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H94

Potent piperidinylpyrazolopyridine activator of LCAT Kobayashi H, Ohkawa N, Takano M, Kubota H, Onoda T, Kaneko T, Arai M, Terasaka N, inventors. Piperidinylpyrazolopyridine derivative. 9150575. United States Patent. 2015a, Onoda T, Kaneko T, Arai M, Kobayashi H, Terasaka N, inventors. Imidazopyridine Derivative. 2015087996. World Intellectual Property Organization. 2015

General

Type : Trifluoro, Cyanide, Pyridine, Piperidine, Pyrazole

Chemical_Nomenclature : 6-{4-[(4R)-4-hydroxy-6-oxo-4-(trifluoromethyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridin-3-yl]piperidin-1-yl}-4-(trifluoromethyl)pyridine-3-carbonitrile

Canonical SMILES : C1CN(CCC1C2=C3C(=NN2)NC(=O)CC3(C(F)(F)F)O)C4=NC=C(C(=C4)C(F)(F)F)C#N

InChI : InChI=1S\/C19H16F6N6O2\/c20-18(21,22)11-5-12(27-8-10(11)7-26)31-3-1-9(2-4-31)15-14-16(30-29-15)28-13(32)6-17(14,33)19(23,24)25\/h5,8-9,33H,1-4,6H2,(H2,28,29,30,32)\/t17-\/m1\/s1

InChIKey : VTEXGUOJJDWHCA-QGZVFWFLSA-N

Other name(s) :

MW : 474.4

Formula : C19H16F6N6O2

CAS_number :

PubChem : 135567417

UniChem : VTEXGUOJJDWHCA-QGZVFWFLSA-N

Target

Families : PC-sterol_acyltransferase

Protein : human-LCAT

References (1)

Title : Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol - Manthei_2018_Elife_7_
Author(s) : Manthei KA , Yang SM , Baljinnyam B , Chang L , Glukhova A , Yuan W , Freeman LA , Maloney DJ , Schwendeman A , Remaley AT , Jadhav A , Tesmer JJ
Ref : Elife , 7 : , 2018
Abstract :
PubMedSearch : Manthei_2018_Elife_7_
PubMedID: 30479275
Gene_locus related to this paper: human-LCAT