human-PLA2G15
Homo sapiens (Human) Group XV phospholipase A2 lcat-like lysophospholipase (llpl) (unq341/pro540)
Comment
Hypothetical protein FLJ90347 HGNC:17163\; LYPLA3
Relationship
Family : PC-sterol_acyltransferase
Block : L
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMolecular evidence
No mutation
4X90 - Crystal structure of Lysosomal Phospholipase A2
4X91 - Crystal structure of Lysosomal Phospholipase A2 in complex with Isopropyl dodec-11-enylfluorophosphonate (IDFP)
4X92 - Crystal structure of Lysosomal Phospholipase A2-S165A
4X93 - Crystal structure of Lysosomal Phospholipase A2 crystallized in the presence of methyl arachidonyl fluorophosphonate (tetragonal form)
4X94 - Crystal structure of Lysosomal Phospholipase A2 crystallized in the presence of methyl arachidonyl fluorophosphonate (hexagonal form)
4X95 - Crystal structure of fully glycosylated Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)
4X97 - Crystal structure of human Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)
6MTW - Crystal structure of Lysosomal Phospholipase A2 in complex with Zinc
No kinetic
No disease
No substrate
Sequence
Peptide
MGLHLRPYRV GLLPDGLLFL LLLLMLLADP ALPAGRHPPV VLVPGDLGNQ LEAKLDKPTV VHYLCSKKTE SYFTIWLNLE LLLPVIIDCW IDNIRLVYNK TSRATQFPDG VDVRVPGFGK TFSLEFLDPS KSSVGSYFHT MVESLVGWGY TRGEDVRGAP YDWRRAPNEN GPYFLALREM IEEMYQLYGG PVVLVAHSMG NMYTLYFLQR QPQAWKDKYI RAFVSLGAPW GGVAKTLRVL ASGDNNRIPV IGPLKIREQQ RSAVSTSWLL PYNYTWSPEK VFVQTPTINY TLRDYRKFFQ DIGFEDGWLM RQDTEGLVEA TMPPGVQLHC LYGTGVPTPD SFYYESFPDR DPKICFGDGD GTVNLKSALQ CQAWQSRQEH QVLLQELPGS EHIEMLANAT TLAYLKRVLL GP
References (10)
| Title : Lysosomal phospholipase A2 contributes to the biosynthesis of the atypical late endosome lipid bis(monoacylglycero)phosphate - Chen_2023_Commun.Biol_6_210 |
| Author(s) : Chen J , Cazenave-Gassiot A , Xu Y , Piroli P , Hwang R, Jr. , DeFreitas L , Chan RB , Di Paolo G , Nandakumar R , Wenk MR , Marquer C |
| Ref : Commun Biol , 6 :210 , 2023 |
| Abstract : |
| PubMedSearch : Chen_2023_Commun.Biol_6_210 |
| PubMedID: 36823305 |
| Gene_locus related to this paper: human-PLA2G15 |
| Title : Lysosomal phospholipase A2 - Shayman_2019_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1864_932 |
| Author(s) : Shayman JA , Tesmer JJG |
| Ref : Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids , 1864 :932 , 2019 |
| Abstract : |
| PubMedSearch : Shayman_2019_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1864_932 |
| PubMedID: 30077006 |
| Gene_locus related to this paper: human-PLA2G15 |
| Title : Structural Basis of Lysosomal Phospholipase A2 Inhibition by Zn(2) - Bouley_2019_Biochemistry_58_1709 |
| Author(s) : Bouley RA , Hinkovska-Galcheva V , Shayman JA , Tesmer JJG |
| Ref : Biochemistry , 58 :1709 , 2019 |
| Abstract : |
| PubMedSearch : Bouley_2019_Biochemistry_58_1709 |
| PubMedID: 30830753 |
| Gene_locus related to this paper: human-PLA2G15 |
| Title : Group XV phospholipase A, a lysosomal phospholipase A - Shayman_2011_Prog.Lipid.Res_50_1 |
| Author(s) : Shayman JA , Kelly R , Kollmeyer J , He Y , Abe A |
| Ref : Prog Lipid Res , 50 :1 , 2011 |
| Abstract : |
| PubMedSearch : Shayman_2011_Prog.Lipid.Res_50_1 |
| PubMedID: 21074554 |
| Gene_locus related to this paper: human-PLA2G15 |
| Title : Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention - |
| Author(s) : Dennis EA , Cao J , Hsu YH , Magrioti V , Kokotos G |
| Ref : Chem Rev , 111 :6130 , 2011 |
| PubMedID: 21910409 |
| Gene_locus related to this paper: human-PLA2G15 |
| Title : Signal peptide prediction based on analysis of experimentally verified cleavage sites - Zhang_2004_Protein.Sci_13_2819 |
| Author(s) : Zhang Z , Henzel WJ |
| Ref : Protein Science , 13 :2819 , 2004 |
| Abstract : |
| PubMedSearch : Zhang_2004_Protein.Sci_13_2819 |
| PubMedID: 15340161 |
| Gene_locus related to this paper: human-PLA2G15 , human-SCPEP1 |
| Title : Cloning and characterization of a lysosomal phospholipase A2, 1-O-acylceramide synthase - Hiraoka_2002_J.Biol.Chem_277_10090 |
| Author(s) : Hiraoka M , Abe A , Shayman JA |
| Ref : Journal of Biological Chemistry , 277 :10090 , 2002 |
| Abstract : |
| PubMedSearch : Hiraoka_2002_J.Biol.Chem_277_10090 |
| PubMedID: 11790796 |
| Gene_locus related to this paper: bovin-LPLA2 , canfa-q6xpz3 , human-PLA2G15 , mouse-C87498 |
| Title : Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase - Taniyama_1999_Biochem.Biophys.Res.Commun_257_50 |
| Author(s) : Taniyama Y , Shibata S , Kita S , Horikoshi K , Shirafuji H , Sumino Y , Fujino M , Fuse H |
| Ref : Biochemical & Biophysical Research Communications , 257 :50 , 1999 |
| Abstract : |
| PubMedSearch : Taniyama_1999_Biochem.Biophys.Res.Commun_257_50 |
| PubMedID: 10092508 |
| Gene_locus related to this paper: human-PLA2G15 |
| Title : Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library - Suzuki_1997_Gene_200_149 |
| Author(s) : Suzuki Y , Yoshitomo-Nakagawa K , Maruyama K , Suyama A , Sugano S |
| Ref : Gene , 200 :149 , 1997 |
| Abstract : |
| PubMedSearch : Suzuki_1997_Gene_200_149 |
| PubMedID: 9373149 |
| Gene_locus related to this paper: human-ACOT2 , human-LIPF , human-LPL , human-PLA1A , human-PLA2G15 |
| Title : Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides - Maruyama_1994_Gene_138_171 |
| Author(s) : Maruyama K , Sugano S |
| Ref : Gene , 138 :171 , 1994 |
| Abstract : |
| PubMedSearch : Maruyama_1994_Gene_138_171 |
| PubMedID: 8125298 |
| Gene_locus related to this paper: human-ACOT2 , human-LIPF , human-LPL , human-PLA1A , human-PLA2G15 |