Choline-Alfoscerate
It is one of the major osmolyte in the renal medullary cells. It has a role as a parasympatholytic, a neuroprotective agent, a human mouse, Saccharomyces cerevisiae, Escherichia coli metabolite. It is a member of sn-glycerol 3-phosphates and a member of phosphocholines. human-PLA2G15 hydrolyzed lysophosphatidylcholine (lysoPC), a proatherogenic lipid, to glycerophosphorylcholine and a free fatty acid
General
Type : Choline ester
Chemical_Nomenclature : [(2R)-2,3-dihydroxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
Canonical SMILES : C[N+](C)(C)CCOP(=O)([O-])OCC(CO)O
InChI : InChI=1S\/C8H20NO6P\/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10\/h8,10-11H,4-7H2,1-3H3\/t8-\/m1\/s1
InChIKey : SUHOQUVVVLNYQR-MRVPVSSYSA-N
Other name(s) : Choline Alfoscerate || SN-glycero-3-phosphocholine || Choline glycerophosphate || Glycerophosphocholine || Choline Alphoscerate || Choline Glycerophosphate || Glycerol 3 Phosphocholine || Glycerol 3-Phosphocholine || Glycerophosphate, Choline || Glycerophosphorylcholine || Glycerylphosphorylcholine || L alpha Glycerylphosphorylcholine || L-alpha-Glycerylphosphorylcholine || GroPCho || Alpha-GPC
MW :
Formula : C8H20NO6P
CAS_number : 28319-77-9
PubChem : 657272
UniChem : SUHOQUVVVLNYQR-MRVPVSSYSA-N
Wikipedia : Alpha-GPC
Target
Families : No family
Protein : No protein
References (22)
| Title : Association Between the Cholinesterase Inhibitor Donepezil and the Cholinergic Precursor Choline Alphoscerate in the Treatment of Depression in Patients with Alzheimer's Disease - Carotenuto_2022_J.Alzheimers.Dis.Rep_6_235 |
| Author(s) : Carotenuto A , Fasanaro AM , Manzo V , Amenta F , Traini E |
| Ref : J Alzheimers Dis Rep , 6 :235 , 2022 |
| Abstract : Carotenuto_2022_J.Alzheimers.Dis.Rep_6_235 |
| ESTHER : Carotenuto_2022_J.Alzheimers.Dis.Rep_6_235 |
| PubMedSearch : Carotenuto_2022_J.Alzheimers.Dis.Rep_6_235 |
| PubMedID: 35719710 |
| Title : Decrease of an intracellular organic osmolyte contributes to the cytotoxicity of organophosphate in neuroblastoma cells in vitro - Wang_2021_Toxicology__152725 |
| Author(s) : Wang P , Wu YJ , Sun ML |
| Ref : Toxicology , :152725 , 2021 |
| Abstract : Wang_2021_Toxicology__152725 |
| ESTHER : Wang_2021_Toxicology__152725 |
| PubMedSearch : Wang_2021_Toxicology__152725 |
| PubMedID: 33617914 |
| Title : Lipase-catalyzed Synthesis of Oleoyl-lysophosphatidylcholine by Direct Esterification in Solvent-free Medium without Water Removal - Mnasri_2017_J.Oleo.Sci_66_1009 |
| Author(s) : Mnasri T , Ergan F , Herault J , Pencreac'h G |
| Ref : J Oleo Sci , 66 :1009 , 2017 |
| Abstract : Mnasri_2017_J.Oleo.Sci_66_1009 |
| ESTHER : Mnasri_2017_J.Oleo.Sci_66_1009 |
| PubMedSearch : Mnasri_2017_J.Oleo.Sci_66_1009 |
| PubMedID: 28794312 |
| Title : Cerebrovascular and blood-brain barrier morphology in spontaneously hypertensive rats: effect of treatment with choline alphoscerate - Tayebati_2015_CNS.Neurol.Disord.Drug.Targets_14_421 |
| Author(s) : Tayebati SK , Amenta F , Tomassoni D |
| Ref : CNS Neurol Disord Drug Targets , 14 :421 , 2015 |
| Abstract : Tayebati_2015_CNS.Neurol.Disord.Drug.Targets_14_421 |
| ESTHER : Tayebati_2015_CNS.Neurol.Disord.Drug.Targets_14_421 |
| PubMedSearch : Tayebati_2015_CNS.Neurol.Disord.Drug.Targets_14_421 |
| PubMedID: 25714975 |
| Title : The ASCOMALVA (Association between the Cholinesterase Inhibitor Donepezil and the Cholinergic Precursor Choline Alphoscerate in Alzheimer's Disease) Trial: Interim Results after Two Years of Treatment - Amenta_2014_J.Alzheimers.Dis_42_S281 |
| Author(s) : Amenta F , Carotenuto A , Fasanaro AM , Rea R , Traini E |
| Ref : J Alzheimers Dis , 42 :S281 , 2014 |
| Abstract : Amenta_2014_J.Alzheimers.Dis_42_S281 |
| ESTHER : Amenta_2014_J.Alzheimers.Dis_42_S281 |
| PubMedSearch : Amenta_2014_J.Alzheimers.Dis_42_S281 |
| PubMedID: 24898643 |
| Title : Revisiting choline alphoscerate profile: a new, perspective, role in dementia? - Scapicchio_2013_Int.J.Neurosci_123_444 |
| Author(s) : Scapicchio PL |
| Ref : International Journal of Neuroscience , 123 :444 , 2013 |
| Abstract : Scapicchio_2013_Int.J.Neurosci_123_444 |
| ESTHER : Scapicchio_2013_Int.J.Neurosci_123_444 |
| PubMedSearch : Scapicchio_2013_Int.J.Neurosci_123_444 |
| PubMedID: 23387341 |
| Title : Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipid with a still interesting profile as cognition enhancing agent - Traini_2013_Curr.Alzheimer.Res_10_1070 |
| Author(s) : Traini E , Bramanti V , Amenta F |
| Ref : Curr Alzheimer Res , 10 :1070 , 2013 |
| Abstract : Traini_2013_Curr.Alzheimer.Res_10_1070 |
| ESTHER : Traini_2013_Curr.Alzheimer.Res_10_1070 |
| PubMedSearch : Traini_2013_Curr.Alzheimer.Res_10_1070 |
| PubMedID: 24156263 |
| Title : The ASCOMALVA trial: Association between the cholinesterase inhibitor donepezil and the cholinergic precursor choline alphoscerate in Alzheimer's disease with cerebrovascular injury: Interim results - Amenta_2012_J.Neurol.Sci_322_96 |
| Author(s) : Amenta F , Carotenuto A , Fasanaro AM , Rea R , Traini E |
| Ref : Journal of Neurology Sci , 322 :96 , 2012 |
| Abstract : Amenta_2012_J.Neurol.Sci_322_96 |
| ESTHER : Amenta_2012_J.Neurol.Sci_322_96 |
| PubMedSearch : Amenta_2012_J.Neurol.Sci_322_96 |
| PubMedID: 22959283 |
| Title : Neuroprotective effect of treatment with galantamine and choline alphoscerate on brain microanatomy in spontaneously hypertensive rats - Tayebati_2009_J.Neurol.Sci_283_187 |
| Author(s) : Tayebati SK , Di Tullio MA , Tomassoni D , Amenta F |
| Ref : Journal of Neurology Sci , 283 :187 , 2009 |
| Abstract : Tayebati_2009_J.Neurol.Sci_283_187 |
| ESTHER : Tayebati_2009_J.Neurol.Sci_283_187 |
| PubMedSearch : Tayebati_2009_J.Neurol.Sci_283_187 |
| PubMedID: 19304299 |
| Title : Analysis of the effect of the polyprenol preparation ropren and the choline alphoscerate preparation gliatilin on the membrane-bound and soluble forms of cholinesterases and monoamine oxidase of rat brain and serum in the tetrachloromethane model system of hepatic encephalopathy - |
| Author(s) : Sviderskii VL , Sultanov VS , Roshchin VI , Khovanskikh AE , Rozengart EV , Moralev SN , Yagodina OV , Gorelkina VS , Kormilitsyn BN , Basova IN , Nikitina TV |
| Ref : Dokl Biochem Biophys , 412 :33 , 2007 |
| PubMedID: 17506350 |
| Title : Association with the cholinergic precursor choline alphoscerate and the cholinesterase inhibitor rivastigmine: an approach for enhancing cholinergic neurotransmission - Amenta_2006_Mech.Ageing.Dev_127_173 |
| Author(s) : Amenta F , Tayebati SK , Vitali D , Di Tullio MA |
| Ref : Mech Ageing Dev , 127 :173 , 2006 |
| Abstract : Amenta_2006_Mech.Ageing.Dev_127_173 |
| ESTHER : Amenta_2006_Mech.Ageing.Dev_127_173 |
| PubMedSearch : Amenta_2006_Mech.Ageing.Dev_127_173 |
| PubMedID: 16297435 |
| Title : Neuropathy target esterase catalyzes osmoprotective renal synthesis of glycerophosphocholine in response to high NaCl - Gallazzini_2006_Proc.Natl.Acad.Sci.U.S.A_103_15260 |
| Author(s) : Gallazzini M , Ferraris JD , Kunin M , Morris RG , Burg MB |
| Ref : Proc Natl Acad Sci U S A , 103 :15260 , 2006 |
| Abstract : Gallazzini_2006_Proc.Natl.Acad.Sci.U.S.A_103_15260 |
| ESTHER : Gallazzini_2006_Proc.Natl.Acad.Sci.U.S.A_103_15260 |
| PubMedSearch : Gallazzini_2006_Proc.Natl.Acad.Sci.U.S.A_103_15260 |
| PubMedID: 17015841 |
| Title : Neuropathy target esterase and phospholipid deacylation - Glynn_2005_Biochim.Biophys.Acta_1736_87 |
| Author(s) : Glynn P |
| Ref : Biochimica & Biophysica Acta , 1736 :87 , 2005 |
| Abstract : Glynn_2005_Biochim.Biophys.Acta_1736_87 |
| ESTHER : Glynn_2005_Biochim.Biophys.Acta_1736_87 |
| PubMedSearch : Glynn_2005_Biochim.Biophys.Acta_1736_87 |
| PubMedID: 16137924 |
| Title : Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients - Walter_2004_Neurobiol.Aging_25_1299 |
| Author(s) : Walter A , Korth U , Hilgert M , Hartmann J , Weichel O , Fassbender K , Schmitt A , Klein J |
| Ref : Neurobiology of Aging , 25 :1299 , 2004 |
| Abstract : Walter_2004_Neurobiol.Aging_25_1299 |
| ESTHER : Walter_2004_Neurobiol.Aging_25_1299 |
| PubMedSearch : Walter_2004_Neurobiol.Aging_25_1299 |
| PubMedID: 15465626 |
| Title : Neuropathy target esterase and its yeast homologue degrade phosphatidylcholine to glycerophosphocholine in living cells - Zaccheo_2004_J.Biol.Chem_279_24024 |
| Author(s) : Zaccheo O , Dinsdale D , Meacock PA , Glynn P |
| Ref : Journal of Biological Chemistry , 279 :24024 , 2004 |
| Abstract : Zaccheo_2004_J.Biol.Chem_279_24024 |
| ESTHER : Zaccheo_2004_J.Biol.Chem_279_24024 |
| PubMedSearch : Zaccheo_2004_J.Biol.Chem_279_24024 |
| PubMedID: 15044461 |
| Title : Prolonged treatment with glycerophosphocholine, an acetylcholine precursor, does not disclose the potentiating effect of cholinesterase inhibitors on GHRH-induced somatotroph secretion in anorexia nervosa - Fassino_2003_J.Endocrinol.Invest_26_503 |
| Author(s) : Fassino S , Lanfranco F , Abbate Daga G , Mondelli V , Destefanis S , Rovera GG , Camanni F , Ghigo E , Arvat E , Gianotti L |
| Ref : J Endocrinol Invest , 26 :503 , 2003 |
| Abstract : Fassino_2003_J.Endocrinol.Invest_26_503 |
| ESTHER : Fassino_2003_J.Endocrinol.Invest_26_503 |
| PubMedSearch : Fassino_2003_J.Endocrinol.Invest_26_503 |
| PubMedID: 12952362 |
| Title : Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase - Taniyama_1999_Biochem.Biophys.Res.Commun_257_50 |
| Author(s) : Taniyama Y , Shibata S , Kita S , Horikoshi K , Shirafuji H , Sumino Y , Fujino M , Fuse H |
| Ref : Biochemical & Biophysical Research Communications , 257 :50 , 1999 |
| Abstract : Taniyama_1999_Biochem.Biophys.Res.Commun_257_50 |
| ESTHER : Taniyama_1999_Biochem.Biophys.Res.Commun_257_50 |
| PubMedSearch : Taniyama_1999_Biochem.Biophys.Res.Commun_257_50 |
| PubMedID: 10092508 |
| Gene_locus related to this paper: human-PLA2G15 |
| Title : Ectopic epididymal expression of guinea pig intestinal phospholipase B. Possible role in sperm maturation and activation by limited proteolytic digestion - Delagebeaudeuf_1998_J.Biol.Chem_273_13407 |
| Author(s) : Delagebeaudeuf C , Gassama-Diagne A , Nauze M , Ragab A , Li RY , Capdevielle J , Ferrara P , Fauvel J , Chap H |
| Ref : Journal of Biological Chemistry , 273 :13407 , 1998 |
| Abstract : Delagebeaudeuf_1998_J.Biol.Chem_273_13407 |
| ESTHER : Delagebeaudeuf_1998_J.Biol.Chem_273_13407 |
| PubMedSearch : Delagebeaudeuf_1998_J.Biol.Chem_273_13407 |
| PubMedID: 9593672 |
| Title : Choline acetyltransferase and acetylcholinesterase in the hippocampus of aged rats: sensitivity to choline alphoscerate treatment - Amenta_1994_Mech.Ageing.Dev_74_47 |
| Author(s) : Amenta F , Bronzetti E , Mancini M , Vega JA , Zaccheo D |
| Ref : Mech Ageing Dev , 74 :47 , 1994 |
| Abstract : Amenta_1994_Mech.Ageing.Dev_74_47 |
| ESTHER : Amenta_1994_Mech.Ageing.Dev_74_47 |
| PubMedSearch : Amenta_1994_Mech.Ageing.Dev_74_47 |
| PubMedID: 7934207 |
| Title : Cholinergic neurotransmission in the hippocampus of aged rats: influence of L-alpha-glycerylphosphorylcholine treatment - Amenta_1993_Ann.N.Y.Acad.Sci_695_311 |
| Author(s) : Amenta F , Franch F , Ricci A , Vega JA |
| Ref : Annals of the New York Academy of Sciences , 695 :311 , 1993 |
| Abstract : Amenta_1993_Ann.N.Y.Acad.Sci_695_311 |
| ESTHER : Amenta_1993_Ann.N.Y.Acad.Sci_695_311 |
| PubMedSearch : Amenta_1993_Ann.N.Y.Acad.Sci_695_311 |
| PubMedID: 8239302 |
| Title : Effect of ipsilateral lesioning of the nucleus basalis magnocellularis and of L-alpha-glyceryl phosphorylcholine treatment on choline acetyltransferase and acetylcholinesterase in the rat fronto-parietal cortex - Bronzetti_1993_Neurosci.Lett_164_47 |
| Author(s) : Bronzetti E , Felici L , Amenta F |
| Ref : Neuroscience Letters , 164 :47 , 1993 |
| Abstract : Bronzetti_1993_Neurosci.Lett_164_47 |
| ESTHER : Bronzetti_1993_Neurosci.Lett_164_47 |
| PubMedSearch : Bronzetti_1993_Neurosci.Lett_164_47 |
| PubMedID: 8152614 |