OJ , Glaubitz C , Hammes HP , Popp R , Fleming I
Ref : Nature , 552 :248 , 2017
PubMedID: 29211719

Title : Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors - Inceoglu_2017_Prostaglandins.Other.Lipid.Mediat_133_68
Author(s) : Inceoglu B , Bettaieb A , Haj FG , Gomes AV , Hammock BD
Ref : Prostaglandins Other Lipid Mediat , 133 :68 , 2017
PubMedID: 28847566

Title : Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase - Hu_2017_Biochim.Biophys.Acta_1863_1382
Author(s) : Hu P , Wu X , Khandelwal AR , Yu W , Xu Z , Chen L , Yang J , Weisbrod RM , Lee KSS , Seta F , Hammock BD , Cohen RA , Zeng C , Tong X
Ref : Biochimica & Biophysica Acta , 1863 :1382 , 2017
PubMedID: 28185955

Title : Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice - Wagner_2017_Behav.Brain.Res_326_69
Author(s) : Wagner K , Gilda J , Yang J , Wan D , Morisseau C , Gomes AV , Hammock BD
Ref : Behavioural Brain Research , 326 :69 , 2017
PubMedID: 28259677

Title : Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia - Bettaieb_2017_Biochim.Biophys.Acta_1861_2758
Author(s) : Bettaieb A , Koike S , Hsu MF , Ito Y , Chahed S , Bachaalany S , Gruzdev A , Calvo-Rubio M , Lee KSS , Inceoglu B , Imig JD , Villalba JM , Zeldin DC , Hammock BD , Haj FG
Ref : Biochimica & Biophysica Acta , 1861 :2758 , 2017
PubMedID: 28757338

Title : Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa - Kitamura_2016_J.Med.Chem_59_4790
Author(s) : Kitamura S , Hvorecny KL , Niu J , Hammock BD , Madden DR , Morisseau C
Ref : Journal of Medicinal Chemistry , 59 :4790 , 2016
PubMedID: 27120257
Gene_locus related to this paper: pseae-PA2934

Title : Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents - Pessah_2016_Ann.N.Y.Acad.Sci_1378_124
Author(s) : Pessah IN , Rogawski MA , Tancredi DJ , Wulff H , Zolkowska D , Bruun DA , Hammock BD , Lein PJ
Ref : Annals of the New York Academy of Sciences , 1378 :124 , 2016
PubMedID: 27467073

Title : Soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3- (1-propionylpiperidin-4-yl) urea attenuates bleomycin-induced pulmonary fibrosis in mice - Zhou_2016_Cell.Tissue.Res_363_399
Author(s) : Zhou Y , Sun GY , Liu T , Duan JX , Zhou HF , Lee KS , Hammock BD , Fang X , Jiang JX , Guan CX
Ref : Cell Tissue Research , 363 :399 , 2016
PubMedID: 26310139

Title : Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa - Shih_2016_Mol.Psychiatry_21_537
Author(s) : Shih PB , Yang J , Morisseau C , German JB , Zeeland AA , Armando AM , Quehenberger O , Bergen AW , Magistretti P , Berrettini W , Halmi KA , Schork N , Hammock BD , Kaye W
Ref : Mol Psychiatry , 21 :537 , 2016
PubMedID: 25824304
Gene_locus related to this paper: human-EPHX2

Title : Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation - Kodani_2016_Toxicol.Lett_262_92
Author(s) : Kodani SD , Overby HB , Morisseau C , Chen J , Zhao L , Hammock BD
Ref : Toxicol Lett , 262 :92 , 2016
PubMedID: 27659731

Title : Anti-Ulcer Efficacy of Soluble Epoxide Hydrolase Inhibitor TPPU on Diclofenac-Induced Intestinal Ulcers - Goswami_2016_J.Pharmacol.Exp.Ther_357_529
Author(s) : Goswami SK , Wan D , Yang J , Trindade da Silva CA , Morisseau C , Kodani SD , Yang GY , Inceoglu B , Hammock BD
Ref : Journal of Pharmacology & Experimental Therapeutics , 357 :529 , 2016
PubMedID: 26989141

Title : Ingestion of the epoxide hydrolase inhibitor AUDA modulates immune responses of the mosquito, Culex quinquefasciatus during blood feeding - Xu_2016_Insect.Biochem.Mol.Biol_76_62
Author(s) : Xu J , Morisseau C , Yang J , Lee KS , Kamita SG , Hammock BD
Ref : Insect Biochemistry & Molecular Biology , 76 :62 , 2016
PubMedID: 27369469

Title : Inhibition of soluble epoxide hydrolase alleviated atherosclerosis by reducing monocyte infiltration in Ldlr(-\/-) mice - Li_2016_J.Mol.Cell.Cardiol_98_128
Author(s) : Li D , Liu Y , Zhang X , Lv H , Pang W , Sun X , Gan LM , Hammock BD , Ai D , Zhu Y
Ref : Journal of Molecular & Cellular Cardiology , 98 :128 , 2016
PubMedID: 27496380

Title : Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress - Ren_2016_Proc.Natl.Acad.Sci.U.S.A_113_E1944
Author(s) : Ren Q , Ma M , Ishima T , Morisseau C , Yang J , Wagner KM , Zhang JC , Yang C , Yao W , Dong C , Han M , Hammock BD , Hashimoto K
Ref : Proc Natl Acad Sci U S A , 113 :E1944 , 2016
PubMedID: 26976569
Gene_locus related to this paper: mouse-hyes

Title : Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension - Ulu_2016_J.Clin.Toxicol_6_
Author(s) : Ulu A , Inceoglu B , Yang J , Singh V , Vito S , Wulff H , Hammock BD
Ref : J Clinical Toxicology , 6 : , 2016
PubMedID: 28255523

Title : Screening of soluble epoxide hydrolase inhibitory ingredients from traditional Chinese medicines for anti-inflammatory use - Liu_2016_J.Ethnopharmacol_194_475
Author(s) : Liu JY , Morisseau C , Huang H , Hammock BD
Ref : J Ethnopharmacol , 194 :475 , 2016
PubMedID: 27702689

Title : Effects of juvenile hormone (JH) analog insecticides on larval development and JH esterase activity in two spodopterans - El-Sheikh_2016_Pestic.Biochem.Physiol_128_30
Author(s) : El-Sheikh el SA , Kamita SG , Hammock BD
Ref : Pestic Biochem Physiol , 128 :30 , 2016
PubMedID: 26969437

Title : Inhibition of soluble epoxide hydrolase does not improve the course of congestive heart failure and the development of renal dysfunction in rats with volume overload induced by aorto-caval fistula - Cervenka_2015_Physiol.Res_64_857
Author(s) : Cervenka L , Melenovsky V , Huskova Z , Sporkova A , Burgelova M , Skaroupkova P , Hwang SH , Hammock BD , Imig JD , Sadowski J
Ref : Physiol Res , 64 :857 , 2015
PubMedID: 26047375

Title : Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE2 induced pain model - Goswami_2015_Toxicol.Appl.Pharmacol_289_419
Author(s) : Goswami SK , Inceoglu B , Yang J , Wan D , Kodani SD , da Silva CA , Morisseau C , Hammock BD
Ref : Toxicol Appl Pharmacol , 289 :419 , 2015
PubMedID: 26522832

Title : Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo - Kitamura_2015_PLoS.One_10_e0117438
Author(s) : Kitamura S , Morisseau C , Inceoglu B , Kamita SG , De Nicola GR , Nyegue M , Hammock BD
Ref : PLoS ONE , 10 :e0117438 , 2015
PubMedID: 25659109

Title : Soluble Epoxide Hydrolase Pharmacological Inhibition Ameliorates Experimental Acute Pancreatitis in Mice - Bettaieb_2015_Mol.Pharmacol_88_281
Author(s) : Bettaieb A , Chahed S , Bachaalany S , Griffey S , Hammock BD , Haj FG
Ref : Molecular Pharmacology , 88 :281 , 2015
PubMedID: 25993999

Title : 1,3-Disubstituted and 1,3,3-trisubstituted adamantyl-ureas with isoxazole as soluble epoxide hydrolase inhibitors - Burmistrov_2015_Bioorg.Med.Chem.Lett_25_5514
Author(s) : Burmistrov V , Morisseau C , Danilov D , Harris TR , Dalinger I , Vatsadze I , Shkineva T , Butov GM , Hammock BD
Ref : Bioorganic & Medicinal Chemistry Lett , 25 :5514 , 2015
PubMedID: 26520661

Title : Inhibition of soluble epoxide hydrolase in mice promotes reverse cholesterol transport and regression of atherosclerosis - Shen_2015_Atherosclerosis_239_557
Author(s) : Shen L , Peng H , Peng R , Fan Q , Zhao S , Xu D , Morisseau C , Chiamvimonvat N , Hammock BD
Ref : Atherosclerosis , 239 :557 , 2015
PubMedID: 25733327

Title : In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors - Liu_2015_Biochem.Pharmacol_98_718
Author(s) : Liu JY , Tsai HJ , Morisseau C , Lango J , Hwang SH , Watanabe T , Kim IH , Hammock BD
Ref : Biochemical Pharmacology , 98 :718 , 2015
PubMedID: 26494425

Title : Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive - Sasso_2015_Pharmacol.Res_97_7
Author(s) : Sasso O , Wagner K , Morisseau C , Inceoglu B , Hammock BD , Piomelli D
Ref : Pharmacol Res , 97 :7 , 2015
PubMedID: 25882247

Title : Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice - Harris_2015_Toxicol.Appl.Pharmacol_286_102
Author(s) : Harris TR , Bettaieb A , Kodani S , Dong H , Myers R , Chiamvimonvat N , Haj FG , Hammock BD
Ref : Toxicol Appl Pharmacol , 286 :102 , 2015
PubMedID: 25827057

Title : Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (TPPU): Resulting drug levels and modulation of oxylipin pattern - Ostermann_2015_Prostaglandins.Other.Lipid.Mediat_121_131
Author(s) : Ostermann AI , Herbers J , Willenberg I , Chen R , Hwang SH , Greite R , Morisseau C , Gueler F , Hammock BD , Schebb NH
Ref : Prostaglandins Other Lipid Mediat , 121 :131 , 2015
PubMedID: 26117215

Title : Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: role for omega-3 epoxides - Lopez-Vicario_2015_Proc.Natl.Acad.Sci.U.S.A_112_536
Author(s) : Lopez-Vicario C , Alcaraz-Quiles J , Garcia-Alonso V , Rius B , Hwang SH , Titos E , Lopategi A , Hammock BD , Arroyo V , Claria J
Ref : Proc Natl Acad Sci U S A , 112 :536 , 2015
PubMedID: 25550510

Title : Identification of potent inhibitors of the chicken soluble epoxide hydrolase - Shihadih_2015_Bioorg.Med.Chem.Lett_25_276
Author(s) : Shihadih DS , Harris TR , Yang J , Merzlikin O , Lee KS , Hammock BD , Morisseau C
Ref : Bioorganic & Medicinal Chemistry Lett , 25 :276 , 2015
PubMedID: 25479771

Title : Juvenile hormone (JH) esterase activity but not JH epoxide hydrolase activity is downregulated in larval Adoxophyes honmai following nucleopolyhedroviruses infection - Saito_2015_J.Insect.Physiol_80_71
Author(s) : Saito Y , Kamita SG , Hammock BD , Kunimi Y , Inoue MN , Nakai M
Ref : J Insect Physiol , 80 :71 , 2015
PubMedID: 25727179
Gene_locus related to this paper: adoho-a0a0g4dcw7

Title : Epoxide hydrolase activities and epoxy fatty acids in the mosquito Culex quinquefasciatus - Xu_2015_Insect.Biochem.Mol.Biol_59_41
Author(s) : Xu J , Morisseau C , Yang J , Mamatha DM , Hammock BD
Ref : Insect Biochemistry & Molecular Biology , 59 :41 , 2015
PubMedID: 25686802

Title : A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase - Nollmann_2015_Chembiochem_16_766
Author(s) : Nollmann FI , Heinrich AK , Brachmann AO , Morisseau C , Mukherjee K , Casanova-Torres AM , Strobl F , Kleinhans D , Kinski S , Schultz K , Beeton ML , Kaiser M , Chu YY , Phan Ke L , Thanwisai A , Bozhuyuk KA , Chantratita N , Gotz F , Waterfield NR , Vilcinskas A , Stelzer EH , Goodrich-Blair H , Hammock BD , Bode HB
Ref : Chembiochem , 16 :766 , 2015
PubMedID: 25711603

Title : Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR - Bahl_2015_Angew.Chem.Int.Ed.Engl_54_9881
Author(s) : Bahl CD , Hvorecny KL , Bomberger JM , Stanton BA , Hammock BD , Morisseau C , Madden DR
Ref : Angew Chem Int Ed Engl , 54 :9881 , 2015
PubMedID: 26136396
Gene_locus related to this paper: pseae-PA2934

Title : Structure-activity relationships of amide-phosphonate derivatives as inhibitors of the human soluble epoxide hydrolase - Kim_2015_Bioorg.Med.Chem_23_7199
Author(s) : Kim IH , Park YK , Nishiwaki H , Hammock BD , Nishi K
Ref : Bioorganic & Medicinal Chemistry , 23 :7199 , 2015
PubMedID: 26507430

Title : The 2014 bernard B. Brodie award lecture-epoxide hydrolases: drug metabolism to therapeutics for chronic pain - Kodani_2015_Drug.Metab.Dispos_43_788
Author(s) : Kodani SD , Hammock BD
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 43 :788 , 2015
PubMedID: 25762541

Title : Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain - Inceoglu_2015_Proc.Natl.Acad.Sci.U.S.A_112_9082
Author(s) : Inceoglu B , Bettaieb A , Trindade da Silva CA , Lee KS , Haj FG , Hammock BD
Ref : Proc Natl Acad Sci U S A , 112 :9082 , 2015
PubMedID: 26150506

Title : Heavy chain single-domain antibodies to detect native human soluble epoxide hydrolase - Cui_2015_Anal.Bioanal.Chem_407_7275
Author(s) : Cui Y , Li D , Morisseau C , Dong JX , Yang J , Wan D , Rossotti MA , Gee SJ , Gonzalez-Sapienza GG , Hammock BD
Ref : Anal Bioanal Chem , 407 :7275 , 2015
PubMedID: 26229025

Title : Effects of soluble epoxide hydrolase deficiency on acute pancreatitis in mice - Bettaieb_2014_PLoS.One_9_e113019
Author(s) : Bettaieb A , Chahed S , Tabet G , Yang J , Morisseau C , Griffey S , Hammock BD , Haj FG
Ref : PLoS ONE , 9 :e113019 , 2014
PubMedID: 25402489

Title : Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation - Morisseau_2014_J.Lipid.Res_55_1131
Author(s) : Morisseau C , Wecksler AT , Deng C , Dong H , Yang J , Lee KS , Kodani SD , Hammock BD
Ref : J Lipid Res , 55 :1131 , 2014
PubMedID: 24771868

Title : Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy - Kim_2014_Am.J.Physiol.Renal.Physiol__ajprenal 00531 2014
Author(s) : Kim J , Yoon SP , Toews ML , Imig JD , Hwang SH , Hammock BD , Padanilam BJ
Ref : American Journal of Physiology Renal Physiol , :ajprenal 00531 2014 , 2014
PubMedID: 25377915

Title : Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy - Lee_2014_J.Med.Chem_57_7016
Author(s) : Lee KS , Liu JY , Wagner KM , Pakhomova S , Dong H , Morisseau C , Fu SH , Yang J , Wang P , Ulu A , Mate CA , Nguyen LV , Hwang SH , Edin ML , Mara AA , Wulff H , Newcomer ME , Zeldin DC , Hammock BD
Ref : Journal of Medicinal Chemistry , 57 :7016 , 2014
PubMedID: 25079952
Gene_locus related to this paper: human-EPHX2

Title : Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB - Wecksler_2014_Anticancer.Drugs_25_433
Author(s) : Wecksler AT , Hwang SH , Wettersten HI , Gilda JE , Patton A , Leon LJ , Carraway KL, 3rd , Gomes AV , Baar K , Weiss RH , Hammock BD
Ref : Anticancer Drugs , 25 :433 , 2014
PubMedID: 24525589

Title : Aberrant soluble epoxide hydrolase and oxylipin levels in a porcine arteriovenous graft stenosis model - Terry_2014_J.Vasc.Res_51_269
Author(s) : Terry CM , Carlson ML , He Y , Ulu A , Morisseau C , Blumenthal DK , Hammock BD , Cheung AK
Ref : J Vasc Res , 51 :269 , 2014
PubMedID: 25196102

Title : Structure-activity relationships of substituted oxyoxalamides as inhibitors of the human soluble epoxide hydrolase - Kim_2014_Bioorg.Med.Chem_22_1163
Author(s) : Kim IH , Lee IH , Nishiwaki H , Hammock BD , Nishi K
Ref : Bioorganic & Medicinal Chemistry , 22 :1163 , 2014
PubMedID: 24433964

Title : Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis - Zhang_2014_Proc.Natl.Acad.Sci.U.S.A_111_11127
Author(s) : Zhang G , Panigrahy D , Hwang SH , Yang J , Mahakian LM , Wettersten HI , Liu JY , Wang Y , Ingham ES , Tam S , Kieran MW , Weiss RH , Ferrara KW , Hammock BD
Ref : Proc Natl Acad Sci U S A , 111 :11127 , 2014
PubMedID: 25024195

Title : Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors - Kalai_2014_Eur.J.Med.Chem_77C_343
Author(s) : Kalai T , Altman R , Maezawa I , Balog M , Morisseau C , Petrlova J , Hammock BD , Jin LW , Trudell JR , Voss JC , Hideg K
Ref : Eur Journal of Medicinal Chemistry , 77C :343 , 2014
PubMedID: 24657571

Title : Opposite effects of gene deficiency and pharmacological inhibition of soluble epoxide hydrolase on cardiac fibrosis - Li_2014_PLoS.One_9_e94092
Author(s) : Li L , Li N , Pang W , Zhang X , Hammock BD , Ai D , Zhu Y
Ref : PLoS ONE , 9 :e94092 , 2014
PubMedID: 24718617

Title : Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors - Burmistrov_2014_Bioorg.Med.Chem.Lett_24_2193
Author(s) : Burmistrov V , Morisseau C , Lee KS , Shihadih DS , Harris TR , Butov GM , Hammock BD
Ref : Bioorganic & Medicinal Chemistry Lett , 24 :2193 , 2014
PubMedID: 24685540

Title : The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling - Wagner_2014_Prostaglandins.Other.Lipid.Mediat_113-115_2
Author(s) : Wagner K , Vito S , Inceoglu B , Hammock BD
Ref : Prostaglandins Other Lipid Mediat , 113-115 :2 , 2014
PubMedID: 25240260

Title : Expression and characterization of an epoxide hydrolase from Anopheles gambiae with high activity on epoxy fatty acids - Xu_2014_Insect.Biochem.Mol.Biol_54C_42
Author(s) : Xu J , Morisseau C , Hammock BD
Ref : Insect Biochemistry & Molecular Biology , 54C :42 , 2014
PubMedID: 25173592

Title : Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase - Charles_2014_Proc.Natl.Acad.Sci.U.S.A_111_8167
Author(s) : Charles RL , Rudyk O , Prysyazhna O , Kamynina A , Yang J , Morisseau C , Hammock BD , Freeman BA , Eaton P
Ref : Proc Natl Acad Sci U S A , 111 :8167 , 2014
PubMedID: 24843165

Title : Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication - Vito_2014_Toxicol.Appl.Pharmacol_281_185
Author(s) : Vito ST , Austin AT , Banks CN , Inceoglu B , Bruun DA , Zolkowska D , Tancredi DJ , Rogawski MA , Hammock BD , Lein PJ
Ref : Toxicol Appl Pharmacol , 281 :185 , 2014
PubMedID: 25448683

Title : Soluble epoxide hydrolase: Gene structure, expression and deletion - Harris_2013_Gene_526_61
Author(s) : Harris TR , Hammock BD
Ref : Gene , 526 :61 , 2013
PubMedID: 23701967

Title : Soluble epoxide hydrolase inhibitor, TUPS, protects against isoprenaline-induced cardiac hypertrophy - Althurwi_2013_Br.J.Pharmacol_168_1794
Author(s) : Althurwi HN , Tse MM , Abdelhamid G , Zordoky BN , Hammock BD , El-Kadi AO
Ref : British Journal of Pharmacology , 168 :1794 , 2013
PubMedID: 23176298

Title : Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors - Hwang_2013_Bioorg.Med.Chem.Lett_23_3732
Author(s) : Hwang SH , Wecksler AT , Zhang G , Morisseau C , Nguyen LV , Fu SH , Hammock BD
Ref : Bioorganic & Medicinal Chemistry Lett , 23 :3732 , 2013
PubMedID: 23726028

Title : A potent soluble epoxide hydrolase inhibitor, t-AUCB, acts through PPARgamma to modulate the function of endothelial progenitor cells from patients with acute myocardial infarction - Xu_2013_Int.J.Cardiol_167_1298
Author(s) : Xu DY , Davis BB , Wang ZH , Zhao SP , Wasti B , Liu ZL , Li N , Morisseau C , Chiamvimonvat N , Hammock BD
Ref : Int J Cardiol , 167 :1298 , 2013
PubMedID: 22525341

Title : Characterization of HOVI-MEH1, a microsomal epoxide hydrolase from the glassy-winged sharpshooter Homalodisca vitripennis - Kamita_2013_Arch.Insect.Biochem.Physiol_83_171
Author(s) : Kamita SG , Oshita GH , Wang P , Morisseau C , Hammock BD , Nandety RS , Falk BW
Ref : Archives of Insect Biochemistry & Physiology , 83 :171 , 2013
PubMedID: 23704009

Title : Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors - Pecic_2013_Bioorg.Med.Chem.Lett_23_417
Author(s) : Pecic S , Pakhomova S , Newcomer ME , Morisseau C , Hammock BD , Zhu Z , Rinderspacher A , Deng SX
Ref : Bioorganic & Medicinal Chemistry Lett , 23 :417 , 2013
PubMedID: 23237835
Gene_locus related to this paper: human-EPHX2

Title : Antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats is mediated by suppression of the intrarenal renin-angiotensin system - Varcabova_2013_Clin.Exp.Pharmacol.Physiol_40_273
Author(s) : Varcabova S , Huskova Z , Kramer HJ , Hwang SH , Hammock BD , Imig JD , Kitada K , Cervenka L
Ref : Clinical & Experimental Pharmacology & Physiology , 40 :273 , 2013
PubMedID: 23039246

Title : Development of On-line Liquid Chromatography-Biochemical Detection for Soluble Epoxide Hydrolase Inhibitors in Mixtures - Falck_2013_Chromatographia_76_13
Author(s) : Falck D , Schebb NH , Prihatiningtyas S , Zhang J , Heus F , Morisseau C , Kool J , Hammock BD , Niessen WM
Ref : Chromatographia , 76 :13 , 2013
PubMedID: 23526703

Title : Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke - Shaik_2013_Am.J.Physiol.Heart.Circ.Physiol_305_H1605
Author(s) : Shaik JS , Ahmad M , Li W , Rose ME , Foley LM , Hitchens TK , Graham SH , Hwang SH , Hammock BD , Poloyac SM
Ref : American Journal of Physiology Heart Circ Physiol , 305 :H1605 , 2013
PubMedID: 24043255

Title : Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides - Morisseau_2013_Bioorg.Med.Chem.Lett_23_3818
Author(s) : Morisseau C , Pakhomova S , Hwang SH , Newcomer ME , Hammock BD
Ref : Bioorganic & Medicinal Chemistry Lett , 23 :3818 , 2013
PubMedID: 23684894
Gene_locus related to this paper: human-EPHX2

Title : Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model - Chen_2013_Prostaglandins.Other.Lipid.Mediat_104-105_42
Author(s) : Chen L , Fan C , Zhang Y , Bakri M , Dong H , Morisseau C , Maddipati KR , Luo P , Wang CY , Hammock BD , Wang MH
Ref : Prostaglandins Other Lipid Mediat , 104-105 :42 , 2013
PubMedID: 23247129

Title : Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health - Morisseau_2013_Annu.Rev.Pharmacol.Toxicol_53_37
Author(s) : Morisseau C , Hammock BD
Ref : Annual Review of Pharmacology & Toxicology , 53 :37 , 2013
PubMedID: 23020295

Title : Soluble Epoxide Hydrolase Deficiency Inhibits Dextran Sulfate Sodium-induced Colitis and Carcinogenesis in Mice - Zhang_2013_Anticancer.Res_33_5261
Author(s) : Zhang W , Li H , Dong H , Liao J , Hammock BD , Yang GY
Ref : Anticancer Research , 33 :5261 , 2013
PubMedID: 24324059

Title : Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie - Poli_2013_Life.Sci_92_1145
Author(s) : Poli G , Corda E , Martino PA , Dall'ara P , Bareggi SR , Bondiolotti G , Iulini B , Mazza M , Casalone C , Hwang SH , Hammock BD , Inceoglu B
Ref : Life Sciences , 92 :1145 , 2013
PubMedID: 23651659

Title : Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models - Liu_2013_Eur.J.Pharm.Sci_48_619
Author(s) : Liu JY , Lin YP , Qiu H , Morisseau C , Rose TE , Hwang SH , Chiamvimonvat N , Hammock BD
Ref : Eur J Pharm Sci , 48 :619 , 2013
PubMedID: 23291046

Title : Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens - Kamita_2013_Insect.Biochem.Mol.Biol_43_219
Author(s) : Kamita SG , Yamamoto K , Dadala MM , Pha K , Morisseau C , Escaich A , Hammock BD
Ref : Insect Biochemistry & Molecular Biology , 43 :219 , 2013
PubMedID: 23276675
Gene_locus related to this paper: helvi-l7r9x8

Title : Frster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase - Lee_2013_Anal.Biochem_434_259
Author(s) : Lee KS , Morisseau C , Yang J , Wang P , Hwang SH , Hammock BD
Ref : Analytical Biochemistry , 434 :259 , 2013
PubMedID: 23219719

Title : Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates Diet-induced Endoplasmic Reticulum Stress in Liver and Adipose Tissue - Bettaieb_2013_J.Biol.Chem_288_14189
Author(s) : Bettaieb A , Nagata N , Aboubechara D , Chahed S , Morisseau C , Hammock BD , Haj FG
Ref : Journal of Biological Chemistry , 288 :14189 , 2013
PubMedID: 23576437

Title : Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indications -
Author(s) : Shen HC , Hammock BD
Ref : Journal of Medicinal Chemistry , 55 :1789 , 2012
PubMedID: 22168898

Title : Soluble Epoxide Hydrolase Inhibition Exhibits Antihypertensive Actions Independently of Nitric Oxide in Mice with Renovascular Hypertension - Kopkan_2012_Kidney.Blood.Press.Res_35_595
Author(s) : Kopkan L , Huskova Z , Sporkova A , Varcabova S , Honetschlagerova Z , Hwang SH , Tsai HJ , Hammock BD , Imig JD , Kramer HJ , Burgelova M , Vojtiskova A , Kujal P , Vernerova Z , Cervenka L
Ref : Kidney Blood Press Res , 35 :595 , 2012
PubMedID: 22948718

Title : Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension - Neckar_2012_Clin.Sci.(Lond)_122_513
Author(s) : Neckar J , Kopkan L , Huskova Z , Kolar F , Papousek F , Kramer HJ , Hwang SH , Hammock BD , Imig JD , Maly J , Netuka I , Ostadal B , Cervenka L
Ref : Clinical Science (Lond) , 122 :513 , 2012
PubMedID: 22324471

Title : Soluble epoxide hydrolase gene deficiency or inhibition attenuates chronic active inflammatory bowel disease in IL-10(-\/-) mice - Zhang_2012_Dig.Dis.Sci_57_2580
Author(s) : Zhang W , Yang AL , Liao J , Li H , Dong H , Chung YT , Bai H , Matkowskyj KA , Hammock BD , Yang GY
Ref : Digestive Diseases & Sciences , 57 :2580 , 2012
PubMedID: 22588244

Title : Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats - Iyer_2012_Exp.Diabetes.Res_2012_758614
Author(s) : Iyer A , Kauter K , Alam MA , Hwang SH , Morisseau C , Hammock BD , Brown L
Ref : Exp Diabetes Res , 2012 :758614 , 2012
PubMedID: 22007192

Title : Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats - Guglielmino_2012_Am.J.Physiol.Heart.Circ.Physiol_303_H853
Author(s) : Guglielmino K , Jackson K , Harris TR , Vu V , Dong H , Dutrow G , Evans JE , Graham J , Cummings BP , Havel PJ , Chiamvimonvat N , Despa S , Hammock BD , Despa F
Ref : American Journal of Physiology Heart Circ Physiol , 303 :H853 , 2012
PubMedID: 22865388

Title : Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase - Pecic_2012_Bioorg.Med.Chem.Lett_22_601
Author(s) : Pecic S , Deng SX , Morisseau C , Hammock BD , Landry DW
Ref : Bioorganic & Medicinal Chemistry Lett , 22 :601 , 2012
PubMedID: 22079754

Title : EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides - Decker_2012_J.Lipid.Res_53_2038
Author(s) : Decker M , Adamska M , Cronin A , Di Giallonardo F , Burgener J , Marowsky A , Falck JR , Morisseau C , Hammock BD , Gruzdev A , Zeldin DC , Arand M
Ref : J Lipid Res , 53 :2038 , 2012
PubMedID: 22798687
Gene_locus related to this paper: human-EPHX3 , human-EPHX4

Title : Inhibition of soluble epoxide hydrolase attenuates high-fat-diet-induced hepatic steatosis by reduced systemic inflammatory status in mice - Liu_2012_PLoS.One_7_e39165
Author(s) : Liu Y , Dang H , Li D , Pang W , Hammock BD , Zhu Y
Ref : PLoS ONE , 7 :e39165 , 2012
PubMedID: 22720061

Title : Development of monoclonal antibodies to human microsomal epoxide hydrolase and analysis of preneoplastic antigen-like molecules - Duan_2012_Toxicol.Appl.Pharmacol_260_17
Author(s) : Duan H , Yoshimura K , Kobayashi N , Sugiyama K , Sawada J , Saito Y , Morisseau C , Hammock BD , Akatsuka T
Ref : Toxicol Appl Pharmacol , 260 :17 , 2012
PubMedID: 22310175

Title : Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy - Inoue_2011_Cancer.Biol.Ther_12_827
Author(s) : Inoue H , Hwang SH , Wecksler AT , Hammock BD , Weiss RH
Ref : Cancer Biol Ther , 12 :827 , 2011
PubMedID: 21878748

Title : Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension - Honetschlagerova_2011_J.Physiol_589_207
Author(s) : Honetschlagerova Z , Z ZH , Vanourkova Z , Sporkova A , Kramer HJ , Hwang SH , Tsai HJ , Hammock BD , Imig JD , Cervenka L , Kopkan L
Ref : The Journal of Physiology , 589 :207 , 2011
PubMedID: 21078594

Title : Increases in plasma trans-EETs and blood pressure reduction in spontaneously hypertensive rats - Jiang_2011_Am.J.Physiol.Heart.Circ.Physiol_300_H1990
Author(s) : Jiang H , Quilley J , Doumad AB , Zhu AG , Falck JR , Hammock BD , Stier CT, Jr. , Carroll MA
Ref : American Journal of Physiology Heart Circ Physiol , 300 :H1990 , 2011
PubMedID: 21398593

Title : Structure-activity relationships of cycloalkylamide derivatives as inhibitors of the soluble epoxide hydrolase - Kim_2011_J.Med.Chem_54_1752
Author(s) : Kim IH , Park YK , Hammock BD , Nishi K
Ref : Journal of Medicinal Chemistry , 54 :1752 , 2011
PubMedID: 21338111

Title : 1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia - Anandan_2011_Bioorg.Med.Chem.Lett_21_983
Author(s) : Anandan SK , Webb HK , Chen D , Wang YX , Aavula BR , Cases S , Cheng Y , Do ZN , Mehra U , Tran V , Vincelette J , Waszczuk J , White K , Wong KR , Zhang LN , Jones PD , Hammock BD , Patel DV , Whitcomb R , MacIntyre DE , Sabry J , Gless R
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :983 , 2011
PubMedID: 21211973

Title : Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors - Schebb_2011_Anal.Bioanal.Chem_400_1359
Author(s) : Schebb NH , Huby M , Morisseau C , Hwang SH , Hammock BD
Ref : Anal Bioanal Chem , 400 :1359 , 2011
PubMedID: 21479549

Title : Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation - Charles_2011_Circ.Res_108_324
Author(s) : Charles RL , Burgoyne JR , Mayr M , Weldon SM , Hubner N , Dong H , Morisseau C , Hammock BD , Landar A , Eaton P
Ref : Circulation Research , 108 :324 , 2011
PubMedID: 21164107

Title : Improvement of endothelium-dependent vasodilations by SKA-31 and SKA-20, activators of small- and intermediate-conductance Ca2+ -activated K+ -channels - Hasenau_2011_Acta.Physiol.(Oxf)_203_117
Author(s) : Hasenau AL , Nielsen G , Morisseau C , Hammock BD , Wulff H , Kohler R
Ref : Acta Physiol (Oxf) , 203 :117 , 2011
PubMedID: 21362152

Title : Juvenile hormone (JH) esterase of the mosquito Culex quinquefasciatus is not a target of the JH analog insecticide methoprene - Kamita_2011_PLoS.One_6_e28392
Author(s) : Kamita SG , Samra AI , Liu JY , Cornel AJ , Hammock BD
Ref : PLoS ONE , 6 :e28392 , 2011
PubMedID: 22174797
Gene_locus related to this paper: culqu-b0w3q7

Title : Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase - Hwang_2011_J.Med.Chem_54_3037
Author(s) : Hwang SH , Wagner KM , Morisseau C , Liu JY , Dong H , Wecksler AT , Hammock BD
Ref : Journal of Medicinal Chemistry , 54 :3037 , 2011
PubMedID: 21434686

Title : Epoxygenated fatty acids and soluble epoxide hydrolase inhibition: novel mediators of pain reduction - Wagner_2011_J.Agric.Food.Chem_59_2816
Author(s) : Wagner K , Inceoglu B , Gill SS , Hammock BD
Ref : Journal of Agricultural and Food Chemistry , 59 :2816 , 2011
PubMedID: 20958046

Title : Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies - Morisseau_2011_Anal.Biochem_414_154
Author(s) : Morisseau C , Bernay M , Escaich A , Sanborn JR , Lango J , Hammock BD
Ref : Analytical Biochemistry , 414 :154 , 2011
PubMedID: 21371418
Gene_locus related to this paper: human-EPHX1 , ratno-hyep

Title : Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP - Inceoglu_2011_Proc.Natl.Acad.Sci.U.S.A_108_5093
Author(s) : Inceoglu B , Wagner K , Schebb NH , Morisseau C , Jinks SL , Ulu A , Hegedus C , Rose T , Brosnan R , Hammock BD
Ref : Proc Natl Acad Sci U S A , 108 :5093 , 2011
PubMedID: 21383170

Title : Inhibition of soluble epoxide hydrolase confers cardioprotection and prevents cardiac cytochrome P450 induction by benzo(a)pyrene - Aboutabl_2011_J.Cardiovasc.Pharmacol_57_273
Author(s) : Aboutabl ME , Zordoky BN , Hammock BD , El-Kadi AO
Ref : J Cardiovasc Pharmacol , 57 :273 , 2011
PubMedID: 21383588

Title : 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain - Rose_2010_J.Med.Chem_53_7067
Author(s) : Rose TE , Morisseau C , Liu JY , Inceoglu B , Jones PD , Sanborn JR , Hammock BD
Ref : Journal of Medicinal Chemistry , 53 :7067 , 2010
PubMedID: 20812725

Title : Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties - Huang_2010_J.Med.Chem_53_8376
Author(s) : Huang SX , Li HY , Liu JY , Morisseau C , Hammock BD , Long YQ
Ref : Journal of Medicinal Chemistry , 53 :8376 , 2010
PubMedID: 21070033

Title : Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice - Revermann_2010_Arterioscler.Thromb.Vasc.Biol_30_909
Author(s) : Revermann M , Schloss M , Barbosa-Sicard E , Mieth A , Liebner S , Morisseau C , Geisslinger G , Schermuly RT , Fleming I , Hammock BD , Brandes RP
Ref : Arterioscler Thromb Vasc Biol , 30 :909 , 2010
PubMedID: 20224052

Title : Function of phenylalanine 259 and threonine 314 within the substrate binding pocket of the juvenile hormone esterase of Manduca sexta - Kamita_2010_Biochemistry_49_3733
Author(s) : Kamita SG , Wogulis MD , Law CS , Morisseau C , Tanaka H , Huang H , Wilson DK , Hammock BD
Ref : Biochemistry , 49 :3733 , 2010
PubMedID: 20307057

Title : Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids - Morisseau_2010_J.Lipid.Res_51_3481
Author(s) : Morisseau C , Inceoglu B , Schmelzer K , Tsai HJ , Jinks SL , Hegedus CM , Hammock BD
Ref : J Lipid Res , 51 :3481 , 2010
PubMedID: 20664072

Title : Juvenile hormone esterase: biochemistry and structure - Kamita_2010_J.Pestic.Sci_35_265
Author(s) : Kamita SG , Hammock BD
Ref : Journal of Pesticide Science , 35 :265 , 2010
PubMedID: 23543805

Title : Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease - Jung_2010_PLoS.One_5_e11979
Author(s) : Jung O , Jansen F , Mieth A , Barbosa-Sicard E , Pliquett RU , Babelova A , Morisseau C , Hwang SH , Tsai C , Hammock BD , Schaefer L , Geisslinger G , Amann K , Brandes RP
Ref : PLoS ONE , 5 :e11979 , 2010
PubMedID: 20694143

Title : Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis - Luo_2010_J.Pharmacol.Exp.Ther_334_430
Author(s) : Luo P , Chang HH , Zhou Y , Zhang S , Hwang SH , Morisseau C , Wang CY , Inscho EW , Hammock BD , Wang MH
Ref : Journal of Pharmacology & Experimental Therapeutics , 334 :430 , 2010
PubMedID: 20439437

Title : DNA methylation of the promoter of soluble epoxide hydrolase silences its expression by an SP-1-dependent mechanism - Zhang_2010_Biochim.Biophys.Acta_1799_659
Author(s) : Zhang D , Ai D , Tanaka H , Hammock BD , Zhu Y
Ref : Biochimica & Biophysica Acta , 1799 :659 , 2010
PubMedID: 20888937

Title : Inhibition of soluble epoxide hydrolase by trans-4- [4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is protective against ischemia-reperfusion injury - Chaudhary_2010_J.Cardiovasc.Pharmacol_55_67
Author(s) : Chaudhary KR , Abukhashim M , Hwang SH , Hammock BD , Seubert JM
Ref : J Cardiovasc Pharmacol , 55 :67 , 2010
PubMedID: 19834332

Title : Epoxyeicosatrienoic acids and soluble epoxide hydrolase: potential therapeutic targets for inflammation and its induced carcinogenesis - Norwood_2010_Am.J.Transl.Res_2_447
Author(s) : Norwood S , Liao J , Hammock BD , Yang GY
Ref : Am J Transl Res , 2 :447 , 2010
PubMedID: 20733953

Title : Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model - Liu_2010_Biochem.Pharmacol_79_880
Author(s) : Liu JY , Yang J , Inceoglu B , Qiu H , Ulu A , Hwang SH , Chiamvimonvat N , Hammock BD
Ref : Biochemical Pharmacology , 79 :880 , 2010
PubMedID: 19896470

Title : Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs - Tsai_2010_Eur.J.Pharm.Sci_40_222
Author(s) : Tsai HJ , Hwang SH , Morisseau C , Yang J , Jones PD , Kasagami T , Kim IH , Hammock BD
Ref : Eur J Pharm Sci , 40 :222 , 2010
PubMedID: 20359531

Title : Crystal structure of the CFTR inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor. - Bahl_2010_J.Bacteriol_192_1785
Author(s) : Bahl CD , Morisseau C , Bomberger JM , Stanton BA , Hammock BD , O'Toole GA , Madden DR
Ref : Journal of Bacteriology , 192 :1785 , 2010
PubMedID: 20118260
Gene_locus related to this paper: pseae-PA2934

Title : Reactivity versus steric effects in fluorinated ketones as esterase inhibitors: a quantum mechanical and molecular dynamics study - Rayo_2010_J.Mol.Model_16_1753
Author(s) : Rayo J , Munoz L , Rosell G , Hammock BD , Guerrero A , Luque FJ , Pouplana R
Ref : J Mol Model , 16 :1753 , 2010
PubMedID: 20676708

Title : Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo - Liu_2009_Mol.Cancer.Ther_8_2193
Author(s) : Liu JY , Park SH , Morisseau C , Hwang SH , Hammock BD , Weiss RH
Ref : Mol Cancer Ther , 8 :2193 , 2009
PubMedID: 19671760

Title : Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase - Parrish_2009_Cell.Biol.Toxicol_25_217
Author(s) : Parrish AR , Chen G , Burghardt RC , Watanabe T , Morisseau C , Hammock BD
Ref : Cell Biol Toxicol , 25 :217 , 2009
PubMedID: 18386137

Title : Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches - Li_2009_J.Mol.Cell.Cardiol_47_835
Author(s) : Li N , Liu JY , Timofeyev V , Qiu H , Hwang SH , Tuteja D , Lu L , Yang J , Mochida H , Low R , Hammock BD , Chiamvimonvat N
Ref : Journal of Molecular & Cellular Cardiology , 47 :835 , 2009
PubMedID: 19716829

Title : Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation - Liu_2009_Br.J.Pharmacol_156_284
Author(s) : Liu JY , Tsai HJ , Hwang SH , Jones PD , Morisseau C , Hammock BD
Ref : British Journal of Pharmacology , 156 :284 , 2009
PubMedID: 19154430

Title : Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension - Manhiani_2009_Am.J.Physiol.Renal.Physiol_297_F740
Author(s) : Manhiani M , Quigley JE , Knight SF , Tasoobshirazi S , Moore T , Brands MW , Hammock BD , Imig JD
Ref : American Journal of Physiology Renal Physiol , 297 :F740 , 2009
PubMedID: 19553349

Title : Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases - Imig_2009_Nat.Rev.Drug.Discov_8_794
Author(s) : Imig JD , Hammock BD
Ref : Nat Rev Drug Discov , 8 :794 , 2009
PubMedID: 19794443

Title : 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition - Falck_2009_J.Med.Chem_52_5069
Author(s) : Falck JR , Kodela R , Manne R , Atcha KR , Puli N , Dubasi N , Manthati VL , Capdevila JH , Yi XY , Goldman DH , Morisseau C , Hammock BD , Campbell WB
Ref : Journal of Medicinal Chemistry , 52 :5069 , 2009
PubMedID: 19653681

Title : Inhibition of the soluble epoxide hydrolase by tyrosine nitration - Barbosa-Sicard_2009_J.Biol.Chem_284_28156
Author(s) : Barbosa-Sicard E , Fromel T , Keseru B , Brandes RP , Morisseau C , Hammock BD , Braun T , Kruger M , Fleming I
Ref : Journal of Biological Chemistry , 284 :28156 , 2009
PubMedID: 19704161

Title : Differential subcellular distribution and colocalization of the microsomal and soluble epoxide hydrolases in cultured neonatal rat brain cortical astrocytes - Rawal_2009_J.Neurosci.Res_87_218
Author(s) : Rawal S , Morisseau C , Hammock BD , Shivachar AC
Ref : Journal of Neuroscience Research , 87 :218 , 2009
PubMedID: 18711743

Title : Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein e-knockout mouse model - Ulu_2008_J.Cardiovasc.Pharmacol_52_314
Author(s) : Ulu A , Davis BB , Tsai HJ , Kim IH , Morisseau C , Inceoglu B , Fiehn O , Hammock BD , Weiss RH
Ref : J Cardiovasc Pharmacol , 52 :314 , 2008
PubMedID: 18791465

Title : Transcriptional regulation of the human soluble epoxide hydrolase gene EPHX2 - Tanaka_2008_Biochim.Biophys.Acta_1779_17
Author(s) : Tanaka H , Kamita SG , Wolf NM , Harris TR , Wu Z , Morisseau C , Hammock BD
Ref : Biochimica & Biophysica Acta , 1779 :17 , 2008
PubMedID: 18078836

Title : Applications of carboxylesterase activity in environmental monitoring and toxicity identification evaluations (TIEs) - Wheelock_2008_Rev.Environ.Contam.Toxicol_195_117
Author(s) : Wheelock CE , Phillips BM , Anderson BS , Miller JL , Miller MJ , Hammock BD
Ref : Rev Environ Contam Toxicol , 195 :117 , 2008
PubMedID: 18418956

Title : Hydrolysis of cis- and trans-epoxyeicosatrienoic acids by rat red blood cells - Jiang_2008_J.Pharmacol.Exp.Ther_326_330
Author(s) : Jiang H , Zhu AG , Mamczur M , Morisseau C , Hammock BD , Falck JR , McGiff JC
Ref : Journal of Pharmacology & Experimental Therapeutics , 326 :330 , 2008
PubMedID: 18445784

Title : Soluble epoxide hydrolase homologs in Strongylocentrotus purpuratus suggest a gene duplication event and subsequent divergence - Harris_2008_DNA.Cell.Biol_27_467
Author(s) : Harris TR , Aronov PA , Hammock BD
Ref : DNA & Cell Biology , 27 :467 , 2008
PubMedID: 18554159
Gene_locus related to this paper: strpu-b2mwn2

Title : Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH) - Wheelock_2008_Bioorg.Med.Chem_16_2114
Author(s) : Wheelock CE , Nishi K , Ying A , Jones PD , Colvin ME , Olmstead MM , Hammock BD
Ref : Bioorganic & Medicinal Chemistry , 16 :2114 , 2008
PubMedID: 18023188

Title : Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation - Fife_2008_J.Pharmacol.Exp.Ther_327_707
Author(s) : Fife KL , Liu Y , Schmelzer KR , Tsai HJ , Kim IH , Morisseau C , Hammock BD , Kroetz DL
Ref : Journal of Pharmacology & Experimental Therapeutics , 327 :707 , 2008
PubMedID: 18815352

Title : The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor - Biswal_2008_J.Mol.Biol_381_897
Author(s) : Biswal BK , Morisseau C , Garen G , Cherney MM , Garen C , Niu C , Hammock BD , James MN
Ref : Journal of Molecular Biology , 381 :897 , 2008
PubMedID: 18585390
Gene_locus related to this paper: myctu-ephB

Title : Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease - Monti_2008_Nat.Genet_40_529
Author(s) : Monti J , Fischer J , Paskas S , Heinig M , Schulz H , Gosele C , Heuser A , Fischer R , Schmidt C , Schirdewan A , Gross V , Hummel O , Maatz H , Patone G , Saar K , Vingron M , Weldon SM , Lindpaintner K , Hammock BD , Rohde K , Dietz R , Cook SA , Schunck WH , Luft FC , Hubner N
Ref : Nat Genet , 40 :529 , 2008
PubMedID: 18443590

Title : Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical - Morisseau_2008_Pest.Manag.Sci_64_594
Author(s) : Morisseau C , Hammock BD
Ref : Pest Manag Sci , 64 :594 , 2008
PubMedID: 18383502

Title : Identification of two epoxide hydrolases in Caenorhabditis elegans that metabolize mammalian lipid signaling molecules - Harris_2008_Arch.Biochem.Biophys_472_139
Author(s) : Harris TR , Aronov PA , Jones PD , Tanaka H , Arand M , Hammock BD
Ref : Archives of Biochemistry & Biophysics , 472 :139 , 2008
PubMedID: 18267101
Gene_locus related to this paper: caeel-K07C5.5

Title : Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response - Keseru_2008_FASEB.J_22_4306
Author(s) : Keseru B , Barbosa-Sicard E , Popp R , Fisslthaler B , Dietrich A , Gudermann T , Hammock BD , Falck JR , Weissmann N , Busse R , Fleming I
Ref : FASEB Journal , 22 :4306 , 2008
PubMedID: 18725458

Title : Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase - Morisseau_2008_Chem.Res.Toxicol_21_951
Author(s) : Morisseau C , Newman JW , Wheelock CE , Hill Iii T , Morin D , Buckpitt AR , Hammock BD
Ref : Chemical Research in Toxicology , 21 :951 , 2008
PubMedID: 18363382
Gene_locus related to this paper: human-EPHX1 , ratno-hyep

Title : 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties - Kim_2007_J.Med.Chem_50_5217
Author(s) : Kim IH , Tsai HJ , Nishi K , Kasagami T , Morisseau C , Hammock BD
Ref : Journal of Medicinal Chemistry , 50 :5217 , 2007
PubMedID: 17894481

Title : Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase - Kim_2007_Bioorg.Med.Chem_15_312
Author(s) : Kim IH , Nishi K , Tsai HJ , Bradford T , Koda Y , Watanabe T , Morisseau C , Blanchfield J , Toth I , Hammock BD
Ref : Bioorganic & Medicinal Chemistry , 15 :312 , 2007
PubMedID: 17046265
Gene_locus related to this paper: human-EPHX2

Title : Soluble epoxide hydrolase: a novel therapeutic target in stroke - Zhang_2007_J.Cereb.Blood.Flow.Metab_27_1931
Author(s) : Zhang W , Koerner IP , Noppens R , Grafe M , Tsai HJ , Morisseau C , Luria A , Hammock BD , Falck JR , Alkayed NJ
Ref : Journal of Cerebral Blood Flow & Metabolism , 27 :1931 , 2007
PubMedID: 17440491
Gene_locus related to this paper: human-EPHX2

Title : Hydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterases from Lucilia cuprina - Devonshire_2007_Insect.Biochem.Mol.Biol_37_891
Author(s) : Devonshire AL , Heidari R , Huang HZ , Hammock BD , Russell RJ , Oakeshott JG
Ref : Insect Biochemistry & Molecular Biology , 37 :891 , 2007
PubMedID: 17681228
Gene_locus related to this paper: luccu-E3aest7

Title : The soluble epoxide hydrolase as a pharmaceutical target for hypertension - Chiamvimonvat_2007_J.Cardiovasc.Pharmacol_50_225
Author(s) : Chiamvimonvat N , Ho CM , Tsai HJ , Hammock BD
Ref : J Cardiovasc Pharmacol , 50 :225 , 2007
PubMedID: 17878749

Title : Orally bioavailable potent soluble epoxide hydrolase inhibitors - Hwang_2007_J.Med.Chem_50_3825
Author(s) : Hwang SH , Tsai HJ , Liu JY , Morisseau C , Hammock BD
Ref : Journal of Medicinal Chemistry , 50 :3825 , 2007
PubMedID: 17616115

Title : Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds - Wadkins_2007_Mol.Pharmacol_71_713
Author(s) : Wadkins RM , Hyatt JL , Edwards CC , Tsurkan L , Redinbo MR , Wheelock CE , Jones PD , Hammock BD , Potter PM
Ref : Molecular Pharmacology , 71 :713 , 2007
PubMedID: 17167034

Title : Development of a high-throughput screen for soluble epoxide hydrolase inhibition - Wolf_2006_Anal.Biochem_355_71
Author(s) : Wolf NM , Morisseau C , Jones PD , Hock B , Hammock BD
Ref : Analytical Biochemistry , 355 :71 , 2006
PubMedID: 16729954

Title : Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta - Wogulis_2006_Biochemistry_45_4045
Author(s) : Wogulis M , Wheelock CE , Kamita SG , Hinton AC , Whetstone PA , Hammock BD , Wilson DK
Ref : Biochemistry , 45 :4045 , 2006
PubMedID: 16566578
Gene_locus related to this paper: manse-jhest

Title : Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors - Schmelzer_2006_Proc.Natl.Acad.Sci.U.S.A_103_13646
Author(s) : Schmelzer KR , Inceoglu B , Kubala L , Kim IH , Jinks SL , Eiserich JP , Hammock BD
Ref : Proc Natl Acad Sci U S A , 103 :13646 , 2006
PubMedID: 16950874
Gene_locus related to this paper: human-EPHX2

Title : Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2 - Nishi_2006_Arch.Biochem.Biophys_445_115
Author(s) : Nishi K , Huang H , Kamita SG , Kim IH , Morisseau C , Hammock BD
Ref : Archives of Biochemistry & Biophysics , 445 :115 , 2006
PubMedID: 16359636
Gene_locus related to this paper: human-CES1 , human-CES2

Title : Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels - Olearczyk_2006_J.Pharmacol.Exp.Ther_318_1307
Author(s) : Olearczyk JJ , Field MB , Kim IH , Morisseau C , Hammock BD , Imig JD
Ref : Journal of Pharmacology & Experimental Therapeutics , 318 :1307 , 2006
PubMedID: 16772540
Gene_locus related to this paper: human-EPHX2

Title : Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids - Gomez_2006_Protein.Sci_15_58
Author(s) : Gomez GA , Morisseau C , Hammock BD , Christianson DW
Ref : Protein Science , 15 :58 , 2006
PubMedID: 16322563
Gene_locus related to this paper: human-EPHX2

Title : Use of carboxylesterase activity to remove pyrethroid-associated toxicity to Ceriodaphnia dubia and Hyalella azteca in toxicity identification evaluations - Wheelock_2006_Environ.Toxicol.Chem_25_973
Author(s) : Wheelock CE , Miller JL , Miller MJ , Phillips BM , Huntley SA , Gee SJ , Tjeerdema RS , Hammock BD
Ref : Environ Toxicol Chem , 25 :973 , 2006
PubMedID: 16629136

Title : Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study - Lee_2006_Hum.Mol.Genet_15_1640
Author(s) : Lee CR , North KE , Bray MS , Fornage M , Seubert JM , Newman JW , Hammock BD , Couper DJ , Heiss G , Zeldin DC
Ref : Hum Mol Genet , 15 :1640 , 2006
PubMedID: 16595607

Title : Evaluation of chiral alpha-cyanoesters as general fluorescent substrates for screening enantioselective esterases - Huang_2006_J.Agric.Food.Chem_54_694
Author(s) : Huang H , Nishi K , Gee SJ , Hammock BD
Ref : Journal of Agricultural and Food Chemistry , 54 :694 , 2006
PubMedID: 16448170

Title : Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases - Huang_2005_Chem.Res.Toxicol_18_1371
Author(s) : Huang H , Fleming CD , Nishi K , Redinbo MR , Hammock BD
Ref : Chemical Research in Toxicology , 18 :1371 , 2005
PubMedID: 16167828

Title : Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility - Kim_2005_J.Med.Chem_48_3621
Author(s) : Kim IH , Heirtzler FR , Morisseau C , Nishi K , Tsai HJ , Hammock BD
Ref : Journal of Medicinal Chemistry , 48 :3621 , 2005
PubMedID: 15887969

Title : Identification and characterization of an ovary-selective isoform of epoxide hydrolase - Hennebold_2005_Biol.Reprod_72_968
Author(s) : Hennebold JD , Mah K , Perez W , Vance JE , Stouffer RL , Morisseau C , Hammock BD , Adashi EY
Ref : Biol Reprod , 72 :968 , 2005
PubMedID: 15601917

Title : Soluble epoxide hydrolase is a therapeutic target for acute inflammation - Schmelzer_2005_Proc.Natl.Acad.Sci.U.S.A_102_9772
Author(s) : Schmelzer KR , Kubala L , Newman JW , Kim IH , Eiserich JP , Hammock BD
Ref : Proc Natl Acad Sci U S A , 102 :9772 , 2005
PubMedID: 15994227
Gene_locus related to this paper: human-EPHX2

Title : Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat - Sellers_2005_FASEB.J_19_626
Author(s) : Sellers KW , Sun C , Diez-Freire C , Waki H , Morisseau C , Falck JR , Hammock BD , Paton JF , Raizada MK
Ref : FASEB Journal , 19 :626 , 2005
PubMedID: 15659536

Title : Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension - Jung_2005_Hypertension_45_759
Author(s) : Jung O , Brandes RP , Kim IH , Schweda F , Schmidt R , Hammock BD , Busse R , Fleming I
Ref : Hypertension , 45 :759 , 2005
PubMedID: 15699457

Title : Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos - Wheelock_2005_Aquat.Toxicol_74_172
Author(s) : Wheelock CE , Eder KJ , Werner I , Huang H , Jones PD , Brammell BF , Elskus AA , Hammock BD
Ref : Aquat Toxicol , 74 :172 , 2005
PubMedID: 16011852

Title : Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles - Morisseau_2005_Annu.Rev.Pharmacol.Toxicol_45_311
Author(s) : Morisseau C , Hammock BD
Ref : Annual Review of Pharmacology & Toxicology , 45 :311 , 2005
PubMedID: 15822179

Title : Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor - Smith_2005_Proc.Natl.Acad.Sci.U.S.A_102_2186
Author(s) : Smith KR , Pinkerton KE , Watanabe T , Pedersen TL , Ma SJ , Hammock BD
Ref : Proc Natl Acad Sci U S A , 102 :2186 , 2005
PubMedID: 15684051

Title : Epoxide hydrolases: their roles and interactions with lipid metabolism - Newman_2005_Prog.Lipid.Res_44_1
Author(s) : Newman JW , Morisseau C , Hammock BD
Ref : Prog Lipid Res , 44 :1 , 2005
PubMedID: 15748653

Title : Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels - Fang_2004_Am.J.Physiol.Heart.Circ.Physiol_287_H2412
Author(s) : Fang X , Weintraub NL , McCaw RB , Hu S , Harmon SD , Rice JB , Hammock BD , Spector AA
Ref : American Journal of Physiology Heart Circ Physiol , 287 :H2412 , 2004
PubMedID: 15284062

Title : Cytochrome p450-dependent lipid metabolism in preovulatory follicles - Newman_2004_Endocrinology_145_5097
Author(s) : Newman JW , Stok JE , Vidal JD , Corbin CJ , Huang Q , Hammock BD , Conley AJ
Ref : Endocrinology , 145 :5097 , 2004
PubMedID: 15308618
Gene_locus related to this paper: pig-q6q2c2

Title : Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis - Stok_2004_Arch.Biochem.Biophys_430_247
Author(s) : Stok JE , Goloshchapov A , Song C , Wheelock CE , Derbel MB , Morisseau C , Hammock BD
Ref : Archives of Biochemistry & Biophysics , 430 :247 , 2004
PubMedID: 15369824
Gene_locus related to this paper: ratno-Ces1d

Title : Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes - Stok_2004_J.Biol.Chem_279_29863
Author(s) : Stok JE , Huang H , Jones PD , Wheelock CE , Morisseau C , Hammock BD
Ref : Journal of Biological Chemistry , 279 :29863 , 2004
PubMedID: 15123619
Gene_locus related to this paper: mouse-Ces2a , mouse-Ces2e

Title : Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis - Gomez_2004_Biochemistry_43_4716
Author(s) : Gomez GA , Morisseau C , Hammock BD , Christianson DW
Ref : Biochemistry , 43 :4716 , 2004
PubMedID: 15096040
Gene_locus related to this paper: human-EPHX2

Title : Pyrethroid tolerance in Culex pipiens pipiens var molestus from Marin County, California - McAbee_2004_Pest.Manag.Sci_60_359
Author(s) : McAbee RD , Kang K-D , Stanich MA , Christiansen JA , Wheelock CE , Inman AD , Hammock BD , Cornel AJ
Ref : Pest Manag Sci , 60 :359 , 2004
PubMedID: 15119598

Title : Development of toxicity identification evaluation procedures for pyrethroid detection using esterase activity - Wheelock_2004_Environ.Toxicol.Chem_23_2699
Author(s) : Wheelock CE , Miller JL , Miller MJ , Gee SJ , Shan G , Hammock BD
Ref : Environ Toxicol Chem , 23 :2699 , 2004
PubMedID: 15559286

Title : Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism - DuTeaux_2004_Toxicol.Sci_78_187
Author(s) : DuTeaux SB , Newman JW , Morisseau C , Fairbairn EA , Jelks K , Hammock BD , Miller MG
Ref : Toxicol Sci , 78 :187 , 2004
PubMedID: 14737000

Title : Vascular localization of soluble epoxide hydrolase in the human kidney - Yu_2004_Am.J.Physiol.Renal.Physiol_286_F720
Author(s) : Yu Z , Davis BB , Morisseau C , Hammock BD , Olson JL , Kroetz DL , Weiss RH
Ref : American Journal of Physiology Renal Physiol , 286 :F720 , 2004
PubMedID: 14665429

Title : Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility - Kim_2004_J.Med.Chem_47_2110
Author(s) : Kim IH , Morisseau C , Watanabe T , Hammock BD
Ref : Journal of Medicinal Chemistry , 47 :2110 , 2004
PubMedID: 15056008

Title : Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage - Zhao_2004_J.Am.Soc.Nephrol_15_1244
Author(s) : Zhao X , Yamamoto T , Newman JW , Kim IH , Watanabe T , Hammock BD , Stewart J , Pollock JS , Pollock DM , Imig JD
Ref : J Am Soc Nephrol , 15 :1244 , 2004
PubMedID: 15100364

Title : In vitro expression and biochemical characterization of juvenile hormone esterase from Manduca sexta - Hinton_2003_Insect.Biochem.Mol.Biol_33_317
Author(s) : Hinton AC , Hammock BD
Ref : Insect Biochemistry & Molecular Biology , 33 :317 , 2003
PubMedID: 12609517

Title : The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity - Newman_2003_Proc.Natl.Acad.Sci.U.S.A_100_1558
Author(s) : Newman JW , Morisseau C , Harris TR , Hammock BD
Ref : Proc Natl Acad Sci U S A , 100 :1558 , 2003
PubMedID: 12574510
Gene_locus related to this paper: human-EPHX2

Title : Polymorphisms in human soluble epoxide hydrolase - Przybyla-Zawislak_2003_Mol.Pharmacol_64_482
Author(s) : Przybyla-Zawislak BD , Srivastava PK , Vazquez-Matias J , Mohrenweiser HW , Maxwell JE , Hammock BD , Bradbury JA , Enayetallah AE , Zeldin DC , Grant DF
Ref : Molecular Pharmacology , 64 :482 , 2003
PubMedID: 12869654
Gene_locus related to this paper: human-EPHX2

Title : Characterization and cDNA cloning of a clofibrate-inducible microsomal epoxide hydrolase in Drosophila melanogaster - Taniai_2003_Eur.J.Biochem_270_4696
Author(s) : Taniai K , Inceoglu AB , Yukuhiro K , Hammock BD
Ref : European Journal of Biochemistry , 270 :4696 , 2003
PubMedID: 14622257
Gene_locus related to this paper: drome-CG15102

Title : Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes - Wheelock_2003_Anal.Biochem_315_208
Author(s) : Wheelock CE , Wheelock AM , Zhang R , Stok JE , Morisseau C , Le Valley SE , Green CE , Hammock BD
Ref : Analytical Biochemistry , 315 :208 , 2003
PubMedID: 12689831
Gene_locus related to this paper: mouse-Ces2e

Title : Use of classical and 3-D QSAR to examine the hydration state of juvenile hormone esterase inhibitors - Wheelock_2003_Bioorg.Med.Chem_11_5101
Author(s) : Wheelock CE , Nakagawa Y , Akamatsu M , Hammock BD
Ref : Bioorganic & Medicinal Chemistry , 11 :5101 , 2003
PubMedID: 14604674

Title : Juvenile hormone esterase (JHE) from Tenebrio molitor: full-length cDNA sequence, in vitro expression, and characterization of the recombinant protein - Hinton_2003_Insect.Biochem.Mol.Biol_33_477
Author(s) : Hinton AC , Hammock BD
Ref : Insect Biochemistry & Molecular Biology , 33 :477 , 2003
PubMedID: 12706627
Gene_locus related to this paper: tenmo-Q8WRD8

Title : Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas) - Denton_2003_Environ.Toxicol.Chem_22_336
Author(s) : Denton DL , Wheelock CE , Murray SA , Deanovic LA , Hammock BD , Hinton DE
Ref : Environ Toxicol Chem , 22 :336 , 2003
PubMedID: 12558165

Title : In vitro metabolism of the mammalian soluble epoxide hydrolase inhibitor, 1-cyclohexyl-3-dodecyl-urea - Watanabe_2003_Drug.Metab.Dispos_31_846
Author(s) : Watanabe T , Morisseau C , Newman JW , Hammock BD
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 31 :846 , 2003
PubMedID: 12814960

Title : Juvenile hormone (JH) esterase: why are you so JH specific? - Kamita_2003_Insect.Biochem.Mol.Biol_33_1261
Author(s) : Kamita SG , Hinton AC , Wheelock CE , Wogulis MD , Wilson DK , Wolf NM , Stok JE , Hock B , Hammock BD
Ref : Insect Biochemistry & Molecular Biology , 33 :1261 , 2003
PubMedID: 14599498

Title : QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds - McElroy_2003_J.Med.Chem_46_1066
Author(s) : McElroy NR , Jurs PC , Morisseau C , Hammock BD
Ref : Journal of Medicinal Chemistry , 46 :1066 , 2003
PubMedID: 12620084

Title : Molecular cloning, characterization, and expression of a redox-responsive cutinase from Monilinia fructicola (Wint.) Honey - Wang_2002_Fungal.Genet.Biol_35_261
Author(s) : Wang GY , Michailides TJ , Hammock BD , Lee YM , Bostock RM
Ref : Fungal Genet Biol , 35 :261 , 2002
PubMedID: 11929215
Gene_locus related to this paper: monfr-CUT1

Title : Development of a simple and sensitive fluorimetric method for isolation of coumaphos-hydrolysing bacteria - Harcourt_2002_Lett.Appl.Microbiol_34_263
Author(s) : Harcourt RL , Horne I , Sutherland TD , Hammock BD , Russell RJ , Oakeshott JG
Ref : Lett Appl Microbiol , 34 :263 , 2002
PubMedID: 11940156

Title : Structural refinement of inhibitors of urea-based soluble epoxide hydrolases - Morisseau_2002_Biochem.Pharmacol_63_1599
Author(s) : Morisseau C , Goodrow MH , Newman JW , Wheelock CE , Dowdy DL , Hammock BD
Ref : Biochemical Pharmacology , 63 :1599 , 2002
PubMedID: 12007563

Title : Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation - Davis_2002_Proc.Natl.Acad.Sci.U.S.A_99_2222
Author(s) : Davis BB , Thompson DA , Howard LL , Morisseau C , Hammock BD , Weiss RH
Ref : Proc Natl Acad Sci U S A , 99 :2222 , 2002
PubMedID: 11842228

Title : Urea and amide-based inhibitors of the juvenile hormone epoxide hydrolase of the tobacco hornworm (Manduca sexta: Sphingidae) - Severson_2002_Insect.Biochem.Mol.Biol_32_1741
Author(s) : Severson TF , Goodrow MH , Morisseau C , Dowdy DL , Hammock BD
Ref : Insect Biochemistry & Molecular Biology , 32 :1741 , 2002
PubMedID: 12429126

Title : Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension - Imig_2002_Hypertension_39_690
Author(s) : Imig JD , Zhao X , Capdevila JH , Morisseau C , Hammock BD
Ref : Hypertension , 39 :690 , 2002
PubMedID: 11882632

Title : Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors - Wheelock_2002_J.Med.Chem_45_5576
Author(s) : Wheelock CE , Colvin ME , Uemura I , Olmstead MM , Sanborn JR , Nakagawa Y , Jones AD , Hammock BD
Ref : Journal of Medicinal Chemistry , 45 :5576 , 2002
PubMedID: 12459025

Title : Polymorphism in soluble epoxide hydrolase and blood pressure in spontaneously hypertensive rats - Fornage_2002_Hypertension_40_485
Author(s) : Fornage M , Hinojos CA , Nurowska BW , Boerwinkle E , Hammock BD , Morisseau C , Doris PA
Ref : Hypertension , 40 :485 , 2002
PubMedID: 12364351

Title : Fenoxycarb levels and their effects on general and juvenile hormone esterase activity in the hemolymph of the silkworm, Bombyx mori - Dedos_2002_Pestic.Biochem.Physiol_73_174
Author(s) : Dedos SG , Szurdoki F , Szekacs A , Shiotsuki T , Hammock BD , Shimada J , Fugo H
Ref : Pesticide Biochemistry and Physiology , 73 :174 , 2002
PubMedID:

Title : Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition - Fang_2001_J.Biol.Chem_276_14867
Author(s) : Fang X , Kaduce TL , Weintraub NL , Harmon S , Teesch LM , Morisseau C , Thompson DA , Hammock BD , Spector AA
Ref : Journal of Biological Chemistry , 276 :14867 , 2001
PubMedID: 11278979

Title : Purification of juvenile hormone esterase and molecular cloning of the cDNA from Manduca sexta - Hinton_2001_Insect.Biochem.Mol.Biol_32_57
Author(s) : Hinton AC , Hammock BD
Ref : Insect Biochemistry & Molecular Biology , 32 :57 , 2001
PubMedID: 11719069
Gene_locus related to this paper: manse-jhest

Title : Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility - Wheelock_2001_Chem.Res.Toxicol_14_1563
Author(s) : Wheelock CE , Severson TF , Hammock BD
Ref : Chemical Research in Toxicology , 14 :1563 , 2001
PubMedID: 11743738

Title : Rapid determination of soluble epoxide hydrolase inhibitors in rat hepatic microsomes by high-performance liquid chromatography with electrospray tandem mass spectrometry - Watanabe_2001_Anal.Biochem_299_227
Author(s) : Watanabe T , Hammock BD
Ref : Analytical Biochemistry , 299 :227 , 2001
PubMedID: 11730347

Title : Development of sensitive esterase assays based on alpha-cyano-containing esters - Shan_2001_Anal.Biochem_299_54
Author(s) : Shan G , Hammock BD
Ref : Analytical Biochemistry , 299 :54 , 2001
PubMedID: 11726184

Title : Inhibition of microsomal epoxide hydrolases by ureas, amides, and amines - Morisseau_2001_Chem.Res.Toxicol_14_409
Author(s) : Morisseau C , Newman JW , Dowdy DL , Goodrow MH , Hammock BD
Ref : Chemical Research in Toxicology , 14 :409 , 2001
PubMedID: 11304129

Title : Evaluation of fish models of soluble epoxide hydrolase inhibition - Newman_2001_Environ.Health.Perspect_109_61
Author(s) : Newman JW , Denton DL , Morisseau C , Koger CS , Wheelock CE , Hinton DE , Hammock BD
Ref : Environmental Health Perspectives , 109 :61 , 2001
PubMedID: 11171526

Title : Cellular characterization of leukotoxin diol-induced mitochondrial dysfunction - Sisemore_2001_Arch.Biochem.Biophys_392_32
Author(s) : Sisemore MF , Zheng J , Yang JC , Thompson DA , Plopper CG , Cortopassi GA , Hammock BD
Ref : Archives of Biochemistry & Biophysics , 392 :32 , 2001
PubMedID: 11469791

Title : The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells - Slim_2001_Toxicol.Appl.Pharmacol_171_184
Author(s) : Slim R , Hammock BD , Toborek M , Robertson LW , Newman JW , Morisseau C , Watkins BA , Saraswathi V , Hennig B
Ref : Toxicol Appl Pharmacol , 171 :184 , 2001
PubMedID: 11243918

Title : Leukotoxin-diol: a putative toxic mediator involved in acute respiratory distress syndrome - Zheng_2001_Am.J.Respir.Cell.Mol.Biol_25_434
Author(s) : Zheng J , Plopper CG , Lakritz J , Storms DH , Hammock BD
Ref : American Journal of Respiratory Cellular & Molecular Biology , 25 :434 , 2001
PubMedID: 11694448

Title : Identification of a juvenile hormone esterase gene by matching its peptide mass fingerprint with a sequence from the Drosophila genome project - Campbell_2001_Insect.Biochem.Mol.Biol_31_513
Author(s) : Campbell PM , Harcourt RL , Crone EJ , Claudianos C , Hammock BD , Russell RJ , Oakeshott JG
Ref : Insect Biochemistry & Molecular Biology , 31 :513 , 2001
PubMedID: 11267890
Gene_locus related to this paper: drome-CG8424 , drome-CG8425

Title : Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids - Yu_2000_Circ.Res_87_992
Author(s) : Yu Z , Xu F , Huse LM , Morisseau C , Draper AJ , Newman JW , Parker C , Graham L , Engler MM , Hammock BD , Zeldin DC , Kroetz DL
Ref : Circulation Research , 87 :992 , 2000
PubMedID: 11090543

Title : Characterization and affinity purification of juvenile hormone esterase from Bombyx mori - Shiotsuki_2000_Biosci.Biotechnol.Biochem_64_1681
Author(s) : Shiotsuki T , Bonning BC , Hirai M , Kikuchi K , Hammock BD
Ref : Biosci Biotechnol Biochem , 64 :1681 , 2000
PubMedID: 10993156

Title : Isolation of juvenile hormone esterase and its partial cDNA clone from the beetle, Tenebrio molitor - Thomas_2000_Insect.Biochem.Mol.Biol_30_529
Author(s) : Thomas BA , Hinton AC , Moskowitz H , Severson TF , Hammock BD
Ref : Insect Biochemistry & Molecular Biology , 30 :529 , 2000
PubMedID: 10844245

Title : Affinity purification and characterization of a cutinase from the fungal plant pathogen Monilinia fructicola (Wint.) honey - Wang_2000_Arch.Biochem.Biophys_382_31
Author(s) : Wang GY , Michailides TJ , Hammock BD , Lee YM , Bostock RM
Ref : Archives of Biochemistry & Biophysics , 382 :31 , 2000
PubMedID: 11051094
Gene_locus related to this paper: monfr-CUT1

Title : Isolation and characterization of juvenile hormone esterase from hemolymph of Lymantria dispar by affinity- and by anion-exchange chromatography - Nussbaumer_2000_Insect.Biochem.Mol.Biol_30_307
Author(s) : Nussbaumer C , Hinton AC , Schopf A , Stradner A , Hammock BD
Ref : Insect Biochemistry & Molecular Biology , 30 :307 , 2000
PubMedID: 10727897

Title : Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase - Draper_2000_Arch.Biochem.Biophys_376_199
Author(s) : Draper AJ , Hammock BD
Ref : Archives of Biochemistry & Biophysics , 376 :199 , 2000
PubMedID: 10729206

Title : Biochemical evidence for the involvement of tyrosine in epoxide activation during the catalytic cycle of epoxide hydrolase - Yamada_2000_J.Biol.Chem_275_23082
Author(s) : Yamada T , Morisseau C , Maxwell JE , Argiriadi MA , Christianson DW , Hammock BD
Ref : Journal of Biological Chemistry , 275 :23082 , 2000
PubMedID: 10806198

Title : Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation - Argiriadi_2000_J.Biol.Chem_275_15265
Author(s) : Argiriadi MA , Morisseau C , Goodrow MH , Dowdy DL , Hammock BD , Christianson DW
Ref : Journal of Biological Chemistry , 275 :15265 , 2000
PubMedID: 10747889

Title : Development of phase II xenobiotic metabolizing enzymes in differentiating murine clara cells - Fanucchi_2000_Toxicol.Appl.Pharmacol_168_253
Author(s) : Fanucchi MV , Buckpitt AR , Murphy ME , Storms DH , Hammock BD , Plopper CG
Ref : Toxicol Appl Pharmacol , 168 :253 , 2000
PubMedID: 11042098

Title : Toxicity of epoxy fatty acids and related compounds to cells expressing human soluble epoxide hydrolase - Greene_2000_Chem.Res.Toxicol_13_217
Author(s) : Greene JF , Newman JW , Williamson KC , Hammock BD
Ref : Chemical Research in Toxicology , 13 :217 , 2000
PubMedID: 10775319