van Helden HP

General

Full name : van Helden Herman PM

First name : Herman PM

Mail : NO Defence, Security and Safety, BU Biological and Chemical Protection, Rijswijk

Zip Code :

City :

Country : The Netherlands

Email : herman.vanhelden@tno.nl

Phone :

Fax :

Website :

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References (27)

Title : Timing of decontamination and treatment in case of percutaneous VX poisoning: A mini review - Joosen_2013_Chem.Biol.Interact_203_149
Author(s) : Joosen MJ , van der Schans MJ , Kuijpers WC , van Helden HP , Noort D
Ref : Chemico-Biological Interactions , 203 :149 , 2013
Abstract :
PubMedSearch : Joosen_2013_Chem.Biol.Interact_203_149
PubMedID: 23085122

Title : Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine? - Joosen_2011_Arch.Toxicol_85_227
Author(s) : Joosen MJ , Smit AB , van Helden HP
Ref : Archives of Toxicology , 85 :227 , 2011
Abstract :
PubMedSearch : Joosen_2011_Arch.Toxicol_85_227
PubMedID: 20842348

Title : Increasing oxime efficacy by blood-brain barrier modulation - Joosen_2011_Toxicol.Lett_206_67
Author(s) : Joosen MJ , van der Schans MJ , van Dijk CG , Kuijpers WC , Wortelboer HM , van Helden HP
Ref : Toxicol Lett , 206 :67 , 2011
Abstract :
PubMedSearch : Joosen_2011_Toxicol.Lett_206_67
PubMedID: 21600273

Title : Non-enzymatic pretreatment of nerve agent (soman) poisoning: a brief state-of-the-art review - van Helden_2011_Toxicol.Lett_206_35
Author(s) : van Helden HP , Joosen MJ , Philippens IH
Ref : Toxicol Lett , 206 :35 , 2011
Abstract :
PubMedSearch : van Helden_2011_Toxicol.Lett_206_35
PubMedID: 21554933

Title : Percutaneous exposure to the nerve agent VX: Efficacy of combined atropine, obidoxime and diazepam treatment - Joosen_2010_Chem.Biol.Interact_188_255
Author(s) : Joosen MJ , van der Schans MJ , van Helden HP
Ref : Chemico-Biological Interactions , 188 :255 , 2010
Abstract :
PubMedSearch : Joosen_2010_Chem.Biol.Interact_188_255
PubMedID: 20599844

Title : Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning - Joosen_2009_Neurotoxicol_30_72
Author(s) : Joosen MJ , Jousma E , van den Boom TM , Kuijpers WC , Smit AB , Lucassen PJ , van Helden HP
Ref : Neurotoxicology , 30 :72 , 2009
Abstract :
PubMedSearch : Joosen_2009_Neurotoxicol_30_72
PubMedID: 19100287

Title : Percutaneous exposure to VX: clinical signs, effects on brain acetylcholine levels and EEG - Joosen_2008_Neurochem.Res_33_308
Author(s) : Joosen MJ , van der Schans MJ , van Helden HP
Ref : Neurochem Res , 33 :308 , 2008
Abstract :
PubMedSearch : Joosen_2008_Neurochem.Res_33_308
PubMedID: 17940880

Title : Correlations between acetylcholinesterase inhibition, acetylcholine levels and EEG changes during perfusion with neostigmine and N6-cyclopentyladenosine in rat brain - Joosen_2007_Eur.J.Pharmacol_555_122
Author(s) : Joosen MJ , van Helden HP
Ref : European Journal of Pharmacology , 555 :122 , 2007
Abstract :
PubMedSearch : Joosen_2007_Eur.J.Pharmacol_555_122
PubMedID: 17113068

Title : Therapeutic efficacy in organophosphate poisoning by inhibiting central release of acetylcholine. -
Author(s) : Bueters TJ , Groen B , Harrison PK , Tattersall JE , Ijzerman AP , Danhof M , van Helden HP
Ref : Cholinergic Mechanisms, CRC Press :255 , 2004
PubMedID:

Title : Cardiovascular effects of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) decisive for its therapeutic efficacy in sarin poisoning - Joosen_2004_Arch.Toxicol_78_34
Author(s) : Joosen MJ , Bueters TJ , van Helden HP
Ref : Archives of Toxicology , 78 :34 , 2004
Abstract :
PubMedSearch : Joosen_2004_Arch.Toxicol_78_34
PubMedID: 14508639

Title : Low-level exposure of guinea pigs and marmosets to sarin vapour in air: lowest-observable-adverse-effect level (LOAEL) for miosis - van Helden_2004_J.Appl.Toxicol_24_59
Author(s) : van Helden HP , Trap HC , Kuijpers WC , Oostdijk JP , Benschop HP , Langenberg JP
Ref : J Appl Toxicol , 24 :59 , 2004
Abstract :
PubMedSearch : van Helden_2004_J.Appl.Toxicol_24_59
PubMedID: 14745848

Title : Protection of rats against perfluoroisobutene (PFIB)-induced pulmonary edema by curosurf and N-acetylcysteine - van Helden_2004_Inhal.Toxicol_16_549
Author(s) : van Helden HP , van de Meent D , Oostdijk JP , Joosen MJ , van Esch JH , Hammer AH , Diemel RV
Ref : Inhal Toxicol , 16 :549 , 2004
Abstract :
PubMedSearch : van Helden_2004_Inhal.Toxicol_16_549
PubMedID: 15204746

Title : Partial adenosine A(1) receptor agonists inhibit sarin-induced epileptiform activity in the hippocampal slice - Harrison_2003_Eur.J.Pharmacol_471_97
Author(s) : Harrison PK , Bueters TJ , Ijzerman AP , van Helden HP , Tattersall JE
Ref : European Journal of Pharmacology , 471 :97 , 2003
Abstract :
PubMedSearch : Harrison_2003_Eur.J.Pharmacol_471_97
PubMedID: 12818696

Title : Long-term, low-level exposure of guinea pigs and marmosets to sarin vapor in air: lowest observable effect level - Van Helden_2003_Toxicol.Appl.Pharmacol_189_170
Author(s) : van Helden HP , Trap HC , Oostdijk JP , Kuijpers WC , Langenberg JP , Benschop HP
Ref : Toxicol Appl Pharmacol , 189 :170 , 2003
Abstract :
PubMedSearch : Van Helden_2003_Toxicol.Appl.Pharmacol_189_170
PubMedID: 12791302

Title : Adenosine A1 receptor agonist N6-cyclopentyladenosine affects the inactivation of acetylcholinesterase in blood and brain by sarin - Bueters_2003_J.Pharmacol.Exp.Ther_304_1307
Author(s) : Bueters TJ , Joosen MJ , van Helden HP , Ijzerman AP , Danhof M
Ref : Journal of Pharmacology & Experimental Therapeutics , 304 :1307 , 2003
Abstract :
PubMedSearch : Bueters_2003_J.Pharmacol.Exp.Ther_304_1307
PubMedID: 12604711

Title : Therapeutic efficacy of the adenosine A(1) receptor agonist N(6)- cyclopentyladenosine (CPA) against organophosphate intoxication - Bueters_2002_Arch.Toxicol_76_650
Author(s) : Bueters TJ , Groen B , Danhof M , AP IJ , van Helden HP
Ref : Archives of Toxicology , 76 :650 , 2002
Abstract :
PubMedSearch : Bueters_2002_Arch.Toxicol_76_650
PubMedID: 12415428

Title : Inhalation toxicokinetics of soman stereoisomers in the atropinized guinea pig with nose-only exposure to soman vapor - Langenberg_1998_Toxicol.Appl.Pharmacol_151_79
Author(s) : Langenberg JP , Spruit HE , van der Wiel HJ , Trap HC , Helmich RB , Bergers WW , van Helden HP , Benschop HP
Ref : Toxicol Appl Pharmacol , 151 :79 , 1998
Abstract :
PubMedSearch : Langenberg_1998_Toxicol.Appl.Pharmacol_151_79
PubMedID: 9705889

Title : Effects of low doses of cholinesterase inhibitors on behavioral performance of robot-tested marmosets - Wolthuis_1995_Pharmacol.Biochem.Behav_51_443
Author(s) : Wolthuis OL , Groen B , Busker RW , van Helden HP
Ref : Pharmacology, Biochemistry & Behavior , 51 :443 , 1995
Abstract :
PubMedSearch : Wolthuis_1995_Pharmacol.Biochem.Behav_51_443
PubMedID: 7667367

Title : Comparison of the therapeutic effects and pharmacokinetics of HI-6, HLo-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats - van Helden_1994_Arch.Toxicol_68_224
Author(s) : van Helden HP , van der Wiel HJ , Zijlstra JJ , Melchers BP , Busker RW
Ref : Archives of Toxicology , 68 :224 , 1994
Abstract :
PubMedSearch : van Helden_1994_Arch.Toxicol_68_224
PubMedID: 8067894

Title : The functional role of molecular forms of acetylcholinesterase in neuromuscular transmission - Busker_1994_Neurochem.Res_19_713
Author(s) : Busker RW , Zijlstra JJ , van der Wiel HJ , van Helden HP
Ref : Neurochemical Research , 19 :713 , 1994
Abstract :
PubMedSearch : Busker_1994_Neurochem.Res_19_713
PubMedID: 8065529

Title : Search for a therapy against soman-intoxication. - Wolthuis_1994_Neurosci.Biobehav.Rev_18_469
Author(s) : Wolthuis OL , van Helden HP , Melchers BP , Busker RW , de Groot DM
Ref : Neurosci Biobehav Rev , 18 :469 , 1994
Abstract :
PubMedSearch : Wolthuis_1994_Neurosci.Biobehav.Rev_18_469
PubMedID: 7708361

Title : Non-reactivating effects of HI-6 on hippocampal neurotransmission - Melchers_1994_Arch.Toxicol_69_118
Author(s) : Melchers BP , van der Laaken AL , Busker RW , Bruijnzeel PL , van Helden HP
Ref : Archives of Toxicology , 69 :118 , 1994
Abstract :
PubMedSearch : Melchers_1994_Arch.Toxicol_69_118
PubMedID: 7717860

Title : Therapeutic efficacy of HI-6 in soman-poisoned marmoset monkeys - van Helden_1992_Toxicol.Appl.Pharmacol_115_50
Author(s) : van Helden HP , van der Wiel HJ , de Lange J , Busker RW , Melchers BP , Wolthuis OL
Ref : Toxicol Appl Pharmacol , 115 :50 , 1992
Abstract :
PubMedSearch : van Helden_1992_Toxicol.Appl.Pharmacol_115_50
PubMedID: 1631893

Title : Organophosphate poisoning: a method to test therapeutic effects of oximes other than acetylcholinesterase reactivation in the rat - Busker_1991_Toxicology_69_331
Author(s) : Busker RW , Zijlstra JJ , van der Wiel HJ , Melchers BP , van Helden HP
Ref : Toxicology , 69 :331 , 1991
Abstract :
PubMedSearch : Busker_1991_Toxicology_69_331
PubMedID: 1658986

Title : On the existence of a Soman depot -
Author(s) : van Helden HP , Berends F , Wolthuis OL , Benschop HP
Ref : In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases , (Brzin M, Barnard EA, Sket D, Eds) De Gruyter :375 , 1984
PubMedID:

Title : New simulators in the prophylaxis against soman poisoning: structural specificity for the depot site(s) - Van Helden_1984_J.Pharm.Pharmacol_36_305
Author(s) : van Helden HP , Benschop HP , Wolthuis OL
Ref : J Pharm Pharmacol , 36 :305 , 1984
Abstract :
PubMedSearch : Van Helden_1984_J.Pharm.Pharmacol_36_305
PubMedID: 6145765

Title : Therapy of organophosphate poisoning: the marmoset as a model for man - van Helden_1983_Br.J.Pharmacol_78_579
Author(s) : van Helden HP , van der Wiel HJ , Wolthuis OL
Ref : British Journal of Pharmacology , 78 :579 , 1983
Abstract :
PubMedSearch : van Helden_1983_Br.J.Pharmacol_78_579
PubMedID: 6301602