References (1)

Title : A magnetic nanoprobe technology for detecting molecular interactions in live cells - Won_2005_Science_309_121
Author(s) : Won J , Kim M , Yi YW , Kim YH , Jung N , Kim TK
Ref : Science , 309 :121 , 2005
Abstract : Technologies to assess the molecular targets of biomolecules in living cells are lacking. We have developed a technology called magnetism-based interaction capture (MAGIC) that identifies molecular targets on the basis of induced movement of superparamagnetic nanoparticles inside living cells. Efficient intracellular uptake of superparamagnetic nanoparticles (coated with a small molecule of interest) was mediated by a transducible fusogenic peptide. These nanoprobes captured the small molecule's labeled target protein and were translocated in a direction specified by the magnetic field. Use of MAGIC in genome-wide expression screening identified multiple protein targets of a drug. MAGIC was also used to monitor signal-dependent modification and multiple interactions of proteins.
ESTHER : Won_2005_Science_309_121
PubMedSearch : Won_2005_Science_309_121
PubMedID: 15994554